{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:28:15Z","timestamp":1773242895967,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Academic Medical Center (AMC) Graduate School"},{"name":"AMC Foundation"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Pathology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.carpath.2018.10.002","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T12:52:16Z","timestamp":1539694336000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Renal cystic disease in the Fbn1C1039G\/+ Marfan mouse is associated with enhanced aortic aneurysm formation"],"prefix":"10.1016","volume":"38","author":[{"given":"Stijntje","family":"Hibender","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaynah","family":"Wanga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingeborg","family":"van der Made","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariska","family":"Vos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara JM","family":"Mulder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-1455","authenticated-orcid":false,"given":"Ron","family":"Balm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlie JM","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian","family":"de Waard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.carpath.2018.10.002_bb0005","first-page":"247","article-title":"Marfan's syndrome","volume":"366","author":"Judge","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.carpath.2018.10.002_bb0010","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ijcard.2016.04.186","article-title":"The effect of losartan on progressive aortic dilatation in patients with Marfan's syndrome: a meta-analysis of prospective randomized clinical trials","volume":"217","author":"Gao","year":"2016","journal-title":"Int J Cardiol"},{"issue":"8","key":"10.1016\/j.carpath.2018.10.002_bb0015","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nrcardio.2015.95","article-title":"Aortic disease: Losartan versus atenolol in the Marfan aorta-how to treat?","volume":"12","author":"Franken","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.carpath.2018.10.002_bb0020","article-title":"Pregnancy and thoracic aortic disease\u2014managing the risks","author":"Wanga","year":"2015","journal-title":"Can J Cardiol"},{"issue":"3","key":"10.1016\/j.carpath.2018.10.002_bb0025","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jacc.2014.10.050","article-title":"The risk for type B aortic dissection in Marfan syndrome","volume":"65","author":"den Hartog","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carpath.2018.10.002_bb0030","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jvs.2015.08.095","article-title":"Simple renal cyst and abdominal aortic aneurysm","volume":"63","author":"Takagi","year":"2016","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.carpath.2018.10.002_bb0035","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002248","article-title":"Simple renal cysts as markers of thoracic aortic disease","volume":"5","author":"Ziganshin","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"10.1016\/j.carpath.2018.10.002_bb0040","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/GIM.0b013e3180423cb3","article-title":"Abdominal visceral findings in patients with Marfan syndrome","volume":"9","author":"Chow","year":"2007","journal-title":"Genet Med"},{"issue":"2","key":"10.1016\/j.carpath.2018.10.002_bb0045","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0002-9440(10)63305-6","article-title":"Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury","volume":"165","author":"Schaefer","year":"2004","journal-title":"Am J Pathol"},{"issue":"5770","key":"10.1016\/j.carpath.2018.10.002_bb0050","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1126\/science.1124287","article-title":"Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome","volume":"312","author":"Habashi","year":"2006","journal-title":"Science"},{"issue":"6027","key":"10.1016\/j.carpath.2018.10.002_bb0055","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.1192149","article-title":"Noncanonical TGF\u03b2 signaling contributes to aortic aneurysm progression in Marfan syndrome mice","volume":"332","author":"Holm","year":"2011","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.carpath.2018.10.002_bb0060","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cell.2005.02.003","article-title":"Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors","volume":"120","author":"Campisi","year":"2005","journal-title":"Cell"},{"issue":"15","key":"10.1016\/j.carpath.2018.10.002_bb0065","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1161\/CIRCULATIONAHA.110.007021","article-title":"Cellular senescence, vascular disease, and aging: part 1 of a 2-part review","volume":"123","author":"Kovacic","year":"2011","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.carpath.2018.10.002_bb0070","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/1479-5876-11-208","article-title":"Exploring smooth muscle phenotype and function in a bioreactor model of abdominal aortic aneurysm","volume":"11","author":"Riches","year":"2013","journal-title":"J Transl