{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:39:53Z","timestamp":1773920393038,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82125004"],"award-info":[{"award-number":["82125004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["823B200315"],"award-info":[{"award-number":["823B200315"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Pathology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.carpath.2025.107808","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T17:31:42Z","timestamp":1765560702000},"page":"107808","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Genetic mutations, pathology, and single-nucleus transcriptomic landscape in LVHT patients reveal differential progression to heart transplantation"],"prefix":"10.1016","volume":"81","author":[{"given":"Yifan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiteng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiumeng","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9488-7823","authenticated-orcid":false,"given":"Jiangping","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.carpath.2025.107808_bib0001","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s11886-023-01944-0","article-title":"Accurate Classification of non-ischemic cardiomyopathy","volume":"25","author":"Wang","year":"2023","journal-title":"Curr Cardiol Rep"},{"issue":"6","key":"10.1016\/j.carpath.2025.107808_bib0002","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s00246-018-1882-z","article-title":"Potential common pathogenic pathways for the left ventricular noncompaction cardiomyopathy (LVNC)","volume":"39","author":"Liu","year":"2018","journal-title":"Pediatr Cardiol"},{"issue":"3","key":"10.1016\/j.carpath.2025.107808_bib0003","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/ajmg.c.31369","article-title":"Molecular mechanism of ventricular trabeculation\/compaction and the pathogenesis of the left ventricular noncompaction cardiomyopathy (LVNC)","volume":"163C","author":"Zhang","year":"2013","journal-title":"Am J Med Genet C Semin Med Genet"},{"issue":"37","key":"10.1016\/j.carpath.2025.107808_bib0004","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC guidelines for the management of cardiomyopathies","volume":"44","author":"Arbelo","year":"2023","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.carpath.2025.107808_bib0005","first-page":"754","article-title":"Left ventricular noncompaction cardiomyopathy: left ventricular dilation and dysfunction at baseline portend the risk of death or heart transplantation","volume":"38","author":"Cardoso","year":"2022","journal-title":"Can J Cardiol"},{"issue":"19","key":"10.1016\/j.carpath.2025.107808_bib0006","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/j.jacc.2014.08.035","article-title":"The relationship of left ventricular trabeculation to ventricular function and structure over a 9.5-year follow-up: the MESA study","volume":"64","author":"Zemrak","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.carpath.2025.107808_bib0007","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/eurjhf\/hfq222","article-title":"Myocardial fibrosis in isolated left ventricular non-compaction and its relation to disease severity","volume":"13","author":"Nucifora","year":"2011","journal-title":"Eur J Heart Fail"},{"issue":"8","key":"10.1016\/j.carpath.2025.107808_bib0008","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019209","article-title":"Novel approach to risk stratification in left ventricular non-compaction using A combined cardiac imaging and plasma biomarker approach","volume":"10","author":"Ramchand","year":"2021","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"10.1016\/j.carpath.2025.107808_bib0009","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jjcc.2015.11.008","article-title":"Regression of left ventricular hypertrabeculation is associated with improvement in systolic function and favorable prognosis in adult patients with non-ischemic cardiomyopathy","volume":"68","author":"Minamisawa","year":"2016","journal-title":"J Cardiol"},{"issue":"1","key":"10.1016\/j.carpath.2025.107808_bib0010","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41556-019-0446-7","article-title":"Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function","volume":"22","author":"Wang","year":"2020","journal-title":"Nat Cell Biol"},{"issue":"17","key":"10.1016\/j.carpath.2025.107808_bib0011","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1093\/cvr\/cvae212","article-title":"Abnormal circadian rhythms exacerbate dilated cardiomyopathy by reducing the ventricular mechanical strength","volume":"120","author":"Jia","year":"2024","journal-title":"Cardiovasc Res"},{"issue":"32","key":"10.1016\/j.carpath.2025.107808_bib0012","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202401945","article-title":"PICALM regulating the generation of amyloid beta-peptide to promote anthracycline-induced cardiotoxicity","volume":"11","author":"Bao","year":"2024","journal-title":"Adv Sci"},{"issue":"23","key":"10.1016\/j.carpath.2025.107808_bib0013","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.1242\/dev.062802","article-title":"Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo","volume":"138","author":"Oyama","year":"2011","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.carpath.2025.107808_bib0014","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1161\/CIRCRESAHA.118.313845","article-title":"Aggregation of child cardiac progenitor cells into spheres activates notch signaling and improves treatment of right ventricular heart failure","volume":"124","author":"Trac","year":"2019","journal-title":"Circ Res"},{"issue":"8","key":"10.1016\/j.carpath.2025.107808_bib0015","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/CIRCULATIONAHA.121.056666","article-title":"PRDM16 Is a compact myocardium-enriched transcription factor required to maintain compact myocardial