{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:55:21Z","timestamp":1786985721825,"version":"build-2736575974"},"reference-count":48,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Revascularization Medicine"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.carrev.2020.02.007","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T20:17:39Z","timestamp":1581538659000},"page":"1144-1149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Gender Differences in Platelet Reactivity in Diabetic Patients Receiving Dual Antiplatelet Therapy"],"prefix":"10.1016","volume":"21","author":[{"given":"Monica","family":"Verdoia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Pergolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Nardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Rolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Negro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Gioscia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai","family":"Fierro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arraa Maddalena","family":"Saghir Afifeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Viglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Suryapranata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.carrev.2020.02.007_bb0005","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.atherosclerosis.2009.03.042","article-title":"Diabetes mellitus is associated with distal embolization, impaired myocardial perfusion, and higher mortality in patients with ST-segment elevation myocardial infarction treated with primary angioplasty and glycoprotein IIb-IIIa inhibitors","volume":"207","author":"De Luca","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.carrev.2020.02.007_bb0010","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.atherosclerosis.2009.12.012","article-title":"Impact of diabetes on survival in patients with ST-segment elevation myocardial infarction treated by primary angioplasty: insights from the POLISH STEMI registry","volume":"210","author":"De Luca","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.carrev.2020.02.007_bb0015","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.diabres.2015.05.038","article-title":"Novara Atherosclerosis Study (NAS) group. Impact of diabetes on fibrinogen levels and its relationship with platelet reactivity and coronary artery disease: a single-centre study","volume":"109","author":"Di Giovine","year":"2015","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.carrev.2020.02.007_bb0020","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/1479164110383994","article-title":"Platelet abnormalities in diabetes mellitus","volume":"7","author":"Ferreiro","year":"2010","journal-title":"Diab Vasc Dis Res"},{"key":"10.1016\/j.carrev.2020.02.007_bb0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.thromres.2016.04.021","article-title":"Diabetes mellitus, glucose control parameters and platelet reactivity in ticagrelor treated patients","volume":"143","author":"Nardin","year":"2016","journal-title":"Thromb Res"},{"key":"10.1016\/j.carrev.2020.02.007_bb0030","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.amjcard.2009.01.341","article-title":"Predictors of heightened platelet reactivity despite dual-antiplatelet therapy in patients undergoing percutaneous coronary intervention","volume":"103","author":"Price","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.carrev.2020.02.007_bb0035","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1161\/CIRCULATIONAHA.108.791061","volume":"118","author":"Wiviott","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.carrev.2020.02.007_bb0040","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1016\/j.jacc.2013.07.101","article-title":"Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding","volume":"62","author":"Tantry","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carrev.2020.02.007_bb0045","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.jacc.2015.07.015","article-title":"The shifting pendulum for DAPT after PCI: balancing long-term risks for bleeding and thrombosis","volume":"66","author":"Sharma","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carrev.2020.02.007_bb0050","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.ahj.2004.05.018","article-title":"Sex-related differences in outcome after ST-segment elevation myocardial infarction treated by primary angioplasty: data from the Zwolle Myocardial Infarction study","volume":"148","author":"De Luca","year":"2004","journal-title":"Am Heart J"},{"key":"10.1016\/j.carrev.2020.02.007_bb0055","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.atherosclerosis.2013.05.024","article-title":"Gender-related differences in outcome after BMS or DES implantation in patients with ST-segment elevation myocardial infarction treated by primary angioplasty: insights from the DESERT cooperation","volume":"230","author":"De Luca","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.carrev.2020.02.007_bb0060","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1001\/jamainternmed.2014.4762","article-title":"Sex differences in short-term and long-term all-cause mortality among patients with ST-segment elevation myocardial infarction treated by primary percutaneous intervention: a meta-analysis","volume":"174","author":"Pancholy","year":"2014","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.carrev.2020.02.007_bb0065","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ahj.2010.04.017","volume":"160","author":"Diercks","year":"2010","journal-title":"Am Heart J"},{"key":"10.1016\/j.carrev.2020.02.007_bb0070","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s11239-010-0451-y","article-title":"Gender-related differences in outcome after ST-segment elevation myocardial infarction treated by primary angioplasty and glycoprotein IIb-IIIa inhibitors: insights from the EGYPT cooperation","volume":"30","author":"De Luca","year":"2010","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.carrev.2020.02.007_bb0075","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1001\/jama.295.3.306","article-title":"Aspirin