{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:11:03Z","timestamp":1760962263415,"version":"build-2065373602"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Pathology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.carpath.2023.107560","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T21:48:56Z","timestamp":1689284936000},"page":"107560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Seeing beyond apoptosis: ultrastructural aspects of necrosis in human atherosclerosis"],"prefix":"10.1016","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9061-9776","authenticated-orcid":false,"given":"Ida","family":"Perrotta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.carpath.2023.107560_bib0001","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1161\/CIRCRESAHA.118.313591","article-title":"immunity and inflammation in atherosclerosis","volume":"124","author":"Wolf","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.carpath.2023.107560_bib0002","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.707529","article-title":"Role of lipid accumulation and inflammation in atherosclerosis: focus on molecular and cellular mechanisms","volume":"8","author":"Malekmohammad","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.carpath.2023.107560_bib0003","first-page":"927","article-title":"Atherosclerosis: process, indicators, risk factors and new hopes","volume":"5","author":"Rafieian-Kopaei","year":"2014","journal-title":"Int J Prev Med"},{"key":"10.1016\/j.carpath.2023.107560_bib0004","first-page":"57","article-title":"Molecular biology of atherosclerosis","volume":"5","author":"Mannarino","year":"2008","journal-title":"Clin Cases Miner Bone Metab"},{"key":"10.1016\/j.carpath.2023.107560_bib0005","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1161\/ATVBAHA.117.309229","article-title":"Cell death in the vessel wall: the good, the bad, the ugly","volume":"37","author":"Rayner","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.carpath.2023.107560_bib0006","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41419-022-04923-5","article-title":"Programmed cell death in atherosclerosis and vascular calcification","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.carpath.2023.107560_bib0007","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1007\/s11033-021-06402-0","article-title":"Different types of cell death in vascular diseases","volume":"48","author":"Saberianpour","year":"2021","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.carpath.2023.107560_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1476-5381.2011.01342.x","article-title":"Pharmacological modulation of cell death in atherosclerosis: a promising approach towards plaque stabilization?","volume":"164","author":"Martinet","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.carpath.2023.107560_bib0009","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1042\/CS20040086","article-title":"Role of apoptosis in atherosclerosis and its therapeutic implications","volume":"107","author":"Stoneman","year":"2004","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.carpath.2023.107560_bib0010","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1161\/01.ATV.18.10.1519","article-title":"Apoptosis in the atherosclerotic plaque: quantitative and qualitative aspects","volume":"18","author":"Kockx","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.carpath.2023.107560_bib0011","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/ATVBAHA.111.224873","article-title":"Apoptotic cell death and efferocytosis in atherosclerosis","volume":"32","author":"Van Vr\u00e9","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.carpath.2023.107560_bib0012","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1038\/sj.cdd.4401444","article-title":"Apoptosis and plaque destabilization in atherosclerosis: the role of macrophage apoptosis induced by cholesterol","volume":"11","author":"Tabas","year":"2004","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.carpath.2023.107560_bib0013","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.809516","article-title":"The function, regulation and mechanism of programmed cell death of macrophages in atherosclerosis","volume":"9","author":"Liu","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.carpath.2023.107560_bib0014","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1046\/j.1365-2613.1999.00125.x","article-title":"Vascular smooth muscle cell apoptosis in atherosclerosis","volume":"80","author":"Boyle","year":"1999","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.carpath.2023.107560_bib0015","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1161\/CIRCRESAHA.108.175976","article-title":"Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration","volume":"102","author":"Clarke","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.carpath.2023.107560_bib0016","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0021-9150(98)00013-6","article-title":"Apoptosis of vascular smooth muscle cells in atherosclerosis","volume":"138","author":"Bennett","year":"1998","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.carpath.2023.107560_bib0017","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s00018-018-2983-9","article-title":"Endothelial cell apoptosis and the role of endothelial cell-derived extracellular vesicles in the progression of atherosclerosis","volume":"76","author":"Paone","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.carpath.2023.107560_bib0018","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1006\/jmcc.2001.1419","article-title":"Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis","volume":"33","author":"Choy","year":"2001","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.carpath.2023.107560_bib0019","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1159\/000438511","article-title":"Atherosclerosis-associated