{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:51:58Z","timestamp":1780318318485,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Pathology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.carpath.2019.04.005","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T17:25:07Z","timestamp":1557336307000},"page":"21-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Sp1-induced LncRNA CTBP1-AS2 is a novel regulator in cardiomyocyte hypertrophy by interacting with FUS to stabilize TLR4"],"prefix":"10.1016","volume":"42","author":[{"given":"Xiaojia","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.carpath.2019.04.005_bb0005","first-page":"56","article-title":"Decompensation of cardiac hypertrophy: cellular mechanisms and novel therapeutic targets","volume":"22","author":"Diwan","year":"2007","journal-title":"Phys Ther"},{"key":"10.1016\/j.carpath.2019.04.005_bb0010","first-page":"1437","article-title":"Fat in the right heart: the role of cardiac magnetic resonance imaging in differentiating diffuse lipomatous hypertrophy of the right ventricle from arrhythmogenic right ventricular cardiomyopathy","volume":"20","author":"Daimee","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.carpath.2019.04.005_bb0015","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1136\/bmj.1.5478.2","article-title":"Hypertrophic obstructive cardiomyopathy","volume":"1","author":"Demos","year":"1966","journal-title":"Br Med J"},{"key":"10.1016\/j.carpath.2019.04.005_bb0020","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.pharmthera.2010.04.005","article-title":"Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies","volume":"128","author":"Bernardo","year":"2010","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.carpath.2019.04.005_bb0025","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3920195","article-title":"A review of the molecular mechanisms underlying the development and progression of cardiac remodeling","volume":"2017","author":"Schirone","year":"2017","journal-title":"Oxidative Med Cell Longev"},{"key":"10.1016\/j.carpath.2019.04.005_bb0030","first-page":"345","article-title":"Valsartan attenuates cardiac and renal hypertrophy in rats with experimental cardiorenal syndrome possibly through down-regulating galectin-3 signaling","volume":"20","author":"Zhang","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.carpath.2019.04.005_bb0035","doi-asserted-by":"crossref","first-page":"e303-e","DOI":"10.1097\/MD.0000000000000303","article-title":"Long non-coding RNA LSINCT5 predicts negative prognosis and exhibits oncogenic activity in gastric cancer","volume":"93","author":"Xu","year":"2014","journal-title":"Medicine"},{"key":"10.1016\/j.carpath.2019.04.005_bb0040","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/carcin\/bgr187","article-title":"Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk","volume":"32","author":"Jin","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.carpath.2019.04.005_bb0045","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3389\/fonc.2017.00305","article-title":"Long non-coding RNAs in prostate cancer with emphasis on second chromosome locus associated with prostate-1 expression","volume":"7","author":"Cimadamore","year":"2017","journal-title":"Front Oncol"},{"key":"10.1016\/j.carpath.2019.04.005_bb0050","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrg2521","article-title":"Long non-coding RNAs: insights into functions","volume":"10","author":"Mercer","year":"2009","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.carpath.2019.04.005_bb0055","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/srep00529","article-title":"Position-dependent FUS\u2013RNA interactions regulate alternative splicing events and transcriptions","volume":"2","author":"Ishigaki","year":"2012","journal-title":"Sci Rep"},{"key":"10.1016\/j.carpath.2019.04.005_bb0060","doi-asserted-by":"crossref","first-page":"15635","DOI":"10.1074\/jbc.M111.333450","article-title":"TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells","volume":"287","author":"Colombrita","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.carpath.2019.04.005_bb0065","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.bbrc.2018.12.133","article-title":"MYC upregulated LINC00319 promotes human acute myeloid leukemia (AML) cells growth through stabilizing SIRT6","volume":"509","author":"Zhang","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.carpath.2019.04.005_bb0070","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/cas.13200","article-title":"Long noncoding RNA SchLAH suppresses metastasis of hepatocellular carcinoma through interacting with fused in sarcoma","volume":"108","author":"Ge","year":"2017","journal-title":"Cancer Sci"},{"key":"10.1016\/j.carpath.2019.04.005_bb0075","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12943-018-0884-z","article-title":"The c-Myc-regulated lncRNA NEAT1 and paraspeckles modulate imatinib-induced apoptosis in CML cells","volume":"17","author":"Zeng","year":"2018","journal-title":"Mol Cancer"},{"key":"10.1016\/j.carpath.2019.04.005_bb0080","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12943-017-0756-y","article-title":"STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy","volume":"17","author":"Chen","year":"2018","journal-title":"Mol Cancer"},{"key":"10.1016\/j.carpath.2019.04.005_bb0085","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s13046-018-0875-3","article-title":"SP1-induced lncRNA AGAP2-AS1 expression promotes chemoresistance of breast cancer by epigenetic regulation of MyD88","volume":"37","author":"Dong","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.carpath.2019.04.005_bb0090","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/s41419-018-0962-6","article-title":"SP1-induced lncRNA-ZFAS1 contributes to colorectal cancer progression via the miR-150-5p\/VEGFA axis","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.carpath.2019.04.005_bb0095","article-title":"Long non-coding RNA MALAT1 mediates hypoxia-induced pro-survival autophagy of endometrial stromal cells in