Med"},{"key":"10.1016\/j.carpath.2018.10.002_bb0075","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1161\/ATVBAHA.116.307841","article-title":"Resveratrol inhibits aortic root dilatation in the Fbn1C1039G\/+ Marfan mouse model","volume":"36","author":"Hibender","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"10.1016\/j.carpath.2018.10.002_bb0080","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1172\/JCI119419","article-title":"The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice","volume":"99","author":"Esther","year":"1997","journal-title":"J Clin Invest"},{"issue":"9","key":"10.1016\/j.carpath.2018.10.002_bb0085","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1042\/CS20120097","article-title":"Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms","volume":"123","author":"Lu","year":"2012","journal-title":"Clin Sci (Lond)"},{"issue":"9","key":"10.1016\/j.carpath.2018.10.002_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107221","article-title":"No beneficial effect of general and specific anti-inflammatory therapies on aortic dilatation in Marfan mice","volume":"9","author":"Franken","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.carpath.2018.10.002_bb0095","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1042\/CS20070352","article-title":"Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysm","volume":"114","author":"Lindeman","year":"2008","journal-title":"Clin Sci"},{"issue":"48","key":"10.1016\/j.carpath.2018.10.002_bb0100","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1093\/eurheartj\/ehs354","article-title":"Interleukin-6 receptor pathways in abdominal aortic aneurysm","volume":"34","author":"Harrison","year":"2013","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.carpath.2018.10.002_bb0105","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.atherosclerosis.2010.01.042","article-title":"Systemic MCP1\/CCR2 blockade and leukocyte specific MCP1\/CCR2 inhibition affect aortic aneurysm formation differently","volume":"211","author":"de Waard","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.carpath.2018.10.002_bb0110","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jvs.2005.03.033","article-title":"Type IV thoracoabdominal aortic aneurysm with lymphoplasmacytic aortitis and cystic medial degeneration in a 32-year-old patient with Marfan syndrome","volume":"42","author":"Cordera","year":"2005","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.carpath.2018.10.002_bb0115","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1161\/CIRCULATIONAHA.107.760686","article-title":"Aortitis","volume":"117","author":"Gornik","year":"2008","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.carpath.2018.10.002_bb0120","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/hrt.2010.205328","article-title":"Presence of simple renal cysts is associated with increased risk of aortic dissection: a common manifestation of connective tissue degeneration?","volume":"97","author":"Kim","year":"2011","journal-title":"Heart"},{"key":"10.1016\/j.carpath.2018.10.002_bb0125","first-page":"1","article-title":"A polycystin-centric view of cyst formation and disease: the polycystins revisited","author":"Ong","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.carpath.2018.10.002_bb0130","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1161\/STROKEAHA.110.578740","article-title":"Screening for intracranial aneurysm in 355 patients with autosomal-dominant polycystic kidney disease","volume":"42","author":"Xu","year":"2011","journal-title":"Stroke"},{"issue":"34","key":"10.1016\/j.carpath.2018.10.002_bb0135","doi-asserted-by":"crossref","first-page":"57594","DOI":"10.18632\/oncotarget.16338","article-title":"Risk of aortic aneurysm and dissection in patients with autosomal-dominant polycystic kidney disease: a nationwide population-based cohort study","volume":"8","author":"Sung","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.carpath.2018.10.002_bb0140","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12881-018-0536-6","article-title":"Whole exome sequencing reveals a stop-gain mutation of PKD2 in an autosomal dominant polycystic kidney disease family complicated with aortic dissection","volume":"19","author":"Zhang","year":"2018","journal-title":"BMC Med Genet"},{"issue":"1","key":"10.1016\/j.carpath.2018.10.002_bb0145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1681\/ASN.2012050486","article-title":"A Pkd1-Fbn1 genetic interaction implicates TGF-\u03b2 signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease","volume":"25","author":"Liu","year":"2014","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.carpath.2018.10.002_bb0150","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejvs.2015.09.006","article-title":"Abdominal aortic aneurysm genetic associations: mostly false? A systematic review and meta-analysis","volume":"51","author":"Bradley","year":"2016","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"3","key":"10.1016\/j.carpath.2018.10.002_bb0155","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1161\/ATVBAHA.117.310609","article-title":"Cell type-specific contributions of the angiotensin II type 1a receptor to aorta homeostasis and aneurysmal disease-brief