{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:55:42Z","timestamp":1759452942983,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Revascularization Medicine"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.carrev.2025.08.003","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T21:07:25Z","timestamp":1755810445000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Transcatheter edge-to-edge repair for the management of secondary mitral regurgitation \u2013 CRT 2025 Beyond the Guidelines"],"prefix":"10.1016","volume":"79","author":[{"given":"Dan","family":"Haberman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Reardon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chet","family":"Rihal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana Claudia","family":"Aranzulla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidhi","family":"Madan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojtek","family":"Wojakowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Reisman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lior","family":"Lupu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Chaturvedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Waksman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.carrev.2025.08.003_bb0005","article-title":"Heart disease and stroke statistics\u20142016 update: a report from the American Heart Association","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.carrev.2025.08.003_bb0010","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart disease and stroke statistics\u20142021 update: a report from the American Heart Association","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.carrev.2025.08.003_bb0015","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1432-1033.1975.tb02476.x","article-title":"On the mechanism of ketogenesis and its control. Purification, kinetic mechanism and regulation of different forms of mitochondrial acetoacetyl-CoA thiolases from ox liver","volume":"59","author":"Huth","year":"1975","journal-title":"Eur J Biochem"},{"issue":"1","key":"10.1016\/j.carrev.2025.08.003_bb0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/eurheartj\/ehx402","article-title":"Refining the prognostic impact of functional mitral regurgitation in chronic heart failure","volume":"39","author":"Goliasch","year":"2018","journal-title":"Eur Heart J"},{"issue":"36","key":"10.1016\/j.carrev.2025.08.003_bb0025","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.carrev.2025.08.003_bb0030","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/europace\/eur047","article-title":"Impact of cardiac resynchronization therapy on the severity of mitral regurgitation","volume":"13","author":"Di Biase","year":"2011","journal-title":"Europace"},{"issue":"4","key":"10.1016\/j.carrev.2025.08.003_bb0035","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1161\/CIRCHEARTFAILURE.112.000112","article-title":"Mechanistic features associated with improvement in mitral regurgitation after cardiac resynchronization therapy and their relation to long-term patient outcome","volume":"6","author":"Onishi","year":"2013","journal-title":"Circ Heart Fail"},{"issue":"4","key":"10.1016\/j.carrev.2025.08.003_bb0040","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jacc.2020.11.018","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease","volume":"77","author":"Otto","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.carrev.2025.08.003_bb0045","first-page":"524","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease: developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"75","author":"Vahanian","year":"2022","journal-title":"Rev Esp Cardiol (Eng Ed)"},{"issue":"8","key":"10.1016\/j.carrev.2025.08.003_bb0050","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.jacc.2023.05.061","article-title":"ACC\/AHA and ESC\/EACTS guidelines for the management of valvular heart diseases","volume":"82","author":"Coisne","year":"2023","journal-title":"J Am Coll Cardiol"},{"issue":"18","key":"10.1016\/j.carrev.2025.08.003_bb0055","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"issue":"24","key":"10.1016\/j.carrev.2025.08.003_bb0060","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1056\/NEJMoa1805374","article-title":"Percutaneous repair or medical treatment for secondary mitral regurgitation","volume":"379","author":"Obadia","year":"2018","journal-title":"N Engl J Med"},{"issue":"24","key":"10.1016\/j.carrev.2025.08.003_bb0065","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter mitral-valve repair in patients with heart failure","volume":"379","author":"Stone","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.carrev.2025.08.003_bb0070","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2314328","article-title":"Transcatheter valve repair in heart failure with moderate to severe mitral regurgitation","author":"Anker","year":"2024","journal-title":"N Engl J Med"},{"issue":"24","key":"10.1016\/j.carrev.2025.08.003_bb0075","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1016\/j.jacc.2024.08.026","article-title":"Percutaneous transcatheter edge-to-edge repair for functional mitral regurgitation in heart failure","volume":"84","author":"Anker","year":"2024","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.carrev.2025.08.003_bb0080","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jcmg.2018.11.006","article-title":"Proportionate and disproportionate functional mitral regurgitation","volume":"12","author":"Grayburn","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.carrev.2025.08.003_bb0085","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.carrev.2024.03.003","article-title":"Impact of cardiac index on outcomes in patients with a severely reduced ejection fraction undergoing mitral valve transcatheter edge-to-edge repair","volume":"65","author":"Lo Russo","year":"2024","journal-title":"Cardiovasc Revasc Med"},{"issue":"11","key":"10.1016\/j.carrev.2025.08.003_bb0090","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.jcmg.2022.05.009","article-title":"Transcatheter mitral valve repair in patients with atrial functional