{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:26:15Z","timestamp":1790342775766,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFC1605800"],"award-info":[{"award-number":["2019YFC1605800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20181138"],"award-info":[{"award-number":["BK20181138"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part D: Genomics and Proteomics"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.cbd.2022.100988","type":"journal-article","created":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T02:15:35Z","timestamp":1649470535000},"page":"100988","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["16S rRNA gene sequencing analysis reveals an imbalance in the intestinal flora of Eriocheir sinensis with hepatopancreatic necrosis disease"],"prefix":"10.1016","volume":"42","author":[{"given":"Ming","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjun","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengru","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenghong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangchun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaishun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbd.2022.100988_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.735788","article-title":"Purple bacteria as added-value protein ingredient in shrimp feed: Penaeus vannamei growth performance, and tolerance against vibrio and ammonia stress","volume":"530","author":"Alloul","year":"2021","journal-title":"Aquaculture"},{"issue":"Pt 8","key":"10.1016\/j.cbd.2022.100988_bb0010","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1099\/ijs.0.023184-0","article-title":"Chryseomicrobium imtechense gen. nov., sp. nov., a new member of the family Planococcaceae","volume":"61","author":"Arora","year":"2011","journal-title":"Int. J. Syst. Evol. Microbiol."},{"issue":"3","key":"10.1016\/j.cbd.2022.100988_bb0015","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1073\/pnas.0605374104","article-title":"Mechanisms underlying the resistance to diet-induced obesity in germ-free mice","volume":"104","author":"B\u00e4ckhed","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.cbd.2022.100988_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084772","article-title":"Network analysis highlights complex interactions between pathogen, host and commensal microbiota","volume":"8","author":"Boutin","year":"2013","journal-title":"PloS one"},{"issue":"5","key":"10.1016\/j.cbd.2022.100988_bb0025","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"issue":"4","key":"10.1016\/j.cbd.2022.100988_bb0030","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1007\/s00248-011-9936-2","article-title":"Bacterial community associated with the intestinal tract of P. monodon in commercial farms","volume":"63","author":"Chaiyapechara","year":"2012","journal-title":"Microb. Ecol."},{"issue":"3","key":"10.1016\/j.cbd.2022.100988_bb0035","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/ajcn\/8.3.321","article-title":"Role of vitamins in lipid metabolism","volume":"8","author":"Chow","year":"1960","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cbd.2022.100988_bb0040","first-page":"313","article-title":"Pathological study on \u201cShuibiezi\u201d disease of crab Eriocheir sinensis","volume":"30","author":"Cui","year":"2017","journal-title":"J. Yantai Univ."},{"issue":"9","key":"10.1016\/j.cbd.2022.100988_bb0045","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/jfd.12437","article-title":"First case of hepatopancreatic necrosis disease in pond-reared Chinese mitten crab, Eriocheir sinensis, associated with microsporidian","volume":"39","author":"Ding","year":"2016","journal-title":"J. Fish Dis."},{"issue":"11","key":"10.1016\/j.cbd.2022.100988_bb0050","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1111\/jfd.12624","article-title":"Changes in the gut microbiome of the Chinese mitten crab (Eriocheir sinensis) in response to White Spot Syndrome Virus (WSSV) infection","volume":"40","author":"Ding","year":"2017","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.cbd.2022.100988_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.736199","article-title":"Gastrointestinal microbiota imbalance is triggered by the enrichment of Vibrio in subadult Litopenaeus vannamei with acute hepatopancreatic necrosis disease","volume":"533","author":"Dong","year":"2021","journal-title":"Aquaculture"},{"issue":"16","key":"10.1016\/j.cbd.2022.100988_bb0060","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1093\/bioinformatics\/btr381","article-title":"UCHIME improves sensitivity and speed of chimera detection","volume":"27","author":"Edgar","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cbd.2022.100988_bb0065","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.aquaculture.2019.02.075","article-title":"Characteristics of intestinal microbiota in the Pacific white shrimp Litopenaeus vannamei differing growth performances in the marine cultured environment","volume":"505","author":"Fan","year":"2019","journal-title":"Aquaculture"},{"issue":"10","key":"10.1016\/j.cbd.2022.100988_bb0070","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1111\/j.1462-2920.2008.01672.x","article-title":"Host-specificity of environmentally transmitted Mycoplasma-like isopod symbionts","volume":"10","author":"Fraune","year":"2008","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.cbd.2022.100988_bb0075","series-title":"Physiology