{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:06:33Z","timestamp":1784077593882,"version":"3.55.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.cbi.2007.08.003","type":"journal-article","created":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T07:23:14Z","timestamp":1187076194000},"page":"209-220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"title":["Response of lead-induced oxidative stress and alterations in biogenic amines in different rat brain regions to combined administration of DMSA and MiADMSA"],"prefix":"10.1016","volume":"170","author":[{"given":"S.J.S.","family":"Flora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetu","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratibha","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpinder","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran Dip","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2007.08.003_bib1","series-title":"Lead: Chemistry, Analytical Aspects, Environmental Impacts and Health Effects","first-page":"158","article-title":"Environmental occurrence, health effects and management of lead poisoning","author":"Flora","year":"2006"},{"key":"10.1016\/j.cbi.2007.08.003_bib2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1124\/jpet.107.121996","article-title":"Reversal of lead-induced neuronal apoptosis by chelation treatment in rats: role of ROS and intracellular Ca2+","volume":"322","author":"Flora","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cbi.2007.08.003_bib3","series-title":"Toxicological Profile for Lead","author":"ATSDR","year":"1999"},{"key":"10.1016\/j.cbi.2007.08.003_bib4","series-title":"Measuring Lead Exposure in Infants, Children and other Sensitive Populations","author":"NRC","year":"1999"},{"key":"10.1016\/j.cbi.2007.08.003_bib5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00244-004-0025-0","article-title":"Effects of N-acetylcysteine on lead exposed PC-12 cells","volume":"49","author":"Aykin- Burns","year":"2005","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.cbi.2007.08.003_bib6","first-page":"417","article-title":"Biochemical and ultra structural evidences for toxicity of lead through free radicals in rat brain","volume":"22","author":"Soltaninejad","year":"2002","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.cbi.2007.08.003_bib7","first-page":"199","article-title":"Dimercaptosuccinic acid (DMSA) a non-toxic, water-soluble treatment for heavy metal toxicity","volume":"3","author":"Miller","year":"1998","journal-title":"Alter. Med. Res."},{"key":"10.1016\/j.cbi.2007.08.003_bib8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.pa.30.040190.001431","article-title":"Meso-2,3-dimercapto-succinic acid: chemical, pharmacological and toxicological properties of an orally effective metal chelating agent","volume":"30","author":"Aposhian","year":"1990","journal-title":"Ann. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.cbi.2007.08.003_bib9","series-title":"Coordination Chemistry: A Century of Progress","first-page":"427","article-title":"Design of new chelating agents for removal of intracellular toxic metals","author":"Jones","year":"1994"},{"key":"10.1016\/j.cbi.2007.08.003_bib10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0022-3476(88)80396-2","article-title":"Dose response study of oral 2,3-dimercaptosuccinic acid in children with elevated lead concentrations","volume":"113","author":"Graziano","year":"1988","journal-title":"J. Pediatr."},{"key":"10.1016\/j.cbi.2007.08.003_bib11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0022-3565(25)21043-6","article-title":"Mobilization of lead over the course of DMSA chelation therapy and long term efficacy","volume":"246","author":"Cory Slechta","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cbi.2007.08.003_bib12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/faat.1995.1059","article-title":"Combined therapeutic potential of meso 2,3-dimercaptosuccinic acid and calcium disodium edetate in the mobilization and distribution of lead in experimental lead intoxication in rats","volume":"25","author":"Flora","year":"1995","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.cbi.2007.08.003_bib13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/jbt.20027","article-title":"Lead induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats","volume":"18","author":"Saxena","year":"2004","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.cbi.2007.08.003_bib14","first-page":"211","article-title":"Trends in the management of childhood lead poisonings","volume":"14","author":"Rosen","year":"1993","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.cbi.2007.08.003_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1382-6689(01)00064-3","article-title":"Combined administration of a chelating agent and an antioxidant in the prevention and treatment of acute lead intoxication in rats","volume":"9","author":"Pande","year":"2001","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbi.2007.08.003_bib16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tox.2005.05.026","article-title":"Beneficial role of monoesters of meso 2,3-dimercaptosuccinic acid in the mobilization of lead and recovery of tissue oxidative injury in rats","volume":"214","author":"Saxena","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.cbi.2007.08.003_bib17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.tox.2003.09.010","article-title":"Therapeutic potential of monoisoamyl and monomethyl esters of meso-2,3-dimercaptosuccinic acid in gallium arsenide intoxicated rats","volume":"195","author":"Flora","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.cbi.2007.08.003_bib18","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1016\/j.lfs.2005.04.016","article-title":"Arsenic induced blood and brain oxidative stress and its response to some thiol chelators in rats","volume":"77","author":"Flora","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.cbi.2007.08.003_bib19","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1289\/ehp.01109613","article-title":"Oral succimer decreases the gastrointestinal absorption of lead in juvenile monkeys","volume":"109","author":"Cremin","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cbi.2007.08.003_bib20","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1021\/cr980453a","article-title":"Principles and recent developments in chelation treatment of metal intoxication","volume":"99","author":"Andersen","year":"1999","journal-title":"Chem. Rev."