{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:41:44Z","timestamp":1794004904691,"version":"4.8.0"},"reference-count":158,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Pathology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.carpath.2024.107683","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:13:22Z","timestamp":1722903202000},"page":"107683","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Doxorubicin-related cardiotoxicity: review of fundamental pathways of cardiovascular system injury"],"prefix":"10.1016","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5383-8355","authenticated-orcid":false,"given":"Ashot","family":"Avagimyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Pogosova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lev","family":"Kakturskiy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Sheibani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhiram","family":"Challa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Kogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Fogacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liudmila","family":"Mikhaleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rositsa","family":"Vandysheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Yakubovskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Faggiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Carugo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Urazova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnaz","family":"Jahanbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Lesovaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srujana","family":"Polana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirill","family":"Kirsanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasar","family":"Sattar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artem","family":"Trofimenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Demura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amene","family":"Saghazadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Koliakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davood","family":"Shafie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azin","family":"Alizadehasl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arrigo","family":"Cicero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Costabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Biondi-Zoccai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Ottaviani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizal","family":"Sarrafzadegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.carpath.2024.107683_bib0001","year":"2022","journal-title":"Cancer"},{"issue":"3-4","key":"10.1016\/j.carpath.2024.107683_bib0002","first-page":"79","article-title":"The growing role of precision and personalized medicine for cancer treatment","volume":"6","author":"Krzyszczyk","year":"2018","journal-title":"Technology (Singap World Sci)"},{"issue":"14","key":"10.1016\/j.carpath.2024.107683_bib0003","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.3390\/molecules27144478","article-title":"Doxorubicin-based hybrid compounds as potential anticancer agents: a review","volume":"27","author":"Peter","year":"2022","journal-title":"Molecules"},{"issue":"21","key":"10.1016\/j.carpath.2024.107683_bib0004","doi-asserted-by":"crossref","first-page":"6095","DOI":"10.1111\/febs.15583","article-title":"New insights into the activities and toxicities of the old anticancer drug doxorubicin","volume":"288","author":"Van der Zanden","year":"2021","journal-title":"FEBS J"},{"issue":"25","key":"10.1016\/j.carpath.2024.107683_bib0005","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.2174\/092986709788803312","article-title":"Doxorubicin: the good, the bad and the ugly effect","volume":"16","author":"Carvalho","year":"2009","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.carpath.2024.107683_bib0006","first-page":"16","article-title":"Approaches to management of cardiovascular morbidity in adult cancer patients - cross-sectional survey among cardio-oncology experts","volume":"6","author":"Hedayati","year":"2020","journal-title":"Cardiooncology"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0007","first-page":"15","article-title":"Correction: Approaches for monitoring and treating cardiomyopathy among cancer survivors following anthracycline or thoracic radiation treatment","volume":"8","author":"Delavar","year":"2022","journal-title":"Cardiooncology"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0008","first-page":"17","article-title":"Anthracycline cardiotoxicity: current methods of diagnosis and possible role of 18F-FDG PET\/CT as a new biomarker","volume":"9","author":"Becker","year":"2023","journal-title":"Cardiooncology"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjqcco\/qcac070","article-title":"European Society of Cardiology quality indicators for the prevention and management of cancer therapy-related cardiovascular toxicity in cancer treatment","volume":"9","author":"Lee","year":"2022","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"issue":"18","key":"10.1016\/j.carpath.2024.107683_bib0010","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1093\/eurheartj\/ehaa006","article-title":"Classification, prevalence, and outcomes of anticancer therapy-induced cardiotoxicity: the CARDIOTOX registry","volume":"41","author":"L\u00f3pez-Send\u00f3n","year":"2020","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.carpath.2024.107683_bib0011","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.15829\/1560-4071-2023-5452","article-title":"Cardiovascular prevention 2022. Russian national guidelines","volume":"28","author":"Boytsov","year":"2023","journal-title":"Russ J Cardiology"},{"issue":"8","key":"10.1016\/j.carpath.2024.107683_bib0012","article-title":"Opportunities and challenges in cardio-oncology: a bibliometric analysis from 2010 to 2022","volume":"48","author":"Shuqing","year":"2023","journal-title":"Curr Probl in Cardiol"},{"key":"10.1016\/j.carpath.2024.107683_bib0013","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.toxlet.2019.02.013","article-title":"Oxidative stress injury in doxorubicin-induced cardiotoxicity","volume":"307","author":"Songbo","year":"2019","journal-title":"Toxicol Lett"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0014","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12935-023-02936-4","article-title":"A systematic review of the protective effects of silymarin\/silibinin against doxorubicin-induced