{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:12:16Z","timestamp":1792735936181,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010226","name":"Department of Education of Guangdong Province","doi-asserted-by":"publisher","award":["2022KTSCX052"],"award-info":[{"award-number":["2022KTSCX052"]}],"id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part D: Genomics and Proteomics"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.cbd.2025.101462","type":"journal-article","created":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T11:38:08Z","timestamp":1740829088000},"page":"101462","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Analysis of intestinal metabolites in Litopenaeus vannamei infected with white faeces syndrome based on untargeted metabolomics"],"prefix":"10.1016","volume":"55","author":[{"given":"Tingting","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aobo","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangze","family":"Xv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adinda","family":"Luthfiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beiping","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbd.2025.101462_bb0005","article-title":"Evidences supporting Enterocytozoon hepatopenaei association with white feces syndrome in farmed Penaeus vannamei in Venezuela and Indonesia","volume":"71\u201378","author":"Aranguren Caro","year":"2020","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.cbd.2025.101462_bb0010","article-title":"Experimental reproduction of White feces syndrome in whiteleg shrimp, Penaeus vannamei","volume":"e0261289","author":"Aranguren Caro","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.cbd.2025.101462_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/metabo8020031","article-title":"Software tools and approaches for compound identification of LC-MS\/MS data in metabolomics","volume":"8","author":"Blazenovic","year":"2018","journal-title":"Metabolites"},{"key":"10.1016\/j.cbd.2025.101462_bb0020","article-title":"Nitric oxide production in activated macrophages from channel catfish (Ictalurus punctatus): influence of dietary arginine and culture media","volume":"513\u2013521","author":"Buentello","year":"1999","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101462_bb0025","article-title":"Effects of dietary arginine on hematological parameters and innate immune function of channel catfish","volume":"195\u2013203","author":"Buentello","year":"2007","journal-title":"J. Aquat. Anim. Health"},{"key":"10.1016\/j.cbd.2025.101462_bb0030","article-title":"Penaeus vannamei, white feces syndrome, Vibrio cholerae, pathogenicity, antibiotic susceptibility","author":"Cao","year":"2021","journal-title":"Israeli Journal of Aquaculture-Bamidgeh."},{"key":"10.1016\/j.cbd.2025.101462_bb0035","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1111\/raq.12457","article-title":"Development and current state of seawater shrimp farming, with an emphasis on integrated multi-trophic pond aquaculture farms, in China \u2013 a review","author":"Chang","year":"2020","journal-title":"Rev. Aquac."},{"key":"10.1016\/j.cbd.2025.101462_bb0040","article-title":"Effect of dietary arginine on growth, intestinal enzyme activities and gene expression in muscle, hepatopancreas and intestine of juvenile Jian carp (Cyprinus carpiovar. Jian)","volume":"195\u2013207","author":"Chen","year":"2012","journal-title":"Br. J. Nutr."},{"issue":"1","key":"10.1016\/j.cbd.2025.101462_bb0045","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijdevneu.2014.03.006","article-title":"Dysregulation of the IGF-I\/PI3K\/AKT\/mTOR signaling pathway in autism spectrum disorders","volume":"35","author":"Chen","year":"2014","journal-title":"Int. J. Dev. Neurosci."},{"issue":"1112\u20131130","key":"10.1016\/j.cbd.2025.101462_bb0050","article-title":"Molecular choreography of acute exercise","volume":"181","author":"Contrepois","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cbd.2025.101462_bb0055","series-title":"IOP Conference Series: Earth and Environmental Science","article-title":"Histopathological of the hepatopancreas of Pacific white shrimp (Litopenaeus vannamei) infected by white feces disease","volume":"012016","author":"Damora","year":"2022"},{"key":"10.1016\/j.cbd.2025.101462_bb0060","article-title":"Effects of mannan oligosaccharide (MOS) supplementation on growth performance, feed utilisation, intestinal histology and gut microbiota of gilthead sea bream (Sparus aurata)","volume":"182\u2013188","author":"Dimitroglou","year":"2010","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101462_bb0065","series-title":"Statistics a Quarterly Update on World Seafood Markets","author":"FAO","year":"2019"},{"key":"10.1016\/j.cbd.2025.101462_bb0070","article-title":"Nitric oxide synthases: regulation and function","volume":"829\u2013837","author":"Forstermann","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cbd.2025.101462_bb0075","article-title":"A new insight