},{"key":"10.1016\/j.cbi.2007.08.003_bib21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/taap.2000.8973","article-title":"Succimer and the reduction of tissue lead in juvenile monkeys","volume":"166","author":"Smith","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2007.08.003_bib22","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1600-0773.1992.tb00483.x","article-title":"Cadmium mobilization in vivo by intraperitoneal or oral administration of mono alkyl esters of meso 2,3-dimercaptosuccinic acid","volume":"70","author":"Jones","year":"1992","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.cbi.2007.08.003_bib23","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/S0022-3476(97)70285-3","article-title":"Comparison of dimercaptosuccinic acid and calcium disodium ethylenediaminetetraacetic acid versus dimercaptopropanol and ethylenediaminetetraacetic acid in children with lead poisoning","volume":"130","author":"Besunder","year":"1997","journal-title":"J. Pediatr."},{"key":"10.1016\/j.cbi.2007.08.003_bib24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/(SICI)1099-1263(199905\/06)19:3<143::AID-JAT562>3.0.CO;2-G","article-title":"Combined chelation therapy in reducing tissue lead concentration in suckling rats","volume":"19","author":"Kostial","year":"1999","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.cbi.2007.08.003_bib25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0300-483X(98)00074-2","article-title":"Antioxidant effects of N-acetyl cysteine and succimer in red blood cells from lead exposed rats","volume":"128","author":"Gurer","year":"1998","journal-title":"Toxicology"},{"key":"10.1016\/j.cbi.2007.08.003_bib26","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/jat.871","article-title":"Hematological, hepatic and renal alterations after repeated oral or intraperitoneal administration of monoisoamyl DMSA. I. Changes in male rats","volume":"22","author":"Mehta","year":"2002","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.cbi.2007.08.003_bib27","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1471-4159.1966.tb09873.x","article-title":"Regional studies of catecholamine in the rat brain-IR the disposition of [3H] norepinephrine, [3H] dopamine and [3H] dopa in various regions of the brain","volume":"13","author":"Glowinski","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cbi.2007.08.003_bib28","first-page":"389","article-title":"European standardized method for the determination of delta aminolevulinic dehydratase in blood","volume":"12","author":"Berlin","year":"1974","journal-title":"Z. Klin. Chem. Klin. Biochem."},{"key":"10.1016\/j.cbi.2007.08.003_bib29","first-page":"130","article-title":"A modified spectrophotometric assay of superoxide dismutase","volume":"21","author":"Kakkar","year":"1984","journal-title":"Ind. J. Biochem. Biophys."},{"key":"10.1016\/j.cbi.2007.08.003_bib30","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1211\/jpp.58.4.0015","article-title":"Changes in brain biogenic amines and haem-biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats","volume":"58","author":"Saxena","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.cbi.2007.08.003_bib31","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jat.2550150409","article-title":"Relative efficacy of chelating agents on excretion and tissue distribution of manganese in mice","volume":"15","author":"Sanchez","year":"1995","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.cbi.2007.08.003_bib32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF03259591","article-title":"Biochemical and immunological evaluation of metal chelating drugs in rats","volume":"5","author":"Flora","year":"1993","journal-title":"Drug Invest."},{"key":"10.1016\/j.cbi.2007.08.003_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1539\/joh.47.1","article-title":"Strategies for safe and effective therapeutic measures for chronic arsenic and lead poisoning","volume":"47","author":"Kalia","year":"2005","journal-title":"J. Occup. Health"},{"key":"10.1016\/j.cbi.2007.08.003_bib34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0300-483X(93)90155-L","article-title":"Meso-2,3-dimercaptosuccinic acid monoalkyl esters: effects on mercury levels in mice","volume":"81","author":"Gale","year":"1993","journal-title":"Toxicology"},{"key":"10.1016\/j.cbi.2007.08.003_bib35","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/faat.1995.1094","article-title":"Antidotal efficacy of newly synthesized dimercaptosuccinic acid (DMSA) monoesters in experimental poisoning in mice","volume":"26","author":"Kreppel","year":"1995","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.cbi.2007.08.003_bib36","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/15287399509531995","article-title":"Effect of mono isoamyl meso-2,3-dimercaptosuccinate on pathology of acute cadmium intoxication","volume":"45","author":"Xu","year":"1995","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.cbi.2007.08.003_bib37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0300-483X(92)90020-F","article-title":"Mobilization of lead in mice by administration of monoalkyl esters of meso 2,3-dimercaptosuccinic acid","volume":"76","author":"Walker","year":"1992","journal-title":"Toxicology"},{"key":"10.1016\/j.cbi.2007.08.003_bib38","first-page":"323","article-title":"Monoisoamyl meso 2, 3-dimercaptosuucinate: interaction with metallothionein bound cadmium in vitro and evidence of active transport into renal and hepatic cells in vivo","volume":"76","author":"Tasende","year":"1992","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.cbi.2007.08.003_bib39","first-page":"103","article-title":"Alterations in some membrane properties in rat brain following exposure to lead","volume":"103","author":"Flora","year":"2000","journal-title":"Cytobios"},{"key":"10.1016\/j.cbi.2007.08.003_bib40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0891-5849(92)90071-N","article-title":"Lead induced lipid peroxidation and antioxidant