cardiotoxicity","volume":"23","author":"Singh","year":"2023","journal-title":"Cancer Cell Int"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0015","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12964-023-01077-5","article-title":"Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy","volume":"21","author":"Shi","year":"2023","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.carpath.2024.107683_bib0016","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.toxlet.2019.02.013","article-title":"Oxidative stress injury in doxorubicin-induced cardiotoxicity","volume":"307","author":"Songbo","year":"2019","journal-title":"Toxicol Lett"},{"issue":"6","key":"10.1016\/j.carpath.2024.107683_bib0017","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2174\/1389200216888150915112039","article-title":"Role of drug metabolism in the cytotoxicity and clinical efficacy of anthracyclines","volume":"16","author":"Edwardson","year":"2015","journal-title":"Curr Drug Metab"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0018","doi-asserted-by":"crossref","first-page":"785","DOI":"10.3390\/pharmaceutics15030785","article-title":"Potential roles of nelatonin in Doxorubicin-induced cardiotoxicity: From cellular mechanisms to clinical application","volume":"15","author":"Attachaipanich","year":"2023","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0019","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202200450","article-title":"Scutellarin attenuates Doxorubicin-Induced cardiotoxicity by inhibiting myocardial fibrosis, Apoptosis and autophagy in rats","volume":"20","author":"Sun","year":"2023","journal-title":"Chem Biodivers"},{"issue":"2","key":"10.1016\/j.carpath.2024.107683_bib0020","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/antiox12020320","article-title":"Protection against doxorubicin-induced cardiotoxicity by ergothioneine","volume":"12","author":"Cheah","year":"2023","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0021","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.canlet.2016.02.045","article-title":"Nuclear accumulation of Yes-Associated Protein (YAP) maintains the survival of doxorubicin-induced senescent cells by promoting survivin expression","volume":"375","author":"Ma","year":"2016","journal-title":"Cancer Lett"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0022","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/ehf2.13756","article-title":"Transcriptional co-activators YAP1\u2013TAZ of Hippo signalling in doxorubicin-induced cardiomyopathy","volume":"9","author":"Berecz","year":"2022","journal-title":"ESC Heart Fail"},{"issue":"2","key":"10.1016\/j.carpath.2024.107683_bib0023","doi-asserted-by":"crossref","first-page":"560","DOI":"10.7150\/thno.79227","article-title":"Hippo pathway activation mediates chemotherapy-induced anti-cancer effect and cardiomyopathy through causing mitochondrial damage and dysfunction","volume":"13","author":"She","year":"2023","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0024","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/cbin.11285","article-title":"Involvement of Yes-associated protein 1 (YAP1) in doxorubicin-induced cytotoxicity in H9c2 cardiac cells","volume":"44","author":"Takaguri","year":"2020","journal-title":"Cell Biol Int"},{"issue":"6","key":"10.1016\/j.carpath.2024.107683_bib0025","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1111\/jcmm.15057","article-title":"Melatonin attenuates doxorubicin-induced cardiotoxicity through preservation of YAP expression","volume":"24","author":"Li","year":"2020","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.carpath.2024.107683_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102625","article-title":"Hydropersulfides attenuate doxorubicin-induced cardiotoxicity while boosting its anticancer action","volume":"60","author":"Pharoah","year":"2023","journal-title":"Redox Biol"},{"issue":"5","key":"10.1016\/j.carpath.2024.107683_bib0027","doi-asserted-by":"crossref","first-page":"H1466","DOI":"10.1152\/ajpheart.00795.2008","article-title":"Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro","volume":"296","author":"Mukhopadhyay","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0028","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.3390\/ijms23031912","article-title":"Mitochondrial-Targeted Therapy for Doxorubicin-induced cardiotoxicity","volume":"23","author":"Wu","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.carpath.2024.107683_bib0029","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s00210-023-02382-z","article-title":"Doxorubicin-induced acute cardiotoxicity is associated with increased oxidative stress, autophagy, and inflammation in a murine model","volume":"396","author":"Dulf","year":"2023","journal-title":"Naunyn Schmiedebergs Pharmacol"},{"issue":"6","key":"10.1016\/j.carpath.2024.107683_bib0030","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.169756","article-title":"Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity","volume":"8","author":"Tadokoro","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.carpath.2024.107683_bib0031","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cbi.2019.01.032","article-title":"Oxidized phospholipids in Doxorubicin-induced cardiotoxicity","volume":"303","author":"Koleini","year":"2019","journal-title":"Chem Biol Interact"},{"issue":"12","key":"10.1016\/j.carpath.2024.107683_bib0032","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1007\/s11912-022-01333-w","article-title":"Mitochondrial dynamin-related protein Drp1: a new player in cardio-oncology","volume":"24","author":"Deng","year":"2022","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.carpath.2024.107683_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101523","article-title":"NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy","volume":"34","author":"Zeng","year":"2020","journal-title":"Redox Biol"},{"key":"10.1016\/j.carpath.2024.107683_bib0034","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.862204","article-title":"AMPK Activation alleviates myocardial ischemia-reperfusion injury by regulating Drp1-mediated mitochondrial dynamics","volume":"13","author":"Du","year":"2022","journal-title":"Front Pharmacol"},{"issue":"11","key":"10.1016\/j.carpath.2024.107683_bib0035","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1042\/CS20220074","article-title":"Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection","volume":"136","author":"Maneechote","year":"2022","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.carpath.2024.107683_bib0036","article-title":"Protective