{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:58:52Z","timestamp":1768442332117,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"publisher","award":["123S526"],"award-info":[{"award-number":["123S526"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019791","name":"\u0130stanbul Medipol \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019791","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Pathology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.carpath.2025.107804","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T16:10:08Z","timestamp":1764605408000},"page":"107804","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mapping cardiac innervation in the long QT syndrome type 1 transgenic mouse model using whole heart imaging"],"prefix":"10.1016","volume":"81","author":[{"given":"Behnaz","family":"Forouhar Karadogan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aylin","family":"Karatas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7199-583X","authenticated-orcid":false,"given":"Esra","family":"Cagavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.carpath.2025.107804_bib0001","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/s41598-024-51184-7","article-title":"Enhancing heart disease prediction using a self-attention-based transformer model","volume":"14","author":"Rahman","year":"2024","journal-title":"Sci Rep"},{"issue":"18","key":"10.1016\/j.carpath.2025.107804_bib0002","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1161\/CIRCULATIONAHA.109.863209","article-title":"Prevalence of the congenital long-QT syndrome","volume":"120","author":"Schwartz","year":"2009","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.carpath.2025.107804_bib0003","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jacc.2013.04.044","article-title":"Impact of genetics on the clinical management of channelopathies","volume":"62","author":"Schwartz","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.carpath.2025.107804_bib0004","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s00246-019-02151-x","article-title":"Long QT syndrome: genetics and future perspective","volume":"40","author":"Wallace","year":"2019","journal-title":"Pediatr Cardiol"},{"issue":"12","key":"10.1016\/j.carpath.2025.107804_bib0005","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/j.hrthm.2010.09.017","article-title":"Early afterdepolarizations and cardiac arrhythmias","volume":"7","author":"Weiss","year":"2010","journal-title":"Heart Rhythm"},{"issue":"4","key":"10.1016\/j.carpath.2025.107804_bib0006","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/CIRCEP.111.962019","article-title":"Long-QT syndrome: from genetics to management [published correction appears in Circ Arrhythm Electrophysiol","volume":"5","author":"Schwartz","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"12","key":"10.1016\/j.carpath.2025.107804_bib0007","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1253\/circj.CJ-14-0905","article-title":"Genetic and clinical advances in congenital long QT syndrome","volume":"78","author":"Mizusawa","year":"2014","journal-title":"Circ J"},{"issue":"5","key":"10.1016\/j.carpath.2025.107804_bib0008","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1073\/pnas.041398998","article-title":"Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange-Nielsen Syndrome","volume":"98","author":"Casimiro","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.carpath.2025.107804_bib0009","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ygeno.2004.06.007","article-title":"Targeted point mutagenesis of mouse Kcnq1: phenotypic analysis of mice with point mutations that cause Romano-Ward syndrome in humans","volume":"84","author":"Casimiro","year":"2004","journal-title":"Genomics"},{"issue":"4","key":"10.1016\/j.carpath.2025.107804_bib0010","first-page":"54","article-title":"The intrinsic cardiac nervous system and its role in cardiac pacemaking and conduction","volume":"7","author":"Fedele","year":"2020","journal-title":"J Cardiovasc Dev Dis"},{"issue":"1","key":"10.1016\/j.carpath.2025.107804_bib0011","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1038\/s41467-019-09770-1","article-title":"Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies","volume":"10","author":"Rajendran","year":"2019","journal-title":"Nat Commun"},{"issue":"14","key":"10.1016\/j.carpath.2025.107804_bib0012","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1113\/JP271870","article-title":"Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics","volume":"594","author":"Shivkumar","year":"2016","journal-title":"J Physiol"},{"issue":"1","key":"10.1016\/j.carpath.2025.107804_bib0013","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.hfc.2011.08.007","article-title":"Neurohumoral stimulation","volume":"8","author":"Zucker","year":"2012","journal-title":"Heart Fail Clin"},{"key":"10.1016\/j.carpath.2025.107804_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.autneu.2022.103019","article-title":"Anatomical characterization of vagal nodose afferent innervation and ending morphologies at the murine heart using a transgenic approach","volume":"242","author":"Kazci","year":"2022","journal-title":"Auton