endothelial cell apoptosis by MiR-429-mediated down regulation of Bcl-2","volume":"37","author":"Zhang","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.carpath.2023.107560_bib0020","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0021-9150(96)06037-6","article-title":"Cell death in human atherosclerotic plaques involves both oncosis and apoptosis","volume":"130","author":"Crisby","year":"1997","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.carpath.2023.107560_bib0021","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/BF03257242","article-title":"Mode and role of cell death during progression of atherosclerotic lesions in hypercholesterolemic rabbits","volume":"14","author":"Kunishima","year":"1999","journal-title":"Heart Vessels"},{"key":"10.1016\/j.carpath.2023.107560_bib0022","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-62703-383-1_7","article-title":"Analysis of cell death by electron microscopy","volume":"1004","author":"Burattini","year":"2013","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.carpath.2023.107560_bib0023","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00418-007-0356-9","article-title":"Morphological and cytochemical determination of cell death by apoptosis","volume":"129","author":"Taatjes","year":"2008","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.carpath.2023.107560_bib0024","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ijcard.2005.11.025","article-title":"Electron microscopy characterization of cardiomyocyte apoptosis in ischemic heart disease","volume":"114","author":"Abbate","year":"2007","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.carpath.2023.107560_bib0025","first-page":"1355","article-title":"A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis","volume":"92","author":"Stary","year":"1995","journal-title":"Am Heart Assoc Circ."},{"key":"10.1016\/j.carpath.2023.107560_bib0026","first-page":"18","article-title":"Patterns of cell death","volume":"13","author":"Walker","year":"1988","journal-title":"Methods Achiev Exp Pathol"},{"key":"10.1016\/j.carpath.2023.107560_bib0027","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/sj.cdd.4402148","article-title":"Cell death modalities: classification and pathophysiological implications","volume":"14","author":"Galluzzi","year":"2007","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.carpath.2023.107560_bib0028","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: a review of the major forms of apoptosis, necrosis and autophagy","volume":"43","author":"MS","year":"2019","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.carpath.2023.107560_bib0029","first-page":"3","article-title":"Apoptosis, oncosis, and necrosis. An overview of cell death","volume":"146","author":"Majno","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1016\/j.carpath.2023.107560_bib0030","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/s12276-020-0455-4","article-title":"Autophagy as a decisive process for cell death","volume":"52","author":"Jung","year":"2020","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.carpath.2023.107560_bib0031","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/146282","article-title":"Targeting the mitotic catastrophe signaling pathway in cancer","volume":"2015","author":"Mc Gee","year":"2015","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.carpath.2023.107560_bib0032","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-1-0716-1162-3_12","article-title":"Visualization of necroptotic cell death through transmission electron microscopy","volume":"2255","author":"Golla","year":"2021","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.carpath.2023.107560_bib0033","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ymeth.2007.12.001","article-title":"Apoptosis and necrosis: detection, discrimination and phagocytosis","volume":"44","author":"Krysko","year":"2008","journal-title":"Methods"},{"key":"10.1016\/j.carpath.2023.107560_bib0034","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0014-4827(69)90030-5","article-title":"Studies on induced cellular autophagy. II. Characterization of the membranes bordering autophagosomes in parenchymal liver cells","volume":"56","author":"Ericsson","year":"1969","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.carpath.2023.107560_bib0035","article-title":"Guidelines for regulated cell death assays: a systematic summary, a categorical comparison, a prospective","volume":"9","author":"Hu","year":"2021","journal-title":"Front Cell Dev Biol"},{"year":"1858","series-title":"Cellular Pathology","author":"Virchow","key":"10.1016\/j.carpath.2023.107560_bib0036"},{"key":"10.1016\/j.carpath.2023.107560_bib0037","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0014-4800(68)80004-8","article-title":"Cerebral atherosclerosis in swine: role of necrosis in progression of diet-induced lesions from proliferative to atheromatous stage","volume":"8","author":"Imai","year":"1968","journal-title":"Exp Mol Pathol"},{"issue":"5","key":"10.1016\/j.carpath.2023.107560_bib0038","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1172\/JCI117917","article-title":"Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques","volume":"95","author":"Bennett","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.carpath.2023.107560_bib0039","first-page":"251","article-title":"Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme","volume":"147","author":"Geng","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1016\/j.carpath.2023.107560_bib0040","first-page":"267","article-title":"Evidence for apoptosis in human atherogenesis and in a rat vascular injury model","volume":"147","author":"Han","year":"1995","journal-title":"Am J Pathol"},{"issue":"Suppl G","key":"10.1016\/j.carpath.2023.107560_bib0041","first-page":"G23","article-title":"Apoptosis in atherogenesis: implications for