effects of amauroderma rugosum on doxorubicin-induced cardiotoxicity through suppressing oxidative stress, mitochondrial dysfunction, apoptosis, and activating Akt\/mTOR and Nrf2\/HO-1 signaling pathways","volume":"5","author":"Li","year":"2022","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"10.1016\/j.carpath.2024.107683_bib0037","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s12012-022-09721-1","article-title":"Doxorubicin-induced cardiotoxicity: an overview on pre-clinical therapeutic approaches","volume":"22","author":"Sheibani","year":"2022","journal-title":"Cardiovasc Toxicol"},{"issue":"13","key":"10.1016\/j.carpath.2024.107683_bib0038","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.3390\/cells11132000","article-title":"Mitochondria and doxorubicin-induced cardiomyopathy: a complex interplay","volume":"11","author":"Schirone","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.carpath.2024.107683_bib0039","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.yjmcc.2015.12.010","article-title":"The TGF-\u03b2 pathway mediates doxorubicin effects on cardiac endothelial cells","volume":"90","author":"Sun","year":"2016","journal-title":"J Mol Cell Cardiol"},{"issue":"9","key":"10.1016\/j.carpath.2024.107683_bib0040","doi-asserted-by":"crossref","first-page":"78","DOI":"10.15829\/1560-4071-2019-9-78-85","article-title":"The role of calcium metabolism dysregulation in the pathogenesis of cardiovascular diseases","volume":"24","author":"Mailian","year":"2019","journal-title":"Russian Journal of Cardiology"},{"issue":"12","key":"10.1016\/j.carpath.2024.107683_bib0041","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0278613","article-title":"Store-operated calcium entry via ORAI1 regulates doxorubicin-induced apoptosis and prevents cardiotoxicity in cardiac fibroblasts","volume":"17","author":"Nemoto","year":"2022","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0042","first-page":"263","article-title":"Trimetazidine as a modifier of chemotherapy-induced endothelium homeostasis disturbances","volume":"14","author":"Avagimyan","year":"2022","journal-title":"Cardiology Belarus"},{"key":"10.1016\/j.carpath.2024.107683_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114576","article-title":"Molecular mechanisms of endothelial remodeling under doxorubicin treatment","volume":"162","author":"Podyacheva","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"10.1016\/j.carpath.2024.107683_bib0044","doi-asserted-by":"crossref","first-page":"105","DOI":"10.29001\/2073-8552-2022-37-2-105-111","article-title":"Trimetazidine as a modifier of doxorubicin + cyclophosphamide induced hyperdyslipidemia","volume":"37","author":"Avagimyan","year":"2022","journal-title":"Siberian J Clin Exp Med"},{"issue":"2","key":"10.1016\/j.carpath.2024.107683_bib0045","doi-asserted-by":"crossref","first-page":"8","DOI":"10.35401\/2541-9897-2024-9-2-8-15","article-title":"Speckle-tracking echocardiography in assessment of breast cancer therapy-related subclinical cardiac dysfunction","volume":"4","author":"Akbalaeva","year":"2024","journal-title":"Innovative Medicine of Kuban"},{"issue":"9","key":"10.1016\/j.carpath.2024.107683_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2021.100994","article-title":"AC-mode of chemotherapy as a trigger of cardiac syndrome X: a case study","volume":"47","author":"Avagimyan","year":"2021","journal-title":"Curr Probl Cardiol"},{"key":"10.1016\/j.carpath.2024.107683_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102120","article-title":"Irisin ameliorates doxorubicin-induced cardiac perivascular fibrosis through inhibiting endothelial-to-mesenchymal transition by regulating ROS accumulation and autophagy disorder in endothelial cells","volume":"46","author":"Pan","year":"2021","journal-title":"Redox Biol"},{"issue":"16","key":"10.1016\/j.carpath.2024.107683_bib0048","doi-asserted-by":"crossref","first-page":"8977","DOI":"10.3390\/ijms23168977","article-title":"The impairment of cell metabolism by Doxorubicin is reversed by bergamot polyphenolic fraction treatment in endothelial Cells","volume":"23","author":"Algieri","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.carpath.2024.107683_bib0049","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jacbts.2018.06.005","article-title":"Role of endothelium in Doxorubicin-induced cardiomyopathy","volume":"3","author":"Luu","year":"2018","journal-title":"JACC Basic Transl Sci"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0050","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3390\/hearts5010005","article-title":"Different mechanisms in doxorubicin-induced cardiomyopathy: impact of BRCA1 and BRCA2 mutations","volume":"5","author":"Nguyen","year":"2024","journal-title":"Hearts"},{"key":"10.1016\/j.carpath.2024.107683_bib0051","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.freeradbiomed.2020.10.303","article-title":"Xanthine oxidase inhibition attenuates doxorubicin-induced cardiotoxicity in mice","volume":"162","author":"Tanaka","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.carpath.2024.107683_bib0052","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.905828","article-title":"Combination of panax ginseng C. A. Mey and febuxostat boasted cardioprotective effects against doxorubicin-induced acute cardiotoxicity in rats","volume":"13","author":"Al-Kuraishy","year":"2022","journal-title":"Front Pharmacol"},{"issue":"23","key":"10.1016\/j.carpath.2024.107683_bib0053","doi-asserted-by":"crossref","first-page":"12812","DOI":"10.3390\/ijms222312812","article-title":"Doxorubicin impairs smooth muscle cell contraction","volume":"22","author":"Bosman","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.carpath.2024.107683_bib0054","doi-asserted-by":"crossref","first-page":"706","DOI":"10.18705\/1607-419X-2021-27-6-706-712","article-title":"Chemotherapy as a possible trigger for the myocardial lipomatosis development","volume":"27","author":"Avagimyan","year":"2021","journal-title":"Arterialnaya Gipertenziya"},{"key":"10.1016\/j.carpath.2024.107683_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110525","article-title":"NF-\u03baB pathway activation during endothelial-to-mesenchymal transition in a rat model of doxorubicin-induced cardiotoxicity","volume":"130","author":"Xu","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"10.1016\/j.carpath.2024.107683_bib0056","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1124\/mol.114.093849","article-title":"Adverse effects of