{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:43:02Z","timestamp":1790646182939,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["AZV NU20-02-00244"],"award-info":[{"award-number":["AZV NU20-02-00244"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","award":["945119"],"award-info":[{"award-number":["945119"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Pathology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.carpath.2022.107488","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T02:20:47Z","timestamp":1664850047000},"page":"107488","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia"],"prefix":"10.1016","volume":"62","author":[{"given":"Tom\u00e1\u0161","family":"Ku\u010dera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krist\u00edna","family":"Jedli\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"\u0160ramko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Peichl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Cvek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luk\u00e1\u0161","family":"Knybel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Hurn\u00edk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radek","family":"Neuwirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otakar","family":"Jiravsk\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lud\u011bk","family":"Voska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Kautzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.carpath.2022.107488_bib0001","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1111\/jce.15259","article-title":"Cardiac stereotactic body radiation therapy for ventricular tachycardia: Current experience and technical gaps","volume":"32","author":"Wei","year":"2021","journal-title":"J Cardiovasc Electr"},{"key":"10.1016\/j.carpath.2022.107488_bib0002","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.clon.2021.09.001","article-title":"Leveraging Radiobiology for Arrhythmia Management: A New Treatment Paradigm?","volume":"33","author":"Zhang","year":"2021","journal-title":"Clin Oncol-Uk"},{"key":"10.1016\/j.carpath.2022.107488_bib0003","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/j.hrthm.2015.05.036","article-title":"Freedom from recurrent ventricular tachycardia after catheter ablation is associated with improved survival in patients with structural heart disease: An International VT Ablation Center Collaborative Group study","volume":"12","author":"Tung","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.carpath.2022.107488_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcvm.2020.00108","article-title":"Stereotactic Radiotherapy for the Management of Refractory Ventricular Tachycardia: Promise and Future Directions","volume":"7","author":"Jumeau","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.carpath.2022.107488_bib0005","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.hrthm.2020.03.013","article-title":"Cardiac radioablation-A systematic review","volume":"17","author":"van der Ree","year":"2020","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.carpath.2022.107488_bib0006","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.hrthm.2019.09.028","article-title":"Clinical experience of stereotactic body radiation for refractory ventricular tachycardia in advanced heart failure patients","volume":"17","author":"Lloyd","year":"2020","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.carpath.2022.107488_bib0007","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1056\/NEJMoa1613773","article-title":"Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia","volume":"377","author":"Cuculich","year":"2017","journal-title":"New Engl J Med"},{"key":"10.1016\/j.carpath.2022.107488_bib0008","first-page":"1303","article-title":"Histopathologic and Ultrastructural Findings in Human Myocardium After Stereotactic Body Radiation Therapy for Recalcitrant Ventricular Tachycardia","volume":"13","author":"Kiani","year":"2020","journal-title":"Circ-Arrhythmia Elec"},{"key":"10.1016\/j.carpath.2022.107488_bib0009","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.jacep.2021.07.012","article-title":"Radiation-Induced Changes in Ventricular Myocardium After Stereotactic Body Radiotherapy for Recurrent Ventricular Tachycardia","volume":"7","author":"Kautzner","year":"2021","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.carpath.2022.107488_bib0010","first-page":"1","article-title":"Feasibility Study on Cardiac Arrhythmia Ablation Using High-Energy Heavy Ion Beams","volume":"6","author":"Lehmann","year":"2016","journal-title":"Sci Rep-Uk"},{"key":"10.1016\/j.carpath.2022.107488_bib0011","first-page":"1","article-title":"Biological Cardiac Tissue Effects of High-Energy Heavy Ions - Investigation for Myocardial Ablation","volume":"9","author":"Rapp","year":"2019","journal-title":"Sci Rep-Uk"},{"key":"10.1016\/j.carpath.2022.107488_bib0012","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.hrthm.2010.02.010","article-title":"Noninvasive stereotactic radiosurgery (CyberHeart) for creation of ablation lesions in the atrium","volume":"7","author":"Sharma","year":"2010","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.carpath.2022.107488_bib0013","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3109\/09553002.2014.887869","article-title":"Apoptosis induction of cardiomyocytes and subsequent fibrosis after irradiation and neoadjuvant chemotherapy","volume":"90","author":"Salata","year":"2014","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.carpath.2022.107488_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.117.007193","article-title":"Swine Atrioventricular Node Ablation Using Stereotactic Radiosurgery: Methods and In Vivo Feasibility Investigation for Catheter-Free Ablation of Cardiac Arrhythmias","volume":"6","author":"Refaat","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.carpath.2022.107488_bib0015","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00066-019-01530-w","article-title":"Stereotactic body radiotherapy for ventricular tachycardia (cardiac radiosurgery) First-in-patient treatment in Germany","volume":"196","author":"Krug","year":"2020","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.carpath.2022.107488_bib0016","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1369\/0022155414545334","article-title":"Mast cell function: a new vision of an old cell","volume":"62","author":"da Silva","year":"2014","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.carpath.2022.107488_bib0017","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1385\/IR:34:2:97","article-title":"Development, migration, and survival of mast cells","volume":"34","author":"Okayama","year":"2006","journal-title":"Immunol Res"},{"key":"10.1016\/j.carpath.2022.107488_bib0018","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1510\/icvts.2005.109413","article-title":"Histological findings induced by different energy sources in experimental atrial ablation in sheep","volume":"4","author":"Aupperle","year":"2005","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.carpath.2022.107488_bib0019","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/0192623319826063","article-title":"Pathology Approaches to Determine Safety and Efficacy of Cardiac Ablation Catheters","volume":"47","author":"Stoffregen","year":"2019","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.carpath.2022.107488_bib0020","doi-asserted-by":"crossref","first-page":"ytaa516","DOI":"10.1093\/ehjcr\/ytaa516","article-title":"A case report of successful elimination of recurrent ventricular tachycardia by repeated stereotactic radiotherapy: the importance of accurate target volume delineation","volume":"5","author":"Peichl","year":"2021","journal-title":"Eur Heart J Case Rep"},{"key":"10.1016\/j.carpath.2022.107488_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.845382","article-title":"Case Report: Repeated Stereotactic Radiotherapy of Recurrent Ventricular Tachycardia: Reasons, Feasibility, and Safety","volume":"9","author":"Haskova","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.carpath.2022.107488_bib0022","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ijrobp.2014.02.036","article-title":"Dose-escalation study for cardiac radiosurgery in a porcine model","volume":"89","author":"Blanck","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.carpath.2022.107488_bib0023","first-page":"1","article-title":"Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.carpath.2022.107488_bib0024","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019072","article-title":"Early Changes in Rat Heart After High-Dose Irradiation: Implications for Antiarrhythmic Effects of Cardiac Radioablation","volume":"10","author":"Cha","year":"2021","journal-title":"J Am Heart Assoc"}],"container-title":["Cardiovascular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880722000825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880722000825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:47:07Z","timestamp":1760960827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054880722000825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":24,"alternative-id":["S1054880722000825"],"URL":"https:\/\/doi.org\/10.1016\/j.carpath.2022.107488","relation":{},"ISSN":["1054-8807"],"issn-type":[{"value":"1054-8807","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carpath.2022.107488","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107488"}}