{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:59:02Z","timestamp":1787504342228,"version":"build-2736575974"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001849","name":"Defence Research and Development Organisation","doi-asserted-by":"publisher","award":["ST-SCST-MISC-0011-2023"],"award-info":[{"award-number":["ST-SCST-MISC-0011-2023"]}],"id":[{"id":"10.13039\/501100001849","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001849","name":"Defence Research and Development Organisation","doi-asserted-by":"publisher","award":["DST\/INSPIRE\/03\/2022\/005769"],"award-info":[{"award-number":["DST\/INSPIRE\/03\/2022\/005769"]}],"id":[{"id":"10.13039\/501100001849","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023171","name":"Life Sciences Research Board","doi-asserted-by":"publisher","award":["LSRB\/01\/15001\/M\/LSRB-372\/BTB\/2020"],"award-info":[{"award-number":["LSRB\/01\/15001\/M\/LSRB-372\/BTB\/2020"]}],"id":[{"id":"10.13039\/501100023171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000964","name":"Arthritis National Research Foundation","doi-asserted-by":"publisher","award":["ANRF\/PAIR\/2025\/000002\/PAIR-B"],"award-info":[{"award-number":["ANRF\/PAIR\/2025\/000002\/PAIR-B"]}],"id":[{"id":"10.13039\/100000964","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Anusandhan National Research Foundation","doi-asserted-by":"publisher","award":["SUR\/2022\/000257"],"award-info":[{"award-number":["SUR\/2022\/000257"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["SR\/FST\/CSI-243\/2012"],"award-info":[{"award-number":["SR\/FST\/CSI-243\/2012"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["16-7-2020"],"award-info":[{"award-number":["16-7-2020"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["2692\/ST"],"award-info":[{"award-number":["2692\/ST"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Carbohydrate Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.carres.2026.110053","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:49:32Z","timestamp":1784875772000},"page":"110053","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Design, synthesis, in vitro anticancer evaluation, in silico molecular docking and ADMET profiling of carbohydrate-conjugated pyridine oximes"],"prefix":"10.1016","volume":"568","author":[{"given":"Mohammed Ansar","family":"Ahemad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhabani Shankar","family":"Panda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabita","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotiranjan","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopinatha","family":"Panigrahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudra Narayan","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seetaram","family":"Mohapatra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.carres.2026.110053_bib1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.carres.2026.110053_bib2","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1007\/s11095-008-9661-9","article-title":"Cancer is a preventable disease that requires major lifestyle changes","volume":"25","author":"Anand","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.carres.2026.110053_bib3","first-page":"212","article-title":"The impact of eliminating socioeconomic and racial disparities on premature cancer deaths","volume":"614","author":"Siegel","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.carres.2026.110053_bib4","first-page":"7","article-title":"Cancer statistics","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.carres.2026.110053_bib5","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.3390\/ijms21093233","article-title":"Mechanisms of multidrug resistance in cancer chemotherapy","volume":"21","author":"Bukowski","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.carres.2026.110053_bib6","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/srep01445","article-title":"Cancer drug resistance database","volume":"3","author":"Kumar","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.carres.2026.110053_bib7","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1158\/0008-5472.CAN-15-2355","article-title":"p28-mediated activation of p53 in G2-M phase of the cell cycle enhances the efficacy of DNA damaging and antimitotic chemotherapy","volume":"76","author":"Yamada","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.carres.2026.110053_bib8","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.21873\/anticanres.14494","article-title":"New imidazo [2,1-b][1,3,4] thiadiazole derivatives inhibit FAK phosphorylation and potentiate the antiproliferative effects of gemcitabine through modulation of the human equilibrative nucleoside transporter-1 in peritoneal mesothelioma","volume":"40","author":"Petri","year":"2020","journal-title":"Anticancer Res."