doxorubicin and its metabolic product on cardiac RyR2 and SERCA2A","volume":"86","author":"Hanna","year":"2014","journal-title":"Mol Pharmacol"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0057","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/toxsci\/kfy284","article-title":"Doxorubicin induces ER calcium release via Src in rat ovarian follicles","volume":"168","author":"Aziz","year":"2019","journal-title":"Toxicol Sci"},{"issue":"5","key":"10.1016\/j.carpath.2024.107683_bib0058","doi-asserted-by":"crossref","first-page":"785","DOI":"10.20996\/1819-6446-2021-10-17","article-title":"Relationship between chemotherapy and atrial fibrillation: clinical case","volume":"17","author":"Avagimyan","year":"2021","journal-title":"Rational Pharmacotherapy in Cardiology"},{"issue":"4","key":"10.1016\/j.carpath.2024.107683_bib0059","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.bbadis.2015.12.014","article-title":"Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism","volume":"1862","author":"Ge","year":"2016","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0060","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/s41598-023-28437-y","article-title":"Protective effect of urotensin II receptor antagonist urantide and exercise training on doxorubicin-induced cardiotoxicity","volume":"13","author":"Sun","year":"2023","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0061","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1159\/000512771","article-title":"Anthracycline-induced cardiotoxicity: the role of endothelial dysfunction","volume":"146","author":"Grakova","year":"2021","journal-title":"Cardiology"},{"issue":"322","key":"10.1016\/j.carpath.2024.107683_bib0062","first-page":"158","article-title":"The impact of trimetazidine on the anthropometric parameters of doxorubicin-cyclophosphamide mode in chemotherapy-induced heart alteration","volume":"67","author":"Avagimyan","year":"2022","journal-title":"Georgian Med News"},{"key":"10.1016\/j.carpath.2024.107683_bib0063","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.953078","article-title":"Oxidative stress and inflammation regulation of sirtuins: new insights into common oral diseases","volume":"13","author":"Pan","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.carpath.2024.107683_bib0064","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7176282","article-title":"Mechanisms and drug intervention for doxorubicin-induced cardiotoxicity based on mitochondrial bioenergetics","volume":"2022","author":"Ling","year":"2022","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"10.1016\/j.carpath.2024.107683_bib0065","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/jcsm.12104","article-title":"Doxorubicin caused severe hyperglycaemia and insulin resistance, mediated by inhibition in AMPk signalling in skeletal muscle","volume":"7","author":"De Lima Junior","year":"2016","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"2","key":"10.1016\/j.carpath.2024.107683_bib0066","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.febslet.2012.11.019","article-title":"Doxorubicin treatment inhibits PPAR\u03b3 and may induce lipotoxicity by mimicking a type 2 diabetes-like condition in rodent models","volume":"587","author":"Arunachalam","year":"2013","journal-title":"FEBS Lett"},{"key":"10.1016\/j.carpath.2024.107683_bib0067","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115354","article-title":"SIRT3 attenuates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome via autophagy","volume":"207","author":"Sun","year":"2023","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0068","doi-asserted-by":"crossref","first-page":"e22946","DOI":"10.1002\/jbt.22946","article-title":"The modulation of SIRT1 and SIRT3 by natural compounds as a therapeutic target in doxorubicin-induced cardiotoxicity: a review","volume":"36","author":"Tabrizi","year":"2022","journal-title":"J Biochem Mol Toxicol"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0069","first-page":"28","article-title":"Influence of trimetazidine on myocardial capillarometric parameters during doxorubicin-cyclophosphamide mode of chemotherapy administration","volume":"2","author":"Avagimyan","year":"2022","journal-title":"J Cardiorespiratory Res"},{"issue":"12","key":"10.1016\/j.carpath.2024.107683_bib0070","doi-asserted-by":"crossref","first-page":"7013","DOI":"10.1093\/nar\/gkac538","article-title":"A dual-activity topoisomerase complex regulates mRNA translation and turnover","volume":"50","author":"Su","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0071","doi-asserted-by":"crossref","first-page":"568","DOI":"10.3390\/biom13030568","article-title":"MicroRNA in the diagnosis and treatment of doxorubicin-induced cardiotoxicity","volume":"13","author":"Kuang","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.carpath.2024.107683_bib0072","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1186\/1471-2407-14-842","article-title":"Dexrazoxane may prevent doxorubicin-induced DNA damage via depleting both topoisomerase II isoforms","volume":"14","author":"Deng","year":"2014","journal-title":"BMC Cancer"},{"issue":"24","key":"10.1016\/j.carpath.2024.107683_bib0073","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1039\/D1TB00551K","article-title":"The role of iron in doxorubicin-induced cardiotoxicity: recent advances and implication for drug delivery","volume":"9","author":"Qin","year":"2021","journal-title":"J Mater Chem B"},{"issue":"2","key":"10.1016\/j.carpath.2024.107683_bib0074","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1172\/JCI72931","article-title":"Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation","volume":"124","author":"Ichikawa","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.carpath.2024.107683_bib0075","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0076-6879(04)78025-8","article-title":"Doxorubicin cardiotoxicity and the control of iron metabolism: quinone-dependent and independent mechanisms","volume":"378","author":"Minotti","year":"2004","journal-title":"Methods Enzymol"},{"issue":"4","key":"10.1016\/j.carpath.2024.107683_bib0076","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s00059-011-3470-3","article-title":"Mechanisms and management of doxorubicin cardiotoxicity","volume":"36","author":"Shi","year":"2011","journal-title":"Herz"},{"issue":"7","key":"10.1016\/j.carpath.2024.107683_bib0077","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1182\/blood-2003-03-0869","article-title":"Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin","volume":"102","author":"Miranda","year":"2003","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0078","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s10741-020-09977-1","article-title":"Anthracycline-induced