{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:36:46Z","timestamp":1788262606481,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013152","name":"Shanghai Institute of Materia Medica CAS","doi-asserted-by":"publisher","award":["2022686"],"award-info":[{"award-number":["2022686"]}],"id":[{"id":"10.13039\/501100013152","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Carbohydrate Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.carres.2025.109781","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:56:20Z","timestamp":1764402980000},"page":"109781","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A structurally defined galactoglucan from Arisaema erubescens with a multi-target tumor-associated protein binding domain"],"prefix":"10.1016","volume":"560","author":[{"given":"Yue","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8140-9259","authenticated-orcid":false,"given":"Kan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.carres.2025.109781_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering12040365","article-title":"Beta-glucans in biotechnology: a holistic review with a special focus on yeast","volume":"12","author":"Sarkar","year":"2025","journal-title":"Bioengineering"},{"key":"10.1016\/j.carres.2025.109781_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116715","article-title":"Beta-1,6 glucan converts tumor-associated macrophages into an M1-like phenotype","volume":"247","author":"Cheng","year":"2020","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.carres.2025.109781_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.36519\/idcm.2025.448","article-title":"Fungal \u03b2-Glucans: biological properties, immunomodulatory effects, diagnostic and therapeutic applications","volume":"7","author":"Amirinia","year":"2025","journal-title":"Infect Dis. Clin. Microbiol."},{"issue":"21","key":"10.1016\/j.carres.2025.109781_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27217641","article-title":"Isolation of a new polysaccharide from dandelion leaves and evaluation of its antioxidant, antibacterial, and anticancer activities","volume":"27","author":"Li","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.carres.2025.109781_bib5","article-title":"Purification, characterization, and in vitro antitumor activity of a novel glucan from the purple sweet potato Ipomoea Batatas (L.) Lam","volume":"257","author":"C","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"5","key":"10.1016\/j.carres.2025.109781_bib6","first-page":"645","article-title":"Chemical synthesis and antibody affinity study of Helicobacter pylori lipopolysaccharide antigenic epitope fragments","volume":"55","author":"Hui","year":"2024","journal-title":"J. China Pharm. Univ."},{"key":"10.1016\/j.carres.2025.109781_bib7","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ijbiomac.2020.12.135","article-title":"Structural sequencing and anti-inflammatory, anti-lung cancer activities of 1,4-\u03b1\/\u03b2-sulfomalonoglucan in Antrodia cinnamomea","volume":"170","author":"Mk","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"11","key":"10.1016\/j.carres.2025.109781_bib8","first-page":"2776","article-title":"Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, from Lentinus edodes (Berk.) sing. (an edible Mushroom)1","volume":"30","author":"Chihara","year":"1970","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.carres.2025.109781_bib9","first-page":"366","article-title":"[Results of phase III study of lentinan]","volume":"12","author":"Taguchi","year":"1985","journal-title":"Gan To Kagaku Ryoho"},{"issue":"11","key":"10.1016\/j.carres.2025.109781_bib10","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1007\/s00432-018-2718-1","article-title":"Lentinan as an immunotherapeutic for treating lung cancer: a review of 12 years clinical studies in China","volume":"144","author":"Y","year":"2018","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.carres.2025.109781_bib11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1615\/IntJMedMushrooms.v19.i4.10","article-title":"Medicinal mushrooms in human clinical studies. Part I. Anticancer, oncoimmunological, and immunomodulatory activities: a review","volume":"19","author":"Sp","year":"2017","journal-title":"Int. J. Med. Mushrooms"},{"key":"10.1016\/j.carres.2025.109781_bib12","article-title":"Botanical, traditional use, phytochemical, and toxicological of arisaematis rhizoma, evidence-based complementary and alternative medicine","volume":"2021","author":"Cy","year":"2021","journal-title":"eCAM"},{"issue":"1","key":"10.1016\/j.carres.2025.109781_bib13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.bbrc.2018.06.021","article-title":"Anti-melanogenic activity of schaftoside in rhizoma arisaematis by increasing autophagy in B16F1 cells","volume":"503","author":"Kim","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.carres.2025.109781_bib14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.carbpol.2012.04.063","article-title":"Characterization and antitumor activities of the water-soluble polysaccharide from Rhizoma Arisaematis","volume":"90","author":"G","year":"2012","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"10.1016\/j.carres.2025.109781_bib15","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.carbpol.2010.12.033","article-title":"Elucidation of the structure of a bioactive hydrophilic polysaccharide from Cordyceps sinensis by methylation analysis and NMR spectroscopy","volume":"84","author":"Shaoping","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.carres.2025.109781_bib16","article-title":"Chemical structure and anti-inflammatory effects on intestinal epithelial cells of a novel mannogalactan purified from Typhonium giganteum Engl","volume":"552","author":"H","year":"2025","journal-title":"Carbohydr. Res."