to characterize immunomodulation based on hepatopancreatic transcriptome and humoral immune factor analysis of the Cherax quadricarinatus infected with Aeromonas veronii","volume":"112347","author":"Guo","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbd.2025.101462_bb0080","article-title":"White spot syndrome virus directly activates mTORC1 signaling to facilitate its replication via polymeric immunoglobulin receptor-mediated infection in shrimp","volume":"e1010808","author":"Hong","year":"2022","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cbd.2025.101462_bb0085","article-title":"Immune adaptations that maintain homeostasis with the intestinal microbiota","volume":"159\u2013169","author":"Hooper","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cbd.2025.101462_bb0090","article-title":"How host-microbial interactions shape the nutrient environment of the mammalian intestine","volume":"283\u2013307","author":"Hooper","year":"2002","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.cbd.2025.101462_bb0095","article-title":"Intestinal bacterial signatures of white feces syndrome in shrimp","volume":"3701\u20133709","author":"Hou","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.cbd.2025.101462_bb0105","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-020-00802-3","article-title":"Microecological Koch\u2019s postulates reveal that intestinal microbiota dysbiosis contributes to shrimp white feces syndrome","author":"Huang","year":"2020","journal-title":"Microbiome"},{"key":"10.1016\/j.cbd.2025.101462_bb0110","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-020-00802-3","article-title":"Microecological Koch\u2019s postulates reveal that intestinal microbiota dysbiosis contributes to shrimp white feces syndrome","author":"Huang","year":"2020","journal-title":"Microbiome"},{"key":"10.1016\/j.cbd.2025.101462_bb0115","article-title":"Nutrient signaling to mTOR and cell growth","volume":"233\u2013242","author":"Jewell","year":"2013","journal-title":"Trends Biochem. Sci."},{"issue":"20","key":"10.1016\/j.cbd.2025.101462_bb0120","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1242\/jcs.051011","article-title":"mTOR signaling at a glance","volume":"122","author":"Laplante","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cbd.2025.101462_bb0125","article-title":"Adapting the stress response: viral subversion of the mTOR signaling pathway","volume":"152","author":"Le Sage","year":"2016","journal-title":"Viruses"},{"key":"10.1016\/j.cbd.2025.101462_bb0130","article-title":"Metabolomic profiles in the intestine of shrimp infected by White spot syndrome virus and antiviral function of the metabolite linoleic acid in shrimp","volume":"2075\u20132087","author":"Li","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.cbd.2025.101462_bb0135","article-title":"Using probiotics to improve swine gut health and nutrient utilization","volume":"331\u2013343","author":"Liao","year":"2017","journal-title":"Animal Nutrition"},{"key":"10.1016\/j.cbd.2025.101462_bb0140","article-title":"Metabolomics comparison of metabolites and functional pathways in the gills of Chlamys farreri under cadmium exposure","volume":"103683","author":"Liu","year":"2021","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbd.2025.101462_bb0145","article-title":"The mosquito Anopheles stephensilimits malaria parasite development with inducible synthesis of nitric oxide","volume":"5700\u20135705","author":"Luckhart","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cbd.2025.101462_bb0150","series-title":"China Fisheries Statistical Yearbook","author":"Ministry of Agriculture Fisheries Bureau","year":"2020"},{"key":"10.1016\/j.cbd.2025.101462_bb0155","doi-asserted-by":"crossref","first-page":"2579S","DOI":"10.3945\/jn.115.226621","article-title":"Arginine metabolism revisited","author":"Morris","year":"2016","journal-title":"J. Nutr."},{"key":"10.1016\/j.cbd.2025.101462_bb0160","article-title":"\u201cMetabonomics\u201d: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data","volume":"1181\u20131189","author":"Nicholson","year":"1999","journal-title":"Xenobiotica"},{"issue":"4","key":"10.1016\/j.cbd.2025.101462_bb0165","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1356-9597.2004.00727.x","article-title":"Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function","volume":"9","author":"Oshiro","year":"2004","journal-title":"Genes to cells : devoted to molecular & cellular mechanisms"},{"key":"10.1016\/j.cbd.2025.101462_bb0170","series-title":"A Potential Prokaryotic and Microsporidian Pathobiome That May Cause Shrimp White Feces Syndrome (WFS)","author":"Prachumwat","year":"2021"},{"key":"10.1016\/j.cbd.2025.101462_bb0175","series-title":"Clinical Interventions in Aging, Clinical Interventions in Aging","article-title":"Studies on free radicals, antioxidants, and co-factors","author":"Rahman","year":"2007"},{"key":"10.1016\/j.cbd.2025.101462_bb0180","article-title":"Role of antioxidants in prophylaxis and