cardiotoxicity and renin-angiotensin-aldosterone system-from molecular mechanisms to therapeutic applications","volume":"27","author":"Sobczuk","year":"2022","journal-title":"Heart Fail Rev"},{"issue":"24","key":"10.1016\/j.carpath.2024.107683_bib0079","doi-asserted-by":"crossref","first-page":"9337","DOI":"10.3390\/ijms21249337","article-title":"Deleterious effects of hyperactivity of the renin-angiotensin system and hypertension on the course of chemotherapy-induced heart failure after Doxorubicin administration: a study in Ren-2 transgenic rat","volume":"21","author":"Kala","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.carpath.2024.107683_bib0080","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s11906-010-0146-y","article-title":"Mechanisms of anthracycline cardiotoxicity and strategies to decrease cardiac damage","volume":"12","author":"Geisberg","year":"2010","journal-title":"Curr Hypertens Rep"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0081","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/jcp.25905","article-title":"Mitochondrial ROS-induced ERK1\/2 activation and HSF2-mediated AT1 R upregulation are required for doxorubicin-induced cardiotoxicity","volume":"233","author":"Huang","year":"2018","journal-title":"J Cell Physiol"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0082","first-page":"41","article-title":"Influence of trimetazidine on myocardium energy balance during chemotherapy with doxorubicin and cyclophosphamide","volume":"42","author":"Avagimyan","year":"2022","journal-title":"Siberian Scientific Medical Journal"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0083","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/cvr\/cvaa017","article-title":"MMP inhibitors attenuate doxorubicin cardiotoxicity by preventing intracellular and extracellular matrix remodelling","volume":"117","author":"Chan","year":"2021","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.carpath.2024.107683_bib0084","first-page":"25","article-title":"Effect of trimetazidine on myocardial karyometry during the doxorubicin-cyclophosphamide mode of chemotherapy prescription","volume":"21","author":"Avagimyan","year":"2022","journal-title":"Medicine in Kuzbass"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0085","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00280-019-04019-6","article-title":"Cardioprotective effects of dapsone against doxorubicin-induced cardiotoxicity in rats","volume":"85","author":"Sheibani","year":"2020","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.carpath.2024.107683_bib0086","unstructured":"Avagimyan A, Aznauryan A, Aznauryan V. Morphological aspects of myocardial alteration during doxorubicin intake. Morphology (Russia). 157:(2-3):8-9"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0087","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.apsb.2020.10.017","article-title":"Isorhapontigenin protects against doxorubicin-induced cardiotoxicity via increasing YAP1 expression","volume":"11","author":"Wang","year":"2021","journal-title":"Acta Pharm Sin B"},{"issue":"4","key":"10.1016\/j.carpath.2024.107683_bib0088","doi-asserted-by":"crossref","first-page":"6","DOI":"10.35401\/2541-9897-2023-8-4-6-14","article-title":"Comparison of cardioprotective effects of dapagliflozin and trimetazidine in the model of doxorubicin-cyclophosphamide cardiotoxicity","volume":"8","author":"Avagimyan","year":"2023","journal-title":"Innovative Medicine of Kuban"},{"issue":"41","key":"10.1016\/j.carpath.2024.107683_bib0089","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","volume":"43","author":"Lyon","year":"2022","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0090","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ctm2.13","article-title":"NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases","volume":"10","author":"Wang","year":"2020","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.carpath.2024.107683_bib0091","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101523","article-title":"NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy","volume":"34","author":"Zeng","year":"2020","journal-title":"Redox Biol"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0092","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s12265-020-10049-w","article-title":"Immunomodulation of the NLRP3 inflammasome in atherosclerosis, coronary artery disease, and acute myocardial infarction","volume":"14","author":"Silvis","year":"2021","journal-title":"J Cardiovasc Transl Res"},{"issue":"11","key":"10.1016\/j.carpath.2024.107683_bib0093","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.3390\/biom11111725","article-title":"Role of inflammation and redox status on doxorubicin-induced cardiotoxicity in infant and adult CD-1 male mice","volume":"11","author":"Reis-Mendes","year":"2021","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0094","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41569-022-00759-w","article-title":"Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology","volume":"20","author":"Dobrev","year":"2023","journal-title":"Nat Rev Cardiol"},{"issue":"9","key":"10.1016\/j.carpath.2024.107683_bib0095","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.2174\/138945011796150244","article-title":"FOXO and FOXM1 in cancer: the FOXO-FOXM1 axis shapes the outcome of cancer chemotherapy","volume":"12","author":"Wilson","year":"2011","journal-title":"Curr Drug Targets"},{"issue":"4","key":"10.1016\/j.carpath.2024.107683_bib0096","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/cbf.3704","article-title":"Simultaneous proteasome and autophagy inhibition synergistically enhances cytotoxicity of doxorubicin in breast cancer cells","volume":"40","author":"Loh","year":"2022","journal-title":"Cell Biochem Funct"},{"issue":"8","key":"10.1016\/j.carpath.2024.107683_bib0097","article-title":"Novel mechanisms of anthracycline-induced cardiovascular toxicity: a focus on thrombosis, cardiac atrophy, and programmed cell death","volume":"12","author":"Antoniak","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0098","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005234","article-title":"Doxorubicin exposure causes subacute cardiac atrophy dependent on the striated muscle-specific ubiquitin ligase MuRF1","volume":"12","author":"Willis","year":"2019","journal-title":"Circ Heart Fail"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0099","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1152\/japplphysiol.00210.2014","article-title":"Effects of short-term endurance exercise training on acute doxorubicin-induced FoxO transcription in cardiac and skeletal muscle","volume":"117","author":"Kavazis","year":"2014","journal-title":"J Appl Physiol"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0100","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41418-018-0179-3","article-title":"Programmed Necrosis and Disease: we interrupt your regular programming to bring you necroinflammation","volume":"26","author":"Kim","year":"2019","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0101","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tips.2022.10.003","article-title":"Mitochondrial quality control mechanisms as therapeutic targets in doxorubicin-induced cardiotoxicity","volume":"44","author":"Wu","year":"2023","journal-title":"Trends Pharmacol Sci"},{"issue":"10","key":"10.1016\/j.carpath.2024.107683_bib0102","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/s41419-022-05333-3","article-title":"Gasdermin D mediates endoplasmic reticulum stress via FAM134B to regulate cardiomyocyte autophagy and apoptosis in doxorubicin-induced cardiotoxicity","volume":"13","author":"Qu","year":"2022","journal-title":"Cell Death Dis"},{"issue":"5","key":"10.1016\/j.carpath.2024.107683_bib0103","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.3390\/molecules26051460","article-title":"Cryptotanshinone ameliorates doxorubicin-induced cardiotoxicity by targeting Akt-GSK-3\u03b2-mPTP pathway in vitro","volume":"26","author":"Wang","year":"2021","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0104","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.3390\/ijms23031414","article-title":"Therapeutic targets for DOX-induced cardiomyopathy: role of apoptosis vs. ferroptosis","volume":"23","author":"Kitakata","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0105","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbrc.2019.12.027","article-title":"Dexrazoxane ameliorates doxorubicin-induced cardiotoxicity by inhibiting both apoptosis and necroptosis in cardiomyocytes","volume":"523","author":"Yu","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.carpath.2024.107683_bib0106","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.lfs.2015.11.018","article-title":"Baicalein alleviates doxorubicin-induced cardiotoxicity via suppression of myocardial oxidative stress and apoptosis in mice","volume":"144","author":"Sahu","year":"2016","journal-title":"Life Sci"},{"issue":"517","key":"10.1016\/j.carpath.2024.107683_bib0107","article-title":"Autophagy as a modulator of cell death machinery","volume":"11","author":"Noguchi","year":"2020","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0108","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/febs.15824","article-title":"A guide to the regulation of selective autophagy receptors","volume":"289","author":"Gubas","year":"2021","journal-title":"FEBS J"},{"issue":"10","key":"10.1016\/j.carpath.2024.107683_bib0109","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.3390\/molecules22101589","article-title":"Aspalathin reverts doxorubicin-induced cardiotoxicity through increased autophagy and decreased expression of p53\/mTOR\/p62 signaling","volume":"22","author":"Johnson","year":"2017","journal-title":"Molecules"},{"issue":"23","key":"10.1016\/j.carpath.2024.107683_bib0110","doi-asserted-by":"crossref","first-page":"38022","DOI":"10.18632\/oncotarget.16723","article-title":"Combination therapy in combating cancer","volume":"8","author":"Bayat Mokhtari","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tiv.2018.05.001","article-title":"Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1\/parkin pathway","volume":"51","author":"Yin","year":"2018","journal-title":"Toxicol Vitr"},{"issue":"10","key":"10.1016\/j.carpath.2024.107683_bib0112","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1371\/journal.pone.0077713","article-title":"Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division\/mitophagy inhibitor","volume":"8","author":"Gharanei","year":"2013","journal-title":"PLoS One"},{"issue":"17","key":"10.1016\/j.carpath.2024.107683_bib0113","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1161\/CIRCULATIONAHA.115.017443","article-title":"Doxorubicin blocks cardiomyocyte autophagic flux by inhibiting lysosome acidification","volume":"133","author":"Li","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.carpath.2024.107683_bib0114","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrmicro2070","article-title":"Pyroptosis: host cell death and inflammation","volume":"7","author":"Bergsbaken","year":"2009","journal-title":"Nat Rev Micro"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0115","doi-asserted-by":"crossref","first-page":"25","DOI":"10.20538\/1682-0363-2023-3-25-35","article-title":"Prognostic value of humoral markers in patients with anthracycline-related cardiac dysfunction","volume":"22","author":"Grakova","year":"2023","journal-title":"Bulletin of Siberian Medicine"},{"issue":"2","key":"10.1016\/j.carpath.2024.107683_bib0116","doi-asserted-by":"crossref","first-page":"111","DOI":"10.20538\/1682-0363-2023-2-111-121","article-title":"Inflammasome as an early pathophysiological phenomenon of inflammation in skin diseases and other pathologies","volume":"22","author":"Klimov","year":"2023","journal-title":"Bulletin of Siberian Medicine"},{"issue":"28","key":"10.1016\/j.carpath.2024.107683_bib0117","doi-asserted-by":"crossref","first-page":"7858","DOI":"10.1073\/pnas.1607769113","article-title":"GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes","volume":"113","author":"Aglietti","year":"2016","journal-title":"Proc Nat Acad Sci USA"},{"issue":"9","key":"10.1016\/j.carpath.2024.107683_bib0118","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/s41423-022-00905-x","article-title":"Role of pyroptosis in inflammation and cancer","volume":"19","author":"Wei","year":"2022","journal-title":"Cellular & molecular immunology"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0119","first-page":"3650","article-title":"Gasdermin D mediates doxorubicin-induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage","volume":"248","author":"Ye","year":"2022","journal-title":"Translational research: the journal of laboratory and clinical