{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:20:07Z","timestamp":1780582807010,"version":"3.54.1"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen Inc","doi-asserted-by":"publisher","award":["20187090"],"award-info":[{"award-number":["20187090"]}],"id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Revascularization Medicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.carrev.2024.10.006","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T11:59:06Z","timestamp":1732795146000},"page":"91-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Effect of evolocumab in patients with chronic limb threatening ischemia (Evol-CLI study)"],"prefix":"10.1016","volume":"76","author":[{"given":"Ashwat S.","family":"Dhillon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Caro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongkyu","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Caro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Ram","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Shavelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray V.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo C.","family":"Clavijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"124","key":"10.1016\/j.carrev.2024.10.006_bb0005","first-page":"2020","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.carrev.2024.10.006_bb0010","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS)","volume":"41","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.carrev.2024.10.006_bb0015","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.jvs.2007.01.024","article-title":"The effect of intensified lipid-lowering therapy on long-term prognosis in patients with peripheral arterial disease","volume":"45","author":"Feringa","year":"2007","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.carrev.2024.10.006_bb0020","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.ehj.2004.02.012","article-title":"Statin therapy improves cardiovascular outcome of patients with peripheral artery disease","volume":"25","author":"Schillinger","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.carrev.2024.10.006_bb0025","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jacc.2013.09.073","article-title":"Association between statin medications and mortality, major adverse cardiovascular event, and amputation-free survival in patients with critical limb ischemia","volume":"63","author":"Westin","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carrev.2024.10.006_bb0030","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.jvs.2017.05.115","article-title":"Association between statin therapy and amputation-free survival in patients with critical limb ischemia in the CRITISCH registry","volume":"66","author":"Stavroulakis","year":"2017","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.carrev.2024.10.006_bb0035","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0002-9343(03)00010-X","article-title":"Effects of simvastatin on walking performance and symptoms of intermittent claudication in hypercholesterolemic patients with peripheral vascular disease","volume":"114","author":"Mondillo","year":"2003","journal-title":"Am J Med"},{"key":"10.1016\/j.carrev.2024.10.006_bb0040","series-title":"Proceedings of the 7th Annual Meeting of the Mediterranean League of Angiology and Vascular Surgery, March 22\u201325 1996","first-page":"73","article-title":"Lipid lowering drugs in the treatment of peripheral arterial disease of the lower limbs: results of the SISOPAD (Simvastatin Italian Study on Peripheral Arterial Disease)","author":"Novo","year":"1996"},{"issue":"5","key":"10.1016\/j.carrev.2024.10.006_bb0045","first-page":"354","article-title":"Effect of statins on endothelial function in patients with acute coronary syndrome: a prospective study using adhesion molecules and flow-mediated dilatation","volume":"6","author":"Altun","year":"2014","journal-title":"J Clin Med Res"},{"issue":"9","key":"10.1016\/j.carrev.2024.10.006_bb0050","doi-asserted-by":"crossref","first-page":"40C","DOI":"10.1016\/S0002-9149(99)80469-X","article-title":"Effect of pravastatin on progression and regression of coronary atherosclerosis and vessel wall changes in carotid and femoral arteries: a report from the Regression Growth Evaluation Statin Study","volume":"76","author":"de Groot","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.carrev.2024.10.006_bb0055","doi-asserted-by":"crossref","first-page":"474","DOI":"10.2174\/1570161114666160404125341","article-title":"Plasma VEGF and IL-8 levels in patients with mixed dyslipidaemia. Effect of rosuvastatin monotherapy or its combination at a lower dose with omega-3 fatty acids: a pilot study","volume":"14","author":"Chantzichristos","year":"2016","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1016\/j.carrev.2024.10.006_bb0060","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ijcard.2017.06.087","article-title":"Impact of statin therapy intensity on endothelial progenitor cells after percutaneous coronary intervention in diabetic patients. The REMEDY-EPC late study","volume":"244","author":"Briguori","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.carrev.2024.10.006_bb0065","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMoa1615664","article-title":"Evolocumab and clinical outcomes in patients with cardiovascular disease","volume":"376","author":"Sabatine","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.carrev.2024.10.006_bb0075","doi-asserted-by":"crossref","first-page":"227","DOI":"10.5999\/aps.2012.39.3.227","article-title":"Utility of toe-brachial index for diagnosis of peripheral artery disease","volume":"39","author":"Park","year":"2012","journal-title":"Arch Plast Surg"},{"key":"10.1016\/j.carrev.2024.10.006_bb0080","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/1708538116658392","article-title":"Prognostic significance of ankle brachial pressure index: a systematic review and meta-analysis","volume":"25","author":"Hajibandeh","year":"2017","journal-title":"Vascular"},{"key":"10.1016\/j.carrev.2024.10.006_bb0085","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jvs.2013.03.044","article-title":"The toe-brachial index in the diagnosis of peripheral arterial disease","volume":"58","author":"Hoyer","year":"2013","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.carrev.2024.10.006_bb0090","doi-asserted-by":"crossref","first-page":"B162","DOI":"10.1016\/j.jacc.2013.08.1281","article-title":"Correlation of toe-brachial indices with infragenicular arterial patency in critical limb ischemia","volume":"62","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.carrev.2024.10.006_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carrev.2023.04.020","article-title":"The addition of evolocumab to maximal tolerated statin therapy improves walking performance in patients with peripheral arterial disease and intermittent claudication (Evol-PAD study)","volume":"55","author":"Clavijo","year":"2023","journal-title":"Cardiovasc Revasc Med"},{"key":"10.1016\/j.carrev.2024.10.006_bb0100","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1161\/CIRCULATIONAHA.117.032235","article-title":"For the FOURIER Investigators: low-density lipoprotein cholesterol lowering with evolocumab and outcomes in patients with peripheral artery disease","volume":"137","author":"Bonaca","year":"2018","journal-title":"Circulation"}],"container-title":["Cardiovascular Revascularization Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553838924007036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553838924007036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T04:31:08Z","timestamp":1752640268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1553838924007036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":19,"alternative-id":["S1553838924007036"],"URL":"https:\/\/doi.org\/10.1016\/j.carrev.2024.10.006","relation":{},"ISSN":["1553-8389"],"issn-type":[{"value":"1553-8389","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of evolocumab in patients with chronic limb threatening ischemia (Evol-CLI study)","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Revascularization Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carrev.2024.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}