{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:00:22Z","timestamp":1775638822922,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003581","name":"National Intelligence Service","doi-asserted-by":"publisher","award":["8\\u201310"],"award-info":[{"award-number":["8\\u201310"]}],"id":[{"id":"10.13039\/501100003581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Revascularization Medicine"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.carrev.2024.04.012","type":"journal-article","created":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T04:12:30Z","timestamp":1713067950000},"page":"41-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Emerging trends in nationwide mortality, limb loss, and resource utilization for critical limb ischemia in young adults"],"prefix":"10.1016","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0140-7294","authenticated-orcid":false,"given":"Fidelis","family":"Uwumiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victory","family":"Okpujie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikodili","family":"Nebuwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwakmfonabasi","family":"Umoudoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evaristus","family":"Asobara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Aniaku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Golibe","family":"Makata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Olukorode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.carrev.2024.04.012_bb0005","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/j.tvir.2016.04.001","article-title":"Epidemiology of peripheral arterial disease and critical limb ischemia","volume":"19","author":"Dua","year":"2016","journal-title":"Tech Vasc Interv Radiol"},{"key":"10.1016\/j.carrev.2024.04.012_bb0010","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jvs.2014.03.290","article-title":"Epidemiology of peripheral arterial disease and critical limb ischemia in an insured national population","volume":"60","author":"Nehler","year":"2014","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.carrev.2024.04.012_bb0015","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.jvs.2015.07.065","article-title":"The natural history of untreated severe or critical limb ischemia","volume":"62","author":"Abu Dabrh","year":"2015","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.carrev.2024.04.012_bb0020","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.2147\/CIA.S137570","article-title":"Mortality after major amputation in elderly patients with critical limb ischemia","volume":"12","author":"Klaphake","year":"2017","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.carrev.2024.04.012_bb0025","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2147\/VHRM.S209241","article-title":"The burden of critical limb ischemia: a review of recent literature","volume":"15","author":"Duff","year":"2019","journal-title":"Vasc Health Risk Manag"},{"issue":"4","key":"10.1016\/j.carrev.2024.04.012_bb0030","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ejvs.2017.07.005","article-title":"Amputation rates, mortality, and pre-operative comorbidities in patients revascularised for intermittent claudication or critical limb ischaemia: a population based study","volume":"54","author":"Baubeta Fridh","year":"2017","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.carrev.2024.04.012_bb0035","author":"NIS Database Documentation [Internet]"},{"key":"10.1016\/j.carrev.2024.04.012_bb0040","unstructured":"Update and Key Trendswww.kff.org\/medicare\/fact-sheet\/medicare-advantage\/ Exit Disclaimer. Accessed 26th October 2023."},{"key":"10.1016\/j.carrev.2024.04.012_bb0045","unstructured":"Nationwide Data Use Agreement-HCUP (2022)https:\/\/www.hcup-us.ahrq.gov\/team\/NationwideDUA.jsp. Accessed 5th October 2023."},{"key":"10.1016\/j.carrev.2024.04.012_bb0050","author":"US Department of Health and Human Services-NIH"},{"issue":"2","key":"10.1016\/j.carrev.2024.04.012_bb0055","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.120.007539","article-title":"Contemporary trends in hospital admissions and outcomes in patients with critical limb ischemia: an analysis from the National Inpatient Sample Database","volume":"14","author":"Anantha-Narayanan","year":"2021","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"20","key":"10.1016\/j.carrev.2024.04.012_bb0060","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1001\/jama.2017.17653","article-title":"Adherence to methodological standards in research using the national inpatient sample","volume":"318","author":"Khera","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.carrev.2024.04.012_bb0065","unstructured":"Cost-To-Charge Ratio (Ccr) Files. Agency for Healthcare Research and Quality. Available athttps:\/\/hcup-us.ahrq.gov\/db\/ccr\/costtocharge.jsp. Accessed 25th October 2023."},{"key":"10.1016\/j.carrev.2024.04.012_bb0070","author":"Agency for Healthcare Research and Quality"},{"issue":"6","key":"10.1016\/j.carrev.2024.04.012_bb0075","doi-asserted-by":"crossref","first-page":"558","DOI":"10.4097\/kja.19087","article-title":"Multicollinearity and misleading statistical results","volume":"72","author":"Kim","year":"2019","journal-title":"Korean J Anesthesiol"},{"key":"10.1016\/j.carrev.2024.04.012_bb0080","author":"U.S. Census Bureau"},{"issue":"17","key":"10.1016\/j.carrev.2024.04.012_bb0085","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.029074","article-title":"Racial and ethnic disparities in treatment of critical limb ischemia: a national perspective","volume":"12","author":"Wahood","year":"2023","journal-title":"J Am Heart Assoc"},{"issue":"2","key":"10.1016\/j.carrev.2024.04.012_bb0090","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007425","article-title":"Race and socioeconomic status independently affect risk of major amputation in peripheral artery disease","volume":"7","author":"Arya","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.carrev.2024.04.012_bb0095","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.atherosclerosis.2021.03.031","article-title":"Risk of peripheral artery disease according to