{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:29:19Z","timestamp":1777476559182,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can Assoc Radiol J"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The aim of study is to assess the role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and correlation with tumour angiogenesis in evaluation of urinary bladder cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>The study included 81 patients with recent presumed diagnosis of bladder tumour or who came for follow up after management of histopathologically proven bladder cancer. All had DCE-MRI with time\u2013signal intensity curve. The radiologic results then correlated with the histopathologic results using both haematoxylin and eosin stain and immuno-histochemical staining for localization and evaluation of CD34 immunoreactivity as a detector for the microvessel density (MVD) and tumour angiogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy-one cases were pathologically proven to be malignant: 41 cases (58%) showed type III time\u2013signal intensity curve (descending); 22 cases (31%) showed type II (plateau); and 8 cases (11%) showed type I (ascending) curve. The sensitivity of DCE-MRI in stage T1 bladder tumour was 80%; in stage T2, it was (90.9%); and in stage T3, it was (96.9%). Overall accuracy of DCE-MRI in tumour staging was 89.5% and P = .001 (significant). Values more than the cutoff value = 76.13 MVD are cystitis with sensitivity (90%), specificity (91%), and P value is .001, which is statistically highly significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is a strong positive association between DCE-MRI (staging and washout slope of the time\u2013signal intensity curve) with histopathologic grade, tumour stage, and MVD in bladder cancer. So, DCE-MRI can be used as reliable technique in preoperative predictions of tumour behavior and affect the planning of antiangiogenetic therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.carj.2018.11.004","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T10:28:05Z","timestamp":1553509685000},"page":"254-263","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Diagnostic Tool in the Assessment of Tumour Angiogenesis in Urinary Bladder Cancer"],"prefix":"10.1177","volume":"70","author":[{"given":"Omar Ahmad","family":"Hassanien","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Tanta University, Tanta, Gharbia Governorate, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha T.","family":"Abouelkheir","sequence":"additional","affiliation":[{"name":"Diagnostic Radiology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Dakahlia Governorate, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Ibrahim","family":"Abou El-Ghar","sequence":"additional","affiliation":[{"name":"Urology and Nephrology Center, Faculty of Medicine, Mansoura University, Mansoura, Dakahlia Governorate, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manal Ezzat","family":"Badawy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tanta University, Tanta, Gharbia Governorate, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir Abdel-hakim","family":"El Gamal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tanta University, Tanta, Gharbia Governorate, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Abd","family":"El-Hamid","sequence":"additional","affiliation":[{"name":"Urology and Nephrology Center, Faculty of Medicine, Mansoura University, Mansoura, Dakahlia Governorate, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,8,1]]},"reference":[{"key":"bibr1-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2017.01.013"},{"key":"bibr2-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-250"},{"key":"bibr3-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-007-9104-7"},{"key":"bibr4-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.08.072"},{"key":"bibr5-j.carj.2018.11.004","first-page":"186","volume":"16","author":"T\u00fcrkbey B.","year":"2010","journal-title":"Diagn Interv Radiol"},{"key":"bibr6-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2004.05.009"},{"key":"bibr7-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.3402\/ljm.v6i0.6016"},{"key":"bibr8-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-004-0533-3"},{"key":"bibr9-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.1332"},{"key":"bibr10-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10304"},{"key":"bibr11-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2511080873"},{"key":"bibr12-j.carj.2018.11.004","first-page":"50","volume":"2","author":"Cheng L.","year":"2013","journal-title":"Gland Surg"},{"key":"bibr13-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.8568"},{"key":"bibr14-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2002.37263"},{"key":"bibr15-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2869"},{"key":"bibr16-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.1159\/000164218"},{"key":"bibr17-j.carj.2018.11.004","first-page":"135","volume":"46","author":"Sar\u0131 A.","year":"2007","journal-title":"Ege Journal of Medicine"},{"key":"bibr18-j.carj.2018.11.004","first-page":"2583","volume":"9","author":"Goddard J.C.","year":"2003","journal-title":"Clin Cancer Res"},{"key":"bibr19-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.184.1.01840121"},{"key":"bibr20-j.carj.2018.11.004","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2017.11.014"},{"key":"bibr21-j.carj.2018.11.004","unstructured":"EpsteinJ.I. 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