plaque destabilization","volume":"19","author":"Kockx","year":"1998","journal-title":"Eur Heart J"},{"key":"10.1016\/j.carpath.2023.107560_bib0042","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.3390\/ijms21239090","article-title":"Do TUNEL and other apoptosis assays detect cell death in preclinical studies?","volume":"21","author":"Mirzayans","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.carpath.2023.107560_bib0043","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/002215549804600306","article-title":"TUNEL apoptotic cell detection in tissue sections: critical evaluation and improvement","volume":"46","author":"Labat-Moleur","year":"1998","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.carpath.2023.107560_bib0044","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1161\/01.CIR.91.11.2703","article-title":"Apoptosis in human atherosclerosis and restenosis","volume":"91","author":"Isner","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.carpath.2023.107560_bib0045","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1161\/01.ATV.17.10.2225","article-title":"DNA fragmentation and ultrastructural changes of degenerating cells in atherosclerotic lesions and smooth muscle cells exposed to oxidized LDL in vitro","volume":"17","author":"Jovinge","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.carpath.2023.107560_bib0046","first-page":"1771","article-title":"Biotin- or digoxigenin-conjugated nucleotides bind to matrix vesicles in atherosclerotic plaques","volume":"148","author":"Kockx","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.carpath.2023.107560_bib0047","first-page":"885","article-title":"RNA synthesis and splicing interferes with DNA in situ end labeling techniques used to detect apoptosis","volume":"152","author":"Kockx","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.carpath.2023.107560_bib0048","first-page":"367","article-title":"Apoptosis is abundant in human atherosclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability","volume":"149","author":"Bj\u00f6rkerud","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.carpath.2023.107560_bib0049","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00395-011-0192-x","article-title":"Necrotic cell death in atherosclerosis","volume":"106","author":"Martinet","year":"2011","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.carpath.2023.107560_bib0050","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1161\/01.ATV.18.7.1132","article-title":"Apoptosis in restenosis versus stable-angina atherosclerosis: implications for the pathogenesis of restenosis","volume":"18","author":"Bauriedel","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.carpath.2023.107560_bib0051","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/(SICI)1096-9896(199612)180:4<423::AID-PATH677>3.0.CO;2-1","article-title":"Foam cell apoptosis and the development of the lipid core of human atherosclerosis","volume":"180","author":"Hegyi","year":"1996","journal-title":"J Pathol"},{"key":"10.1016\/j.carpath.2023.107560_bib0052","doi-asserted-by":"crossref","first-page":"33635","DOI":"10.1074\/jbc.M606339200","article-title":"Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent macrophages","volume":"281","author":"Bao","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.carpath.2023.107560_bib0053","series-title":"Pathologic Basis of Veterinary Disease","first-page":"2","article-title":"Mechanisms and Morphology of Cellular Injury, Adaptation, and Death","author":"Miller","year":"2017"},{"key":"10.1016\/j.carpath.2023.107560_bib0054","unstructured":"Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology (10th ed.). 2017;Elsevier - Health Sciences Division."},{"key":"10.1016\/j.carpath.2023.107560_bib0055","first-page":"3084","article-title":"Necrotic pyknosis is a morphologically and biochemically distinct event from apoptotic pyknosis","volume":"129","author":"Hou","year":"2016","journal-title":"J Cell Sci"},{"key":"10.1016\/j.carpath.2023.107560_bib0056","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1136\/hrt.60.6.459","article-title":"Morphology of the endothelium over atherosclerotic plaques in human coronary arteries","volume":"60","author":"Davies","year":"1988","journal-title":"Br Heart J"},{"key":"10.1016\/j.carpath.2023.107560_bib0057","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1161\/01.ATV.11.6.1678","article-title":"The endothelium of advanced arteriosclerotic plaques in humans","volume":"11","author":"B\u00fcrrig","year":"1991","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.carpath.2023.107560_bib0058","first-page":"713","article-title":"Ultrastructural alterations of endothelium covering advanced atherosclerotic plaque in human carotid artery visualised by scanning electron microscope","volume":"53","author":"Walski","year":"2002","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.carpath.2023.107560_bib0059","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.atherosclerosis.2021.11.017","article-title":"Diverse ultrastructural landscape of atherosclerotic endothelium","volume":"339","author":"Kluza","year":"2021","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.carpath.2023.107560_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105599","article-title":"Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis","volume":"168","author":"Duan","year":"2021","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.carpath.2023.107560_bib0061","first-page":"313","article-title":"Endothelial cell morphology in areas of in vivo Evans blue uptake in the aorta of young pigs. II. Ultrastructure of the intima in areas of differing permeability to proteins","volume":"89","author":"Gerrity","year":"1977","journal-title":"Am J