for the primary prevention of cardiovascular events in women and men: a sex-specific meta-analysis of randomized controlled trials","volume":"295","author":"Berger","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.carrev.2020.02.007_bb0080","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ijcard.2017.05.091","article-title":"Sex differences in the effect of diabetes mellitus on platelet reactivity and coronary thrombosis: from the assessment of dual antiplatelet therapy with drug-eluting stents (ADAPT-DES) study","volume":"246","author":"Giustino","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.carrev.2020.02.007_bb0085","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.numecd.2010.08.005","article-title":"Uric acid does not affect the prevalence and extent of coronary artery disease. Results from a prospective study","volume":"22","author":"De Luca","year":"2012","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.carrev.2020.02.007_bb0090","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/eci.12281","article-title":"Vitamin D deficiency is independently associated with the extent of coronary artery disease","volume":"44","author":"Verdoia","year":"2014","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.carrev.2020.02.007_bb0095","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s11239-016-1348-1","article-title":"Impact of diabetes on immature platelets fraction and its relationship with platelet reactivity in patients receiving dual antiplatelet therapy","volume":"42","author":"Verdoia","year":"2016","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.carrev.2020.02.007_bb0100","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1751-553X.2012.01428.x","article-title":"Role of the laboratory in monitoring patients receiving dual antiplatelet therapy","volume":"34","author":"Vidali","year":"2012","journal-title":"Int J Lab Hematol"},{"key":"10.1016\/j.carrev.2020.02.007_bb0105","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.jacc.2010.04.047","article-title":"Working Group on High On-Treatment Platelet Reactivity. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate","volume":"56","author":"Bonello","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carrev.2020.02.007_bb0110","doi-asserted-by":"crossref","first-page":"594","DOI":"10.2174\/1570161113666141229115302","article-title":"Recent advances in optimal adjunctive antithrombotic therapy in STEMI patients undergoing primary angioplasty: an overview","volume":"13","author":"De Luca","year":"2015","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1016\/j.carrev.2020.02.007_bb0115","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1160\/TH11-03-0167","article-title":"Clopidogrel response variability and the advent of personalised antiplatelet therapy. A bench to bedside journey","volume":"106","author":"Gurbel","year":"2011","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.carrev.2020.02.007_bb0120","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1161\/CIRCULATIONAHA.109.883454","article-title":"High residual platelet reactivity after clopidogrel loading and long-term clinical outcome after drug-eluting stenting for unprotected left main coronary disease","volume":"120","author":"Migliorini","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.carrev.2020.02.007_bb0125","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/FJC.0000000000000052","article-title":"Benefits from new ADP antagonists as compared with clopidogrel in patients with stable angina or acute coronary syndrome undergoing invasive management: a meta-analysis of randomized trials","volume":"63","author":"Verdoia","year":"2014","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.carrev.2020.02.007_bb0130","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.vph.2015.04.014","article-title":"Prevalence and predictors of high-on treatment platelet reactivity with ticagrelor in ACS patients undergoing stent implantation","volume":"77","author":"Verdoia","year":"2016","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.carrev.2020.02.007_bb0135","article-title":"Impact of platelet reactivity on 5-year clinical outcomes following percutaneous coronary intervention: a landmark analysis","volume":"15","author":"Mangiacapra","year":"2018","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.carrev.2020.02.007_bb0140","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.jacc.2016.02.064","article-title":"Coronary thrombosis and major bleeding after PCI with drug-eluting stents: risk scores from PARIS","volume":"67","author":"Baber","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carrev.2020.02.007_bb0145","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.ahj.2004.05.018","article-title":"Sex-related differences in outcome after ST-segment elevation myocardial infarction treated by primary angioplasty: data from the Zwolle Myocardial Infarction study","volume":"148","author":"De Luca","year":"2004","journal-title":"Am Heart J"},{"key":"10.1016\/j.carrev.2020.02.007_bb0150","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ahj.2004.10.044","article-title":"Unsuccessful reperfusion in patients with ST-segment elevation myocardial infarction treated by primary angioplasty","volume":"150","author":"De Luca","year":"2005","journal-title":"Am Heart J"},{"key":"10.1016\/j.carrev.2020.02.007_bb0155","first-page":"2","article-title":"Sex differences in treatments, relative survival, and excess mortality following acute myocardial infarction: National Cohort Study Using the SWEDEHEART registry","volume":"61","author":"Alabas","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.carrev.2020.02.007_bb0160","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1160\/TH10-04-0232","article-title":"Impact of race and gender on antithrombotic