{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:39:45Z","timestamp":1761007185633,"version":"build-2065373602"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Pathology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.carpath.2020.107257","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:44:22Z","timestamp":1593218662000},"page":"107257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Kinins and nitric oxide in patients with chronic chagas disease and systemic arterial hypertension"],"prefix":"10.1016","volume":"49","author":[{"given":"Renata","family":"Dellalibera-Joviliano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinaldo B.","family":"Bestetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel S.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary","family":"Furlan-Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenio C.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton","family":"Faria-Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson Iucif","family":"Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"90","key":"10.1016\/j.carpath.2020.107257_bib0001","first-page":"33","article-title":"Chagas disease in Latin America: an epidemiological update based on 2010 estimates","volume":"2015","year":"2015","journal-title":"Wkly Epidemiol Rec"},{"key":"10.1016\/j.carpath.2020.107257_bib0002","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.trre.2010.12.002","article-title":"Recommendations for management of Chagas disease in organ and hematopoietic tissue transplantation programs in nonendemic areas","volume":"25","author":"Pinazo","year":"2011","journal-title":"Transplant Rev (Orlando)"},{"key":"10.1016\/j.carpath.2020.107257_bib0003","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S1473-3099(13)70002-1","article-title":"Global economic burden of Chagas disease: a computational simulation model","volume":"13","author":"Lee","year":"2013","journal-title":"Lancet Infect. Dis."},{"issue":"6","key":"10.1016\/j.carpath.2020.107257_bib0004","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1136\/hrt.2003.018960","article-title":"Value of echocardiography for diagnosis and prognosis of chronic Chagas disease cardiomyopathy without heart failure","volume":"90","author":"Viotti","year":"2004","journal-title":"Heart"},{"key":"10.1016\/j.carpath.2020.107257_bib0005","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0167-5273(92)90236-V","article-title":"Clinical characteristics of acute myocardial infarction in patients with Chagas disease","volume":"35","author":"Bestetti","year":"1992","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.carpath.2020.107257_bib0006","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.healun.2009.10.014","article-title":"Prognostic impact of Chagas disease in patients awaiting heart transplantation","volume":"29","author":"Bertolino","year":"2010","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.carpath.2020.107257_bib0007","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0167-5273(90)90271-6","article-title":"Clinical profile of patients with Chagas disease before and during sustained ventricular tachycardia","volume":"29","author":"Bestetti","year":"1990","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.carpath.2020.107257_bib0008","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.jacc.2017.08.004","article-title":"Chronic Chagas heart disease management: from etiology to cardiomyopathy treatment","volume":"70","author":"Bocchi","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carpath.2020.107257_bib0009","article-title":"Determination of the Th1, Th2, Th17, and Treg cytokine profile in patients with chronic Chagas heart disease and systemic arterial hypertension","author":"Bestetti","year":"2018","journal-title":"Heart Vessels"},{"key":"10.1016\/j.carpath.2020.107257_bib0010","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1006\/jmcc.1998.0887","article-title":"Regulation of cardiac fibroblast extracellular matrix production by bradykinin and nitric oxide","volume":"31","author":"Kim","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.carpath.2020.107257_bib0011","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000323555","article-title":"Nicorandil inhibits angiotensin-II-induced proliferation of cultured rat cardiac fibroblasts","volume":"87","author":"Liou","year":"2011","journal-title":"Pharmacology"},{"key":"10.1016\/j.carpath.2020.107257_bib0012","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11010-012-1223-0","article-title":"Angiotensin-(1\u20137) suppresses the number and function of the circulating fibrocytes by upregulating endothelial nitric oxide synthase expression","volume":"365","author":"Wang","year":"2012","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"10.1016\/j.carpath.2020.107257_bib0013","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/cvr\/cvt181","article-title":"Inhibition of endothelial nitric oxide synthase induces and enhances myocardial fibrosis","volume":"100","author":"Kazakov","year":"2013","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.carpath.2020.107257_bib0014","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/rheumatology\/31.8.509","article-title":"Kinins-key mediators in inflammatory arthritis?","volume":"31","author":"Bhoola","year":"1992","journal-title":"Br J Rheumatol"},{"issue":"1","key":"10.1016\/j.carpath.2020.107257_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6997(25)00058-4","article-title":"Bioregulation of kinins: kallikreins, kininogens, and