},{"issue":"3","key":"10.1016\/j.carres.2025.109781_bib17","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.carbpol.2010.05.029","article-title":"Sugar compositional determination of polysaccharides from Dunaliella salina by modified RP-HPLC method of precolumn derivatization with 1-phenyl-3-methyl-5-pyrazolone","volume":"82","author":"Jun","year":"2010","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"10.1016\/j.carres.2025.109781_bib18","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1021\/ac60111a017","article-title":"Colorimetric method for determination of sugars and related substances","volume":"28","author":"DuBois","year":"1956","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.carres.2025.109781_bib19","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0003-2697(73)90377-1","article-title":"New method for quantitative determination of uronic acids","volume":"54","author":"Blumenkrantz","year":"1973","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.carres.2025.109781_bib20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"issue":"2","key":"10.1016\/j.carres.2025.109781_bib21","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0008-6215(84)85242-8","article-title":"A simple and rapid method for the permethylation of carbohydrates","volume":"131","author":"Ionel","year":"1984","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.carres.2025.109781_bib22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.carbpol.2016.06.110","article-title":"Structure analysis of a heteropolysaccharide from Taraxacum mongolicum Hand.-Mazz. and anticomplementary activity of its sulfated derivatives","volume":"152","author":"Miao-miao","year":"2016","journal-title":"Carbohydr. Polym."},{"issue":"Pt B","key":"10.1016\/j.carres.2025.109781_bib23","article-title":"Structural elucidation of an active arabinoglucan from Gomphrena globosa and its protection effect and mechanism against metabolic dysfunction-associated steatohepatitis","volume":"348","author":"M","year":"2025","journal-title":"Carbohydr. Polym."},{"issue":"28","key":"10.1016\/j.carres.2025.109781_bib24","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.2174\/0109298673325827240926081845","article-title":"Molecular docking in drug discovery: techniques, applications, and advancements","volume":"32","author":"Aguiar","year":"2024","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.carres.2025.109781_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122826","article-title":"A novel pectin-like polysaccharide from crocus sativus targets Galectin-3 to inhibit hepatic stellate cells activation and liver fibrosis","volume":"348","author":"Tang","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.carres.2025.109781_bib26","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.foodchem.2018.07.160","article-title":"Structure identification of \u03b1-glucans from dictyophora echinovolvata by methylation and 1D\/2D NMR spectroscopy","volume":"271","author":"Shi","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.carres.2025.109781_bib27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijbiomac.2021.04.084","article-title":"Structural characterization and immunomodulatory mechanisms of two novel glucans from Morchella importuna fruiting bodies","volume":"183","author":"Wen","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.carres.2025.109781_bib28","doi-asserted-by":"crossref","first-page":"584","DOI":"10.3892\/mco.2015.486","article-title":"Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma","volume":"3","author":"Dinccelik-Aslan","year":"2015","journal-title":"Mol. Clin. Oncol."},{"key":"10.1016\/j.carres.2025.109781_bib29","article-title":"TRPC3-mediated NFATc1 calcium signaling promotes triple negative breast cancer migration through regulating glypican-6 and focal adhesion","author":"Wang","year":"2024","journal-title":"Pflugers Arch. Null"},{"issue":"1","key":"10.1016\/j.carres.2025.109781_bib30","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1042\/BJ20110530","article-title":"NFAT promotes carcinoma invasive migration through glypican-6","volume":"440","author":"Gk","year":"2011","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.carres.2025.109781_bib31","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/hep.24099","article-title":"Up-regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis","volume":"53","author":"Gauglhofer","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.carres.2025.109781_bib32","article-title":"Metastatic immune-related genes for affecting prognosis and immune response in renal clear cell carcinoma","volume":"8","author":"Sun","year":"2021","journal-title":"Front. Mol. Biosci."},{"issue":"4","key":"10.1016\/j.carres.2025.109781_bib33","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2024.5682","article-title":"FGFR-related phenotypic and functional profile of CAFs in prognostication of breast cancer","volume":"65","author":"Solek","year":"2024","journal-title":"Int. J. Oncol."},{"issue":"15","key":"10.1016\/j.carres.2025.109781_bib34","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1007\/s00018-017-2526-9","article-title":"S100A6 protein: functional roles","volume":"74","author":"Donato","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.carres.2025.109781_bib35","article-title":"S100A6 protein-expression and function in norm and pathology","volume":"24","author":"W","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.carres.2025.109781_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154325","article-title":"S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K\/AKT\/mTOR pathway","volume":"242","author":"Chen","year":"2023","journal-title":"Pathol. Res. Pract."},{"issue":"14","key":"10.1016\/j.carres.2025.109781_bib37","article-title":"The function of S100A4 in pulmonary disease: a review","volume":"102","author":"Wang","year":"2023","journal-title":"Medicine (Baltim.)"