endometriosis","volume":"0","author":"Liu","year":"2018","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.carpath.2019.04.005_bb0100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13148-018-0555-3","article-title":"The DNMT1-associated lincRNA DACOR1 reprograms genome-wide DNA methylation in colon cancer","volume":"10","author":"Somasundaram","year":"2018","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.carpath.2019.04.005_bb0105","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1159\/000494605","article-title":"Circulating long noncoding RNAs as biomarkers for predicting head and neck squamous cell carcinoma","volume":"50","author":"Yao","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.carpath.2019.04.005_bb0110","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1159\/000494541","article-title":"Comprehensive analysis of miRNA-mRNA-lncRNA networks in non-smoking and smoking patients with chronic obstructive pulmonary disease","volume":"50","author":"Qian","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.carpath.2019.04.005_bb0115","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.omtn.2017.12.018","article-title":"The lncRNA Plscr4 controls cardiac hypertrophy by regulating miR-214","volume":"10","author":"Lv","year":"2017","journal-title":"Mol Ther-Nucleic Acids"},{"key":"10.1016\/j.carpath.2019.04.005_bb0120","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nm.4179","article-title":"The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy","volume":"22","author":"Wang","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.carpath.2019.04.005_bb0125","doi-asserted-by":"crossref","first-page":"47565","DOI":"10.18632\/oncotarget.17735","article-title":"LncRNA TINCR attenuates cardiac hypertrophy by epigenetically silencing CaMKII","volume":"8","author":"Shao","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.carpath.2019.04.005_bb0130","first-page":"1265","article-title":"Long noncoding RNA myocardial infarction-associated transcript is associated with the microRNA-150-5p\/P300 pathway in cardiac hypertrophy","volume":"42","author":"Li","year":"2018","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.carpath.2019.04.005_bb0135","article-title":"Long intergenic non-coding RNA 271 is predictive of a poorer prognosis of papillary thyroid cancer","volume":"6","author":"Ma","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.carpath.2019.04.005_bb0140","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1755-1536-3-21","article-title":"Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis","volume":"3","author":"Guo","year":"2010","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.carpath.2019.04.005_bb0145","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3389\/fimmu.2017.00719","article-title":"Toll-like receptor 4 inhibition improves oxidative stress and mitochondrial health in isoproterenol-induced cardiac hypertrophy in rats","volume":"8","author":"Katare","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.carpath.2019.04.005_bb0150","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.intimp.2017.12.019","article-title":"Inhibition of myocardial hypertrophy by magnesium isoglycyrrhizinate through the TLR4\/NF-\u03baB signaling pathway in mice","volume":"55","author":"Ma","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.carpath.2019.04.005_bb0155","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1016\/j.bbrc.2018.06.169","article-title":"Upregulation of lncRNA VDR\/CASC15 induced by facilitates cardiac hypertrophy through modulating miR-432-5p\/TLR4 axis","volume":"503","author":"Li","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.carpath.2019.04.005_bb0160","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.ejphar.2017.11.031","article-title":"LncRNA myocardial infarction-associated transcript (MIAT) contributed to cardiac hypertrophy by regulating TLR4 via miR-93","volume":"818","author":"Li","year":"2018","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.carpath.2019.04.005_bb0165","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1161\/HYPERTENSIONAHA.109.139519","article-title":"Reciprocal repression between microRNA-133 and calcineurin regulates cardiac hypertrophy: a novel mechanism for progressive cardiac hypertrophy","volume":"55","author":"Dong","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.carpath.2019.04.005_bb0170","doi-asserted-by":"crossref","first-page":"8903","DOI":"10.1128\/MCB.20.23.8903-8915.2000","article-title":"A novel Rb- and p300-binding protein inhibits transactivation by MyoD","volume":"20","author":"MacLellan","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.carpath.2019.04.005_bb0175","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1142\/S0192415X18500532","article-title":"Dendropanax morbifera prevents cardiomyocyte hypertrophy by inhibiting the Sp1\/GATA4 pathway","volume":"46","author":"Sun","year":"2018","journal-title":"Am J Chin Med"},{"key":"10.1016\/j.carpath.2019.04.005_bb0180","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1159\/000475396","article-title":"(\u2212)-Epicatechin suppresses angiotensin II-induced cardiac hypertrophy via the activation of the SP1\/SIRT1 signaling pathway","volume":"41","author":"Dong","year":"2017","journal-title":"Cell Physiol Biochem"}],"container-title":["Cardiovascular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880719300432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880719300432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:45:22Z","timestamp":1760960722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054880719300432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":36,"alternative-id":["S1054880719300432"],"URL":"https:\/\/doi.org\/10.1016\/j.carpath.2019.04.005","relation":{},"ISSN":["1054-8807"],"issn-type":[{"value":"1054-8807","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sp1-induced LncRNA CTBP1-AS2 is a novel regulator in cardiomyocyte hypertrophy by interacting with FUS to stabilize TLR4","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carpath.2019.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}