Pathol"},{"key":"10.1016\/j.carpath.2023.107560_bib0062","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.bbabio.2006.06.014","article-title":"Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response","volume":"1757","author":"Festjens","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.carpath.2023.107560_bib0063","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1530\/jrf.0.1170325","article-title":"Sequence of apoptosis and inflammatory necrosis within the formative ovulatory site of sheep follicles","volume":"117","author":"Murdoch","year":"1999","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.carpath.2023.107560_bib0064","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ni0503-416","article-title":"Caspase-independent cell death in T lymphocytes","volume":"4","author":"J\u00e4\u00e4ttel\u00e4","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.carpath.2023.107560_bib0065","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.clim.2014.05.002","article-title":"The role of necrotic cell death in the pathogenesis of immune mediated nephropathies","volume":"153","author":"Jog","year":"2014","journal-title":"Clin Immunol"},{"key":"10.1016\/j.carpath.2023.107560_bib0066","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/imm.13325","article-title":"Cell death as part of innate immunity: cause or consequence?","volume":"163","author":"Riera Romo","year":"2021","journal-title":"Immunology"},{"key":"10.1016\/j.carpath.2023.107560_bib0067","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1302\/0301-620X.82B4.0820601","article-title":"Physiological cell death of chondrocytes in vivo is not confined to apoptosis. New observations on the mammalian growth plate","volume":"82","author":"Roach","year":"2000","journal-title":"J Bone Joint Surg Br"},{"issue":"3","key":"10.1016\/j.carpath.2023.107560_bib0068","first-page":"308","article-title":"Cell death of intestinal epithelial cells in intestinal diseases","volume":"72","author":"Subramanian","year":"2020","journal-title":"Sheng Li Xue Bao"},{"key":"10.1016\/j.carpath.2023.107560_bib0069","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/250762","article-title":"Apoptosis, necrosis, and necroptosis in the gut and intestinal homeostasis","volume":"2015","author":"Negroni","year":"2015","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.carpath.2023.107560_bib0070","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2174\/156720209789630375","article-title":"Oxidative stress-induced necrotic cell death via mitochondira-dependent burst of reactive oxygen species","volume":"6","author":"Choi","year":"2009","journal-title":"Curr Neurovasc Res"},{"key":"10.1016\/j.carpath.2023.107560_bib0071","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3390\/biomedicines10010127","article-title":"Interplay of oxidative stress and necrosis-like cell death in cardiac ischemia\/reperfusion injury: a focus on necroptosis","volume":"10","author":"Adameova","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.carpath.2023.107560_bib0072","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-62703-383-1_9","article-title":"Quantitation of acute necrosis after experimental myocardial infarction","volume":"1004","author":"Yeap","year":"2013","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.carpath.2023.107560_bib0073","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1161\/01.CIR.97.8.795","article-title":"Progression of myocardial necrosis during reperfusion of ischemic myocardium","volume":"97","author":"Matsumura","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.carpath.2023.107560_bib0074","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.csbj.2015.03.004","article-title":"The role of excitotoxic programmed necrosis in acute brain injury","volume":"13","author":"Fujikawa","year":"2015","journal-title":"Comput Struct Biotechnol J"},{"issue":"4","key":"10.1016\/j.carpath.2023.107560_bib0075","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1750-3639.1993.tb00768.x","article-title":"Excitotoxicity and selective neuronal loss in epilepsy","volume":"3","author":"Meldrum","year":"1993","journal-title":"Brain Pathol"},{"key":"10.1016\/j.carpath.2023.107560_bib0076","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.937133","article-title":"Neuronal cell death mechanisms in Alzheimer's disease: An insight","volume":"15","author":"Goel","year":"2022","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.carpath.2023.107560_bib0077","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3389\/fphys.2017.00600","article-title":"Oxidative stress-mediated atherosclerosis: mechanisms and therapies","volume":"8","author":"Yang","year":"2017","journal-title":"Front Physiol"},{"issue":"23","key":"10.1016\/j.carpath.2023.107560_bib0078","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.3390\/cells11233843","article-title":"The role of oxidative stress in atherosclerosis","volume":"11","author":"Batty","year":"2022","journal-title":"Cells."},{"key":"10.1016\/j.carpath.2023.107560_bib0079","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0891-5849(96)00235-3","article-title":"Apoptotic vs. nonapoptotic cytotoxicity induced by hydrogen peroxide","volume":"22","author":"Gardner","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.carpath.2023.107560_bib0080","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/sj.cdd.4401249","article-title":"The selection between apoptosis and necrosis is differentially regulated in hydrogen peroxide-treated and glutathione-depleted human promonocytic cells","volume":"10","author":"Troyano","year":"2003","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.carpath.2023.107560_bib0081","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1096\/fj.99-0986com","article-title":"Mildly oxidized low density lipoprotein activates multiple apoptotic signaling pathways in human coronary cells","volume":"14","author":"Napoli","year":"2000","journal-title":"FASEB