{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:58:00Z","timestamp":1762541880820,"version":"build-2065373602"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011798","name":"Ministry of Agriculture and Rural Affairs of the People's Republic of China","doi-asserted-by":"publisher","award":["20240202"],"award-info":[{"award-number":["20240202"]}],"id":[{"id":"10.13039\/501100011798","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32273117"],"award-info":[{"award-number":["32273117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part D: Genomics and Proteomics"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.cbd.2025.101643","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:04:56Z","timestamp":1758704696000},"page":"101643","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrated application of transcriptomics and metabolomics provides insights into sexual dimorphism in Apostichopus japonicus"],"prefix":"10.1016","volume":"56","author":[{"given":"Jingjing","family":"Cong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abudula","family":"Abulizi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqing","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2024","series-title":"2023 China Fishery Statistical Yearbook","key":"10.1016\/j.cbd.2025.101643_bb0005"},{"key":"10.1016\/j.cbd.2025.101643_bb0010","article-title":"Decoding the role of CYP450 enzymes in metabolism and disease: a comprehensive review","volume":"12","author":"Abdelmonem","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.cbd.2025.101643_bb0015","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1111\/jfb.12372","article-title":"Seasonal and life-phase related differences in growth in Scarus ferrugineus on a southern Red Sea fringing reef","volume":"84","author":"Afeworki","year":"2014","journal-title":"J. Fish Biol."},{"key":"10.1016\/j.cbd.2025.101643_bb0020","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.fsi.2019.10.019","article-title":"Lactobacillus fermentum and\/or ferulic acid improved the immune responses, antioxidative defence and resistance against Aeromonas hydrophila in common carp (Cyprinus carpio) fingerlings","volume":"94","author":"Ahmadifar","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbd.2025.101643_bb0025","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj9466","article-title":"Trade-off between sex and growth in diatoms: molecular mechanisms and demographic implications","volume":"8","author":"Annunziata","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cbd.2025.101643_bb0030","doi-asserted-by":"crossref","first-page":"12110","DOI":"10.1073\/pnas.92.26.12110","article-title":"Activation of a serine\/threonine kinase signaling pathway by transforming growth factor type beta","volume":"92","author":"Atfi","year":"1995","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cbd.2025.101643_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/md16110423","article-title":"Distribution of saponins in the sea cucumber Holothuria lessoni; the body wall versus the viscera, and their biological activities","volume":"16","author":"Bahrami","year":"2018","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.cbd.2025.101643_bb0040","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0044-8486(01)00590-7","article-title":"Monosex male production in finfish as exemplified by tilapia: applications, problems, and prospects","author":"Beardmore","year":"2001","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101643_bb0045","first-page":"1","article-title":"De novo transcriptome analysis of the sandworm (Sipunculus nudus) and identification of differentially expressed genes associated with body size","volume":"72","author":"Cai","year":"2020","journal-title":"Isr. J. Aquac. Bamidgeh."},{"key":"10.1016\/j.cbd.2025.101643_bb0050","series-title":"Echinoderm Aquaculture","first-page":"317","article-title":"Sea cucumber aquaculture in China","author":"Chen","year":"2015"},{"key":"10.1016\/j.cbd.2025.101643_bb0055","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3390\/cells9030662","article-title":"Diversity of RNA-binding proteins modulating post-transcriptional regulation of protein expression in the maturing mammalian oocyte","volume":"9","author":"Christou-Kent","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.cbd.2025.101643_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.740475","article-title":"Sex differences in the growth of sea cucumber (Apostichopus japonicus)","volume":"582","author":"Cong","year":"2024","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101643_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/ph14070629","article-title":"The influence of long-term treatment with asenapine on liver cytochrome p450 expression and activity in the rat. The involvement of different mechanisms","volume":"14","author":"Danek","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.cbd.2025.101643_bb0070","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1530\/ror.0.0020048","article-title":"Reactive oxygen species and sperm physiology","volume":"2","author":"De Lamirande","year":"1997","journal-title":"Rev. Reprod."