of the Gastrointestinal Tract","first-page":"1119","article-title":"Gastrointestinal microbial ecology with perspectives on health and disease","author":"Gillilland","year":"2012"},{"issue":"6","key":"10.1016\/j.cbd.2022.100988_bb0080","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/ANC.0000000000000237","article-title":"Mode of birth influences preterm infant intestinal colonization with bacteroides over the early neonatal period","volume":"15","author":"Gregory","year":"2015","journal-title":"Adv. Neonatal Care"},{"key":"10.1016\/j.cbd.2022.100988_bb0085","first-page":"59","article-title":"Investigation and analysis on the correlation of pesticides and hypoxia with \u201cShuibiezi\u201d disease of Eriocheir sinensis","volume":"4","author":"Gu","year":"2017","journal-title":"Sci. Fish Farming"},{"issue":"3","key":"10.1016\/j.cbd.2022.100988_bb0090","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1101\/gr.112730.110","article-title":"Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons","volume":"21","author":"Haas","year":"2011","journal-title":"Genome Res."},{"issue":"1","key":"10.1016\/j.cbd.2022.100988_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-32366-6","article-title":"Commensal microbiota induces colonic barrier structure and functions that contribute to homeostasis","volume":"8","author":"Hayes","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbd.2022.100988_bb0100","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.fsi.2017.09.007","article-title":"Effects of organic acids and essential oils blend on growth, gut microbiota, immune response and disease resistance of Pacific white shrimp (Litopenaeus vannamei) against Vibrio parahaemolyticus","volume":"70","author":"He","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbd.2022.100988_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138276","article-title":"Effects of imidacloprid on the oxidative stress, detoxification and gut microbiota of Chinese mitten crab, Eriocheir sinensis","volume":"729","author":"Hong","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"8","key":"10.1016\/j.cbd.2022.100988_bb0110","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1007\/s00253-018-8855-2","article-title":"Intestinal bacterial signatures of white feces syndrome in shrimp","volume":"102","author":"Hou","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.cbd.2022.100988_bb0115","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/toxsci\/kfv115","article-title":"Oral exposure of mice to carbendazim induces hepatic lipid metabolism disorder and gut microbiota dysbiosis","volume":"147","author":"Jin","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbd.2022.100988_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envpol.2016.11.045","article-title":"Effects of environmental pollutants on gut microbiota","volume":"222","author":"Jin","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbd.2022.100988_bb0125","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.aquaculture.2016.02.007","article-title":"Utilisation of dietary carbohydrates in farmed fishes: new insights on influencing factors, biological limitations and future strategies","volume":"467","author":"Kamalam","year":"2017","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2022.100988_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112471","article-title":"Ammonia stress influences intestinal histomorphology, immune status and microbiota of Chinese striped-neck turtle (Mauremys sinensis)","volume":"222","author":"Khan","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"17","key":"10.1016\/j.cbd.2022.100988_bb0135","doi-asserted-by":"crossref","first-page":"5566","DOI":"10.1128\/AEM.02468-06","article-title":"\u201cCandidatus Bacilloplasma\u201d, a novel lineage of Mollicutes associated with the hindgut wall of the terrestrial isopod Porcellio scaber (Crustacea: Isopoda)","volume":"73","author":"Kostanjsek","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"issue":"1","key":"10.1016\/j.cbd.2022.100988_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00248-018-1204-2","article-title":"Microbial community composition and putative biogeochemical functions in the sediment and water of tropical granite quarry lakes","volume":"77","author":"Kumar","year":"2019","journal-title":"Microb. Ecol."},{"issue":"2","key":"10.1016\/j.cbd.2022.100988_bb0145","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.fsi.2015.11.008","article-title":"Pathogenesis of acute hepatopancreatic necrosis disease (AHPND) in shrimp","volume":"47","author":"Lai","year":"2015","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.cbd.2022.100988_bb0150","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/gbe\/evu020","article-title":"Phylogenomics of \u201cCandidatus Hepatoplasma crinochetorum\u201d, a lineage of mollicutes associated with noninsect arthropods","volume":"6","author":"Leclercq","year":"2014","journal-title":"Genome Biol. Evol."