},{"key":"10.1016\/j.carres.2026.110053_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1089\/adt.2022.085","article-title":"Design, synthesis, and biological evaluation of novel dihydropyrimidinone derivatives as potential anticancer agents and tubulin polymerization inhibitors","volume":"21","author":"Rawal","year":"2023","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.carres.2026.110053_bib10","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2174\/0115734064278334231211054053","article-title":"Nitrogen-fused heterocycles empowering anticancer drug discovery","volume":"20","author":"Biswas","year":"2024","journal-title":"Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116727","article-title":"Design and synthesis of novel thiazolo[5, 4-b]pyridine derivatives as potent and selective EGFR-TK inhibitors targeting resistance mutations in non-small cell lung cancer","volume":"276","author":"Borude","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2023.132727","article-title":"1,2,3-Triazolyl-linked benzimidazolone derivatives as new eco-friendly corrosion inhibitors for mild steel in 1M HCl solution: experimental and computational studies","volume":"681","author":"Ettahiri","year":"2024","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.carres.2026.110053_bib13","doi-asserted-by":"crossref","DOI":"10.1107\/S2414314623004091","article-title":"5,6,7,8-Tetrahydro-[1,2,4]triazolo[5,1-b]quinazolin-9(4H)-one","volume":"8","author":"Ettahiri","year":"2023","journal-title":"IUCrData"},{"key":"10.1016\/j.carres.2026.110053_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2023.122652","article-title":"Surface interactions and improved corrosion resistance of mild steel by addition of new triazolyl-benzimidazolone derivatives in acidic environment","volume":"387","author":"Ech-chihbi","year":"2023","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.carres.2026.110053_bib15","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.2147\/DDDT.S329547","article-title":"The expanding role of pyridine and dihydropyridine scaffolds in drug design","author":"Ling","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.carres.2026.110053_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116497","article-title":"Design, synthesis of combretastatin A-4 piperazine derivatives as potential antitumor agents by inhibiting tubulin polymerization and inducing autophagy in HCT116 cells","volume":"272","author":"Zhang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.139323","article-title":"Microwave-assisted click synthesis, characterisation, and in silico studies of novel 2H-chromene-1,2,3-triazolyl glycoconjugates as potent anticancer and antibacterial agents","volume":"1318","author":"Panda","year":"2024","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.carres.2026.110053_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3906\/kim-1806-7","article-title":"An insight into the therapeutic potential of piperazine-based anticancer agents","volume":"43","author":"Walayat","year":"2019","journal-title":"Turk. J. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib19","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1128\/AAC.10.2.288","article-title":"In vitro evaluation of the new oral cephalosporin cefatrizine comparison with other cephalosporins","volume":"10","author":"Blackwell","year":"1976","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.carres.2026.110053_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042310","article-title":"Carboxy amido triazole-orotate inhibits the growth of imatinib-resistant chronic myeloid leukaemia cells and modulates exosomes-stimulated angiogenesis","volume":"7","author":"Corrado","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.carres.2026.110053_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115820","article-title":"Pyridine alkaloids with activity in the central nervous system","volume":"28","author":"Lin","year":"2020","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib22","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/maco.202112708","article-title":"Corrosion protection properties of poly (4-vinyl pyridine) containing multilayer poly meric coatings on magnesium alloy AZ31","volume":"73","author":"Das","year":"2022","journal-title":"Mater. Corros."},{"key":"10.1016\/j.carres.2026.110053_bib23","first-page":"1","article-title":"Medicinal attributes of pyridine scaffold as anticancer targeting agents","volume":"7","author":"Mohamed","year":"2021","journal-title":"Future J. Pharmaceut. Sci."},{"key":"10.1016\/j.carres.2026.110053_bib24","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1038\/s41598-024-53228-4","article-title":"Novel pyridine bearing pentose moiety-based anticancer agents: design, synthesis, radioiodination and bioassessments","volume":"14","author":"Mehany","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.carres.2026.110053_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115969","article-title":"Design, synthesis and anti-inflammatory activity of imidazole-5-yl pyridine derivatives as p38\u03b1\/MAPK14 inhibitor","volume":"31","author":"Ali","year":"2021","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib26","article-title":"Synthesis of some novel pyrimidine, thiophene, coumarin, pyridine and pyrrole derivatives and their biological evaluation as analgesic, antipyretic and anti-inflammatory agents","volume":"54","author":"El-Sharkawy","year":"2019","journal-title":"Braz. J. Pharm. Sci."