{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:56:01Z","timestamp":1771048561427,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009309","name":"Northern Ireland Chest Heart and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009309","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013276","name":"Interreg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001632","name":"Ulster University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Revascularization Medicine"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.carrev.2023.01.007","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T13:06:16Z","timestamp":1673615176000},"page":"26-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Assessment of Indices of Conjunctival Microvascular Function in Patients With and Without Obstructive Coronary Artery Disease"],"prefix":"10.1016","volume":"50","author":[{"given":"Jonathan A.","family":"Mailey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie S.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul F.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes","family":"Awuah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Trucco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.D.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Andrew","family":"Nesbit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara C.B.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Spence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"34","key":"10.1016\/j.carrev.2023.01.007_bb0005","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC guidelines on cardiovascular disease prevention in clinical practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur Heart J"},{"issue":"25","key":"10.1016\/j.carrev.2023.01.007_bb0010","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases writing group. Global burden of cardiovascular diseases and risk factors, 1990\u20132019: update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"25","key":"10.1016\/j.carrev.2023.01.007_bb0015","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1161\/CIRCULATIONAHA.105.537878","article-title":"Pathophysiology of coronary artery disease","volume":"111","author":"Libby","year":"2005","journal-title":"Circulation"},{"issue":"5 pt 1","key":"10.1016\/j.carrev.2023.01.007_bb0020","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1161\/01.CIR.78.5.1157","article-title":"Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease?","volume":"78","author":"Little","year":"1988","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.carrev.2023.01.007_bb0025","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/01.CIR.92.3.657","article-title":"Coronary plaque disruption","volume":"92","author":"Falk","year":"1995","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.carrev.2023.01.007_bb0030","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0735-1097(88)90356-7","article-title":"Angiographic progression of coronary artery disease and the development of myocardial infarction","volume":"12","author":"Ambrose","year":"1988","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"10.1016\/j.carrev.2023.01.007_bb0035","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0002-9149(92)90495-K","article-title":"Relation of the site of acute myocardial infarction to the most severe coronary arterial stenosis at prior angiography","volume":"69","author":"Giroud","year":"1992","journal-title":"Am J Cardiol"},{"issue":"4","key":"10.1016\/j.carrev.2023.01.007_bb0040","doi-asserted-by":"crossref","DOI":"10.1161\/01.CIR.90.4.2126","article-title":"Conner memorial lecture: mechanisms leading to myocardial infarction: insights from studies of vascular biology","volume":"90","author":"Fuster","year":"1994","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.carrev.2023.01.007_bb0045","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/MOL.0b013e3282efa326","article-title":"Molecular mechanisms of plaque instability","volume":"18","author":"Shah","year":"2007","journal-title":"Curr Opin Lipidol"},{"issue":"1","key":"10.1016\/j.carrev.2023.01.007_bb0050","doi-asserted-by":"crossref","first-page":"120","DOI":"10.21037\/cdt-20-684","article-title":"Assessing the impact of PCSK9 inhibition on coronary plaque phenotype with optical coherence tomography: rationale and design of the randomized, placebo-controlled HUYGENS study","volume":"11","author":"Nicholls","year":"2021","journal-title":"Cardiovasc Diagn Ther"},{"issue":"1","key":"10.1016\/j.carrev.2023.01.007_bb0055","doi-asserted-by":"crossref","first-page":"7660","DOI":"10.1038\/s41598-021-87315-7","article-title":"Assessment of the conjunctival microcirculation for patients presenting with acute myocardial infarction compared to healthy controls","volume":"11","author":"Brennan","year":"2021","journal-title":"Sci Rep"},{"issue":"18","key":"10.1016\/j.carrev.2023.01.007_bb0060","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"72","author":"Thygesen","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carrev.2023.01.007_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2019.103907","article-title":"Quantitative assessment of the conjunctival microcirculation using a smartphone and slit-lamp biomicroscope","volume":"126","author":"Brennan","year":"2019","journal-title":"Microvasc Res"},{"key":"10.1016\/j.carrev.2023.01.007_bb0070","doi-asserted-by":"crossref","unstructured":"PF Brennan., et al. Assessment of the conjunctival microcirculation in adult patients with cyanotic congenital heart disease compared to healthy controls, Microvasc Res 136, 9 p., 104167.","DOI":"10.1016\/j.mvr.2021.104167"},{"issue":"636","key":"10.1016\/j.carrev.2023.01.007_bb0075","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3399\/bjgp15X685933","article-title":"Cardiovascular risk assessment and lipid modification: NICE guideline","volume":"65","author":"Duerden","year":"2015","journal-title":"Br J Gen Pract"},{"key":"10.1016\/j.carrev.2023.01.007_bb0080","article-title":"Nontraditional risk factors in cardiovascular disease risk assessment: updated evidence report and systematic review for the US Preventive Services Task Force","volume":"320","author":"Lin","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.carrev.2023.01.007_bb0085","doi-asserted-by":"crossref","DOI":"10.1136\/heartjnl-2011-300747","article-title":"Improvements in risk stratification for the occurrence of cardiovascular disease by imaging subclinical atherosclerosis: a systematic review","volume":"98","author":"Peters","year":"2012","journal-title":"Heart"},{"issue":"4","key":"10.1016\/j.carrev.2023.01.007_bb0090","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1161\/CIRCULATIONAHA.104.488916","article-title":"Coronary