mitral regurgitation","volume":"15","author":"Doldi","year":"2022","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.carrev.2025.08.003_bb0095","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.amjcard.2023.11.007","article-title":"Impact of transcatheter edge-to-edge mitral valve repair on atrial functional mitral regurgitation from the GIOTTO Registry","volume":"211","author":"Masiero","year":"2024","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.carrev.2025.08.003_bb0100","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijcard.2021.11.027","article-title":"Transcatheter edge-to-edge mitral valve repair in atrial functional mitral regurgitation: insights from the multi-center MITRA-TUNE registry","volume":"349","author":"Popolo Rubbio","year":"2022","journal-title":"Int J Cardiol"},{"issue":"13","key":"10.1016\/j.carrev.2025.08.003_bb0105","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jacc.2024.01.031","article-title":"Mitral transcatheter edge-to-edge repair in patients with atrial functional mitral regurgitation","volume":"83","author":"Moras","year":"2024","journal-title":"J Am Coll Cardiol"},{"issue":"17","key":"10.1016\/j.carrev.2025.08.003_bb0110","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.jcin.2022.07.023","article-title":"Clinical outcomes with transcatheter edge-to-edge repair in atrial functional MR from the EXPAND study","volume":"15","author":"Sodhi","year":"2022","journal-title":"JACC Cardiovasc Interv"},{"issue":"4","key":"10.1016\/j.carrev.2025.08.003_bb0115","doi-asserted-by":"crossref","first-page":"e250","DOI":"10.4244\/EIJ-D-23-00819","article-title":"Outcomes of transcatheter edge-to-edge repair for atrial functional mitral regurgitation","volume":"20","author":"Tanaka","year":"2024","journal-title":"EuroIntervention"},{"issue":"19","key":"10.1016\/j.carrev.2025.08.003_bb0120","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1056\/NEJMoa2408739","article-title":"Transcatheter repair versus mitral-valve surgery for secondary mitral regurgitation","volume":"391","author":"Baldus","year":"2024","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.carrev.2025.08.003_bb0125","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019882","article-title":"Survival following edge-to-edge transcatheter mitral valve repair in patients with cardiogenic shock: a nationwide analysis","volume":"10","author":"Tang","year":"2021","journal-title":"JAHA"},{"issue":"22","key":"10.1016\/j.carrev.2025.08.003_bb0130","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/j.jacc.2022.09.006","article-title":"Transcatheter edge-to-edge mitral valve repair in patients with severe mitral regurgitation and cardiogenic shock","volume":"80","author":"Simard","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.carrev.2025.08.003_bb0135","first-page":"1259","article-title":"Use of MitraClip for mitral valve repair in patients with acute mitral regurgitation following acute myocardial infarction: effect of cardiogenic shock on outcomes (IREMMI Registry)","volume":"97","author":"Est\u00e9vez-Loureiro","year":"2021","journal-title":"Cathet Cardio Intervent"},{"issue":"7","key":"10.1016\/j.carrev.2025.08.003_bb0140","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/eurheartj\/ehab496","article-title":"Conservative, surgical, and percutaneous treatment for mitral regurgitation shortly after acute myocardial infarction","volume":"43","author":"Haberman","year":"2022","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.carrev.2025.08.003_bb0145","article-title":"Use of edge-to-edge percutaneous mitral valve repair for severe mitral regurgitation in cardiogenic shock: a multicenter observational experience (MITRA-SHOCK study)","volume":"98","author":"Falasconi","year":"2021","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.carrev.2025.08.003_bb0150","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.carrev.2024.04.006","article-title":"Outcomes of mitral valve transcatheter edge-to-edge repair for patients with hemodynamic instability: a systematic review and meta-analysis","volume":"67","author":"Yokoyama","year":"2024","journal-title":"Cardiovasc Revasc Med"},{"key":"10.1016\/j.carrev.2025.08.003_bb0155","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ahj.2022.08.008","article-title":"Transcatheter mitral valve repair for inotrope dependent cardiogenic shock \u2013 design and rationale of the CAPITAL MINOS trial","volume":"254","author":"Parlow","year":"2022","journal-title":"Am Heart J"},{"issue":"12","key":"10.1016\/j.carrev.2025.08.003_bb0160","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.healun.2020.09.005","article-title":"MitraClip in secondary mitral regurgitation as a bridge to heart transplantation: 1-year outcomes from the International MitraBridge Registry","volume":"39","author":"Godino","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.carrev.2025.08.003_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2023.131139","article-title":"2-year outcomes of MitraClip as a bridge to heart transplantation: the international MitraBridge registry","volume":"390","author":"Munaf\u00f2","year":"2023","journal-title":"Int J Cardiol"}],"container-title":["Cardiovascular Revascularization Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553838925004075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553838925004075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T19:05:02Z","timestamp":1759431902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1553838925004075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":33,"alternative-id":["S1553838925004075"],"URL":"https:\/\/doi.org\/10.1016\/j.carrev.2025.08.003","relation":{},"ISSN":["1553-8389"],"issn-type":[{"type":"print","value":"1553-8389"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcatheter edge-to-edge repair for the management of secondary mitral regurgitation \u2013 CRT 2025 Beyond the Guidelines","name":"articletitle","label":"Article Title"},{"value":"Cardiovascular Revascularization Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.carrev.2025.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}