{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:10:04Z","timestamp":1792725004081,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004084","name":"Korea Science and Engineering Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013391","name":"Ministry of Education and Human Resources Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.cbi.2006.03.008","type":"journal-article","created":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T07:10:13Z","timestamp":1143529813000},"page":"125-138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":105,"title":["Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine"],"prefix":"10.1016","volume":"161","author":[{"given":"Young Woo","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hwan","family":"Ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Rok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Chan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Geon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2006.03.008_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1207\/S15327914nc391_1","article-title":"Licorice and cancer","volume":"39","author":"Wang","year":"2001","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.cbi.2006.03.008_bib2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/10715760400027888","article-title":"Glycyrrhizae radix attenuates peroxynitrite-induced renal oxidative damage through inhibition of protein nitration","volume":"39","author":"Yokozawa","year":"2005","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.cbi.2006.03.008_bib3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0027-5107(01)00200-7","article-title":"Cell proliferation in cancer prevention: effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cells","volume":"480\/481","author":"Mori","year":"2001","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.cbi.2006.03.008_bib4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0014-2999(03)01728-X","article-title":"Antitussive principles of Glycyrrhizae radix, a main component of the Kampo preparations Bakumondo-to (Mai-men-dong-tang)","volume":"469","author":"Kamei","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbi.2006.03.008_bib5","first-page":"233","article-title":"Glycyrrhizin induces apoptosis in human stomach cancer KATO III and human promyelotic leukemia HL-60 cells","volume":"16","author":"Hibasami","year":"2005","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.cbi.2006.03.008_bib6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000084114","article-title":"Glycyrrhizin inhibits R5 HIV replication in peripheral blood monocytes treated with 1-methyladenosine","volume":"72","author":"Takei","year":"2005","journal-title":"Pathobiology"},{"key":"10.1016\/j.cbi.2006.03.008_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.tox.2004.01.010","article-title":"Cytoprotective effects of Glycyrrhizae radix extract and its active component liquiritigenin against cadmium-induced toxicity: effects on bad translocation and cytochrome c-mediated PARP cleavage","volume":"197","author":"Kim","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.cbi.2006.03.008_bib8","series-title":"Hepatology","first-page":"759","article-title":"Drug-induced liver disease","author":"Zakin","year":"1990"},{"key":"10.1016\/j.cbi.2006.03.008_bib9","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1016\/S0021-9258(19)67754-9","article-title":"Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes","volume":"266","author":"Burcham","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2006.03.008_bib10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.cbi.2005.04.006","article-title":"Garlic oil and DDB, comprised in a pharmaceutical composition for the treatment of patients with viral hepatitis, prevents acute liver injuries potentiated by glutathione deficiency in rats","volume":"155","author":"Park","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2006.03.008_bib11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jhep.2004.09.015","article-title":"Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice","volume":"42","author":"Masubuchi","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2006.03.008_bib12","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1021\/tx950153d","article-title":"Mechanism of acetaminophen-induced hepatotoxicity: covalent binding versus oxidative stress","volume":"9","author":"Gibson","year":"1996","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbi.2006.03.008_bib13","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0022-3565(25)29665-3","article-title":"Acetaminophen-induced hepatic necrosis. III. Cytochrome-P450-mediated covalent binding in vitro","volume":"187","author":"Potter","year":"1973","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cbi.2006.03.008_bib14","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0006-2952(01)00780-8","volume":"62","author":"Son","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2006.03.008_bib15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0378-4274(03)00233-9","article-title":"Cadmium-induced non-apoptotic cell death mediated by oxidative stress under the condition of sulfhydryl deficiency","volume":"144","author":"Kim","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbi.2006.03.008_bib16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0009-2797(01)00286-1","article-title":"Inhibition