{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:26:18Z","timestamp":1783441578155,"version":"3.54.6"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005366","name":"University of Oslo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part D: Genomics and Proteomics"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.cbd.2021.100915","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T02:56:06Z","timestamp":1632797766000},"page":"100915","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Chitosan nanoparticle formulation attenuates poly (I:C) induced innate immune responses against inactivated virus vaccine in Atlantic salmon (Salmo salar)"],"prefix":"10.1016","volume":"40","author":[{"given":"Adriana Magalh\u00e3es Santos","family":"Andresen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor","family":"Gj\u00f8en","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbd.2021.100915_bb0005","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-stranded RNA and activation of NF-\u03baB by toll-like receptor 3","volume":"413","author":"Alexopoulou","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cbd.2021.100915_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0219625","article-title":"Interaction between dietary fatty acids and genotype on immune response in Atlantic salmon (Salmo salar) after vaccination: a transcriptome study","volume":"14","author":"Andresen","year":"2019","journal-title":"PloS one"},{"key":"10.1016\/j.cbd.2021.100915_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2014.03.023","article-title":"Effects of TLR agonists and viral infection on cytokine and TLR expression in Atlantic salmon (Salmo salar)","volume":"46","author":"Arnemo","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0020","series-title":"Comprehensive Biomaterials","first-page":"221","article-title":"2.213 - chitosan","author":"Barbosa","year":"2011"},{"key":"10.1016\/j.cbd.2021.100915_bb0025","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.fsi.2014.05.017","article-title":"Evaluation of the impact of camelina oil-containing diets on the expression of genes involved in the innate anti-viral immune response in Atlantic cod (Gadus morhua)","volume":"41","author":"Booman","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0030","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s12864-017-3728-0","article-title":"Gene expression profile during proliferation and differentiation of rainbow trout adipocyte precursor cells","volume":"18","author":"Bou","year":"2017","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cbd.2021.100915_bb0035","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.fsi.2017.02.040","article-title":"The dietary replacement of marine ingredients by terrestrial animal and plant alternatives modulates the antiviral immune response of Atlantic salmon (Salmo salar)","volume":"64","author":"Caballero-Solares","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0040","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1016\/j.jinf.2016.04.031","article-title":"Systems immunology: beyond antibody titers","volume":"72","author":"Cao","year":"2016","journal-title":"J. Infect."},{"key":"10.1016\/j.cbd.2021.100915_bb0045","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.fsi.2015.08.032","article-title":"Transcriptome comparative analysis revealed poly(I:C) activated RIG-I\/MDA5-mediated signaling pathway in miiuy croaker","volume":"47","author":"Chu","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0050","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3390\/vaccines3030730","article-title":"Chitosan-poly (I:C)-PADRE based nanoparticles as delivery vehicles for synthetic peptide vaccines","volume":"3","author":"Correia-Pinto","year":"2015","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.cbd.2021.100915_bb0055","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1365-2761.1993.tb00868.x","article-title":"Leucocytes from Atlantic salmon, Salmo salar L., experimentally infected with infectious salmon anaemia (ISA) exhibit an impaired response to mitogens","volume":"16","author":"Dannevig","year":"1993","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.cbd.2021.100915_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13337-013-0186-4","article-title":"Viral vaccines for farmed finfish","volume":"25","author":"Dhar","year":"2014","journal-title":"Virusdisease"},{"key":"10.1016\/j.cbd.2021.100915_bb0065","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.fsi.2017.01.004","article-title":"Transcriptome profiling of spleen provides insights into the antiviral mechanism in Schizothorax prenanti after poly (I: C) challenge","volume":"62","author":"Du","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0070","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.dci.2016.05.021","article-title":"Transcriptome profiling of the antiviral immune response in Atlantic cod macrophages","volume":"63","author":"Eslamloo","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0075","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1186\/s12864-017-4099-2","article-title":"Transcriptome profiling of antiviral immune and dietary fatty acid dependent responses of Atlantic salmon macrophage-like cells","volume":"18","author":"Eslamloo","year":"2017","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cbd.2021.100915_bb0080","doi-asserted-by":"crossref","first-page":"9016","DOI":"10.1128\/jvi.71.12.9016-9023.1997","article-title":"Characterization of infectious salmon anemia virus, an orthomyxo-like virus isolated from Atlantic salmon (Salmo salar