kininases","volume":"44","author":"Bhoola","year":"1992","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.carpath.2020.107257_bib0016","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1097\/00005344-199015061-00007","article-title":"Kinin subtypes","volume":"15","author":"Regoli","year":"1990","journal-title":"J Cardiovasc Pharmcol"},{"issue":"2","key":"10.1016\/j.carpath.2020.107257_bib0017","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2174\/1570161112666140226121627","article-title":"Kinin receptors in vascular biology and pathology","volume":"12","author":"Couture","year":"2014","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1016\/j.carpath.2020.107257_bib0018","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.12659\/MSM.898454","article-title":"Substance P Inhibits the Collagen Synthesis of Rat Myocardial Fibroblasts Induced by Ang II","volume":"22","author":"Yang","year":"2016","journal-title":"Med Sci Monit"},{"issue":"3","key":"10.1016\/j.carpath.2020.107257_bib0019","first-page":"485","article-title":"Kinins and cytokines in plasma and cerebrospinal fluid of patients with neuropsychiatric lupus","volume":"30","author":"Dellalibera-Joviliano","year":"2003","journal-title":"J Rheumatol"},{"issue":"2","key":"10.1016\/j.carpath.2020.107257_bib0020","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1365-3083.2010.02408.x","article-title":"Determination of kininogens levels and kallikrein\/kininase II activities in patients with thromboangiitis obliterans","volume":"72","author":"Dellalibera-Joviliano","year":"2010","journal-title":"Scand J Immunol"},{"issue":"1","key":"10.1016\/j.carpath.2020.107257_bib0021","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1365-2249.2012.04624.x","article-title":"Activation of cytokines corroborate with development of inflammation and autoimmunity in thromboangiitis obliterans patients","volume":"170","author":"Dellalibera-Joviliano","year":"2012","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"10.1016\/j.carpath.2020.107257_bib0022","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1365-3083.2010.02373.x","article-title":"The kinin system in patients with systemic lupus erythematosus exhibiting mucocutaneous lesions: a clinical study","volume":"71","author":"Dellalibera-Joviliano","year":"2010","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.carpath.2020.107257_bib0023","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/S1567-5769(01)00109-6","article-title":"Kinin system in lupus nephritis","volume":"1","author":"Dellalibera-Joviliano","year":"2001","journal-title":"Int Immunopharmacol"},{"issue":"3\/4","key":"10.1016\/j.carpath.2020.107257_bib0024","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/BF01972790","article-title":"The kallikrein-kininogen-kinin system in chronic inflammation","volume":"27","author":"Burch","year":"1989","journal-title":"Agents Actions"},{"key":"10.1016\/j.carpath.2020.107257_bib0025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1172\/JCI119502","article-title":"Kallistatin is a potent new vasodilator","volume":"100","author":"Chao","year":"1997","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.carpath.2020.107257_bib0026","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1113\/expphysiol.2004.028464","article-title":"Kallikrein\u2013kinin in stroke, cardiovascular and renal disease","volume":"90","author":"Chao","year":"2005","journal-title":"Exp Physiol"},{"issue":"2","key":"10.1016\/j.carpath.2020.107257_bib0027","doi-asserted-by":"crossref","first-page":"215\u2010228","DOI":"10.1007\/s10456-017-9589-y","article-title":"IL-11 facilitates a novel connection between RA joint fibroblasts and endothelial cells","volume":"21","author":"Elshabrawy","year":"2018","journal-title":"Angiogenesis"},{"issue":"10","key":"10.1016\/j.carpath.2020.107257_bib0028","doi-asserted-by":"crossref","first-page":"1359\u20101368","DOI":"10.1038\/s41416-018-0072-3","article-title":"Suppression of TGF\u03b2-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition","volume":"118","author":"Kim","year":"2018","journal-title":"Br J Cancer"},{"issue":"Suppl 3","key":"10.1016\/j.carpath.2020.107257_bib0029","first-page":"1","article-title":"I Latin America guidelines for the diagnosis and treatment of Chagas cardiomyopathy","volume":"97","author":"Andrade","year":"2011","journal-title":"Arq Bras Cardiol"},{"key":"10.1016\/j.carpath.2020.107257_bib0030","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0167-5273(96)02877-X","article-title":"A rationale approach for mortality risk stratification in Chagas heart disease","volume":"58","author":"Bestetti","year":"1997","journal-title":"Int J Cardiol"},{"issue":"4","key":"10.1016\/j.carpath.2020.107257_bib0031","doi-asserted-by":"crossref","first-page":"1003\u20101011","DOI":"10.1002\/1521-4141(200204)32:4<1003::AID-IMMU1003>3.0.CO;2-P","article-title":"Cruzipain, a major Trypanosoma cruzi antigen, conditions the host immune response in favor of parasite","volume":"32","author":"Giordanengo","year":"2002","journal-title":"Eur J Immunol"},{"issue":"2","key":"10.1016\/j.carpath.2020.107257_bib0032","doi-asserted-by":"crossref","first-page":"119\u2010127","DOI":"10.1016\/j.actatropica.2008.02.004","article-title":"Cruzipain and SP600125 induce p38 activation, alter NO\/arginase balance and favor the survival of Trypanosoma cruzi in macrophages","volume":"106","author":"Stempin","year":"2008","journal-title":"Acta Trop"},{"key":"10.1016\/j.carpath.2020.107257_bib0033","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1096\/fj.02-0477fje","article-title":"Trypanosoma cruzi induces edematogenic responses in mice and invades cardiomyocytes and endothelial cells in vitro by activating distinct kinin receptor (B1\/B2) subtypes","volume":"17","author":"Todorov","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.carpath.2020.107257_bib0034","doi-asserted-by":"crossref","first-page":"25713","DOI":"10.1074\/jbc.272.41.25713","article-title":"Kininogenase activity by the major cysteinyl proteinase (cruzipain) from Trypanosoma cruzi","volume":"272","author":"Del Nery","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.carpath.2020.107257_bib0035","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1084\/jem.192.9.1289","article-title":"Host cell invasion by Trypanosoma cruzi is potentiated by activation of bradykinin B(2) receptors","volume":"192","author":"Scharfstein","year":"2000","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.carpath.2020.107257_bib0036","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/00005344-199100182-00006","article-title":"Experimental cardiovascular benefits of angiotensinconverting enzyme inhibitors: beyond blood pressure reduction","volume":"18","author":"Sch\u00f6lkens","year":"1991","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.carpath.2020.107257_bib0037","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1161\/HYPERTENSIONAHA.107.091181","article-title":"ACE Activity Is Modulated by Kinin B2 Receptor","volume":"51","author":"Sabatini","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.carpath.2020.107257_bib0038","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0022-3565(24)39112-8","article-title":"Protein kinase C and phosphatase inhibitors block the ability of angiotensin I-converting enzyme inhibitors to resensitize the receptor to bradykinin without altering the primary effects of bradykinin","volume":"294","author":"Marcie","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"10.1016\/j.carpath.2020.107257_bib0039","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/j.2040-4603.2011.tb00347.x","article-title":"The kallikrein-kinin system as a regulator of cardiovascular and renal function","volume":"1","author":"NE1","year":"2011","journal-title":"Compr Physiol"},{"key":"10.1016\/j.carpath.2020.107257_bib0040","first-page":"36","article-title":"Bradykinin-mediated metabolic effects in isolated perfused rat hearts","volume":"38","author":"Schoelkens","year":"1992","journal-title":"Agents Actions Suppl"},{"issue":"4","key":"10.1016\/j.carpath.2020.107257_bib0041","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation","volume":"62","author":"Paulus","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.carpath.2020.107257_bib0042","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1590\/0074-0276140033","article-title":"Severity of chronic experimental Chagas' heart disease parallels tumour necrosis factor and nitric oxide levels in the serum: models of mild and severe disease","volume":"109","author":"Pereira","year":"2014","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"9005","key":"10.1016\/j.carpath.2020.107257_bib0043","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0140-6736(96)91403-8","article-title":"Role of parasites in the pathogenesis of Chagas' cardiomyopathy","volume":"347","author":"Bestetti","year":"1996","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.carpath.2020.107257_bib0044","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/cvr\/21.12.916","article-title":"Ability of the electrocardiogram to detect myocardial lesions in isoproterenol induced rat cardiomyopathy","volume":"21","author":"Bestetti","year":"1987","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.carpath.2020.107257_bib0045","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.jnutbio.2011.05.015","article-title":"Puerarin prevents isoprenaline induced myocardial fibrosis in mice by reduction of myocardial TGF-Beta1 expression","volume":"23","author":"Chen","year":"2012","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.carpath.2020.107257_bib0046","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/cvr\/24.7.521","article-title":"Effects of long-term metoprolol administration on the electrocardiogram of rats infected with Trypanosoma cruzi","volume":"24","author":"Bestetti","year":"1990","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.carpath.2020.107257_bib0047","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0014-5793(89)81331-6","article-title":"Bradykinin stimulates tumor necrosis factor and interleukin-1 release from macrophages","volume":"247","author":"Tiffany","year":"1989","journal-title":"FEBS Lett"},{"issue":"Suppl 1","key":"10.1016\/j.carpath.2020.107257_bib0048","first-page":"404","article-title":"Correlation between Th1, Th2, Th17 and Treg cytokines serum levels with autonomic function in patients with chronic Chagas disease and systemic arterial hypertension (abstract)","volume":"20","author":"Bestetti","year":"2018","journal-title":"Eur J Heart Fail"}],"container-title":["Cardiovascular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880720300612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880720300612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:46:10Z","timestamp":1760960770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054880720300612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":48,"alternative-id":["S1054880720300612"],"URL":"https:\/\/doi.org\/10.1016\/j.carpath.2020.107257","relation":{},"ISSN":["1054-8807"],"issn-type":[{"type":"print","value":"1054-8807"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kinins and nitric oxide in patients with chronic chagas disease and systemic arterial hypertension","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carpath.2020.107257","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107257"}}