},{"issue":"1","key":"10.1016\/j.cbd.2022.100988_bb0155","first-page":"1","article-title":"Alterations of the gut microbiome of largemouth bronze gudgeon (Coreius guichenoti) suffering from furunculosis","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbd.2022.100988_bb0160","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.scitotenv.2019.06.265","article-title":"Effects of microplastics on the innate immunity and intestinal microflora of juvenile Eriocheir sinensis","volume":"685","author":"Liu","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"10","key":"10.1016\/j.cbd.2022.100988_bb0165","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrmicro3344","article-title":"The gut microbiota, bacterial metabolites and colorectal cancer","volume":"12","author":"Louis","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"issue":"21","key":"10.1016\/j.cbd.2022.100988_bb0170","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","article-title":"FLASH: fast length adjustment of short reads to improve genome assemblies","volume":"27","author":"Mago\u010d","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cbd.2022.100988_bb0175","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.aquatox.2017.11.019","article-title":"Microbiota and environmental stress: how pollution affects microbial communities in Manila clams","volume":"194","author":"Milan","year":"2018","journal-title":"Aquat. Toxicol."},{"issue":"1","key":"10.1016\/j.cbd.2022.100988_bb0180","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.marpolbul.2016.02.040","article-title":"Isolation, screening, and characterization of surface-active agent-producing, oil-degrading marine bacteria of Mumbai Harbor","volume":"105","author":"Mohanram","year":"2016","journal-title":"Mar. Pollut. Bull."},{"issue":"1","key":"10.1016\/j.cbd.2022.100988_bb0185","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/MOG.0b013e3282f2b0d7","article-title":"Alterations in intestinal microbial flora and human disease","volume":"24","author":"Othman","year":"2008","journal-title":"Curr. Opin. Gastroenterol."},{"issue":"3","key":"10.1016\/j.cbd.2022.100988_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2150-3508.1000220","article-title":"Pathological changes and risk factors of hepatopancreas necrosis disease of mitten crab,Eriocheir Sinensis","volume":"8","author":"Pan","year":"2017","journal-title":"Fish. Aquac. J."},{"issue":"D1","key":"10.1016\/j.cbd.2022.100988_bb0195","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbd.2022.100988_bb0200","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jip.2015.11.004","article-title":"Bacterial dynamics in intestines of the black tiger shrimp and the Pacific white shrimp during Vibrio harveyi exposure","volume":"133","author":"Rungrassamee","year":"2016","journal-title":"J. Invertebr. Pathol."},{"issue":"3","key":"10.1016\/j.cbd.2022.100988_bb0205","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.chom.2012.08.003","article-title":"Microbiota regulate intestinal absorption and metabolism of fatty acids in the zebrafish","volume":"12","author":"Semova","year":"2012","journal-title":"Cell Host Microbe"},{"issue":"4","key":"10.1016\/j.cbd.2022.100988_bb0210","first-page":"366","article-title":"Biochemical and genetically identification of solvent tolerant novel Bacillus subtilis Pa2","volume":"3","author":"Shah","year":"2012","journal-title":"J. Biochem. Technol."},{"issue":"3","key":"10.1016\/j.cbd.2022.100988_bb0215","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00447-15","article-title":"Near-full-length genome sequence of a novel reovirus from the Chinese mitten crab,Eriocheir sinensis","volume":"3","author":"Shen","year":"2015","journal-title":"Genome Announc."},{"key":"10.1016\/j.cbd.2022.100988_bb0220","doi-asserted-by":"crossref","first-page":"732","DOI":"10.3389\/fmicb.2017.00732","article-title":"A meta-transcriptomics survey reveals changes in the microbiota of the Chinese mitten crab Eriocheir sinensis infected with hepatopancreatic necrosis disease","volume":"8","author":"Shen","year":"2017","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.cbd.2022.100988_bb0225","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3748\/wjg.v24.i1.5","article-title":"Relationship between intestinal microbiota and ulcerative colitis: mechanisms and clinical application of probiotics and fecal microbiota transplantation","volume":"24","author":"Shen","year":"2018","journal-title":"World J. Gastroenterol."},{"issue":"5","key":"10.1016\/j.cbd.2022.100988_bb0230","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1111\/are.15081","article-title":"Hepatopancreatic necrosis disease (HPND) in Chinese mitten crab Eriocheir sinensis tightly linked to low concentration of two insecticides","volume":"52","author":"Shen","year":"2021","journal-title":"Aquac. Res."},{"issue":"9","key":"10.1016\/j.cbd.2022.100988_bb0235","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tibtech.2015.06.011","article-title":"Proteobacteria: microbial signature of dysbiosis in gut microbiota","volume":"33","author":"Shin","year":"2015","journal-title":"Trends Biotechnol."