L.)","volume":"71","author":"Falk","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.cbd.2021.100915_bb0085","series-title":"The State of World Fisheries and Aquaculture 2018. Meeting the Sustainable Development Goals","year":"2018"},{"key":"10.1016\/j.cbd.2021.100915_bb0090","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.57306","article-title":"Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling","volume":"9","author":"Fenech","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.cbd.2021.100915_bb0095","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fcimb.2013.00013","article-title":"Vaccine delivery using nanoparticles","volume":"3","author":"Gregory","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.cbd.2021.100915_bb0100","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0165-2427(99)00133-6","article-title":"Recent developments in fish vaccinology","volume":"72","author":"Gudding","year":"1999","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.cbd.2021.100915_bb0105","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nrmicro1681","article-title":"The perfect mix: recent progress in adjuvant research","volume":"5","author":"Guy","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"issue":"10","key":"10.1016\/j.cbd.2021.100915_bb0110","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.addr.2013.05.013","article-title":"Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant","volume":"65","author":"Hafner","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.cbd.2021.100915_bb0115","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.dci.2011.01.008","article-title":"Sensing disease and danger: a survey of vertebrate PRRs and their origins","volume":"35","author":"Hansen","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0120","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1186\/1471-2164-13-431","article-title":"A moderate increase in ambient temperature modulates the Atlantic cod (Gadus morhua) spleen transcriptome response to intraperitoneal viral mimic injection","volume":"13","author":"Hori","year":"2012","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cbd.2021.100915_bb0125","first-page":"325","article-title":"The duality of Fgl2 - secreted immune checkpoint regulator versus membrane-associated procoagulant: therapeutic potential and implications","volume":"35","author":"Hu","year":"2016","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0130","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/jam.13628","article-title":"A modified dose-response model that describes the relationship between haemagglutination inhibition titre and protection against influenza infection","volume":"124","author":"Huang","year":"2017","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.cbd.2021.100915_bb0135","doi-asserted-by":"crossref","first-page":"16693","DOI":"10.1074\/jbc.M709923200","article-title":"CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes","volume":"283","author":"Huysamen","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbd.2021.100915_bb0140","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1128\/JVI.79.5.2910-2919.2005","article-title":"Synthetic double-stranded RNA poly(I:C) combined with mucosal vaccine protects against influenza virus infection","volume":"79","author":"Ichinohe","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.cbd.2021.100915_bb0145","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ni1112","article-title":"Toll-like receptor control of the adaptive immune responses","volume":"5","author":"Iwasaki","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0150","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.molimm.2016.04.007","article-title":"Differences in gene expression in Atlantic salmon parr and smolt after challenge with Piscine orthoreovirus (PRV)","volume":"73","author":"Johansen","year":"2016","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0155","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1084\/jem.20080091","article-title":"Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5","volume":"205","author":"Kato","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cbd.2021.100915_bb0160","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/zeb.2015.1126","article-title":"Use of poly(I:C) stabilized with chitosan as a vaccine-adjuvant against viral hemorrhagic septicemia virus infection in zebrafish","volume":"12","author":"Kavaliauskis","year":"2015","journal-title":"Zebrafish"},{"key":"10.1016\/j.cbd.2021.100915_bb0165","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.dci.2016.04.010","article-title":"Protective effect of a recombinant VHSV-G vaccine using poly(I:C) loaded nanoparticles as an adjuvant in zebrafish (Danio rerio) infection model","volume":"61","author":"Kavaliauskis","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0170","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.antiviral.2012.06.003","article-title":"Countermeasures against viral diseases of farmed fish","volume":"95","author":"Kibenge","year":"2012","journal-title":"Antivir. Res."