therapy: a pharmaceutical perspective","volume":"189\u2013207","author":"Ratnam","year":"2006","journal-title":"J. Control. Release"},{"issue":"4","key":"10.1016\/j.cbd.2025.101462_bb0185","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.21608\/ejabf.2022.257181","article-title":"Comparative study on length-weight relationship and Vibrio composition between normal and stunted growth in pond-cultured whiteleg shrimp, Litopenaeus vannamei","volume":"26","author":"Rukimin","year":"2022","journal-title":"Egyptian Journal of Aquatic Biology and Fisheries"},{"key":"10.1016\/j.cbd.2025.101462_bb0190","article-title":"Shedding the light on Litopenaeus vannamei differential muscle and hepatopancreas immune responses in white spot syndrome virus (WSSV) exposure","volume":"805","author":"Santos","year":"2020","journal-title":"Genes"},{"key":"10.1016\/j.cbd.2025.101462_bb0195","article-title":"Lysozyme: an important defence molecule of fish innate immune system","volume":"223\u2013239","author":"Saurabh","year":"2008","journal-title":"Aquac. Res."},{"issue":"7615","key":"10.1016\/j.cbd.2025.101462_bb0200","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nature19079","article-title":"Mechanism of arginine sensing by CASTOR1 upstream of mTORC1","volume":"536","author":"Saxton","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cbd.2025.101462_bb0205","article-title":"L-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells","volume":"1227\u20131235","author":"Tan","year":"2010","journal-title":"Amino Acids"},{"key":"10.1016\/j.cbd.2025.101462_bb0210","article-title":"Dense populations of the microsporidian Enterocytozoon hepatopenaei (EHP) in feces of Penaeus vannamei exhibiting white feces syndrome and pathways of their transmission to healthy shrimp","volume":"1\u20137","author":"Tang","year":"2016","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.cbd.2025.101462_bb0215","article-title":"Molecular cloning of the TOR gene from Fenneropenaeus chinensis and its expression in response to arginine or leucine","author":"Wang","year":"2010","journal-title":"Mar. Sci."},{"key":"10.1016\/j.cbd.2025.101462_bb0220","article-title":"Insights into the histopathology and microbiome of Pacific white shrimp, Penaeus vannamei, suffering from white feces syndrome","volume":"735447","author":"Wang","year":"2020","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101462_bb0225","article-title":"Arginine metabolism and nutrition in growth, health and disease","volume":"153\u2013168","author":"Wu","year":"2009","journal-title":"Amino Acids"},{"key":"10.1016\/j.cbd.2025.101462_bb0230","article-title":"Gut epithelial TSC1\/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer","volume":"2111\u20132128","author":"Xie","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbd.2025.101462_bb0235","article-title":"Vitamin D3 identified from metabolomic analysis of intestinal contents promotes an antibacterial response in shrimp intestinal immunity","volume":"735951","author":"Yang","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101462_bb0240","article-title":"Identification of multigene biomarker for shrimp White feces syndrome by full-length transcriptome sequencing","author":"Zeng","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.cbd.2025.101462_bb0245","article-title":"Adaptive immune education by gut microbiota antigens","volume":"28\u201337","author":"Zhao","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.cbd.2025.101462_bb0250","article-title":"Dietary choline regulates antibacterial activity, inflammatory response and barrier function in the gills of grass carp (Ctenopharyngodon idella)","volume":"139\u2013150","author":"Zhao","year":"2016","journal-title":"Fish & Shellfish Immunology"},{"key":"10.1016\/j.cbd.2025.101462_bb0255","article-title":"Contrasting ecological processes and functional compositions between intestinal bacterial community in healthy and diseased shrimp","volume":"975\u2013985","author":"Zhu","year":"2016","journal-title":"Microb. Ecol."}],"container-title":["Comparative Biochemistry and Physiology Part D: Genomics and Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744117X25000504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744117X25000504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T23:04:41Z","timestamp":1762556681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744117X25000504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":50,"alternative-id":["S1744117X25000504"],"URL":"https:\/\/doi.org\/10.1016\/j.cbd.2025.101462","relation":{},"ISSN":["1744-117X"],"issn-type":[{"value":"1744-117X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of intestinal metabolites in Litopenaeus vannamei infected with white faeces syndrome based on untargeted metabolomics","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part D: Genomics and Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbd.2025.101462","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101462"}}