{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:07:09Z","timestamp":1773976029694,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Pathology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.carpath.2022.107478","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T03:41:53Z","timestamp":1663904513000},"page":"107478","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Structural abnormalities in the non-dilated ascending aortic wall of bicuspid aortic valve patients"],"prefix":"10.1016","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9981-8336","authenticated-orcid":false,"given":"Nimrat","family":"Grewal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evaldas","family":"Girdauskas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Idhrees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bashi","family":"Velayudhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Klautz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Driessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Poelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.carpath.2022.107478_bib0001","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1016\/j.jacc.2009.12.068","article-title":"Bicuspid aortic valve disease","volume":"55","author":"Siu","year":"2010","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.carpath.2022.107478_bib0002","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1586\/14779072.3.2.295","article-title":"Bicuspid aortic valve disease: recent insights in pathophysiology and treatment","volume":"3","author":"Fedak","year":"2005","journal-title":"Expert review of cardiovascular therapy"},{"key":"10.1016\/j.carpath.2022.107478_bib0003","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s12471-014-0576-2","article-title":"Normal and abnormal development of the aortic wall and valve: correlation with clinical entities","volume":"22","author":"Grewal","year":"2014","journal-title":"Netherlands heart journal: monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation"},{"key":"10.1016\/j.carpath.2022.107478_bib0004","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0022-5223(19)33931-5","article-title":"The neural crest as a possible pathogenetic factor in coarctation of the aorta and bicuspid aortic valve","volume":"102","author":"Kappetein","year":"1991","journal-title":"The Journal of thoracic and cardiovascular surgery"},{"key":"10.1016\/j.carpath.2022.107478_bib0005","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.pcad.2020.06.008","article-title":"Embryonic development of bicuspid aortic valves","volume":"63","author":"Soto-Navarrete","year":"2020","journal-title":"Progress in cardiovascular diseases"},{"key":"10.1016\/j.carpath.2022.107478_bib0006","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1161\/ATVBAHA.117.309599","article-title":"Smooth muscle cells derived from second heart field and cardiac neural crest reside in spatially distinct domains in the media of the ascending aorta-brief report","volume":"37","author":"Sawada","year":"2017","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"10.1016\/j.carpath.2022.107478_bib0007","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nbt.2107","article-title":"Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility","volume":"30","author":"Cheung","year":"2012","journal-title":"Nature biotechnology"},{"key":"10.1016\/j.carpath.2022.107478_bib0008","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ebiom.2016.06.045","article-title":"Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves","volume":"10","author":"Jiao","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.carpath.2022.107478_bib0009","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1161\/CIR.0000000000000331","article-title":"Surgery for aortic dilatation in patients with bicuspid aortic valves: a statement of clarification from the american college of cardiology\/american heart association task force on clinical practice guidelines","volume":"133","author":"Hiratzka","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.carpath.2022.107478_bib0010","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/physrev.00041.2003","article-title":"Molecular regulation of vascular smooth muscle cell differentiation in development and disease","volume":"84","author":"Owens","year":"2004","journal-title":"Physiological reviews"},{"key":"10.1016\/j.carpath.2022.107478_bib0011","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1001\/jama.2011.1286","article-title":"Incidence of aortic complications in patients with bicuspid aortic valves","volume":"306","author":"Michelena","year":"2011","journal-title":"Jama"},{"issue":"4","key":"10.1016\/j.carpath.2022.107478_bib0012","doi-asserted-by":"crossref","first-page":"380","DOI":"10.21037\/acs-2021-bav-14","article-title":"Normal and abnormal development of the aortic valve and ascending aortic wall: a comprehensive overview of the embryology and pathology of the bicuspid aortic valve","volume":"11","author":"Grewal","year":"2022","journal-title":"Annals of cardiothoracic surgery"},{"key":"10.1016\/j.carpath.2022.107478_bib0013","article-title":"Association of TGF-\u03b2 Canonical signaling-related core genes with aortic aneurysms and aortic dissections","volume":"13","author":"Chen","year":"2022","journal-title":"Frontiers in pharmacology"},{"key":"10.1016\/j.carpath.2022.107478_bib0014","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.jtcvs.2014.01.027","article-title":"Ascending aorta dilation in association with bicuspid aortic valve: a maturation defect of the aortic wall","volume":"148","author":"Grewal","year":"2014","journal-title":"The Journal of thoracic and cardiovascular surgery"},{"key":"10.1016\/j.carpath.2022.107478_bib0015","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijcard.2020.04.011","article-title":"Impact of histopathological changes in ascending aortic diseases","volume":"311","author":"Amemiya","year":"2020","journal-title":"International journal of cardiology"},{"key":"10.1016\/j.carpath.2022.107478_bib0016","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1274034","article-title":"Cardiovascular disease in ageing: an overview on thoracic aortic aneurysm as an emerging inflammatory disease","volume":"2017","author":"Pisano","year":"2017","journal-title":"Mediators of inflammation"},{"key":"10.1016\/j.carpath.2022.107478_bib0017","first-page":"54","article-title":"Histopathological grading of ascending aortic aneurysm: comparison of patients with bicuspid versus tricuspid aortic valve","volume":"12","author":"Matthias Bechtel","year":"2003","journal-title":"The Journal of heart valve disease"},{"key":"10.1016\/j.carpath.2022.107478_bib0018","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9040908","article-title":"The development of the ascending aortic wall in tricuspid and bicuspid aortic valve: a process from maturation to degeneration","volume":"9","author":"Grewal","year":"2020","journal-title":"Journal of clinical medicine"},{"key":"10.1016\/j.carpath.2022.107478_bib0019","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.020080","article-title":"The extent of coronary artery disease in patients with stenotic bicuspid versus tricuspid aortic valves","author":"Dolmaci","year":"2021","journal-title":"Journal of the American Heart Association"},{"issue":"5","key":"10.1016\/j.carpath.2022.107478_bib0020","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003200","article-title":"Impact of valve morphology on the prevalence of coronary artery disease: a systematic review and meta-analysis","volume":"5","author":"Poggio","year":"2016","journal-title":"Journal of the American Heart Association"},{"key":"10.1016\/j.carpath.2022.107478_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.734550","article-title":"Endothelial to mesenchymal transition: an insight in atherosclerosis","volume":"8","author":"Huang","year":"2021","journal-title":"Frontiers in cardiovascular medicine"},{"key":"10.1016\/j.carpath.2022.107478_bib0022","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1161\/01.RES.80.4.444","article-title":"Embryonic endothelial cells transdifferentiate into mesenchymal cells expressing smooth muscle actins in vivo and in vitro","volume":"80","author":"DeRuiter","year":"1997","journal-title":"Circulation research"},{"key":"10.1016\/j.carpath.2022.107478_bib0023","doi-asserted-by":"crossref","first-page":"35712","DOI":"10.1038\/srep35712","article-title":"Mesenchymal state of intimal cells may explain higher propensity to ascending aortic aneurysm in bicuspid aortic valves","volume":"6","author":"Maleki","year":"2016","journal-title":"Scientific reports"}],"container-title":["Cardiovascular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880722000722?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880722000722?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:46:53Z","timestamp":1760960813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054880722000722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":23,"alternative-id":["S1054880722000722"],"URL":"https:\/\/doi.org\/10.1016\/j.carpath.2022.107478","relation":{},"ISSN":["1054-8807"],"issn-type":[{"value":"1054-8807","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural abnormalities in the non-dilated ascending aortic wall of bicuspid aortic valve patients","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carpath.2022.107478","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107478"}}