},{"issue":"1\u20132","key":"10.1016\/j.cbd.2021.100915_bb0175","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.molimm.2011.08.007","article-title":"Genomic survey of early responses to viruses in Atlantic salmon, Salmo salar L","volume":"49","author":"Krasnov","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0180","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01372-19","article-title":"Vesicular stomatitis virus transcription is inhibited by TRIM69 in the interferon-induced antiviral state","volume":"93","author":"Kueck","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.cbd.2021.100915_bb0185","first-page":"5","article-title":"Isolation and characterization of serum extracellular vesicles (EVs) from Atlantic Salmon infected with piscirickettsia salmonis","author":"Lagos","year":"2017","journal-title":"Proteomes"},{"key":"10.1016\/j.cbd.2021.100915_bb0190","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1016\/j.jmb.2013.09.033","article-title":"The antiviral innate immune response in fish: evolution and conservation of the IFN system","volume":"425","author":"Langevin","year":"2013","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.cbd.2021.100915_bb0195","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.4049\/jimmunol.1900804","article-title":"IFN-stimulated genes in zebrafish and humans define an ancient arsenal of antiviral immunity","volume":"203","author":"Levraud","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0200","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/intimm\/dxm023","article-title":"Dexamethasone-induced ras-related protein 1 is a potential regulatory protein in B lymphocytes","volume":"19","author":"Lindsey","year":"2007","journal-title":"Int. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0205","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.fsi.2016.04.029","article-title":"Transcriptome analysis of genes responding to NNV infection in Asian seabass epithelial cells","volume":"54","author":"Liu","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0210","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.12688\/f1000research.7035.1","article-title":"RNA-seq workflow: gene-level exploratory analysis and differential expression","volume":"4","author":"Love","year":"2015","journal-title":"F1000Res"},{"key":"10.1016\/j.cbd.2021.100915_bb0215","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.cbd.2021.100915_bb0220","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.fsi.2016.01.017","article-title":"Identification of endonuclease domain-containing 1 gene in Japanese flounder Paralichthys olivaceus","volume":"50","author":"Lyu","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0225","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/eji.200737984","article-title":"Nanoparticles target distinct dendritic cell populations according to their size","volume":"38","author":"Manolova","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0230","doi-asserted-by":"crossref","first-page":"24759","DOI":"10.1074\/jbc.M700188200","article-title":"Polyinosinic acid is a ligand for toll-like receptor 3","volume":"282","author":"Marshall-Clarke","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbd.2021.100915_bb0235","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.dci.2016.03.014","article-title":"Transcriptomic responses in the fish intestine","volume":"64","author":"Martin","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0240","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1586\/14760584.2015.966085","article-title":"Vaccine adjuvant uses of poly-IC and derivatives","volume":"14","author":"Martins","year":"2015","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.cbd.2021.100915_bb0245","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.3389\/fmicb.2018.01284","article-title":"Current status of the use of antibiotics and the antimicrobial resistance in the Chilean Salmon farms","volume":"9","author":"Miranda","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cbd.2021.100915_bb0250","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1007\/s00705-005-0588-8","article-title":"Susceptibility and immune responses following experimental infection of MHC compatible Atlantic salmon (Salmo salar L.) with different infectious salmon anaemia virus isolates","volume":"150","author":"Mjaaland","year":"2005","journal-title":"Arch. Virol."},{"key":"10.1016\/j.cbd.2021.100915_bb0255","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.47615","article-title":"Endangered wild salmon infected by newly discovered viruses","volume":"8","author":"Mordecai","year":"2019","journal-title":"elife"},{"key":"10.1016\/j.cbd.2021.100915_bb0260","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1186\/s12864-015-1759-y","article-title":"Infectious hematopoietic necrosis virus (IHNV) persistence in Sockeye Salmon: influence on brain transcriptome and subsequent response to the viral mimic poly(I:C)","volume":"16","author":"M\u00fcller","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cbd.2021.100915_bb0265","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.fsi.2018.03.060","article-title":"Correlates of protective immunity for fish vaccines","volume":"85","author":"Munang'andu","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0270","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.molimm.2017.09.018","article-title":"Innate immune transcriptomic evaluation of PBMC isolated from sheep after infection with E. ruminantium Welgevonden strain","volume":"91","author":"Nefefe","year":"2017","journal-title":"Mol. Immunol."},{"issue":"Suppl. 