},{"key":"10.1016\/j.cbd.2025.101643_bb0075","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13783","article-title":"PACSIN proteins in vivo: roles in development and physiology","volume":"234","author":"Dumont","year":"2022","journal-title":"Acta Physiol."},{"key":"10.1016\/j.cbd.2025.101643_bb0080","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1007\/s10499-022-00876-w","article-title":"Dietary astaxanthin modulated the performance, gastrointestinal histology, and antioxidant and immune responses and enhanced the resistance of Litopenaeus vannamei against Vibrio harveyi infection","volume":"30","author":"Eldessouki","year":"2022","journal-title":"Aquac. Int."},{"key":"10.1016\/j.cbd.2025.101643_bb0085","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.aquaculture.2003.08.001","article-title":"Sex ratios in the progeny of androgenetic and gynogenetic YY male Nile tilapia, Oreochromis niloticus L","volume":"232","author":"Ezaz","year":"2004","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101643_bb0090","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1139\/cjfas-2013-0600","article-title":"Trade-offs between growth and reproduction in wild Atlantic cod","volume":"71","author":"Folkvord","year":"2014","journal-title":"Can. J. Fish. Aquat. Sci."},{"key":"10.1016\/j.cbd.2025.101643_bb0095","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41586-023-06669-2","article-title":"Molecular evidence of anteroposterior patterning in adult echinoderms","volume":"623","author":"Formery","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cbd.2025.101643_bb0100","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwac239","article-title":"Origin and chromatin remodeling of young X\/Y sex chromosomes in catfish with sexual plasticity","volume":"10","author":"Gong","year":"2023","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.cbd.2025.101643_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2021.214189","article-title":"The SOUL family of heme-binding proteins: structure and function 15 years later","volume":"448","author":"Goodfellow","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.cbd.2025.101643_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738041","article-title":"A high-density genetic linkage map and QTL mapping for growth related traits in grass carp (Ctenopharyngodon idella)","volume":"552","author":"Guo","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101643_bb0115","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.fsi.2017.02.038","article-title":"Comparative analysis of immunocompetence between females and males in the sea cucumber Apostichopus japonicus","volume":"63","author":"Jiang","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbd.2025.101643_bb0120","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.fsi.2019.04.051","article-title":"Gender specific differences of immune competence in the sea cucumber Apostichopus japonicus before and after spawning","volume":"90","author":"Jiang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbd.2025.101643_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110852","article-title":"Population genomic analysis reveals a polygenic sex determination system in Apostichopus japonicus","volume":"27","author":"Jiang","year":"2024","journal-title":"Iscience"},{"year":"2020","series-title":"YOUMARES 9-The Oceans: Our Research, Our Future: Proceedings of the 2018 Conference for Young Marine Researcher in Oldenburg, Germany","author":"Jungblut","key":"10.1016\/j.cbd.2025.101643_bb0130"},{"key":"10.1016\/j.cbd.2025.101643_bb0135","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1572-5995(08)80006-3","article-title":"Triterpene glycosides from sea cucucmbers (holothurioidea, echinodermata). Biological activities and functions","volume":"35","author":"Kalinin","year":"2008","journal-title":"Stud. Nat. Prod. Chem."},{"key":"10.1016\/j.cbd.2025.101643_bb0140","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cbd.2025.101643_bb0145","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.tig.2024.10.003","article-title":"Yes, polygenic sex determination is a thing!","volume":"40","author":"Kocher","year":"2024","journal-title":"Trends Genet."},{"key":"10.1016\/j.cbd.2025.101643_bb0150","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/ede.12332","article-title":"von Willebrand factor D and EGF domains is an evolutionarily conserved and required feature of blastemas capable of multitissue appendage regeneration","volume":"22","author":"Leigh","year":"2020","journal-title":"Evol. Dev."