therapy","volume":"104","author":"Capodanno","year":"2010","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.carrev.2020.02.007_bb0165","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/253355a0","article-title":"Sex and age differences in human platelet aggregation","volume":"253","author":"Johnson","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.carrev.2020.02.007_bb0170","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/gme.0b013e31825ebafd","article-title":"Platelet reactivity and thrombogenicity in postmenopausal women","volume":"20","author":"Singla","year":"2013","journal-title":"Menopause"},{"key":"10.1016\/j.carrev.2020.02.007_bb0175","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.116.003577","article-title":"Sex differences in the clinical impact of high platelet reactivity after percutaneous coronary intervention with drug-eluting stents: results from the ADAPT-DES Study (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents)","volume":"10","author":"Yu","year":"2017","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.carrev.2020.02.007_bb0180","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1001\/jama.295.12.1420","article-title":"Sex differences in platelet reactivity and response to low-dose aspirin therapy","volume":"295","author":"Becker","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.carrev.2020.02.007_bb0185","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s12471-011-0189-y","article-title":"Effect of gender difference on platelet reactivity","volume":"19","author":"Breet","year":"2011","journal-title":"Neth Heart J"},{"key":"10.1016\/j.carrev.2020.02.007_bb0190","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10557-016-6646-5","article-title":"Gender differences in platelet reactivity in patients receiving dual antiplatelet therapy","volume":"30","author":"Verdoia","year":"2016","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.carrev.2020.02.007_bb0195","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1093\/eurheartj\/ehu075","article-title":"The efficacy of ticagrelor is maintained in women with acute coronary syndromes participating in the prospective, randomized, PLATelet inhibition and patient outcomes (PLATO) trial","volume":"35","author":"Husted","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.carrev.2020.02.007_bb0200","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s12265-013-9534-4","article-title":"Gender and anti-thrombotic therapy: from biology to clinical implications","volume":"7","author":"Marcucci","year":"2014","journal-title":"J Cardiovasc Transl Res"},{"key":"10.1016\/j.carrev.2020.02.007_bb0205","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jacc.2013.05.023","article-title":"Prasugrel 5 mg in the very elderly attenuates platelet inhibition but maintains noninferiority to prasugrel 10 mg in nonelderly patients: the GENERATIONS trial, a pharmacodynamic and pharmacokinetic study in stable coronary artery disease patients","volume":"62","author":"Erlinge","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carrev.2020.02.007_bb0210","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.4155\/tde.11.117","article-title":"A GENS-based approach to cardiovascular pharmacology: impact on metabolism, pharmacokinetics and pharmacodynamics","volume":"2","author":"Franconi","year":"2011","journal-title":"Ther Deliv"},{"key":"10.1016\/j.carrev.2020.02.007_bb0215","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/eurheartj\/ehx419","volume":"39","author":"Valgimigli","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.carrev.2020.02.007_bb0220","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/j.ijcard.2012.05.040","article-title":"Personalized antiplatelet treatment after percutaneous coronary intervention: the MADONNA study","volume":"167","author":"Siller-Matula","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.carrev.2020.02.007_bb0225","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s12325-013-0003-x","article-title":"Effect of pioglitazone versus metformin on cardiovascular risk markers in type 2 diabetes","volume":"30","author":"Genovese","year":"2013","journal-title":"Adv Ther"},{"key":"10.1016\/j.carrev.2020.02.007_bb0230","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1309\/AJCPTE3K1SGAPOIZ","article-title":"Assessment of platelet function on whole blood by multiple electrode aggregometry in high-risk patients with coronary artery disease receiving antiplatelet therapy","volume":"131","author":"Paniccia","year":"2009","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.carrev.2020.02.007_bb0235","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2337\/dc06-1121","article-title":"Food intake enhances thromboxane receptor-mediated platelet activation in type 2 diabetic patients but not in healthy subjects","volume":"30","author":"Razmara","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.carrev.2020.02.007_bb0240","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1042\/CS20140310","article-title":"The net clinical benefit of personalized antiplatelet therapy in patients undergoing percutaneous coronary intervention","volume":"128","author":"Siller-Matula","year":"2015","journal-title":"Clin Sci (Lond)"}],"container-title":["Cardiovascular Revascularization Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553838920300774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553838920300774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:19:18Z","timestamp":1761560358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1553838920300774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S1553838920300774"],"URL":"https:\/\/doi.org\/10.1016\/j.carrev.2020.02.007","relation":{},"ISSN":["1553-8389"],"issn-type":[{"value":"1553-8389","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gender Differences in Platelet Reactivity in Diabetic Patients Receiving Dual Antiplatelet Therapy","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Revascularization Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carrev.2020.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}