{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:29:08Z","timestamp":1777476548791,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Direction g\u00e9n\u00e9rale de sant\u00e9 publique"},{"name":"Direction g\u00e9n\u00e9rale de canc\u00e9rologie"},{"name":"Quebec Ministry of Health"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can Assoc Radiol J"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To examine the relation between breast cancer location and screening mammogram sensitivity, and assess whether this association is modified by body mass index (BMI) or breast density.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study is based on all interval cancers (n = 481) and a random sample of screen-detected cancers (n = 481) diagnosed in Quebec Breast Cancer Screening Program participants in 2007. Film-screening mammograms, diagnostic mammograms, and ultrasound reports (when available) were requested for these cases. The breast cancer was then localised in mediolateral oblique (MLO) and craniocaudal (CC) projections of the breast by 1 experienced radiologist. The association between cancer location and screening sensitivity was assessed by logistic regression. Adjusted sensitivity and sensitivity ratios were obtained by marginal standardisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 369 screen-detected and 268 interval cancers could be localised in MLO and\/or CC projections. The 2-year sensitivity reached 68%. Overall, sensitivity was not statistically associated with location of the cancer. However, sensitivity seems lower in MLO posterior inferior area for women with BMI \u2265 25 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      compared to sensitivity in central area for women with lower BMI (adjusted sensitivity ratio: 0.58, 95% confidence interval [CI]: 0.17\u20130.98). Lower sensitivity was also observed in subareolar areas for women with breast density \u2265 50% compared to the central areas for women with lower breast density (for MLO and CC projections, adjusted sensitivity ratio and 95% CI of, respectively, 0.54 [0.13\u20130.96] and 0.46 [0.01\u20130.93]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Screening sensitivity seems lower in MLO posterior inferior area in women with higher BMI and in subareolar areas in women with higher breast density. When interpreting screening mammograms, radiologists need to pay special attention to these areas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.carj.2018.10.007","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T22:39:38Z","timestamp":1551998378000},"page":"186-192","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Screening Sensitivity According to Breast Cancer Location"],"prefix":"10.1177","volume":"70","author":[{"given":"Isabelle","family":"Th\u00e9berge","sequence":"first","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec, Quebec City, Qu\u00e9bec, Canada"},{"name":"D\u00e9partement de m\u00e9decine sociale et pr\u00e9ventive, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval, Quebec City, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Guertin","sequence":"additional","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec, Quebec City, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Vandal","sequence":"additional","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec, Quebec City, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Centre hospitalier affili\u00e9 - H\u00f4pital du Saint-Sacrement, Quebec City, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel-Pierre","family":"Dufresne","sequence":"additional","affiliation":[{"name":"H\u00f4pital Maisonneuve-Rosemont, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9ric","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec, Quebec City, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Brisson","sequence":"additional","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec, Quebec City, Qu\u00e9bec, Canada"},{"name":"D\u00e9partement de m\u00e9decine sociale et pr\u00e9ventive, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval, Quebec City, Qu\u00e9bec, Canada"},{"name":"Centre de Recherche du CHU de Qu\u00e9bec, Axe Oncologie, Quebec City, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,1]]},"reference":[{"key":"bibr1-j.carj.2018.10.007","unstructured":"VainioH. 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