{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:50:24Z","timestamp":1785927024258,"version":"3.56.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Turkish Diabetes Foundation"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Pathology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.carpath.2019.107192","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T21:20:58Z","timestamp":1575580858000},"page":"107192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Relationships between visceral\/subcutaneous adipose tissue FABP4 expression and coronary atherosclerosis in patients with metabolic syndrome"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3546-3369","authenticated-orcid":false,"given":"Selcuk","family":"Gormez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Refik","family":"Erdim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokce","family":"Akan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bar\u0131s","family":"Caynak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan","family":"Duran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demet","family":"Gunay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkan","family":"Sozer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatmahan","family":"Atalar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.carpath.2019.107192_bib1","series-title":"The metabolic syndrome","first-page":"1","article-title":"The epidemiology of the metabolic syndrome and its association with diabetes, cardiovascular disease and other conditions","author":"Wild","year":"2011"},{"key":"10.1016\/j.carpath.2019.107192_bib2","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.carpath.2019.107192_bib3","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1210\/jc.2003-030698","article-title":"Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk","volume":"88","author":"Iacobellis","year":"2003","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.carpath.2019.107192_bib4","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1536\/ihj.17-709","article-title":"Association of epicardial adipose tissue volume and total coronary plaque burden in patients with coronary artery disease","volume":"59","author":"Yamashita","year":"2018","journal-title":"Int Heart J"},{"key":"10.1016\/j.carpath.2019.107192_bib5","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1530\/EJE-10-1195","article-title":"FABP 4 is associated with inflammatory markers and metabolic syndrome in morbidly obese women","volume":"164","author":"Terra","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.carpath.2019.107192_bib6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000115365","article-title":"Adipokines in obesity","volume":"36","author":"Ahima","year":"2008","journal-title":"Front Horm Res"},{"key":"10.1016\/j.carpath.2019.107192_bib7","first-page":"23","article-title":"Fatty acid-binding protein 4 (FABP4): pathophysiological insights and potent clinical biomarker of metabolic and cardiovascular diseases","volume":"8","author":"Furuhashi","year":"2015","journal-title":"Clin Med Insights Cardiol"},{"key":"10.1016\/j.carpath.2019.107192_bib8","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1161\/ATVBAHA.116.307225","article-title":"Local production of fatty acid-binding protein 4 in epicardial\/perivascular fat and macrophages is linked to coronary atherosclerosis","volume":"36","author":"Furuhashi","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.carpath.2019.107192_bib9","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.carpath.2008.02.006","article-title":"Presence of fatty-acid-binding protein 4 expression in human epicardial adipose tissue in metabolic syndrome","volume":"17","author":"Vural","year":"2008","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.carpath.2019.107192_bib10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1530\/JOE-17-0031","article-title":"Role of the fatty acid-binding protein 4 in heart failure and cardiovascular disease","volume":"233","author":"Rodr\u00edguez-Calvo","year":"2017","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.carpath.2019.107192_bib11","first-page":"236","article-title":"Lipids, lipoproteins and apolipoproteins among turks, and impact on coronary heart disease","volume":"4","author":"Onat","year":"2004","journal-title":"Anadolu Kardiyol Derg"},{"key":"10.1016\/j.carpath.2019.107192_bib12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.metabol.2005.10.005","article-title":"Discordance between insulin resistance and metabolic syndrome: features and associated cardiovascular risk in adults with normal glucose regulation","volume":"55","author":"Onat","year":"2006","journal-title":"Metabolism"},{"key":"10.1016\/j.carpath.2019.107192_bib13","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/S0002-8703(05)80173-5","article-title":"A\u00a0new method of scoring coronary angiograms to reflect extent of coronary atherosclerosis and improve correlation with major risk factors","volume":"119","author":"Sullivan","year":"1990","journal-title":"Am Heart J"},{"key":"10.1016\/j.carpath.2019.107192_bib14","doi-asserted-by":"crossref","first-page":"e837","DOI":"10.1161\/CIRCULATIONAHA.111.077602","article-title":"Ectopic fat depots and cardiovascular disease","volume":"124","author":"Britton","year":"2011","journal-title":"Circulation"},{"issue":"1\u20132","key":"10.1016\/j.carpath.2019.107192_bib15","first-page":"1","article-title":"Ectopic fat deposition and global cardiometabolic risk: new paradigm in cardiovascular medicine","volume":"60","author":"Shimabukuro","year":"2013","journal-title":"J\u00a0Med Invest"},{"key":"10.1016\/j.carpath.2019.107192_bib16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.5551\/jat.1735","article-title":"Adipokines in periaortic and epicardial adipose tissue: differential expression and relation to atherosclerosis","volume":"17","author":"Spiroglou","year":"2010","journal-title":"J\u00a0Atheroscler Thromb"},{"key":"10.1016\/j.carpath.2019.107192_bib17","first-page":"4328","article-title":"Epicardial fat volume is correlated with coronary lesion and its severity","volume":"83","author":"Bo","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.carpath.2019.107192_bib18","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.atherosclerosis.2005.08.004","article-title":"Subepicardial adipose tissue and the presence and severity of coronary artery disease","volume":"186","author":"Chaowalit","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.carpath.2019.107192_bib19","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.amjcard.2008.08.010","article-title":"Relation of epicardial adipose tissue to coronary atherosclerosis","volume":"102","author":"Djaberi","year":"2008","journal-title":"Am J