race and sex: the Atherosclerosis Risk in Communities (ARIC) study","volume":"324","author":"Hicks","year":"2021","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.carrev.2024.04.012_bb0100","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2147\/VHRM.S125065","article-title":"Critical limb ischemia: current challenges and future prospects","volume":"14","author":"Uccioli","year":"2018","journal-title":"Vasc Health Risk Manag"},{"key":"10.1016\/j.carrev.2024.04.012_bb0105","article-title":"Dyslipidemia profiles in patients with peripheral artery disease","volume":"21(6):42","author":"Aday","year":"2019","journal-title":"Curr Cardiol Rep"},{"issue":"10","key":"10.1016\/j.carrev.2024.04.012_bb0110","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.amjmed.2019.04.043","article-title":"Peripheral artery disease: past, present, and future","volume":"132","author":"Campia","year":"2019","journal-title":"Am J Med"},{"issue":"2","key":"10.1016\/j.carrev.2024.04.012_bb0115","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.115.001946","article-title":"Management of critical limb ischemia","volume":"9","author":"Kinlay","year":"2016","journal-title":"Circ Cardiovasc Interv"},{"issue":"21","key":"10.1016\/j.carrev.2024.04.012_bb0120","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1016\/j.jacc.2021.09.025","article-title":"Increasing prevalence of critical limb ischemia hospitalizations with distinct mental health burden among younger adults","volume":"78","author":"Harris","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"6S","key":"10.1016\/j.carrev.2024.04.012_bb0125","article-title":"Global vascular guidelines on the management of chronic limb-threatening ischemia [published correction appears in J Vasc Surg. 2019 Aug;70(2):662]","volume":"69","author":"Conte","year":"2019","journal-title":"J Vasc Surg"},{"issue":"4","key":"10.1016\/j.carrev.2024.04.012_bb0130","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/HCO.0000000000001049","article-title":"Hypertensive crisis: diagnosis, presentation, and treatment","volume":"38","author":"Stewart","year":"2023","journal-title":"Curr. Opin. Cardiol."},{"issue":"6","key":"10.1016\/j.carrev.2024.04.012_bb0135","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/HYP.0000000000000066","volume":"71","author":"Whelton","year":"2018","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.carrev.2024.04.012_bb0140","doi-asserted-by":"crossref","first-page":"351","DOI":"10.7326\/M17-3203","article-title":"2017 ACC\/AHA Hypertension Guideline Writing Committee. Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis of the 2017 American College of Cardiology\/American Heart Association Hypertension Guideline","volume":"168","author":"Carey","year":"2018","journal-title":"Ann Intern Med"},{"issue":"12","key":"10.1016\/j.carrev.2024.04.012_bb0145","first-page":"e686","volume":"135","author":"Gerhard-Herman","year":"2017","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.carrev.2024.04.012_bb0150","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jacc.2014.12.043","article-title":"Supervised exercise, stent revascularization, or medical therapy for claudication due to aortoiliac peripheral artery disease: the CLEVER study [published correction appears in J Am Coll Cardiol. 2015 May 12;65(18):2055]","volume":"65","author":"Murphy","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.carrev.2024.04.012_bb0155","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1053\/j.semvascsurg.2009.10.002","article-title":"Impact of comorbidities on decision-making in chronic critical limb ischemia","volume":"22","author":"Schanzer","year":"2009","journal-title":"Semin Vasc Surg"},{"issue":"12","key":"10.1016\/j.carrev.2024.04.012_bb0160","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.008015","article-title":"Predictive model for mortality risk including the wound, ischemia, foot infection classification in patients undergoing revascularization for critical limb ischemia","volume":"12","author":"Azuma","year":"2019","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.carrev.2024.04.012_bb0165","author":"Rungkhachonsak"},{"issue":"6","key":"10.1016\/j.carrev.2024.04.012_bb0170","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1089\/pop.2023.0095","article-title":"Perspectives on lower extremity peripheral artery disease: a qualitative study of early diagnosis and treatment and the impact of health disparities","volume":"26","author":"Grant","year":"2023","journal-title":"Popul Health Manag"},{"key":"10.1016\/j.carrev.2024.04.012_bb0175","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.atherosclerosis.2018.05.033","article-title":"Update on peripheral artery disease: epidemiology and evidence-based facts","volume":"275","author":"Shu","year":"2018","journal-title":"Atherosclerosis"},{"issue":"9","key":"10.1016\/j.carrev.2024.04.012_bb0180","first-page":"e171","article-title":"Lower extremity peripheral artery disease: contemporary epidemiology, management gaps, and future directions: a scientific statement from the American Heart Association [published correction appears in circulation. 2021 Aug 31;144(9):e193]","volume":"144","author":"Criqui","year":"2021","journal-title":"Circulation"}],"container-title":["Cardiovascular Revascularization Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553838924001556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553838924001556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T21:53:29Z","timestamp":1726610009000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1553838924001556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":36,"alternative-id":["S1553838924001556"],"URL":"https:\/\/doi.org\/10.1016\/j.carrev.2024.04.012","relation":{},"ISSN":["1553-8389"],"issn-type":[{"value":"1553-8389","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging trends in nationwide mortality, limb loss, and resource utilization for critical limb ischemia in young adults","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Revascularization Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carrev.2024.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}