defense components of developing chick embryos","volume":"13","author":"Somashekariah","year":"1992","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2007.08.003_bib41","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s002440010102","article-title":"A role for oxidative stress in suppressing serum immunoglobulin levels in lead-exposed Fisher 344 rats","volume":"39","author":"Ercal","year":"2000","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.cbi.2007.08.003_bib42","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0891-5849(00)00413-5","article-title":"Can antioxidants be beneficial in the treatment of lead poisoning?","volume":"29","author":"Gurer","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2007.08.003_bib43","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF00378406","article-title":"Biomonitoring lead exposure with ALAD activity ratios","volume":"51","author":"Farrant","year":"1982","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.cbi.2007.08.003_bib44","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF02789081","article-title":"Effect of lead on lipid peroxidation in liver of rats","volume":"48","author":"Sandhir","year":"1995","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.cbi.2007.08.003_bib45","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0891-5849(96)00020-2","article-title":"In vivo indices of oxidative stress in lead exposed C57BL\/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetyl cysteine","volume":"21","author":"Ercal","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2007.08.003_bib46","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0278-6915(01)00046-1","article-title":"Possible role of metal redistribution, hepatotoxicity and oxidative stress in chelating agents\u2019 induced hepatic and renal metallothionein in rats","volume":"39","author":"Mehta","year":"2001","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2007.08.003_bib47","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/(SICI)1099-1263(199609)16:5<431::AID-JAT372>3.0.CO;2-H","article-title":"Neurotoxic effects of gestational administration of low-dose lead acetate","volume":"16","author":"Antonio","year":"1996","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.cbi.2007.08.003_bib48","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0031-6989(80)80115-9","article-title":"Brain neurotransmitter system and chronic lead intoxication","volume":"12","author":"Govoni","year":"1980","journal-title":"Pharmacol. Res. Commun."},{"key":"10.1016\/j.cbi.2007.08.003_bib49","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1146\/annurev.pa.35.040195.002135","article-title":"Relationship between lead-induced learning impairment and changes in dopaminergic, cholinergic and glutamatergic neurotransmitter system function","volume":"35","author":"Cory-Slechta","year":"1995","journal-title":"Ann. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.cbi.2007.08.003_bib50","first-page":"209","article-title":"Postnatal lead exposure and MK-801 sensitivity","volume":"18","author":"Cory Slechta","year":"1997","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.cbi.2007.08.003_bib51","first-page":"509","article-title":"Post weaning lead exposure enhances the stimulus properties of N-methyl-d-aspartate: possible dopaminergic involvement?","volume":"17","author":"Cory-Slechta","year":"1996","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.cbi.2007.08.003_bib52","series-title":"Handbook of Neurotoxicology","first-page":"61","article-title":"Lead neurotoxicity","author":"Cory-Slechta","year":"1995"},{"key":"10.1016\/j.cbi.2007.08.003_bib53","first-page":"79","article-title":"Recoveries in lead induced alteration in rat brain biogenic amines levels following combined chelation therapy with meso 2,3-dimercaptosuccinic acid and calcium disodium versenate","volume":"13","author":"Flora","year":"1997","journal-title":"Biogenic Amines"},{"key":"10.1016\/j.cbi.2007.08.003_bib54","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1023\/A:1022596115897","article-title":"Molecular mechanisms of lead neurotoxicity","volume":"24","author":"Bressler","year":"1999","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.cbi.2007.08.003_bib55","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0892-0362(97)00075-5","article-title":"Relations of bone and blood lead to cognitive function: the VA Normative Aging Study","volume":"20","author":"Payton","year":"1998","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.cbi.2007.08.003_bib56","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/0006-8993(96)00665-8","article-title":"Chronic developmental lead exposure increases the threshold for long-term potentiation in rat dentate gyrus in vivo","volume":"736","author":"Gilbert","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.cbi.2007.08.003_bib57","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0009-2797(03)00025-5","article-title":"Beneficial effect of combined administration of some naturally occurring antioxidants (vitamins) and thiol chelators in the treatment of chronic lead intoxication","volume":"145","author":"Flora","year":"2002","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2007.08.003_bib58","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.reprotox.2005.05.008","article-title":"Monoisoamyl dimercaptosuccinic acid induced changes in pregnant female rats during late gestation and lactation","volume":"21","author":"Mehta","year":"2006","journal-title":"Rep. Toxicol."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279707002591?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279707002591?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:14:19Z","timestamp":1757855659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279707002591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0009279707002591"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2007.08.003","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Response of lead-induced oxidative stress and alterations in biogenic amines in different rat brain regions to combined administration of DMSA and MiADMSA","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2007.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}