cardiomyocyte identity in left ventricle","volume":"145","author":"Wu","year":"2022","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.carpath.2025.107808_bib0016","doi-asserted-by":"crossref","first-page":"H10","DOI":"10.1152\/ajpheart.00401.2002","article-title":"Myocardial fibrosis blunts nitric oxide synthase-related preload reserve in human dilated cardiomyopathy","volume":"284","author":"Bronzwaer","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"10","key":"10.1016\/j.carpath.2025.107808_bib0017","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/nbm.3372","article-title":"Characterization of the ultrashort-TE (UTE) MR collagen signal","volume":"28","author":"Siu","year":"2015","journal-title":"NMR Biomed"},{"issue":"4","key":"10.1016\/j.carpath.2025.107808_bib0018","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s10741-021-10128-3","article-title":"Ventricular non-compaction review","volume":"27","author":"Srivastava","year":"2022","journal-title":"Heart Fail Rev"},{"issue":"3","key":"10.1016\/j.carpath.2025.107808_bib0019","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/cge.13484","article-title":"Targeted panel sequencing in adult patients with left ventricular non-compaction reveals a large genetic heterogeneity","volume":"95","author":"Richard","year":"2019","journal-title":"Clin Genet"},{"issue":"4","key":"10.1016\/j.carpath.2025.107808_bib0020","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1161\/CIRCGENETICS.110.959270","article-title":"Sarcomere gene mutations in isolated left ventricular noncompaction cardiomyopathy do not predict clinical phenotype","volume":"4","author":"Probst","year":"2011","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.carpath.2025.107808_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.722926","article-title":"Reduced systolic function and not genetic variants determine outcome in pediatric and adult left ventricular noncompaction cardiomyopathy","volume":"9","author":"Schultze-Berndt","year":"2021","journal-title":"Front Pediatr"},{"issue":"7838","key":"10.1016\/j.carpath.2025.107808_bib0022","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41586-020-2797-4","article-title":"Cells of the adult human heart","volume":"588","author":"Litvinukova","year":"2020","journal-title":"Nature"},{"issue":"7921","key":"10.1016\/j.carpath.2025.107808_bib0023","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41586-022-04817-8","article-title":"Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy","volume":"608","author":"Chaffin","year":"2022","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.carpath.2025.107808_bib0024","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s44161-023-00260-8","article-title":"Defining cardiac functional recovery in end-stage heart failure at single-cell resolution","volume":"2","author":"Amrute","year":"2023","journal-title":"Nat Cardiovasc Res"},{"issue":"41","key":"10.1016\/j.carpath.2025.107808_bib0025","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1093\/eurheartj\/ehab298","article-title":"Endocardial\/endothelial angiocrines regulate cardiomyocyte development and maturation and induce features of ventricular non-compaction","volume":"42","author":"Rhee","year":"2021","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.carpath.2025.107808_bib0026","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00018-022-04669-5","article-title":"Functional screening of congenital heart disease risk loci identifies 5 genes essential for heart development in zebrafish","volume":"80","author":"Ma","year":"2022","journal-title":"Cell Mol Life Sci"},{"issue":"6220","key":"10.1016\/j.carpath.2025.107808_bib0027","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhlen","year":"2015","journal-title":"Science"},{"issue":"14","key":"10.1016\/j.carpath.2025.107808_bib0028","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1177\/1535370218810892","article-title":"Inhibition of Mastermind-like 1 alleviates liver fibrosis induced by carbon tetrachloride in rats","volume":"243","author":"Zheng","year":"2018","journal-title":"Exp Biol Med"},{"issue":"14","key":"10.1016\/j.carpath.2025.107808_bib0029","doi-asserted-by":"crossref","first-page":"6393","DOI":"10.1128\/MCB.24.14.6393-6402.2004","article-title":"Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins","volume":"24","author":"Phair","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"17","key":"10.1016\/j.carpath.2025.107808_bib0030","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/j.jacc.2014.08.030","article-title":"Left ventricular noncompaction: a distinct cardiomyopathy or a trait shared by different cardiac diseases?","volume":"64","author":"Arbustini","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"9995","key":"10.1016\/j.carpath.2025.107808_bib0031","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0140-6736(14)61282-4","article-title":"Left ventricular non-compaction cardiomyopathy","volume":"386","author":"Towbin","year":"2015","journal-title":"Lancet"}],"container-title":["Cardiovascular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880725000936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054880725000936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:54:02Z","timestamp":1773903242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054880725000936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":31,"alternative-id":["S1054880725000936"],"URL":"https:\/\/doi.org\/10.1016\/j.carpath.2025.107808","relation":{},"ISSN":["1054-8807"],"issn-type":[{"value":"1054-8807","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic mutations, pathology, and single-nucleus transcriptomic landscape in LVHT patients reveal differential progression to heart transplantation","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carpath.2025.107808","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107808"}}