{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T22:40:59Z","timestamp":1788734459163,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Pathology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.carpath.2020.107211","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T11:50:58Z","timestamp":1581681058000},"page":"107211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Immunomodulatory treatment of immune checkpoint inhibitor-induced myocarditis: Pathway toward precision-based therapy"],"prefix":"10.1016","volume":"47","author":[{"given":"Dinu Valentin","family":"Balanescu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1067-1081","authenticated-orcid":false,"given":"Teodora","family":"Donisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Palaskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Lopez-Mattei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Y.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis Maximilian","family":"Buja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis M.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon A.","family":"Kobashigawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Bernard","family":"Durand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezar A.","family":"Iliescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.carpath.2020.107211_bib0001","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2017.77.6385","article-title":"Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American society of clinical oncology clinical practice guideline","author":"Brahmer","year":"2018","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.carpath.2020.107211_bib0002","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1056\/NEJMoa1609214","article-title":"Fulminant myocarditis with combination immune checkpoint blockade","volume":"375","author":"Johnson","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.carpath.2020.107211_bib0003","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1161\/CIRCULATIONAHA.117.029626","article-title":"Cardiac Toxicity of Immune Checkpoint Inhibitors: Cardio-Oncology Meets Immunology","volume":"136","author":"Varricchi","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.carpath.2020.107211_bib0004","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11912-018-0690-1","article-title":"Cardiotoxicity of Immunotherapy: Incidence, Diagnosis, and Management","volume":"20","author":"Asnani","year":"2018","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.carpath.2020.107211_bib0005","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0046-8177(87)80363-5","article-title":"Myocarditis: the Dallas criteria","volume":"18","author":"Aretz","year":"1987","journal-title":"Hum Pathol"},{"key":"10.1016\/j.carpath.2020.107211_bib0006","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1161\/CIRCULATIONAHA.105.589663","article-title":"Diagnosis of myocarditis: death of Dallas criteria","volume":"113","author":"Baughman","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.carpath.2020.107211_bib0007","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2017.1361097","article-title":"Comparative immunologic characterization of autoimmune giant cell myocarditis with ipilimumab","volume":"6","author":"Reuben","year":"2017","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.carpath.2020.107211_bib0008","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.jacc.2018.02.038","article-title":"Cardiac toxicity in patients treated with immune checkpoint inhibitors: it is now time for cardio-immuno-oncology","volume":"71","author":"Tocchetti","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carpath.2020.107211_bib0009","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0140-6736(18)30533-6","article-title":"Increased reporting of fatal immune checkpoint inhibitor-associated myocarditis","volume":"391","author":"Moslehi","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.carpath.2020.107211_bib0010","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.jacc.2018.02.037","article-title":"Myocarditis in patients treated with immune checkpoint inhibitors","volume":"71","author":"Mahmood","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carpath.2020.107211_bib0011","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/imj.93_13578","article-title":"P93: Antithymocyte globulin for the treatment of checkpoint inhibitor mediated myocarditis","volume":"47","author":"Ange","year":"2017","journal-title":"Intern Med J"},{"key":"10.1016\/j.carpath.2020.107211_bib0012","article-title":"Late-onset fulminant myocarditis with immune checkpoint inhibitor nivolumab","volume":"34","author":"Yamaguchi","year":"2018","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.carpath.2020.107211_bib0013","doi-asserted-by":"crossref","DOI":"10.1097\/CJI.0000000000000239","article-title":"Autoimmune myocarditis caused by immune checkpoint inhibitors treated with antithymocyte globulin","author":"Jain","year":"2018","journal-title":"J Immunother"},{"key":"10.1016\/j.carpath.2020.107211_bib0014","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/jjco\/hyx154","article-title":"Immune checkpoint inhibitor-related myocarditis","volume":"48","author":"Tajiri","year":"2018","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.carpath.2020.107211_bib0015","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s40425-017-0296-4","article-title":"Smoldering myocarditis following immune checkpoint blockade","volume":"5","author":"Norwood","year":"2017","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.carpath.2020.107211_bib0016","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1161\/CIR.0000000000000093","article-title":"Antibody-mediated rejection in cardiac transplantation: emerging knowledge in diagnosis and management: a scientific statement from the American Heart Association","volume":"131","author":"Colvin","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.carpath.2020.107211_bib0017","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1126\/science.291.5502.319","article-title":"Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice","volume":"291","author":"Nishimura","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.carpath.2020.107211_bib0018","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1158\/1078-0432.CCR-18-4083","article-title":"Myocarditis in cynomolgus monkeys following treatment with immune checkpoint inhibitors","volume":"25","author":"Ji","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.carpath.2020.107211_bib0019","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/82219","article-title":"Statins as a newly recognized type of immunomodulator","volume":"6","author":"Kwak","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.carpath.2020.107211_bib0020","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1097\/01.ASN.0000018400.39687.8C","article-title":"Immunomodulatory effects of statins: mechanisms and potential impact on arteriosclerosis","volume":"13","author":"Palinski","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.carpath.2020.107211_bib0021","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/89058","article-title":"Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site","volume":"7","author":"Weitz-Schmidt","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.carpath.2020.107211_bib0022","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1097\/00007890-200005270-00006","article-title":"Effects of humanized monoclonal antibody to rhesus CD11a in rhesus monkey cardiac allograft recipients","volume":"69","author":"Poston","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.carpath.2020.107211_bib0023","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1161\/01.CIR.0000140694.67251.9C","article-title":"Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection","volume":"110","author":"Lee","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.carpath.2020.107211_bib0024","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1189\/jlb.0713413","article-title":"Simvastatin attenuates rhinovirus-induced interferon and CXCL10 secretion from monocytic cells in vitro","volume":"95","author":"Wickert","year":"2014","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.carpath.2020.107211_bib0025","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/CJI.0000000000000190","article-title":"Life-threatening Autoimmune Cardiomyopathy Reproducibly Induced in a Patient by Checkpoint Inhibitor Therapy","volume":"41","author":"Tajmir-Riahi","year":"2018","journal-title":"J Immunother"}],"container-title":["Cardiovascular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880720300156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880720300156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:45:39Z","timestamp":1760960739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054880720300156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":25,"alternative-id":["S1054880720300156"],"URL":"https:\/\/doi.org\/10.1016\/j.carpath.2020.107211","relation":{},"ISSN":["1054-8807"],"issn-type":[{"value":"1054-8807","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunomodulatory treatment of immune checkpoint inhibitor-induced myocarditis: Pathway toward precision-based therapy","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carpath.2020.107211","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107211"}}