Neurosci"},{"issue":"3","key":"10.1016\/j.carpath.2025.107804_bib0015","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/jnr.25150","article-title":"High-resolution mapping of sensory fibers at the healthy and post-myocardial infarct whole transgenic hearts","volume":"101","author":"Sahoglu","year":"2023","journal-title":"J Neurosci Res"},{"issue":"2","key":"10.1016\/j.carpath.2025.107804_bib0016","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0008-6363(00)00308-4","article-title":"Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death","volume":"50","author":"Chen","year":"2001","journal-title":"Cardiovasc Res"},{"issue":"16","key":"10.1016\/j.carpath.2025.107804_bib0017","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1161\/01.CIR.101.16.1960","article-title":"Relationship between regional cardiac hyperinnervation and ventricular arrhythmia","volume":"101","author":"Cao","year":"2000","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.carpath.2025.107804_bib0018","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0046-8177(91)90035-N","article-title":"Nerve fibers in human myocardial scars","volume":"22","author":"Vracko","year":"1991","journal-title":"Hum Pathol"},{"issue":"2","key":"10.1016\/j.carpath.2025.107804_bib0019","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1113\/JP271165","article-title":"Myocardial infarction induces structural and functional remodelling of the intrinsic cardiac nervous system","volume":"594","author":"Rajendran","year":"2016","journal-title":"J Physiol"},{"issue":"7","key":"10.1016\/j.carpath.2025.107804_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182072","article-title":"Quantification of sympathetic hyperinnervation and denervation after myocardial infarction by three-dimensional assessment of the cardiac sympathetic network in cleared transparent murine hearts","volume":"12","author":"Yokoyama","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.carpath.2025.107804_bib0021","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1161\/01.RES.0000133678.22968.e3","article-title":"Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs","volume":"95","author":"Zhou","year":"2004","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.carpath.2025.107804_bib0022","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2014.10.010","article-title":"iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging","volume":"159","author":"Renier","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.carpath.2025.107804_bib0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2017.10.017","article-title":"BranchAnalysis2D\/3D automates morphometry analyses of branching structures","volume":"294","author":"Srinivasan","year":"2018","journal-title":"J Neurosci Methods"},{"issue":"1","key":"10.1016\/j.carpath.2025.107804_bib0024","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/joa.12400","article-title":"Innervation of the rabbit cardiac ventricles","volume":"228","author":"Pauziene","year":"2016","journal-title":"J Anat"},{"key":"10.1016\/j.carpath.2025.107804_bib0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.autneu.2016.08.006","article-title":"Characterization of the intrinsic cardiac nervous system","volume":"199","author":"Wake","year":"2016","journal-title":"Auton Neurosci"},{"issue":"16","key":"10.1016\/j.carpath.2025.107804_bib0026","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1001\/jama.289.16.2041","article-title":"Long QT syndrome","volume":"289","author":"Moss","year":"2003","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.carpath.2025.107804_bib0027","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jacep.2022.02.017","article-title":"Congenital Long QT syndrome","volume":"8","author":"Krahn","year":"2022","journal-title":"JACC Clin Electrophysiol"},{"issue":"6","key":"10.1016\/j.carpath.2025.107804_bib0028","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/CIRCULATIONAHA.119.043132","article-title":"An international, multicentered, evidence-based reappraisal of genes reported to cause congenital long QT syndrome","volume":"141","author":"Adler","year":"2020","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.carpath.2025.107804_bib0029","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/heartjnl-2020-318259","article-title":"Diagnosis, management and therapeutic strategies for congenital long QT syndrome","volume":"108","author":"Wilde","year":"2022","journal-title":"Heart"},{"issue":"2","key":"10.1016\/j.carpath.2025.107804_bib0030","doi-asserted-by":"crossref","first-page":"2ra6","DOI":"10.1126\/scitranslmed.3000289","article-title":"Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death","volume":"1","author":"Goldman","year":"2009","journal-title":"Sci Transl Med"},{"issue":"2","key":"10.1016\/j.carpath.2025.107804_bib0031","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/epi.13978","article-title":"Pharmacogenetics of KCNQ channel activation in 2 potassium channelopathy mouse models of epilepsy","volume":"59","author":"Vanhoof-Villalba","year":"2018","journal-title":"Epilepsia"},{"issue":"23","key":"10.1016\/j.carpath.2025.107804_bib0032","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.008919","article-title":"Pulmonary vein ganglia are