},{"key":"10.1016\/j.cbd.2025.101643_bb0155","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s11427-021-2075-x","article-title":"Sex determination mechanisms and sex control approaches in aquaculture animals","volume":"65","author":"Li","year":"2022","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.cbd.2025.101643_bb0160","article-title":"Soluble adenylyl cyclase, the cell-autonomous member of the family","volume":"1870","author":"Li","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.cbd.2025.101643_bb0165","article-title":"The formin-like regulates innate immunity and antibacterial immune responses in Scylla paramamosain","author":"Li","year":"2025","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101643_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.830934","article-title":"Effects and mechanism of different phospholipid diets on ovary development in female broodstock Pacific White Shrimp, Litopenaeus vannamei","volume":"9","author":"Liang","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.cbd.2025.101643_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034397","article-title":"Polygenic sex determination system in zebrafish","volume":"7","author":"Liew","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cbd.2025.101643_bb0180","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/raq.12200","article-title":"Astaxanthin as feed supplement in aquatic animals","volume":"10","author":"Lim","year":"2018","journal-title":"Rev. Aquac."},{"key":"10.1016\/j.cbd.2025.101643_bb0185","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/s41586-021-03742-6","article-title":"Structure of a mammalian sperm cation channel complex","volume":"595","author":"Lin","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cbd.2025.101643_bb0190","article-title":"Improving red-color performance, immune response and resistance to Vibrio parahaemolyticus on white shrimp Penaeus vannamei by an engineered astaxanthin yeast","volume":"13","author":"Lin","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbd.2025.101643_bb0195","article-title":"The catsper channel is present and plays a key role in sperm motility of the Atlantic salmon (Salmo salar)","volume":"241","author":"Lissabet","year":"2020","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.cbd.2025.101643_bb0200","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10126-012-9487-7","article-title":"Genetic manipulation of sex ratio for the large-scale breeding of YY super-male and XY all-male yellow catfish (Pelteobagrus fulvidraco (Richardson))","volume":"15","author":"Liu","year":"2013","journal-title":"Mar. Biotechnol."},{"key":"10.1016\/j.cbd.2025.101643_bb0205","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.aquaculture.2018.01.012","article-title":"De novo sequencing and transcriptome analysis of Stichopus horrens to reveal genes related to biosynthesis of triterpenoids","volume":"491","author":"Liu","year":"2018","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101643_bb0210","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210190","article-title":"tRNA copy number and codon usage in the sea cucumber genome provide insights into adaptive translation for saponin biosynthesis","volume":"11","author":"Liu","year":"2021","journal-title":"Open Biol."},{"key":"10.1016\/j.cbd.2025.101643_bb0215","article-title":"Identification and functional analysis of Dmrt1 gene and the SoxE gene in the sexual development of sea cucumber, Apostichopus japonicus","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Genet."},{"key":"10.1016\/j.cbd.2025.101643_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygcen.2024.114464","article-title":"Characterization of insulin-like growth factor 3 and its potential role in the spotted steed Hemibarbus maculatus ovary development","volume":"349","author":"Liu","year":"2024","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.cbd.2025.101643_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.735854","article-title":"The role of myosin-9 in Scylla paramamosain against Vibrio alginolyticus and white spot syndrome virus infection","volume":"531","author":"Ma","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101643_bb0230","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1007\/BF01897485","article-title":"Distribution and seasonal variation of toxic principles of sea-cucumber (Holothuria leucospilota brandt)","volume":"25","author":"Matsuno","year":"1969","journal-title":"Experientia"},{"key":"10.1016\/j.cbd.2025.101643_bb0235","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s11427-014-4797-9","article-title":"Genetic basis and biotechnological manipulation of sexual dimorphism and sex determination in fish","volume":"58","author":"Mei","year":"2015","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.cbd.2025.101643_bb0240","first-page":"183","article-title":"The breeding pattern and variations in timing and reproductive output of the commercial sea cucumber Holothuria fuscogilva in Kenya","volume":"8","author":"Muthiga","year":"2009","journal-title":"West. Indian Ocean J. Mar. Sci."