calcification improves cardiovascular risk prediction in the elderly","volume":"112","author":"Vliegenthart","year":"2005","journal-title":"Circulation"},{"issue":"42","key":"10.1016\/j.carrev.2023.01.007_bb0095","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1093\/eurheartj\/eht293","article-title":"Prognostic value of coronary computed tomography angiography during 5 years of follow-up in patients with suspected coronary artery disease","volume":"34","author":"Hadamitzky","year":"2013","journal-title":"Eur Heart J"},{"issue":"12","key":"10.1016\/j.carrev.2023.01.007_bb0100","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1161\/CIRCULATIONAHA.121.055340","article-title":"Prevalence of subclinical coronary artery atherosclerosis in the general population","volume":"144","author":"Bergstr\u00f6m","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.carrev.2023.01.007_bb0105","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2012.9630","article-title":"Common carotid intimamedia thickness measurements in cardiovascular risk prediction: a meta-analysis","volume":"308","author":"Den Ruijter","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.carrev.2023.01.007_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2009.10.061","article-title":"Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis","volume":"55","author":"Vlachopoulos","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"17","key":"10.1016\/j.carrev.2023.01.007_bb0115","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1001\/jama.2014.14681","article-title":"Nonobstructive coronary artery disease and risk of myocardial infarction","volume":"312","author":"Maddox","year":"2014","journal-title":"JAMA"},{"issue":"23 Pt A","key":"10.1016\/j.carrev.2023.01.007_bb0120","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1016\/j.jacc.2018.09.006","article-title":"Stratified medical therapy using invasive coronary function testing in angina: the CorMicA Trial","volume":"72","author":"Ford","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carrev.2023.01.007_bb0125","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1113\/jphysiol.2004.079640","article-title":"The microcirculation: a motor for the systemic inflammatory response and large vessel disease induced by hypercholesterolemia?","volume":"562","author":"Stokes","year":"2005","journal-title":"J Physiol"},{"issue":"17","key":"10.1016\/j.carrev.2023.01.007_bb0130","doi-asserted-by":"crossref","first-page":"12746","DOI":"10.1364\/OE.16.012746","article-title":"In vivo measurement of erythrocyte velocity and retinal blood flow using adaptive optics scanning laser ophthalmoscopy","volume":"16","author":"Zhong","year":"2018","journal-title":"Opt Express"},{"key":"10.1016\/j.carrev.2023.01.007_bb0135","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-2342-12-37","article-title":"An automated method for analysis of microcirculation videos for accurate assessment of tissue perfusion","volume":"12","author":"Demir","year":"2012","journal-title":"BMC Med Imaging"},{"issue":"2","key":"10.1016\/j.carrev.2023.01.007_bb0140","first-page":"318","article-title":"A microscope-television system for studying flow velocity in human skin capillaries","volume":"233","author":"Fagrell","year":"1997","journal-title":"Am J Physiol"},{"issue":"5","key":"10.1016\/j.carrev.2023.01.007_bb0145","doi-asserted-by":"crossref","first-page":"e306","DOI":"10.1016\/S2589-7500(21)00043-1","article-title":"Deep-learning-based cardiovascular risk stratification using coronary artery calcium scores predicted from retinal photographs","volume":"3","author":"Rim","year":"2021","journal-title":"Lancet Digit Health"},{"issue":"11","key":"10.1016\/j.carrev.2023.01.007_bb0150","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/CIRCULATIONAHA.116.024534","article-title":"Ischemia and no obstructive coronary artery disease (INOCA): developing evidence-based therapies and research agenda for the next decade","volume":"135","author":"Bairey Merz","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.carrev.2023.01.007_bb0155","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/heartjnl-2017-311446","article-title":"Stable coronary syndromes: pathophysiology, diagnostic advances and therapeutic need","volume":"104","author":"Ford","year":"2018","journal-title":"Heart"},{"key":"10.1016\/j.carrev.2023.01.007_bb0160","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1161\/CIRCULATIONAHA.118.031373","article-title":"Reappraisal of ischemic heart disease","volume":"138","author":"Kaski","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.carrev.2023.01.007_bb0165","doi-asserted-by":"crossref","first-page":"358","DOI":"10.4158\/EP.7.5.358","article-title":"Microvascular abnormalities in the bulbar conjunctiva of patients with type 2 diabetes mellitus","volume":"7","author":"Cheung","year":"2001","journal-title":"Endocr Pract"},{"issue":"7","key":"10.1016\/j.carrev.2023.01.007_bb0170","doi-asserted-by":"crossref","first-page":"531","DOI":"10.5152\/akd.2014.5578","article-title":"Coronary slow flow: benign or ominous?","volume":"15","author":"Sadr-Ameli","year":"2014","journal-title":"Anatol J Cardiol"},{"key":"10.1016\/j.carrev.2023.01.007_bb0175","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mvr.2015.04.007","article-title":"Feasibility of assessment of conjunctival microvascular hemodynamics in unilateral ischemic stroke","volume":"100","author":"Kord Valeshabad","year":"2015","journal-title":"Microvasc Res"},{"key":"10.1016\/j.carrev.2023.01.007_bb0180","doi-asserted-by":"crossref","first-page":"45916","DOI":"10.1038\/srep45916","article-title":"Assessment of conjunctival microvascular hemodynamics in stages of diabetic microvasculopathy","volume":"7","author":"Khansari","year":"2017","journal-title":"Sci Rep"}],"container-title":["Cardiovascular Revascularization Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S155383892300009X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S155383892300009X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:25:59Z","timestamp":1761560759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S155383892300009X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":36,"alternative-id":["S155383892300009X"],"URL":"https:\/\/doi.org\/10.1016\/j.carrev.2023.01.007","relation":{},"ISSN":["1553-8389"],"issn-type":[{"value":"1553-8389","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of Indices of Conjunctival Microvascular Function in Patients With and Without Obstructive Coronary Artery Disease","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Revascularization Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carrev.2023.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}