of dimethylnitrosamine-induced liver fibrosis by [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) in rats: suppression of transforming growth factor-beta1 and tumor necrosis factor-alpha expression","volume":"139","author":"Kang","year":"2002","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2006.03.008_bib17","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1093\/clinchem\/24.11.1971","article-title":"Aspartate aminotransferase activity and isoenzyme proportions in human liver tissues","volume":"24","author":"Rej","year":"1978","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cbi.2006.03.008_bib18","series-title":"Diseases of the Liver and Biliary System","author":"Sherlock","year":"2002"},{"key":"10.1016\/j.cbi.2006.03.008_bib19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0378-8741(94)90084-1","article-title":"The effect of Chinese hepatoprotective medicines on experimental liver injury in mice","volume":"42","author":"Liu","year":"1994","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2006.03.008_bib20","first-page":"246","article-title":"Hepatotoxicity in acetaminophen poisoning","volume":"52","author":"Ferguson","year":"1977","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.cbi.2006.03.008_bib21","series-title":"A Histopathologic Classification of chemical-induced Injury of the Liver, Hepatotoxicology","author":"Meeks","year":"1991"},{"key":"10.1016\/j.cbi.2006.03.008_bib22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0378-4274(01)00523-9","article-title":"Role of glutathione in metabolic degradation of dichloromethane in rats","volume":"129","author":"Oh","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbi.2006.03.008_bib23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/hep.20300","article-title":"Acetaminophen misconceptions","volume":"40","author":"Rumack","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2006.03.008_bib24","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/hep.20293","article-title":"Acetaminophen and the U.S. acute liver failure study group: lowering the risks of hepatic failure","volume":"40","author":"Lee","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2006.03.008_bib25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0022-3565(25)29663-X","article-title":"Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism","volume":"187","author":"Mitchell","year":"1973","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cbi.2006.03.008_bib26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-3565(25)29664-1","article-title":"Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo","volume":"187","author":"Jollow","year":"1973","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cbi.2006.03.008_bib27","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/hep.20703","article-title":"AASLD position paper: the management of acute liver failure","volume":"41","author":"Polson","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2006.03.008_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1248\/bpb.22.93","article-title":"Effect of dimethyl-4,4\u2032-dimethoxy-5,6,5\u2032,6\u2032-dimethylenedioxybiphenyl-2,2\u2032-dicarboxylate (DDB) on chemical-induced liver injury","volume":"22","author":"Kim","year":"1999","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.cbi.2006.03.008_bib29","first-page":"300","article-title":"The effect of dimethyl dimethoxy biphenyl dicarboxylate (DDB) against tamoxifen-induced liver injury in rats: DDB use is curative or protective","volume":"38","author":"El-Beshbishy","year":"2005","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1016\/j.cbi.2006.03.008_bib30","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/hep.510260436","article-title":"Correlation of biochemical response to interferon alfa with histological improvement in hepatitis C: a meta-analysis of diagnostic test characteristics","volume":"26","author":"Bonis","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2006.03.008_bib31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1034\/j.1600-0676.2000.020004319.x","article-title":"Inhibition of lipopolysaccharide-induced I-kappaB degradation and tumor necrosis factor-alpha expression by dimethyl-4,4\u2032-dimethoxy-5,6,5\u2032,6\u2032-dimethylene dioxybiphenyl-2,2\u2032-dicarboxylate (DDB): minor role in hepatic detoxifying enzyme expression","volume":"20","author":"Kim","year":"2000","journal-title":"Liver"},{"key":"10.1016\/j.cbi.2006.03.008_bib32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejphar.2004.11.042","article-title":"Pharmacokinetic and pharmacodynamic profiles of the antitussive principles of Glycyrrhizae radix (licorice), a main component of the Kampo preparation Bakumondo-to (Mai-men-dong-tang)","volume":"507","author":"Kamei","year":"2005","journal-title":"Eur. J. Pharmacol."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279706000603?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279706000603?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:43:30Z","timestamp":1762112610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279706000603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0009279706000603"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2006.03.008","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2006.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}