},{"key":"10.1016\/j.carres.2026.110053_bib27","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1021\/acs.chemmater.1c02813","article-title":"Molecularly imprinted polymers with enhanced selectivity based on 4-(aminomethyl) pyridine-functionalized poly(2-oxazoline)s for detecting hazardous herbicide contaminants","volume":"34","author":"Ceg\u0142owski","year":"2022","journal-title":"Chem. Mater."},{"key":"10.1016\/j.carres.2026.110053_bib28","doi-asserted-by":"crossref","first-page":"6695","DOI":"10.1016\/j.bmc.2017.11.012","article-title":"Discovery of imidazo [1,2-a] pyridine-based anthelmintic targeting cholinergic receptors of Haemonchus contortus","volume":"25","author":"N'Guessan","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/aoc.6473","article-title":"Development of DNA intercalative, HSA binder pyridine-based novel Schiff base Cu(II), Ni(II) complexes with effective anticancer property: a combined experimental and theoretical approach","volume":"36","author":"Satapathi","year":"2022","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib30","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.2174\/1389557521666210126143558","article-title":"Antiviral activities of pyridine fused and pyridine containing heterocycles: a review (from 2000 to 2020)","volume":"21","author":"Alizadeh","year":"2021","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2021.131287","article-title":"Molecular modeling and antioxidant evaluation of new di-2-thienyl ketones festooned with thiazole or pyridine moiety","volume":"1247","author":"Althagafi","year":"2022","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.carres.2026.110053_bib32","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1134\/S1070363222010182","article-title":"Design, synthesis, and insecticidal activity of novel diacylhydrazine derivatives containing an isoxazole carboxamide or a pyridine carboxamide moiety","volume":"92","author":"Li","year":"2022","journal-title":"Russ. J. Gen. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib33","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s11030-021-10224-4","article-title":"In vitro antimicrobial evaluation and in silico studies of coumarin derivatives tagged with pyrano-pyridine and pyrano-pyrimidine moieties as DNA gyrase inhibitors","volume":"26","author":"Fayed","year":"2021","journal-title":"Mol. Divers."},{"key":"10.1016\/j.carres.2026.110053_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.carres.2023.108846","article-title":"Click inspired synthesis of piperazine-triazolyl sugar-conjugates as potent Anti-Hela activity","volume":"529","author":"Bose","year":"2023","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.carres.2026.110053_bib35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.7439\/ijasr.v1i1.1766","article-title":"Piperazine and Pyrazine containing molecules and their diverse pharmacological activities","volume":"1","author":"Asif","year":"2015","journal-title":"Int. J. Adv. Sci. Res."},{"key":"10.1016\/j.carres.2026.110053_bib36","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.2174\/13895575113139990073","article-title":"An evolving role of piperazine moieties in drug design and discovery","volume":"13","author":"Patel","year":"2013","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib37","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2174\/0929867322666150227150127","article-title":"Recent trends in 1,2,3-triazolo-nucleosides as promising anti-infective and anticancer agents","volume":"22","author":"Silvana","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib38","first-page":"316","article-title":"Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B: cell host","volume":"3","author":"Bach","year":"2008","journal-title":"Microbe"},{"key":"10.1016\/j.carres.2026.110053_bib39","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1016\/j.bmcl.2009.04.134","article-title":"Synthesis of novel 3-(1-(1-substituted piperidin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-5(4H)-one as antifungal agents","volume":"19","author":"Sangshetti","year":"2009","journal-title":"Biorg. Med. Chem. Lett."