},{"issue":"1\u20132","key":"10.1016\/j.cbd.2022.100988_bb0240","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.aquaculture.2010.06.021","article-title":"Larviculture techniques of Chinese mitten crab Eriocheir sinensis","volume":"315","author":"Sui","year":"2011","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2022.100988_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2019.734518","article-title":"Microbiota comparison in the intestine of juvenile Chinese mitten crab Eriocheir sinensis fed different diets","volume":"515","author":"Sun","year":"2020","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2022.100988_bb0250","series-title":"R: A Language And Environment for Statistical Computing","year":"2013"},{"issue":"11","key":"10.1016\/j.cbd.2022.100988_bb0255","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.cbd.2022.100988_bb0260","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1099\/mic.0.26664-0","article-title":"A spiroplasma associated with tremor disease in the Chinese mitten crab (Eriocheir sinensis)","volume":"150","author":"Wang","year":"2004","journal-title":"Microbiology"},{"issue":"5","key":"10.1016\/j.cbd.2022.100988_bb0265","doi-asserted-by":"crossref","DOI":"10.1002\/mbo3.727","article-title":"Change in the intestinal bacterial community structure associated with environmental microorganisms during the growth of Eriocheir sinensis","volume":"8","author":"Wang","year":"2019","journal-title":"Microbiol. Open"},{"key":"10.1016\/j.cbd.2022.100988_bb0270","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.fsi.2020.08.019","article-title":"Effects of dietary T-2 toxin on gut health and gut microbiota composition of the juvenile Chinese mitten crab (Eriocheir sinensis)","volume":"106","author":"Wang","year":"2020","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.cbd.2022.100988_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030603","article-title":"Bacterial community assembly and turnover within the intestines of developing zebrafish","volume":"7","author":"Yan","year":"2012","journal-title":"PloS one"},{"key":"10.1016\/j.cbd.2022.100988_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2019.734579","article-title":"Transcriptomic analysis reveals that hepatopancreatic necrosis disease in Eriocheir sinensis (Chinese mitten crabs) may be the result of autophagy and apoptosis","volume":"515","author":"Yan","year":"2020","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.cbd.2022.100988_bb0285","first-page":"17","article-title":"Etiological and histopathological study on hepatopancreatic necrosis syndrome in Eriocheir sinensis","volume":"42","author":"Yang","year":"2018","journal-title":"Acta Hydrobiol. Sin."},{"key":"10.1016\/j.cbd.2022.100988_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2019.105243","article-title":"Effects of the glyphosate-based herbicide roundup on the survival, immune response, digestive activities and gut microbiota of the Chinese mitten crab,Eriocheir sinensis","volume":"214","author":"Yang","year":"2019","journal-title":"Aquat. Toxicol."},{"issue":"2","key":"10.1016\/j.cbd.2022.100988_bb0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0228623","article-title":"Transcriptome analysis of hepatopancreas of Eriocheir sinensis with hepatopancreatic necrosis disease (HPND)","volume":"15","author":"Yang","year":"2020","journal-title":"PloS one"},{"issue":"1","key":"10.1016\/j.cbd.2022.100988_bb0300","first-page":"1","article-title":"Grain-rich diets altered the colonic fermentation and mucosa-associated bacterial communities and induced mucosal injuries in goats","volume":"6","author":"Ye","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cbd.2022.100988_bb0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148135","article-title":"Symbiotic bacteria in gills and guts of Chinese mitten crab (Eriocheir sinensis) differ from the free-living bacteria in water","volume":"11","author":"Zhang","year":"2016","journal-title":"PloS one"},{"issue":"C","key":"10.1016\/j.cbd.2022.100988_bb0310","article-title":"Microcystin-LR-induced changes of hepatopancreatic transcriptome, intestinal microbiota, and histopathology of freshwater crayfish (Procambarus clarkii)","volume":"711","author":"Zhang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbd.2022.100988_bb0315","series-title":"BioMed Res. Int.","article-title":"Lower level of bacteroides in the gut microbiota is associated with inflammatory bowel disease: a meta-analysis","volume":"2016","author":"Zhou","year":"2016"},{"key":"10.1016\/j.cbd.2022.100988_bb0320","first-page":"13","article-title":"Inducement and prevention technology of \u201cShuibiezi\u201d disease of Chinese mitten crab Eriocheir sinensis","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci. Fish Farming"},{"issue":"7687","key":"10.1016\/j.cbd.2022.100988_bb0325","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nature25172","article-title":"Precision editing of the gut microbiota ameliorates colitis","volume":"553","author":"Zhu","year":"2018","journal-title":"Nature"}],"container-title":["Comparative Biochemistry and Physiology Part D: Genomics and Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744117X22000302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744117X22000302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:39:42Z","timestamp":1761676782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744117X22000302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":65,"alternative-id":["S1744117X22000302"],"URL":"https:\/\/doi.org\/10.1016\/j.cbd.2022.100988","relation":{},"ISSN":["1744-117X"],"issn-type":[{"value":"1744-117X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"16S rRNA gene sequencing analysis reveals an imbalance in the intestinal flora of Eriocheir sinensis with hepatopancreatic necrosis disease","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part D: Genomics and Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbd.2022.100988","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100988"}}