{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:20:59Z","timestamp":1773285659254,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Revascularization Medicine"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.carrev.2022.09.005","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T02:03:01Z","timestamp":1662948181000},"page":"8-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Hypothermia as an Adjunctive Therapy to Percutaneous Intervention in ST-Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis of Randomized Control Trials"],"prefix":"10.1016","volume":"47","author":[{"given":"Mohammed","family":"Mhanna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghana","family":"Ranabothu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Al-Abdouh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Jabri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azizullah","family":"Beran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Sajdeya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Barbarawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias B.","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.carrev.2022.09.005_bb0005","first-page":"485","article-title":"Temporal trends of reperfusion strategies and hospital mortality for patients with STEMI in percutaneous coronary intervention\u2013capable hospitals","volume":"33","author":"Tran","year":"2017","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.carrev.2022.09.005_bb0010","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/eurheartj\/eht090","article-title":"Myocardial reperfusion injury: looking beyond primary PCI","volume":"34","author":"Fr\u00f6hlich","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.carrev.2022.09.005_bb0015","first-page":"935","article-title":"Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations","volume":"38","author":"Hausenloy","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.carrev.2022.09.005_bb0020","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/cvr\/28.7.1014","article-title":"\u201cNormothermic range\u201d temperature affects myocardial infarct size","volume":"28","author":"Chien","year":"1994","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.carrev.2022.09.005_bb0025","first-page":"612","article-title":"Therapeutic hypothermia after cardiac arrest","author":"Safar","year":"2002","journal-title":"Mass Med Soc"},{"key":"10.1016\/j.carrev.2022.09.005_bb0030","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1136\/heartjnl-2015-308559","article-title":"Therapeutic hypothermia in ST elevation myocardial infarction: a systematic review and meta-analysis of randomised control trials","volume":"102","author":"Villablanca","year":"2016","journal-title":"Heart"},{"key":"10.1016\/j.carrev.2022.09.005_bb0035","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.carrev.2022.09.005_bb0040","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1177\/0962280216669183","article-title":"Optimally estimating the sample mean from the sample size, median, mid-range, and\/or mid-quartile range","volume":"27","author":"Luo","year":"2018","journal-title":"Stat Methods Med Res"},{"key":"10.1016\/j.carrev.2022.09.005_bb0045","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.carrev.2022.09.005_bb0050","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0140-6736(98)01085-X","article-title":"Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?","volume":"352","author":"Moher","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.carrev.2022.09.005_bb0055","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1089\/ther.2020.0018","article-title":"Cooling as an adjunctive therapy to percutaneous intervention in acute myocardial infarction: COOL-MI InCor trial","volume":"11","author":"Dallan","year":"2021","journal-title":"Ther Hypothermia Temp Manag"},{"key":"10.1016\/j.carrev.2022.09.005_bb0060","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/S0735-1097(02)02567-6","article-title":"Induction of mild systemic hypothermia with endovascular cooling during primary percutaneous coronary intervention for acute myocardial infarction","volume":"40","author":"Dixon","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carrev.2022.09.005_bb0065","first-page":"2047","article-title":"Safety of selective intracoronary hypothermia during primary percutaneous coronary intervention in patients with anterior STEMI","volume":"14","author":"El Farissi","year":"2021","journal-title":"Cardiovasc Interv"},{"key":"10.1016\/j.carrev.2022.09.005_bb0070","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/j.jacc.2013.12.027","volume":"63","author":"Erlinge","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carrev.2022.09.005_bb0075","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/CIRCINTERVENTIONS.110.957902","article-title":"A pilot study of rapid cooling by cold saline and endovascular cooling before reperfusion in patients with ST-elevation myocardial infarction","volume":"3","author":"G\u00f6tberg","year":"2010","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.carrev.2022.09.005_bb0080","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.114.001965","article-title":"Prospective, multicenter, randomized, controlled pilot trial of peritoneal hypothermia in patients with ST-segment\u2014elevation myocardial infarction","volume":"8","author":"Nichol","year":"2015","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.carrev.2022.09.005_bb0085","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4244\/EIJ-D-17-00279","article-title":"COOL AMI EU pilot trial: a multicentre, prospective, randomised controlled trial to assess cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction","volume":"13","author":"Noc","year":"2017","journal-title":"EuroIntervention"},{"key":"10.1016\/j.carrev.2022.09.005_bb0090","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4244\/EIJ-D-21-00348","article-title":"A multicentre, prospective, randomised controlled trial to assess the safety and effectiveness of cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction: the COOL AMI EU pivotal trial","volume":"17","author":"Noc","year":"2021","journal-title":"EuroIntervention"},{"key":"10.1016\/j.carrev.2022.09.005_bb0095","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/heartjnl-2018-313705","article-title":"Out-of-hospital initiation of hypothermia in ST-segment elevation myocardial infarction: a randomised trial","volume":"105","author":"Testori","year":"2019","journal-title":"Heart"},{"key":"10.1016\/j.carrev.2022.09.005_bb0100","first-page":"E433","article-title":"A pilot clinical study of adjunctive therapy with selective intracoronary hypothermia in patients with ST-segment elevation myocardial infarction","volume":"92","author":"Wang","year":"2018","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.carrev.2022.09.005_bb0105","first-page":"1","article-title":"Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive","volume":"114","author":"Kohlhauer","year":"2019","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.carrev.2022.09.005_bb0110","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1089\/ther.2011.0008","article-title":"A review of mild hypothermia as an adjunctive treatment for ST-elevation myocardial infarction","volume":"1","author":"Erlinge","year":"2011","journal-title":"Ther Hypothermia Temp Manag"},{"key":"10.1016\/j.carrev.2022.09.005_bb0115","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/joic.12485","article-title":"Effects of endovascular cooling on infarct size in ST-segment elevation myocardial infarction: a patient-level pooled analysis from randomized trials","volume":"31","author":"Dae","year":"2018","journal-title":"J Interv Cardiol"},{"key":"10.1016\/j.carrev.2022.09.005_bb0120","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1001\/jama.283.22.2941","article-title":"Relationship of symptom-onset-to-balloon time and door-to-balloon time with mortality in patients undergoing angioplasty for acute myocardial infarction","volume":"283","author":"Cannon","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.carrev.2022.09.005_bb0125","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/1060028013511228","article-title":"Assessment of adverse events and predictors of neurological recovery after therapeutic hypothermia","volume":"48","author":"MacLaren","year":"2014","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.carrev.2022.09.005_bb0130","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1093\/cvr\/cvz309","article-title":"Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology","volume":"116","author":"Dietrichs","year":"2020","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.carrev.2022.09.005_bb0135","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1161\/ATVBAHA.111.226373","article-title":"Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target","volume":"31","author":"Straub","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.carrev.2022.09.005_bb0140","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/CCM.0b013e3182a276e8","article-title":"Therapeutic hypothermia and the risk of infection: a systematic review and meta-analysis","volume":"42","author":"Geurts","year":"2014","journal-title":"Crit Care Med"}],"container-title":["Cardiovascular Revascularization Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553838922007734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553838922007734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:25:14Z","timestamp":1761560714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1553838922007734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":28,"alternative-id":["S1553838922007734"],"URL":"https:\/\/doi.org\/10.1016\/j.carrev.2022.09.005","relation":{},"ISSN":["1553-8389"],"issn-type":[{"value":"1553-8389","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypothermia as an Adjunctive Therapy to Percutaneous Intervention in ST-Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis of Randomized Control Trials","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Revascularization Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carrev.2022.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}