medicine"},{"issue":"6","key":"10.1016\/j.carpath.2024.107683_bib0120","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3390\/cells12060867","article-title":"New insights into the role of ferroptosis in cardiovascular diseases","volume":"12","author":"Fratta Pasini","year":"2023","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.carpath.2024.107683_bib0121","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.132747","article-title":"Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity","volume":"5","author":"Tadokoro","year":"2020","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.carpath.2024.107683_bib0122","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s12192-019-01045-4","article-title":"Heme as a target for protection against doxorubicin-induced apoptosis in H9c2 cardiomyocytes","volume":"24","author":"Liu","year":"2019","journal-title":"Cell Stress Chaperones"},{"issue":"6","key":"10.1016\/j.carpath.2024.107683_bib0123","first-page":"811","article-title":"Molecular mechanisms and therapeutic targeting of ferroptosis in doxorubicin-induced cardiotoxicity","volume":"9","author":"Wu","year":"2024","journal-title":"JACC: Basic to Translational Science"},{"issue":"758","key":"10.1016\/j.carpath.2024.107683_bib0124","doi-asserted-by":"crossref","first-page":"eabn8017","DOI":"10.1126\/scisignal.abn8017","article-title":"Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis","volume":"15","author":"Abe","year":"2022","journal-title":"Sci Signal"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0125","first-page":"7","volume":"9","author":"Brown","year":"2023","journal-title":"Cardiooncology"},{"issue":"5","key":"10.1016\/j.carpath.2024.107683_bib0126","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1093\/eurheartj\/ehac813","article-title":"The year in cardiovascular medicine 2022: the top 10 papers in cardio-oncology","volume":"44","author":"Herrmann","year":"2023","journal-title":"Eur Heart J"},{"issue":"7","key":"10.1016\/j.carpath.2024.107683_bib0127","doi-asserted-by":"crossref","first-page":"e36593","DOI":"10.1097\/MD.0000000000036593","article-title":"Exploring the mechanism of curcumin in the treatment of doxorubicin-induced cardiotoxicity based on network pharmacology and molecular docking technology","volume":"103","author":"Hu","year":"2024","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.carpath.2024.107683_bib0128","article-title":"Real-world exposure to complex chemical mixtures during pregnancy induces a new molecular signature for hepatitis B virus reactivation","volume":"467","author":"Merhi","year":"2023","journal-title":"Toxicol Appl Pharmacol"},{"issue":"5","key":"10.1016\/j.carpath.2024.107683_bib0129","doi-asserted-by":"crossref","first-page":"507","DOI":"10.4103\/0253-7613.84952","article-title":"Cardioprotective effect of ascorbic acid on doxorubicin-induced myocardial toxicity in rats","volume":"43","author":"Viswanatha Swamy","year":"2011","journal-title":"Indian J Pharmacol"},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0130","doi-asserted-by":"crossref","first-page":"201","DOI":"10.31557\/APJCP.2022.23.1.201","article-title":"Effects of vitamin E on doxorubicin cytotoxicity in human breast cancer cells in vitro","volume":"23","author":"Ahmadi","year":"2022","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.carpath.2024.107683_bib0131","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1289384","article-title":"Melatonin mitigates oxidative damage induced by anthracycline: a systematic-review and meta-analysis of murine models","volume":"10","author":"Faggiano","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.carpath.2024.107683_bib0132","article-title":"Pharmacokinetics of a new orally disintegrating film formulation of theophylline in healthy subjects","volume":"31","author":"Alshememry","year":"2023","journal-title":"Saudi Pharm J"},{"key":"10.1016\/j.carpath.2024.107683_bib0133","unstructured":"Avagimyan A.A. Morphofunctional assessment of the impact of trimetazidine on the doxorubicin-cyclophosphamide mode of chemotherapy-related cardiotoxic and pro-atherogenic potential. [Disseration for PhD Degree]. Moscow,: Federal Satate Institution \u201cResearch Institute of Human Morphology\u201d MoH of Russian Federation; 2022. https:\/\/old.med.ru\/sites\/default\/files\/docs\/Avagimyan_Diss.pdf. Accessed: Dec-13-2023."},{"issue":"10","key":"10.1016\/j.carpath.2024.107683_bib0134","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.2174\/138920112802273245","article-title":"Dexrazoxane for the prevention of cardiac toxicity and treatment of extravasation injury from the anthracycline antibiotics","volume":"13","author":"Doroshow","year":"2012","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.carpath.2024.107683_bib0135","unstructured":"U.S. Food and Drug Administration. Zinecard\u00ae (dexrazoxane) for injection. Highlights of prescribing information. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2014\/020212s017lbl.pdf. Accessed: Dec-13-2023"},{"key":"10.1016\/j.carpath.2024.107683_bib0136","unstructured":"European Medicines Agency. Savene, INN-dexrazoxane. https:\/\/www.ema.europa.eu\/en\/documents\/scientific-discussion\/savene-epar-scientific-discussion_en.pdf Accessed: Dec-13-2023."},{"issue":"1","key":"10.1016\/j.carpath.2024.107683_bib0137","doi-asserted-by":"crossref","first-page":"4","DOI":"10.18087\/cardio.2024.1.n2636","article-title":"Preventive cardiology 2024: state of problem perspectives of development","volume":"64","author":"Pogosova","year":"2024","journal-title":"Kardiologiia"},{"issue":"7","key":"10.1016\/j.carpath.2024.107683_bib0138","first-page":"1867","article-title":"Rab23 regulates ischemia-reperfusion-induced apoptosis by targeting JAK2\/STAT3 signaling pathway in H9c2 cells","volume":"11","author":"Zhu","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.carpath.2024.107683_bib0139","article-title":"Novel insights into the mechanism of action of traditional Chinese medicine in the treatment of myocardial infarction: a network pharmacology approach","volume":"15","author":"Chen","year":"2024","journal-title":"Front Pharmacol"},{"issue":"23","key":"10.1016\/j.carpath.2024.107683_bib0140","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.3390\/cancers14235811","article-title":"SGLT-2 inhibitors in cancer treatment-mechanisms of action and emerging new perspectives","volume":"14","author":"Dutka","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.carpath.2024.107683_bib0141","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.3390\/molecules23051184","article-title":"The cardioprotective effect of metformin