Cardiol"},{"issue":"5","key":"10.1016\/j.carpath.2019.107192_bib20","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/ehjci\/jex314","article-title":"Epicardial adipose tissue volume assessed by computed tomography and coronary artery disease: a systematic review and meta-analysis","volume":"19","author":"Mancio","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"9","key":"10.1016\/j.carpath.2019.107192_bib21","first-page":"909","article-title":"Association of epicardial adipose tissue with progression of coronary artery calcification is more pronounced in the early phase of atherosclerosis: results from the Heinz Nixdorf recall study","volume":"7","author":"Mahabadi","year":"2014","journal-title":"Cardiovasc Imaging"},{"key":"10.1016\/j.carpath.2019.107192_bib22","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/CIRCULATIONAHA.107.743062","article-title":"Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: The Framingham Heart Study","volume":"117","author":"Rosito","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.carpath.2019.107192_bib23","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jcct.2013.02.003","article-title":"Relationship of epicardial fat volume to coronary plaque, severe coronary stenosis, and high-risk coronary plaque features assessed by coronary CT angiography","volume":"17","author":"Rajani","year":"2013","journal-title":"J\u00a0Cardiovasc Comput"},{"key":"10.1016\/j.carpath.2019.107192_bib24","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1161\/01.CIR.0000099542.57313.C5","article-title":"Human epicardial adipose tissue is a source of inflammatory mediators","volume":"108","author":"Mazurek","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.carpath.2019.107192_bib25","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.numecd.2015.12.005","article-title":"Epicardial adipocyte hypertrophy: association with M1-polarization and toll-like receptor pathways in coronary artery disease patients","volume":"26","author":"Vianello","year":"2016","journal-title":"Nutr Metab Cardiovas Dis"},{"key":"10.1016\/j.carpath.2019.107192_bib26","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cmet.2013.06.016","article-title":"Fibrosis and adipose tissue dysfunction","volume":"18 387","author":"Sun","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/j.carpath.2019.107192_bib27","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1210\/jc.2004-0395","article-title":"Adipose tissue as an endocrine organ","volume":"89","author":"Kershaw","year":"2004","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.carpath.2019.107192_bib28","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/89076","article-title":"Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis","volume":"7","author":"Makowski","year":"2001","journal-title":"Nat Med"},{"issue":"11","key":"10.1016\/j.carpath.2019.107192_bib29","doi-asserted-by":"crossref","first-page":"7794","DOI":"10.4049\/jimmunol.177.11.7794","article-title":"Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2","volume":"177","author":"Rolph","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.carpath.2019.107192_bib30","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nature05844","article-title":"Treatment of diabetes and atherosclerosis by inhibiting fatty acid-binding protein aP2","volume":"447","author":"Furuhashi","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.carpath.2019.107192_bib31","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1126\/science.274.5291.1377","article-title":"Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein","volume":"274","author":"Hotamisligil","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.carpath.2019.107192_bib32","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1096\/fj.01-0374fje","article-title":"Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice","volume":"15","author":"Layne","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.carpath.2019.107192_bib33","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cbpb.2010.08.005","article-title":"Adipocyte fatty acid-binding protein: an important gene related to lipid metabolism in chicken adipocytes","volume":"157","author":"Shi","year":"2010","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"10.1016\/j.carpath.2019.107192_bib34","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1161\/CIRCGENETICS.113.000499","article-title":"Low-expression variant of fatty acid-binding protein 4 favors reduced manifestations of atherosclerotic disease and increased plaque stability","volume":"7","author":"Saksi","year":"2014","journal-title":"Circ Cardiovasc Genet"},{"issue":"18","key":"10.1016\/j.carpath.2019.107192_bib35","doi-asserted-by":"crossref","first-page":"6970","DOI":"10.1073\/pnas.0602178103","article-title":"A\u00a0genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease","volume":"103","author":"Tuncman","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.carpath.2019.107192_bib36","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1210\/endo.141.9.7637","article-title":"Improved glucose and lipid metabolism in genetically obese mice lacking aP2","volume":"141","author":"Uysal","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.carpath.2019.107192_bib37","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.atherosclerosis.2010.01.032","article-title":"Serum adipocyte fatty acid-binding protein is independently associated with coronary atherosclerotic burden measured by intravascular ultrasound","volume":"211","author":"Miyoshi","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.carpath.2019.107192_bib38","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1161\/ATVBAHA.110.209296","article-title":"High neutrophil numbers in human carotid atherosclerotic plaques are associated with characteristics of rupture prone lesions","volume":"30","author":"Ionita","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Cardiovascular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880719303576?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880719303576?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T16:28:08Z","timestamp":1762360088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054880719303576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":38,"alternative-id":["S1054880719303576"],"URL":"https:\/\/doi.org\/10.1016\/j.carpath.2019.107192","relation":{},"ISSN":["1054-8807"],"issn-type":[{"value":"1054-8807","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relationships between visceral\/subcutaneous adipose tissue FABP4 expression and coronary atherosclerosis in patients with metabolic syndrome","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carpath.2019.107192","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107192"}}