{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:25:05Z","timestamp":1777476305732,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can Assoc Radiol J"],"published-print":{"date-parts":[[2016,5]]},"abstract":"\n Purpose<\/jats:title>\n \n The objectives of this study were: 1) to determine the accuracy of dual-phase\n 99m<\/jats:sup>\n Tc -methoxyisobutylisonitrile (MIBI) with single-photon emission computed tomography\/computed tomography (SPECT\/CT) for the preoperative localization of parathyroid adenomas in the setting of primary hyperparathyroidism; 2) to determine the accuracy of localization for ectopic glands; and 3) to assess the relationship between accuracy and serum parathyroid hormone (PTH) levels.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Eighty-eight patients who underwent\n 99m<\/jats:sup>\n Tc-MIBI SPECT\/CT imaging for primary hyperparathyroidism at our institution over a 27-month period were retrospectively assessed. The preoperative SPECT\/CT results were compared to intraoperative findings (within 1 year of imaging). The relationship between serum PTH level (within 3 months) and SPECT\/CT accuracy was then evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Accuracy indices for the retrothyroid subgroup were sensitivity 86.7%, specificity 96.4%, positive predictive value 98.1%, negative predictive value 77.1%, and accuracy 89.8%. Accuracy indices for ectopic parathyroid adenomas were sensitivity 81.5%, specificity 100%, positive predictive value 100%, negative predictive value 92.4%, and accuracy 94.3%. For the overall group, SPECT\/CT demonstrated a sensitivity of 85.1% and a PPV of 98.7%. SPECT\/CT correctly identified the abnormal parathyroid gland in 60% of patients with a normal serum PTH (<6.9 pmol\/L), 73% between 6.9-9.9 pmol\/L, 86% between 10.0-14.9 pmol\/L, 100% between 15.0-19.9 pmol\/L, 88% between 20.0-24.5 pmol\/L, and 100% of patients with a PTH greater than 25.0 pmol\/L.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Dual-phase\n 99m<\/jats:sup>\n Tc- MIBI with SPECT\/CT is an accurate and reliable means to correctly localize both retrothyroid and ectopic parathyroid adenomas for the purpose of surgical planning. The accuracy of SPECT\/CT increases with increasing serum PTH levels.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1016\/j.carj.2015.06.002","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T13:29:39Z","timestamp":1450186179000},"page":"115-121","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Accuracy of Dual Phase Single-Photon Emission Computed Tomography\/Computed Tomography in Primary Hyperparathyroidism: Correlation with Serum Parathyroid Hormone Levels"],"prefix":"10.1177","volume":"67","author":[{"given":"Wade","family":"Koberstein","sequence":"first","affiliation":[{"name":"Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristy","family":"Romaniuk","sequence":"additional","affiliation":[{"name":"Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan T.","family":"Abele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,5,1]]},"reference":[{"key":"bibr1-j.carj.2015.06.002","first-page":"193","volume":"33","author":"Shas S.","year":"2008","journal-title":"Minerva Endocrinol"},{"key":"bibr2-j.carj.2015.06.002","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.110.085522"},{"key":"bibr3-j.carj.2015.06.002","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/251410"},{"key":"bibr4-j.carj.2015.06.002","first-page":"1443","volume":"44","author":"Mariani 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