},{"key":"10.1016\/j.carres.2026.110053_bib40","doi-asserted-by":"crossref","first-page":"S3508","DOI":"10.1016\/j.arabjc.2014.02.016","article-title":"Synthesis and antibacterial activity of 1-N-(\u03b2-d-glucopyranosyl)-4-((1-substituted-1H-1,2,3-triazol-4-yl)ethoxymethyl) 1,2,3-triazoles","volume":"10","author":"Mohammed","year":"2017","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib41","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2174\/1573406413666171120165226","article-title":"Synthesis, characterization and biological activities of new symmetric bis-1,2,3-triazoles with click chemistry","volume":"14","author":"Fatih","year":"2018","journal-title":"Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib42","first-page":"294","article-title":"Synthesis and in-vitro antioxidant activities of some coumarin derivatives containing 1,2,3-triazole ring: phosphorus, Sulfur, Silicon Relat","volume":"193","author":"Kumar","year":"2018","journal-title":"Elements"},{"key":"10.1016\/j.carres.2026.110053_bib43","first-page":"845","article-title":"Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability","volume":"104","author":"Nieuwdorp","year":"2008","journal-title":"Appl. Phys. (Berlin)"},{"key":"10.1016\/j.carres.2026.110053_bib44","article-title":"Click chemistry: in vitro evaluation of glycosyl hybrid phosphorylated\/thiophosphorylated 1,2,3-triazole derivatives as irreversible acetyl cholinesterase (AChE) inhibitors","volume":"3","author":"Anjaneyulu","year":"2020","journal-title":"Results Chem."},{"key":"10.1016\/j.carres.2026.110053_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2022.103878","article-title":"SPIONs as a nanomagnetic catalyst for the synthesis and anti-microbial activity of 2-aminothiazoles derivatives","volume":"15","author":"Abubshait","year":"2022","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib46","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ejmech.2014.12.010","article-title":"Design, synthesis and QSAR study of certain isatin-pyridine hybrids as potential anti-proliferative agents","volume":"90","author":"Eldehna","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib47","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.molp.2017.12.014","article-title":"Oximes: unrecognized chameleons in general and specialized plant metabolism","volume":"11","author":"S\u00f8rensen","year":"2018","journal-title":"Mol. Plant"},{"key":"10.1016\/j.carres.2026.110053_bib48","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.poly.2013.03.064","article-title":"A palladium (II) complex: synthesis, structure, characterization, electrochemical behaviour, thermal aspects, BVS calculation and antimicrobial activity","volume":"56","author":"Biswas","year":"2013","journal-title":"Polyhedron"},{"key":"10.1016\/j.carres.2026.110053_bib49","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1016\/j.bmcl.2010.04.144","article-title":"Synthesis, larvicidal activity and SAR studies of new benzoylphenylureas containing oxime ether and oxime ester group","volume":"20","author":"Sun","year":"2010","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.carres.2026.110053_bib50","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1080\/00958970600896076","article-title":"Studies on mononuclear transition metal chelates derived from a novel (E,E)-dioxime: synthesis, characterization and biological activity","volume":"60","author":"Kurtoglu","year":"2007","journal-title":"J. Coord. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib51","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1039\/C3DT53460J","article-title":"Molecular and electronic structure of nonradical homoleptic pyridyl-azo-oxime complexes of cobalt (III) and the azo-oxime anion radical congener: an experimental and theoretical investigation","volume":"43","author":"Pramanik","year":"2014","journal-title":"Dalton Trans."},{"key":"10.1016\/j.carres.2026.110053_bib52","doi-asserted-by":"crossref","first-page":"8708","DOI":"10.1039\/C5NJ01280E","article-title":"Design and synthesis of a novel trinuclear palladium (ii) complex containing an oxime chelate ligand: determining the interaction mechanism with the DNA groove and BSA site I by spectroscopic and molecular dynamics simulation approaches","volume":"39","author":"Karami","year":"2015","journal-title":"New J. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib53","author":"Ashani"},{"key":"10.1016\/j.carres.2026.110053_bib54","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1021\/acs.jmedchem.6b00276","article-title":"Synthesis of \u03b1,\u03b2-unsaturated carbonyl-based compounds, oxime and oxime ether analogs as potential anticancer agents for overcoming cancer multidrug resistance by modulation of efflux pumps in tumor cells","volume":"59","author":"Qin","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib55","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejmech.2017.04.025","article-title":"Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance","volume":"135","author":"Zha","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib56","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1152\/japplphysiol.00440.2007","article-title":"Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability","volume":"104","author":"Nieuwdorp","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.carres.2026.110053_bib57","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1007\/s00044-017-1864-3","article-title":"Synthesis