J"},{"key":"10.1016\/j.carpath.2023.107560_bib0082","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/emm.1999.27","article-title":"Oxidation-dependent effects of oxidized LDL: proliferation or cell death","volume":"31","author":"Han","year":"1999","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.carpath.2023.107560_bib0083","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3389\/fphys.2013.00242","article-title":"Interaction of aldehydes derived from lipid peroxidation and membrane proteins","volume":"4","author":"Pizzimenti","year":"2013","journal-title":"Front Physiol"},{"key":"10.1016\/j.carpath.2023.107560_bib0084","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101119","article-title":"Lipoxidation in cardiovascular diseases","volume":"23","author":"Gianazza","year":"2019","journal-title":"Redox Biol"},{"key":"10.1016\/j.carpath.2023.107560_bib0085","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/mnfr.200500055","article-title":"The relation of lipid peroxidation processes with atherogenesis: a new theory on atherogenesis","volume":"49","author":"Spiteller","year":"2005","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.carpath.2023.107560_bib0086","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/730209","article-title":"Impact of oxLDL on Cholesterol-Rich Membrane Rafts","volume":"2011","author":"Levitan","year":"2011","journal-title":"J Lipids"},{"key":"10.1016\/j.carpath.2023.107560_bib0087","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbrc.2016.10.086","article-title":"Lipid peroxidation in cell death","volume":"482","author":"Gaschler","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.carpath.2023.107560_bib0088","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: Death by Lipid Peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.carpath.2023.107560_bib0089","first-page":"2161","article-title":"Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL","volume":"56","author":"Shimizu","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.carpath.2023.107560_bib0090","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1042\/BST20120345","article-title":"The impact of hypoxia on cell death pathways","volume":"41","author":"Lenihan","year":"2013","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.carpath.2023.107560_bib0091","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/MOL.0b013e3283307be8","article-title":"The role of hypoxia in atherosclerosis","volume":"20","author":"Hult\u00e9n","year":"2009","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.carpath.2023.107560_bib0092","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178877","article-title":"Depletion of ATP and glucose in advanced human atherosclerotic plaques","volume":"12","author":"Ekstrand","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.carpath.2023.107560_bib0093","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.3390\/ijms21082660","article-title":"Inflammation and necrosis as determinants of glioblastoma cancer stem cells progression","volume":"21","author":"Papale","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.carpath.2023.107560_bib0094","doi-asserted-by":"crossref","DOI":"10.1177\/15330338211036304","article-title":"Hypoxia and the tumor microenvironment","volume":"20","author":"Li","year":"2021","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.carpath.2023.107560_bib0095","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12935-020-01719-5","article-title":"The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment","volume":"21","author":"Emami Nejad","year":"2021","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.carpath.2023.107560_bib0096","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-011-0192-x","article-title":"Necrotic cell death in atherosclerosis","volume":"106","author":"Martinet","year":"2011","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.carpath.2023.107560_bib0097","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1476-5381.2011.01342.x","article-title":"Pharmacological modulation of cell death in atherosclerosis: a promising approach towards plaque stabilization?","volume":"164","author":"Martinet","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.carpath.2023.107560_bib0098","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1161\/ATVBAHA.122.318177","article-title":"Regulated Necrosis in Atherosclerosis","volume":"42","author":"Puylaert","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.carpath.2023.107560_bib0099","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114634","article-title":"Pharmacological inhibition of fatty acid oxidation reduces atherosclerosis progression by suppression of macrophage NLRP3 inflammasome activation","volume":"190","author":"Hohensinner","year":"2021","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.carpath.2023.107560_bib0100","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41573-021-00198-1","article-title":"Targeting inflammation in atherosclerosis-from experimental insights to the clinic","volume":"20","author":"Soehnlein","year":"2021","journal-title":"Nat Rev Drug Discov"}],"container-title":["Cardiovascular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880723000443?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880723000443?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:47:09Z","timestamp":1760960829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054880723000443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":100,"alternative-id":["S1054880723000443"],"URL":"https:\/\/doi.org\/10.1016\/j.carpath.2023.107560","relation":{},"ISSN":["1054-8807"],"issn-type":[{"type":"print","value":"1054-8807"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Seeing beyond apoptosis: ultrastructural aspects of necrosis in human atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carpath.2023.107560","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107560"}}