{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:17:45Z","timestamp":1785388665374,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Revascularization Medicine"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.carrev.2018.09.010","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T23:53:00Z","timestamp":1537401180000},"page":"687-694","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Percutaneous Closure of Patent Foramen Ovale in Patients with Cryptogenic Stroke \u2014 An Updated Comprehensive Meta-Analysis"],"prefix":"10.1016","volume":"20","author":[{"given":"Puja","family":"Sitwala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Faisal","family":"Khalid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furqan","family":"Khattak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayant","family":"Bagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhdeep","family":"Bhogal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vatsal","family":"Ladia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrata","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Daggubati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timir K.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.carrev.2018.09.010_bb0005","first-page":"386","article-title":"Cryptogenic stroke: a diagnostic challenge","volume":"4","author":"Yaghi","year":"2014","journal-title":"Neurology: Clinical Practice"},{"key":"10.1016\/j.carrev.2018.09.010_bb0010","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S1474-4422(13)70310-7","article-title":"Embolic strokes of undetermined source: the case for a new clinical construct","volume":"13","author":"Hart","year":"2014","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.carrev.2018.09.010_bb0015","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/ana.410250410","article-title":"Infarcts of undetermined cause: the NINCDS stroke data bank","volume":"25","author":"Sacco","year":"1989","journal-title":"Ann Neurol"},{"key":"10.1016\/j.carrev.2018.09.010_bb0020","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJM198805053181802","article-title":"Prevalence of patent foramen ovale in patients with stroke","volume":"318","author":"Lechat","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.carrev.2018.09.010_bb0025","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/CRD.0000000000000148","article-title":"PFO closure for cryptogenic stroke","volume":"25","author":"Singh","year":"2017","journal-title":"Cardiol Rev"},{"key":"10.1016\/j.carrev.2018.09.010_bb0030","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1056\/NEJMoa1009639","article-title":"Closure or medical therapy for cryptogenic stroke with patent foramen ovale","volume":"366","author":"Furlan","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.carrev.2018.09.010_bb0035","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1056\/NEJMoa1301440","article-title":"Closure of patent foramen ovale versus medical therapy after cryptogenic stroke","volume":"368","author":"Carroll","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.carrev.2018.09.010_bb0040","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1056\/NEJMoa1211716","article-title":"Percutaneous closure of patent foramen ovale in cryptogenic embolism","volume":"368","author":"Meier","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.carrev.2018.09.010_bb0045","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jclinepi.2009.06.006","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"62","author":"Liberati","year":"2009","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.carrev.2018.09.010_bb0050","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.carrev.2018.09.010_bb0055","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.carrev.2018.09.010_bb0060","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0140-6736(88)92944-3","article-title":"Patent foramen ovale in young stroke patients","volume":"2","author":"Webster","year":"1988","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.carrev.2018.09.010_bb0065","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1093\/oxfordjournals.eurheartj.a060524","article-title":"Patent foramen ovale, atrial septal aneurysm and ischemic stroke in young adults","volume":"15","author":"Mas","year":"1994","journal-title":"Eur Heart J"},{"key":"10.1016\/j.carrev.2018.09.010_bb0070","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/0002-8703(95)90212-0","article-title":"Recurrent cerebrovascular events in patients with patent foramen ovale, atrial septal aneurysm, or both and cryptogenic stroke or transient ischemic attack. French study group on patent foramen ovale and atrial septal aneurysm","volume":"130","author":"Mas","year":"1995","journal-title":"Am Heart J"},{"issue":"3","key":"10.1016\/j.carrev.2018.09.010_bb0075","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1161\/01.STR.25.3.582","article-title":"Characteristics of patent foramen ovale associated with cryptogenic stroke. A biplane transesophageal echocardiographic study","volume":"25","author":"Homma","year":"1994","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.carrev.2018.09.010_bb0080","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1161\/01.STR.29.5.944","article-title":"Patent foramen ovale size and embolic brain imaging findings among patients with ischemic stroke","volume":"29","author":"Steiner","year":"1998","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.carrev.2018.09.010_bb0085","first-page":"69","article-title":"Practice parameter: recurrent stroke with patent foramen ovale and atrial septal aneurysm: report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"10","author":"Mess\u00e9","year":"2004","journal-title":"Emerg Infect Dis."