4","key":"10.1016\/j.cbd.2021.100915_bb0275","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1097\/00002030-200216004-00016","article-title":"Novel adjuvants and delivery systems for HIV vaccines","volume":"16","author":"O\u2019Hagan","year":"2002","journal-title":"AIDS"},{"key":"10.1016\/j.cbd.2021.100915_bb0280","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1200\/JCO.2010.30.7744","volume":"29","author":"Okada","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.cbd.2021.100915_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3354\/dao048001","article-title":"Inactivation of infectious salmon anaemia virus, viral haemorrhagic septicaemia virus and infectious pancreatic necrosis virus in water using UVC irradiation","volume":"48","author":"\u00d8ye","year":"2001","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.cbd.2021.100915_bb0290","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.3389\/fimmu.2018.02224","article-title":"Nanoparticle vaccines against infectious diseases","volume":"9","author":"Pati","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0295","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41579-018-0020-5","article-title":"ISG15 in antiviral immunity and beyond","volume":"16","author":"Perng","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cbd.2021.100915_bb0300","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/nprot.2016.095","article-title":"Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown","volume":"11","author":"Pertea","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cbd.2021.100915_bb0305","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.dci.2016.07.011","article-title":"Fish interferon-stimulated genes: the antiviral effectors","volume":"65","author":"Poynter","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0310","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1016\/j.vaccine.2010.01.011","article-title":"Chitosan-based nanoparticles for improving immunization against hepatitis B infection","volume":"28","author":"Prego","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.cbd.2021.100915_bb0315","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1111\/biom.12879","article-title":"Estimation of the optimal surrogate based on a randomized trial","volume":"74","author":"Price","year":"2018","journal-title":"Biometrics"},{"key":"10.1016\/j.cbd.2021.100915_bb0320","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1186\/s12885-017-3330-5","article-title":"Identification of endonuclease domain-containing 1 as a novel tumor suppressor in prostate cancer","volume":"17","author":"Qiu","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cbd.2021.100915_bb0325","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/ni.1688","article-title":"Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans","volume":"10","author":"Querec","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0330","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/imm.13012","article-title":"Systems vaccinology and big data in the vaccine development chain","volume":"156","author":"Raeven","year":"2019","journal-title":"Immunology"},{"key":"10.1016\/j.cbd.2021.100915_bb0335","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.vetimm.2011.11.023","article-title":"Identification of differentially expressed protective genes in liver of two rainbow trout strains","volume":"145","author":"Rebl","year":"2012","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.cbd.2021.100915_bb0340","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A simple method of estimating fifty per cent endpoints12","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.cbd.2021.100915_bb0345","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.dci.2008.01.002","article-title":"Functional genomic analysis of the response of Atlantic cod (Gadus morhua) spleen to the viral mimic polyriboinosinic polyribocytidylic acid (pIC)","volume":"32","author":"Rise","year":"2008","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0350","doi-asserted-by":"crossref","first-page":"e1003001","DOI":"10.1371\/journal.ppat.1003001","article-title":"Vaccines: from empirical development to rational design","volume":"8","author":"Rueckert","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cbd.2021.100915_bb0355","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s10126-012-9466-z","article-title":"Characterization of European sea bass transcripts by RNA SEQ after Oral vaccine against V. anguillarum","volume":"14","author":"Sarropoulou","year":"2012","journal-title":"Mar. Biotechnol."},{"key":"10.1016\/j.cbd.2021.100915_bb0360","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1365-3016.2008.00956.x","article-title":"To pool or not to pool, from whether to when: applications of pooling to biospecimens subject to a limit of detection","volume":"22","author":"Schisterman","year":"2008","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"10.1016\/j.cbd.2021.100915_bb0365","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","article-title":"Interferon-stimulated genes: a complex web of host defenses","volume":"32","author":"Schneider","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0465","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.coviro.2011.10.008","article-title":"Interferon-stimulated genes and their antiviral effector functions","volume":"1","author":"Schoggins","year":"2011","journal-title":"Curr. Opin. Virol."},{"issue":"1","key":"10.1016\/j.cbd.2021.100915_bb0460","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev-virology-092818-015756","article-title":"Interferon-Stimulated Genes: What Do They All Do?","volume":"6","author":"Schoggins","year":"2019","journal-title":"Annu. Rev. Virol."