remodeled in the diabetic heart","volume":"7","author":"Bassil","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"1-2","key":"10.1016\/j.carpath.2025.107804_bib0033","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.autneu.2010.01.004","article-title":"Impairment of baroreflex control of heart rate and structural changes of cardiac ganglia in conscious streptozotocin (STZ)-induced diabetic mice","volume":"155","author":"Lin","year":"2010","journal-title":"Auton Neurosci"},{"issue":"3","key":"10.1016\/j.carpath.2025.107804_bib0034","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1152\/jn.1965.28.3.599","article-title":"Excitability and inhibitability of motoneurons of different sizes","volume":"28","author":"Henneman","year":"1965","journal-title":"J Neurophysiol"},{"issue":"1","key":"10.1016\/j.carpath.2025.107804_bib0035","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options","volume":"7","author":"Uttara","year":"2009","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.carpath.2025.107804_bib0036","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/182303","article-title":"The roles of biomarkers of oxidative stress and antioxidant in Alzheimer's disease: a systematic review","volume":"2014","author":"Chang","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.carpath.2025.107804_bib0037","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1656450","article-title":"The role of oxidative stress in myocardial ischemia and reperfusion injury and remodeling: revisited","volume":"2016","author":"Kurian","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.carpath.2025.107804_bib0038","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2147\/CIA.S158513","article-title":"Oxidative stress, aging, and diseases","volume":"13","author":"Liguori","year":"2018","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.carpath.2025.107804_bib0039","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1320086","article-title":"Oxidative stress and ion channels in neurodegenerative diseases","volume":"15","author":"Orfali","year":"2024","journal-title":"Front Physiol"},{"issue":"12","key":"10.1016\/j.carpath.2025.107804_bib0040","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1113\/JP282828","article-title":"Nerve growth factor transfer from cardiomyocytes to innervating sympathetic neurons activates TrkA receptors at the neuro-cardiac junction","volume":"600","author":"Dokshokova","year":"2022","journal-title":"J Physiol"},{"issue":"7","key":"10.1016\/j.carpath.2025.107804_bib0041","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1242\/dev.087601","article-title":"Coronary veins determine the pattern of sympathetic innervation in the developing heart","volume":"140","author":"Nam","year":"2013","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.carpath.2025.107804_bib0042","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.neuron.2013.09.040","article-title":"The declaration of independence of the neurovascular intimacy","volume":"80","author":"Chauvet","year":"2013","journal-title":"Neuron"},{"issue":"7","key":"10.1016\/j.carpath.2025.107804_bib0043","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1172\/JCI76622","article-title":"Vessel-dependent recruitment of sympathetic axons: looking for innervation in all the right places","volume":"124","author":"Mukouyama","year":"2014","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.carpath.2025.107804_bib0044","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1080\/15513815.2021.2002988","article-title":"Histopathology of the conduction system in long QT syndrome","volume":"41","author":"Rogers","year":"2022","journal-title":"Fetal Pediatr Pathol"},{"issue":"3","key":"10.1016\/j.carpath.2025.107804_bib0045","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1161\/01.RES.79.3.474","article-title":"The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns","volume":"79","author":"el-Sherif","year":"1996","journal-title":"Circ Res"},{"key":"10.1016\/j.carpath.2025.107804_bib0046","doi-asserted-by":"crossref","unstructured":"Lee SE, Nguyen C, Yoon J, Chang HJ, Kim S, Kim CH, Li D. Three-dimensional cardiomyocytes structure revealed by diffusion tensor imaging and its validation using a tissue-clearing technique. Sci Rep. 2018;8(1):6640. doi: 10.1038\/s41598-018-24622-6. PMID: 29703900; PMCID: PMC5923209.","DOI":"10.1038\/s41598-018-24622-6"}],"container-title":["Cardiovascular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880725000894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880725000894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:26:33Z","timestamp":1768404393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054880725000894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":46,"alternative-id":["S1054880725000894"],"URL":"https:\/\/doi.org\/10.1016\/j.carpath.2025.107804","relation":{},"ISSN":["1054-8807"],"issn-type":[{"value":"1054-8807","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mapping cardiac innervation in the long QT syndrome type 1 transgenic mouse model using whole heart imaging","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carpath.2025.107804","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107804"}}