and antimicrobial evaluation of sulfanilamide and carbohydrate-derived 1,4-disubstituted-1,2,3-triazoles via click chemistry","volume":"26","author":"Ay","year":"2017","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.carres.2026.110053_bib58","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.3390\/molecules24203738","article-title":"Synthesis and cytotoxic activity of new 1,3,4-thiadiazole thioglycosides and 1,2,3-triazolyl-1,3,4-thiadiazole N-glycosides","volume":"24","author":"Alminderej","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.carres.2026.110053_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.carres.2025.109395","article-title":"Efficient synthesis of coumarin based triazole linked O-glycoconjugates as new bio-active glycohybrids","volume":"550","author":"Sharma","year":"2025","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.carres.2026.110053_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12039-018-1520-6","article-title":"Design and synthesis of (Z\/E)-2-phenyl\/H-3-styryl-2H-chromene derivatives as antimicrotubule agents","volume":"130","author":"Panda","year":"2018","journal-title":"J. Chem. Sci."},{"key":"10.1016\/j.carres.2026.110053_bib61","doi-asserted-by":"crossref","first-page":"16802","DOI":"10.1039\/C8RA02729C","article-title":"Diastereoselective synthesis of novel spiro indanone fused pyrano[3,2-c]chromene derivatives following hetero-Diels\u2013Alder reaction and in vitro anticancer studies","volume":"8","author":"Panda","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.carres.2026.110053_bib62","article-title":"New 2H-chromene-based hydrazone derivatives as promising anti-breast cancer agents: efficient synthesis, spectral characterization, molecular docking, and ADMET studies","volume":"9","author":"Panda","year":"2024","journal-title":"Chem. Select"},{"key":"10.1016\/j.carres.2026.110053_bib63","doi-asserted-by":"crossref","first-page":"27374","DOI":"10.1039\/D6RA03687B","article-title":"Multicomponent synthesis of 2 H-chromene-fused-thiazolo-triazole derivatives via cascade Michael addition\/cyclization reaction: anticancer, antibacterial and computational evaluations","volume":"16","author":"Samanta","year":"2026","journal-title":"RSC Adv."},{"key":"10.1016\/j.carres.2026.110053_bib64","article-title":"Design, synthesis, and biological evaluation of 3\u2010Nitro\u20102\u2010phenyl\u20101, 2\u2010dihydroquinoline derivatives as potential anti\u2010breast cancer agents","volume":"10","author":"Panigrahi","year":"2025","journal-title":"Chem. Select"},{"key":"10.1016\/j.carres.2026.110053_bib65","doi-asserted-by":"crossref","first-page":"26805","DOI":"10.1039\/D6RA01808D","article-title":"Design, synthesis, and biological evaluation of multifunctional dispiro chromeno-indenoquinoxaline hybrids as dual anticancer and antibacterial agents with metal-ion sensing ability","volume":"16","author":"Prusty","year":"2026","journal-title":"RSC Adv."},{"key":"10.1016\/j.carres.2026.110053_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2025.143205","article-title":"Design, synthesis, characterization and biological evaluation of 2H-chromene based [1,2-c]pyrazolone derivatives as promising anticancer agents: in silico computational studies","volume":"1347","author":"Panda","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.carres.2026.110053_bib67","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00706-021-02752-4","article-title":"Synthesis and muscarinic acetylcholine receptor (mAChR) antagonist activity of substituted piperazine-triazoles","volume":"152","author":"Acharya","year":"2021","journal-title":"Monatsh. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib68","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.carres.2008.02.013","article-title":"Preparation and reactions of sugar azides with alkynes: synthesis of sugar triazoles as antitubercular agents","volume":"343","author":"Singh","year":"2008","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.carres.2026.110053_bib69","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1039\/D4OB00711E","article-title":"Design and synthesis of 1, 2-dihydroquinoline\/chromene fused sugar triazole frameworks by copper-catalyzed one-pot click and intramolecular arylation reactions","volume":"22","author":"Ahemad","year":"2024","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.carres.2024.109222","article-title":"Click-chemistry-inspired synthesis of new series of 1,2,3-triazole fused chromene with glucose triazole conjugates: antibacterial activity assessment with molecular docking