},{"key":"10.1016\/j.cbd.2021.100915_bb0370","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature09907","article-title":"A diverse range of gene products are effectors of the type I interferon antiviral response","volume":"472","author":"Schoggins","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cbd.2021.100915_bb0375","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1128\/MCB.01466-09","article-title":"Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification","volume":"30","author":"Shi","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cbd.2021.100915_bb0380","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1751-7915.2011.00321.x","article-title":"Systems biology in vaccine design","volume":"5","author":"Six","year":"2012","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.cbd.2021.100915_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbd.2019.100597","article-title":"Whole transcriptome analysis of the Atlantic cod vaccine response reveals subtle changes in adaptive immunity","volume":"31","author":"Solbakken","year":"2019","journal-title":"Comp. Biochem. Physiol. D Genomics Proteomics"},{"key":"10.1016\/j.cbd.2021.100915_bb0390","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1099\/0022-1317-78-8-1891","article-title":"Multiplication and haemadsorbing activity of infectious salmon anaemia virus in the established Atlantic salmon cell line","volume":"78","author":"Sommer","year":"1997","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.cbd.2021.100915_bb0395","series-title":"Fiskehelserapporten 2020","author":"Sommerset","year":"2021"},{"key":"10.1016\/j.cbd.2021.100915_bb0400","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.fsi.2013.02.029","article-title":"Adjuvants and immunostimulants in fish vaccines: current knowledge and future perspectives","volume":"35","author":"Tafalla","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0405","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3390\/vaccines2020228","article-title":"Vaccine adjuvants in fish vaccines make a difference: comparing three adjuvants (Montanide ISA763A oil, CpG\/Poly I: C combo and VHSV Glycoprotein) alone or in combination formulated with an inactivated whole salmonid alphavirus antigen","volume":"2","author":"Thim","year":"2014","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.cbd.2021.100915_bb0410","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.fsi.2015.04.003","article-title":"High-throughput transcriptome analysis of ISAV-infected Atlantic salmon Salmo salar unravels divergent immune responses associated to head-kidney, liver and gills tissues","volume":"45","author":"Valenzuela-Miranda","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0415","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1242\/jcs.205468","article-title":"ISGylation - a key to lock the cell gates for preventing the spread of threats","volume":"130","author":"Villarroya-Beltri","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cbd.2021.100915_bb0420","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.dci.2014.07.006","article-title":"Fish viperin exerts a conserved antiviral function through RLR-triggered IFN signaling pathway","volume":"47","author":"Wang","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0425","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1038\/s41467-019-12894-z","article-title":"Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program","volume":"10","author":"Wyler","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbd.2021.100915_bb0430","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.4049\/jimmunol.0900123","article-title":"C-maf regulates IL-10 expression during Th17 polarization","volume":"182","author":"Xu","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0435","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.cbd.2021.100915_bb0440","doi-asserted-by":"crossref","first-page":"e0179067","DOI":"10.1371\/journal.pone.0179067","article-title":"Receptor-transporting protein (RTP) family members play divergent roles in the functional expression of odorant receptors","volume":"12","author":"Yu","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.cbd.2021.100915_bb0445","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4049\/jimmunol.168.2.554","article-title":"Tissue expression of human toll-like receptors and differential regulation of toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines","volume":"168","author":"Zarember","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.cbd.2021.100915_bb0450","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1365-2583.2010.01029.x","article-title":"Chitosan\/double-stranded RNA nanoparticle-mediated RNA interference to silence chitin synthase genes through larval feeding in the African malaria mosquito (Anopheles gambiae)","volume":"19","author":"Zhang","year":"2010","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.cbd.2021.100915_bb0455","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.vaccine.2013.11.069","article-title":"Nanoparticle vaccines","volume":"32","author":"Zhao","year":"2014","journal-title":"Vaccine"}],"container-title":["Comparative Biochemistry and Physiology Part D: Genomics and Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744117X21001271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744117X21001271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:44:38Z","timestamp":1761677078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744117X21001271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":93,"alternative-id":["S1744117X21001271"],"URL":"https:\/\/doi.org\/10.1016\/j.cbd.2021.100915","relation":{},"ISSN":["1744-117X"],"issn-type":[{"value":"1744-117X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chitosan nanoparticle formulation attenuates poly (I:C) induced innate immune responses against inactivated virus vaccine in Atlantic salmon (Salmo salar)","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part D: Genomics and Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbd.2021.100915","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100915"}}