report","volume":"38","author":"Galatioto","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"10.1016\/j.carpath.2018.10.002_bb0160","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.athoracsur.2016.10.077","article-title":"A novel murine model of Marfan syndrome accelerates aortopathy and cardiomyopathy","volume":"104","author":"Cavanaugh","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.carpath.2018.10.002_bb0165","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1161\/CIRCGENETICS.114.000950","article-title":"Beneficial outcome of losartan therapy depends on type of FBN1 mutation in Marfan syndrome","volume":"8","author":"Franken","year":"2015","journal-title":"Circ Cardiovasc Genet"},{"issue":"6","key":"10.1016\/j.carpath.2018.10.002_bb0170","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1001\/archsurg.1990.01410180025004","article-title":"Hydrocortisone rapidly induces aortic rupture in a genetically susceptible mouse","volume":"125","author":"Reilly","year":"1990","journal-title":"Arch Surg"},{"issue":"7","key":"10.1016\/j.carpath.2018.10.002_bb0175","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1161\/ATVBAHA.112.300820","article-title":"Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt","volume":"33","author":"Liu","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"18","key":"10.1016\/j.carpath.2018.10.002_bb0180","doi-asserted-by":"crossref","first-page":"e463","DOI":"10.1161\/CIRCULATIONAHA.110.008573","article-title":"Immunosuppression and the abdominal aortic aneurysm: Doctor Jekyll or Mister Hyde?","volume":"124","author":"Lindeman","year":"2011","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.carpath.2018.10.002_bb0185","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1067\/mva.2003.57","article-title":"The prevalence and natural history of aortic aneurysms in heart and abdominal organ transplant patients","volume":"37","author":"Englesbe","year":"2003","journal-title":"J Vasc Surg"},{"issue":"12","key":"10.1016\/j.carpath.2018.10.002_bb0190","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1172\/JCI38308","article-title":"An adventitial IL-6\/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice","volume":"119","author":"Tieu","year":"2009","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.carpath.2018.10.002_bb0195","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.jtcvs.2011.07.053","article-title":"Bone marrow-derived MCP1 required for experimental aortic aneurysm formation and smooth muscle phenotypic modulation","volume":"142","author":"Moehle","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.carpath.2018.10.002_bb0200","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.avsg.2017.10.001","article-title":"Elevated wall tension initiates Interleukin-6 expression and abdominal aortic dilation","volume":"46","author":"Akerman","year":"2018","journal-title":"Ann Vasc Surg"},{"issue":"10","key":"10.1016\/j.carpath.2018.10.002_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185923","article-title":"The role of IL-6 in pathogenesis of abdominal aortic aneurysm in mice","volume":"12","author":"Nishihara","year":"2017","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.carpath.2018.10.002_bb0210","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.athoracsur.2015.05.009","article-title":"Interleukin-6 receptor inhibition prevents descending thoracic aortic aneurysm formation","volume":"100","author":"Pope","year":"2015","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"10.1016\/j.carpath.2018.10.002_bb0215","doi-asserted-by":"crossref","first-page":"e000476","DOI":"10.1161\/JAHA.113.000476","article-title":"IL-6 regulates extracellular matrix remodeling associated with aortic dilation in a fibrillin-1 hypomorphic mgR\/mgR mouse model of severe Marfan syndrome","volume":"3","author":"Ju","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.carpath.2018.10.002_bb0220","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.atherosclerosis.2016.06.021","article-title":"IL-6: a Janus-like factor in abdominal aortic aneurysm disease","volume":"251","author":"Kokje","year":"2016","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.carpath.2018.10.002_bb0225","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1161\/STROKEAHA.116.015590","article-title":"Monocyte chemotactic protein-1\u2013interleukin-6\u2013osteopontin pathway of intra-aneurysmal tissue healing","volume":"48","author":"Hosaka","year":"2017","journal-title":"Stroke"}],"container-title":["Cardiovascular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880718302199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880718302199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T14:21:26Z","timestamp":1544451686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054880718302199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":45,"alternative-id":["S1054880718302199"],"URL":"https:\/\/doi.org\/10.1016\/j.carpath.2018.10.002","relation":{},"ISSN":["1054-8807"],"issn-type":[{"value":"1054-8807","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Renal cystic disease in the Fbn1C1039G\/+ Marfan mouse is associated with enhanced aortic aneurysm formation","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carpath.2018.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}