evaluation","volume":"543","author":"Ahemad","year":"2024","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.carres.2026.110053_bib71","doi-asserted-by":"crossref","first-page":"8757","DOI":"10.1016\/j.tet.2011.09.024","article-title":"Straightforward and efficient synthesis of 3-benzyloxy-4-bromopicolinate ester and 3-benzyloxy-5-bromopicolinate ester, common building blocks for pharmaceuticals and agrochemicals","volume":"67","author":"Verdelet","year":"2011","journal-title":"Tetrahedron"},{"key":"10.1016\/j.carres.2026.110053_bib72","doi-asserted-by":"crossref","DOI":"10.1002\/cnma.202400056","article-title":"Oxime palladacycle supported on magnetic mesoporous silica: an efficient catalyst for copper\u2010free acyl Sonogashira reaction","volume":"10","author":"Ghahramani","year":"2024","journal-title":"ChemNanoMat"},{"key":"10.1016\/j.carres.2026.110053_bib73","doi-asserted-by":"crossref","DOI":"10.1002\/ajoc.202300129","article-title":"Bimetallic Pd\/Cu-catalyzed Sonogashira coupling-elimination reaction: an efficient synthesis of 2-unsubstituted terminal 1,3-enynes","volume":"12","author":"Shi","year":"2023","journal-title":"Asian J. Org. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib74","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1016\/S0040-4039(02)00807-9","article-title":"Stereocontrolled synthesis of polyenoic acids by a Heck\u2013Sonogashira reaction: easy access to 9,10-didehydroretinoic acids","volume":"43","author":"Abarbri","year":"2002","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.carres.2026.110053_bib75","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1016\/S0040-4039(02)00393-3","article-title":"Sonogashira cross-coupling reaction of 3-iodoisoindazoles with various terminal alkynes: a mild and flexible strategy to design 2-aza tryptamine","volume":"43","author":"Arnautu","year":"2002","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.carres.2026.110053_bib76","doi-asserted-by":"crossref","first-page":"7091","DOI":"10.1016\/S0040-4039(02)01538-1","article-title":"Palladium-catalyzed carbon-carbon coupling reactions using aryl Grignards","volume":"43","author":"Gottardo","year":"2002","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.carres.2026.110053_bib77","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ejmech.2014.03.044","article-title":"Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine-aldoxime and amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase","volume":"78","author":"Kliachyna","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib78","doi-asserted-by":"crossref","first-page":"29164","DOI":"10.1039\/D1RA05138E","article-title":"Aptamer-functionalized pH-sensitive liposomes for a selective delivery of echinomycin into cancer cells","volume":"11","author":"Lafi","year":"2021","journal-title":"RSC Adv."},{"key":"10.1016\/j.carres.2026.110053_bib79","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3390\/ph18081231","article-title":"Novel indole-based sulfonylhydrazones as potential anti-breast cancer agents: synthesis, in vitro evaluation, ADME, and QSAR studies","volume":"18","author":"Angelova","year":"2025","journal-title":"Pharmaceut"},{"key":"10.1016\/j.carres.2026.110053_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.138240","article-title":"Synthesis of citral-tryptamine fused selenium nanospheres (CT@SeNPs) and exploration of their anticancer, antibacterial, and electrochemical sensor applications","volume":"1310","author":"Hemanth","year":"2024","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.carres.2026.110053_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2024.124561","article-title":"Exploring 4-chloro chalcone: synthesis, spectroscopic, chemical reactivity, topological, Hirshfeld surface, drug-likeness, molecular docking and assessment of electronic properties in diverse solvents","volume":"400","author":"Chakkaravarthy","year":"2024","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.carres.2026.110053_bib82","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/1878-0261.12155","article-title":"Emerging functions of the EGFR in cancer","volume":"12","author":"Sigismund","year":"2018","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.carres.2026.110053_bib83","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/35052073","article-title":"Untangling the ErbB signalling network","volume":"2","author":"Yarden","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.carres.2026.110053_bib84","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.gene.2005.10.018","article-title":"Epidermal growth factor receptor (EGFR) signaling in cancer","volume":"366","author":"Normanno","year":"2006","journal-title":"Gene"},{"key":"10.1016\/j.carres.2026.110053_bib85","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd3253","article-title":"Microtubule-binding agents: a dynamic field of cancer therapeutics","volume":"9","author":"Dumontet","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.carres.2026.110053_bib86","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1007\/s11095-012-0828-z","article-title":"An overview of tubulin inhibitors that interact with the colchicine binding site","volume":"29","author":"Lu","year":"2012","journal-title":"Pharm. Res."