},{"issue":"7","key":"10.1016\/j.carres.2025.109781_bib38","article-title":"Targeted destruction of S100A4 inhibits metastasis of triple negative breast cancer cells","volume":"13","author":"Tm","year":"2023","journal-title":"Biomolecules"},{"issue":"45","key":"10.1016\/j.carres.2025.109781_bib39","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1038\/s41388-022-02487-4","article-title":"Src: coordinating metabolism in cancer","volume":"41","author":"Sg","year":"2022","journal-title":"Oncogene"},{"issue":"678","key":"10.1016\/j.carres.2025.109781_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abl7895","article-title":"Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models","volume":"15","author":"Su","year":"2023","journal-title":"Sci. Transl. Med."},{"issue":"7","key":"10.1016\/j.carres.2025.109781_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110286","article-title":"Nuclear NME1 enhances the malignant behavior of A549 cells and impacts lung adenocarcinoma patient prognosis","volume":"27","author":"Xu","year":"2024","journal-title":"iScience"},{"issue":"6","key":"10.1016\/j.carres.2025.109781_bib42","doi-asserted-by":"crossref","first-page":"655","DOI":"10.17219\/acem\/146579","article-title":"MicroRNA-139-5p negatively regulates NME1 expression in hepatocellular carcinoma cells","volume":"31","author":"Yang","year":"2022","journal-title":"Adv. Clin. Exp. Med."},{"issue":"6","key":"10.1016\/j.carres.2025.109781_bib43","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20190425","article-title":"Down-regulated HSDL2 expression suppresses cell proliferation and promotes apoptosis in papillary thyroid carcinoma","volume":"39","author":"Zeng","year":"2019","journal-title":"Biosci. Rep."},{"issue":"1","key":"10.1016\/j.carres.2025.109781_bib44","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20203282","article-title":"The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer","volume":"41","author":"Hang","year":"2021","journal-title":"Biosci. Rep."},{"issue":"5","key":"10.1016\/j.carres.2025.109781_bib45","doi-asserted-by":"crossref","first-page":"7","DOI":"10.14715\/cmb\/2018.64.5.2","article-title":"Immunoexpression of progesterone receptor, epithelial growth factor receptor and galectin-3 in uterine smooth muscle tumors","volume":"64","author":"Soltan","year":"2018","journal-title":"Cell. Mol. Biol."},{"issue":"10","key":"10.1016\/j.carres.2025.109781_bib46","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1080\/14728222.2019.1675638","article-title":"Galectin-3: is this member of a large family of multifunctional lectins (already) a therapeutic target?","volume":"23","author":"Romero","year":"2019","journal-title":"Expert Opin. Ther. Targets"},{"issue":"1","key":"10.1016\/j.carres.2025.109781_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13010046","article-title":"The KEAP1-NRF2 system as a molecular target of cancer treatment","volume":"13","author":"Taguchi","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.carres.2025.109781_bib48","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2492063","article-title":"Epigenetic versus genetic deregulation of the KEAP1\/NRF2 axis in solid tumors: focus on methylation and noncoding RNAs","volume":"2018","author":"Fabrizio","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.carres.2025.109781_bib49","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.ijbiomac.2020.06.020","article-title":"Structural characterization and immunostimulatory activity of a glucan from Cyclina sinensis","volume":"161","author":"Gong","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"Pt 2","key":"10.1016\/j.carres.2025.109781_bib50","article-title":"Impact of molecular weight and gastrointestinal digestion on the immunomodulatory effects of Lycium barbarum polysaccharides","volume":"274","author":"Y","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.carres.2025.109781_bib51","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.ijbiomac.2016.06.067","article-title":"Characteristics and bioactivities of different molecular weight polysaccharides from camellia seed cake","volume":"91","author":"Z","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.carres.2025.109781_bib52","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.foodres.2014.02.047","article-title":"Structural differences and conformational characterization of five bioactive polysaccharides from Lentinus edodes","volume":"62","author":"Kaiping","year":"2014","journal-title":"Food Res. Int."},{"key":"10.1016\/j.carres.2025.109781_bib53","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.carbpol.2015.11.051","article-title":"Chemical characterization of Pleurotus eryngii polysaccharide and its tumor-inhibitory effects against human hepatoblastoma HepG-2 cells","volume":"138","author":"Daoyuan","year":"2016","journal-title":"Carbohydr. Polym."}],"container-title":["Carbohydrate Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008621525004070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008621525004070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:37:48Z","timestamp":1773851868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008621525004070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":53,"alternative-id":["S0008621525004070"],"URL":"https:\/\/doi.org\/10.1016\/j.carres.2025.109781","relation":{},"ISSN":["0008-6215"],"issn-type":[{"value":"0008-6215","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A structurally defined galactoglucan from Arisaema erubescens with a multi-target tumor-associated protein binding domain","name":"articletitle","label":"Article Title"},{"value":"Carbohydrate Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carres.2025.109781","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109781"}}