},{"key":"10.1016\/j.cbd.2025.101643_bb0245","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1194\/jlr.M006429","article-title":"Differentiation-related changes in lipid classes with long-chain and very long-chain polyenoic fatty acids in rat spermatogenic cells","volume":"51","author":"Oresti","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cbd.2025.101643_bb0250","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1530\/REP-13-0199","article-title":"Cell-type-specific regulation of genes involved in testicular lipid metabolism: fatty acid-binding proteins, diacylglycerol acyltransferases and perilipin 2","volume":"146","author":"Oresti","year":"2013","journal-title":"Reproduction"},{"year":"2023","series-title":"Impact of Astaxanthin-enriched Bacterium (Paracoccus carotinifaciens) on Growth, Immune Response, and Reproduction Performance of Broodstock Nile Tilapia During Winter Season","author":"Panase","key":"10.1016\/j.cbd.2025.101643_bb0260"},{"key":"10.1016\/j.cbd.2025.101643_bb0265","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cbd.2025.101643_bb0270","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1002\/jcp.25754","article-title":"Deregulated ALG-2\/HEBP2 axis alters microtubule dynamics and mitotic spindle behavior to stimulate cancer development","volume":"232","author":"Qin","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.cbd.2025.101643_bb0275","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.aquaculture.2005.11.028","article-title":"Effects of different long-day photoperiods on somatic growth and gonadal development in Nile tilapia (Oreochromis niloticus L.)","volume":"255","author":"Rad","year":"2006","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101643_bb0280","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35098027","article-title":"A sperm ion channel required for sperm motility and male fertility","volume":"413","author":"Ren","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cbd.2025.101643_bb0285","series-title":"Stem Cells in Marine Organisms","first-page":"245","article-title":"Regeneration in Hemichordates and echinoderms","author":"Rychel","year":"2009"},{"key":"10.1016\/j.cbd.2025.101643_bb0290","first-page":"2411","article-title":"A review on physiological, behavioral and metabolic role of dietary tryptophan in fish","volume":"8","author":"Sahu","year":"2020","journal-title":"Int. J. Chem. Sci."},{"key":"10.1016\/j.cbd.2025.101643_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2023.105906","article-title":"Chilean sea cucumber: New potential source of biomolecules with high nutritional value and cytotoxic activity","volume":"126","author":"Silva-Ram\u00edrez","year":"2024","journal-title":"J. Food Compos. Anal."},{"key":"10.1016\/j.cbd.2025.101643_bb0300","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1095\/biolreprod.113.110874","article-title":"Gonad differentiation in zebrafish is regulated by the canonical Wnt signaling pathway","volume":"90","author":"Sreenivasan","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.cbd.2025.101643_bb0305","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1023\/A:1007783213963","article-title":"Activity and expression of aspartate aminotransferase during the reproductive cycle of a fresh water fish, Clarias batrachus","volume":"20","author":"Srivastava","year":"1999","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.cbd.2025.101643_bb0310","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cbd.2025.101643_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpb.2020.110536","article-title":"Identification and functional characterization of piwi1 gene in sea cucumber, Apostichopus japonicas","volume":"252","author":"Sun","year":"2021","journal-title":"Comp. Biochem. Physiol. B: Biochem. Mol. Biol."},{"key":"10.1016\/j.cbd.2025.101643_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.gep.2022.119245","article-title":"Identification and functional analysis of foxl2 and nodal in sea cucumber, Apostichopus japonicus","volume":"44","author":"Sun","year":"2022","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.cbd.2025.101643_bb0325","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1365-2109.1994.tb00668.x","article-title":"Reproductive strategies in Atlantic salmon, Salmo salar L","volume":"25","author":"Thorpe","year":"1994","journal-title":"Aquac. Res."},{"key":"10.1016\/j.cbd.2025.101643_bb0330","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jsbmb.2013.01.003","article-title":"Zebrafish and steroids: what do we know and what do we need to know?","volume":"137","author":"Tokarz","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.cbd.2025.101643_bb0335","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cbd.2025.101643_bb0340","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/j.1365-2052.2009.01941.x","article-title":"Isolation of Y-and X-linked SCAR markers in yellow catfish and application in the production of all-male populations","volume":"40","author":"Wang","year":"2009","journal-title":"Anim. Genet."