},{"issue":"5","key":"10.1016\/j.carrev.2018.09.010_bb0090","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1161\/CIRCINTERVENTIONS.109.908533","article-title":"The association of patent foramen ovale morphology and stroke size in patients with paradoxical embolism","volume":"3","author":"Akhondi","year":"2010","journal-title":"Circ Cardiovasc Interv"},{"issue":"3","key":"10.1016\/j.carrev.2018.09.010_bb0095","doi-asserted-by":"crossref","first-page":"229","DOI":"10.5853\/jos.2015.17.3.229","article-title":"Patent foramen ovale and stroke\u2013current status","volume":"17","author":"Bang","year":"2015","journal-title":"J Stroke"},{"key":"10.1016\/j.carrev.2018.09.010_bb0100","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jcin.2012.02.021","article-title":"Meta-analysis of transcatheter closure versus medical therapy for patent foramen ovale in prevention of recurrent neurological events after presumed paradoxical embolism","volume":"5","author":"Agarwal","year":"2012","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.carrev.2018.09.010_bb0105","doi-asserted-by":"crossref","first-page":"357","DOI":"10.14503\/THIJ-13-3879","article-title":"Percutaneous closure versus medical therapy alone for cryptogenic stroke patients with a patent foramen ovale: meta-analysis of randomized controlled trials","volume":"41","author":"Pickett","year":"2014","journal-title":"Tex Heart Inst J"},{"key":"10.1016\/j.carrev.2018.09.010_bb0110","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.jcin.2013.08.001","article-title":"Device closure of patent foramen ovale versus medical therapy in cryptogenic stroke: a systematic review and meta-analysis","volume":"6","author":"Khan","year":"2013","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.carrev.2018.09.010_bb0115","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/eurheartj\/ehu292","article-title":"Percutaneous closure of patent foramen ovale in patients with cryptogenic embolism: a network meta-analysis","volume":"36","author":"Stortecky","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.carrev.2018.09.010_bb0120","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jacc.2015.12.023","article-title":"Device closure of patent foramen ovale after stroke: pooled analysis of completed randomized trials","volume":"67","author":"Kent","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carrev.2018.09.010_bb0125","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1093\/eurheartj\/eht283","article-title":"Long-term results of a randomized trial comparing three different devices for percutaneous closure of a patent foramen ovale","volume":"34","author":"Hornung","year":"2013","journal-title":"European Heart Journal"},{"key":"10.1016\/j.carrev.2018.09.010_bb0130","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1093\/eurheartj\/ehy121","article-title":"Patent foramen ovale closure vs. medical therapy for cryptogenic stroke: a meta-analysis of randomized controlled trials","volume":"39","author":"Ahmad","year":"2018","journal-title":"European Heart Journal"},{"key":"10.1016\/j.carrev.2018.09.010_bb0135","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/joic.12430","article-title":"Effect of patent foramen ovale closure for prevention on recurrent stroke or transient ischemic attack in selected patients with cryptogenic","volume":"31","author":"Kim","year":"2018","journal-title":"J Interv Cardiol"},{"key":"10.1016\/j.carrev.2018.09.010_bb0140","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMoa1705915","article-title":"Patent foramen ovale closure or anticoagulation vs. antiplatelets after stroke","volume":"377","author":"Mas","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.carrev.2018.09.010_bb0145","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJMoa1707404","article-title":"Patent foramen ovale closure or antiplatelet therapy for cryptogenic stroke","volume":"377","author":"S\u00f8ndergaard","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.carrev.2018.09.010_bb0150","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/j.jacc.2018.02.046","article-title":"Cryptogenic stroke and high-risk patent foramen ovale: the DEFENSE-PFO trial","volume":"71","author":"Lee","year":"2018","journal-title":"J Am Coll Cardiol"}],"container-title":["Cardiovascular Revascularization Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553838918304123?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553838918304123?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:15:12Z","timestamp":1761560112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1553838918304123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S1553838918304123"],"URL":"https:\/\/doi.org\/10.1016\/j.carrev.2018.09.010","relation":{},"ISSN":["1553-8389"],"issn-type":[{"value":"1553-8389","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Percutaneous Closure of Patent Foramen Ovale in Patients with Cryptogenic Stroke \u2014 An Updated Comprehensive Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Revascularization Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carrev.2018.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}