},{"key":"10.1016\/j.carres.2026.110053_bib87","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.2174\/1871520622666220324102849","article-title":"A therapeutic journey of pyridine-based heterocyclic compounds as potent anticancer agents: a review (from 2017 to 2021)","volume":"22","author":"Alrooqi","year":"2022","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib88","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1002\/mog2.46","article-title":"Microtubule\u2010targeting agents for cancer treatment: seven binding sites and three strategies","volume":"2","author":"Wang","year":"2023","journal-title":"MedComm - Oncol"},{"key":"10.1016\/j.carres.2026.110053_bib89","doi-asserted-by":"crossref","first-page":"10307","DOI":"10.1039\/D2RA01198K","article-title":"Synthesis and evaluation of new chalcones and oximes as anticancer agents","volume":"12","author":"Bukhari","year":"2022","journal-title":"RSC Adv."},{"key":"10.1016\/j.carres.2026.110053_bib90","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1039\/D4MD00015C","article-title":"Design and synthesis of Meldrum's acid based 7-azaindole anchored 1,2,3-triazole hybrids as anticancer agents","volume":"15","author":"Vanga","year":"2024","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114439","article-title":"Dual-functional antitumor conjugates improving the anti-metastasis effect of combretastatin A4 by targeting tubulin polymerization and matrix metalloproteinases","volume":"238","author":"Yang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib92","doi-asserted-by":"crossref","first-page":"46265","DOI":"10.1074\/jbc.M207135200","article-title":"Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor","volume":"277","author":"Stamos","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib93","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.jmb.2014.02.005","article-title":"The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization","volume":"426","author":"Prota","year":"2014","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.carres.2026.110053_bib94","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.tcb.2018.05.001","article-title":"Microtubule-targeting agents: strategies to hijack the cytoskeleton","volume":"28","author":"Steinmetz","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.carres.2026.110053_bib95","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/cmdc.201600182","article-title":"A BOILED-egg to predict gastrointestinal absorption and brain penetration of small molecules","volume":"11","author":"Daina","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.carres.2026.110053_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.117201","article-title":"Discovery of novel bicyclic and tricyclic cyclohepta[b]thiophene derivatives as multipotent AChE and BChE inhibitors, in-vivo and in-vitro assays, ADMET and molecular docking simulation","volume":"284","author":"Fayed","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmgm.2021.107933","article-title":"Rational design, chemical synthesis and cellular evaluation of novel 1,3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents","volume":"106","author":"Patel","year":"2021","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.carres.2026.110053_bib98","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.carres.2026.110053_bib99","first-page":"1","volume":"420","author":"Studio","year":"2008"},{"key":"10.1016\/j.carres.2026.110053_bib100","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.carres.2026.110053_bib101","doi-asserted-by":"crossref","first-page":"W257","DOI":"10.1093\/nar\/gky318","article-title":"ProTox-II: a webserver for the prediction of toxicity of chemicals","volume":"46","author":"Banerjee","year":"2018","journal-title":"Nucleic Acids Res."}],"container-title":["Carbohydrate Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008621526002429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008621526002429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:16:08Z","timestamp":1786522568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008621526002429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":101,"alternative-id":["S0008621526002429"],"URL":"https:\/\/doi.org\/10.1016\/j.carres.2026.110053","relation":{},"ISSN":["0008-6215"],"issn-type":[{"value":"0008-6215","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, in vitro anticancer evaluation, in silico molecular docking and ADMET profiling of carbohydrate-conjugated pyridine oximes","name":"articletitle","label":"Article Title"},{"value":"Carbohydrate Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carres.2026.110053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110053"}}