},{"key":"10.1016\/j.cbd.2025.101643_bb0345","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.aquaculture.2014.08.021","article-title":"In vitro non-specific immunostimulatory effect of alginate oligosaccharides with different molecular weights and compositions on sea cucumber (Apostichopus japonicus) coelomocytes","volume":"434","author":"Wang","year":"2014","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101643_bb0350","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/s12864-022-08632-3","article-title":"Identification of sex determination locus in sea cucumber Apostichopus japonicus using genome-wide association study","volume":"23","author":"Wang","year":"2022","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cbd.2025.101643_bb0355","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1095\/biolreprod.107.060558","article-title":"Polyunsaturated fatty acids in male and female reproduction1","volume":"77","author":"Wathes","year":"2007","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.cbd.2025.101643_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737021","article-title":"A rapid and reliable method for genetic sex identification in sea cucumber, Apostichopus japonicus","volume":"543","author":"Wei","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101643_bb0365","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ydbio.2006.05.038","article-title":"Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization","volume":"296","author":"Xie","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cbd.2025.101643_bb0370","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.gep.2013.03.001","article-title":"Expression pattern of vasa in gonads of sea cucumber Apostichopus japonicus during gametogenesis and reproductive cycle","volume":"13","author":"Yan","year":"2013","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.cbd.2025.101643_bb0375","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3390\/jpm11030194","article-title":"Estrogen sulfotransferase (SULT1E1): its molecular regulation, polymorphisms, and clinical perspectives","volume":"11","author":"Yi","year":"2021","journal-title":"J. Personalized Med."},{"key":"10.1016\/j.cbd.2025.101643_bb0380","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1111\/are.13319","article-title":"Semisynthetic ferulic acid derivative: an efficient feed additive for Genetically Improved Farmed Tilapia (Oreochromis niloticus)","volume":"48","author":"Yu","year":"2017","journal-title":"Aquac. Res."},{"key":"10.1016\/j.cbd.2025.101643_bb0385","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2003790","article-title":"The sea cucumber genome provides insights into morphological evolution and visceral regeneration","volume":"15","author":"Zhang","year":"2017","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cbd.2025.101643_bb0390","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.aquaculture.2019.05.035","article-title":"Diacylglycerol oil reduces fat accumulation and increases protein content by inducing lipid catabolism and protein metabolism in Nile tilapia (Oreochromis niloticus)","volume":"510","author":"Zhang","year":"2019","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101643_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbd.2021.100790","article-title":"Transcriptome analysis of gender-biased CYP genes in gonads of the sea cucumber Apostichopus japonicus","volume":"38","author":"Zhang","year":"2021","journal-title":"Comp. Biochem. Physiol. Part D Genomics Proteomics"},{"key":"10.1016\/j.cbd.2025.101643_bb0400","article-title":"Relationship between single nucleotide polymorphism of IGF-1 gene in Nile tilapia (Oreochromis niloticus) and weight gain","author":"Zhang","year":"2022","journal-title":"Authorea Preprints."},{"key":"10.1016\/j.cbd.2025.101643_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738787","article-title":"Examination of sex-related differences in intestinal and gonadal lipid metabolism in the sea cucumber Apostichopus japonicus","volume":"562","author":"Zhang","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbd.2025.101643_bb0410","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0235043","article-title":"Metabolomics and gene expressions revealed the metabolic changes of lipid and amino acids and the related energetic mechanism in response to ovary development of Chinese sturgeon (Acipenser sinensis)","volume":"15","author":"Zhu","year":"2020","journal-title":"PLoS One"}],"container-title":["Comparative Biochemistry and Physiology Part D: Genomics and Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744117X25002321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744117X25002321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:50:44Z","timestamp":1762541444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744117X25002321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":81,"alternative-id":["S1744117X25002321"],"URL":"https:\/\/doi.org\/10.1016\/j.cbd.2025.101643","relation":{},"ISSN":["1744-117X"],"issn-type":[{"type":"print","value":"1744-117X"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated application of transcriptomics and metabolomics provides insights into sexual dimorphism in Apostichopus japonicus","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part D: Genomics and Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbd.2025.101643","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101643"}}