in doxorubicin-induced cardiotoxicity: the role of autophagy","volume":"23","author":"Zilinyi","year":"2018","journal-title":"Molecules"},{"issue":"17","key":"10.1016\/j.carpath.2024.107683_bib0142","first-page":"10146","article-title":"\u03b1-mangostin promotes amyloid precursor protein degradation and mitigates amyloid-\u03b2 toxicity in Alzheimer's 3xTg-AD mice","volume":"23","author":"Shityakov","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.carpath.2024.107683_bib0143","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103129","article-title":"Semaglutide attenuates doxorubicin-induced cardiotoxicity by ameliorating BNIP3-Mediated mitochondrial dysfunction","volume":"72","author":"Li","year":"2024","journal-title":"Redox Biol"},{"key":"10.1016\/j.carpath.2024.107683_bib0144","article-title":"Protective effects of novel peptide derived from sea cucumber on oxidative stress-induced neuronal damage","volume":"166","author":"Kim","year":"2024","journal-title":"Peptides"},{"key":"10.1016\/j.carpath.2024.107683_bib0145","article-title":"The role of microRNA-21 in cardiovascular diseases: a comprehensive review","volume":"371","author":"Wang","year":"2023","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.carpath.2024.107683_bib0146","article-title":"Mechanisms of viral pathogenesis and host immune responses in emerging viral infections","volume":"98","author":"Brown","year":"2023","journal-title":"Vet Pathol"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0147","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jacc.2009.03.095","article-title":"Anthracycline-induced cardiomyopathy: clinical relevance and response to pharmacologic therapy","volume":"55","author":"Cardinale","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.carpath.2024.107683_bib0148","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s11739-020-02508-8","article-title":"Prevention of anthracycline-induced cardiotoxicity: a systematic review and meta-analysis","volume":"16","author":"Caspani","year":"2021","journal-title":"Intern Emerg Med"},{"issue":"6","key":"10.1016\/j.carpath.2024.107683_bib0149","doi-asserted-by":"crossref","first-page":"839","DOI":"10.4239\/wjd.v12.i6.839","article-title":"New perspectives on angiotensin-converting enzyme 2 and its related diseases","volume":"12","author":"Liu","year":"2021","journal-title":"World J Diabetes"},{"issue":"11","key":"10.1016\/j.carpath.2024.107683_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294649","article-title":"Impact on clinical outcomes of renin-angiotensin system inhibitors against doxorubicin-related toxicity in patients with breast cancer and hypertension: a nationwide cohort study in South Korea","volume":"18","author":"Hwang","year":"2023","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.carpath.2024.107683_bib0151","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s10741-023-10328-z","article-title":"ACEI\/ARB and beta-blocker therapies for preventing cardiotoxicity of antineoplastic agents in breast cancer: a systematic review and meta-analysis","volume":"28","author":"Gao","year":"2023","journal-title":"Heart Fail Rev"},{"issue":"21","key":"10.1016\/j.carpath.2024.107683_bib0152","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1093\/eurheartj\/ehw022","article-title":"Prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA): a 2 \u00d7 2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol","volume":"37","author":"Gulati","year":"2016","journal-title":"Eur Heart J"},{"issue":"25","key":"10.1016\/j.carpath.2024.107683_bib0153","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1161\/CIRCULATIONAHA.121.054698","article-title":"Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy (PRADA): extended follow-up of a 2\u00d72 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol","volume":"143","author":"Heck","year":"2021","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.carpath.2024.107683_bib0154","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12032-017-0938-x","article-title":"SAFE trial: an ongoing randomized clinical study to assess the role of cardiotoxicity prevention in breast cancer patients treated with anthracyclines with or without trastuzumab","volume":"34","author":"Meattini","year":"2017","journal-title":"Med Oncol"},{"issue":"3","key":"10.1016\/j.carpath.2024.107683_bib0155","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1177\/1074248418821721","article-title":"Effect of rosuvastatin in preventing chemotherapy-induced cardiotoxicity in women with breast cancer: a randomized, single-blind, placebo-controlled trial","volume":"24","author":"Nabati","year":"2019","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"6","key":"10.1016\/j.carpath.2024.107683_bib0156","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1001\/jama.2023.11887","article-title":"Atorvastatin for anthracycline-associated cardiac dysfunction: the STOP-CA randomized clinical trial","volume":"330","author":"Neilan","year":"2023","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.carpath.2024.107683_bib0157","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/ehjcvp\/pvad031","article-title":"Statins to prevent early cardiac dysfunction in cancer patients at increased cardiotoxicity risk receiving anthracyclines","volume":"9","author":"Thavendiranathan","year":"2023","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"issue":"4","key":"10.1016\/j.carpath.2024.107683_bib0158","doi-asserted-by":"crossref","first-page":"580","DOI":"10.3390\/medicina60040580","article-title":"Association between statin use and chemotherapy-induced cardiotoxicity: a meta-analysis","volume":"60","author":"Jaiswal","year":"2024","journal-title":"Medicina (Kaunas)"}],"container-title":["Cardiovascular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880724000796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880724000796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T06:18:58Z","timestamp":1726121938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054880724000796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":158,"alternative-id":["S1054880724000796"],"URL":"https:\/\/doi.org\/10.1016\/j.carpath.2024.107683","relation":{},"ISSN":["1054-8807"],"issn-type":[{"value":"1054-8807","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Doxorubicin-related cardiotoxicity: review of fundamental pathways of cardiovascular system injury","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carpath.2024.107683","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107683"}}