{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:11:37Z","timestamp":1772752297152,"version":"3.50.1"},"reference-count":121,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.cbi.2008.02.007","type":"journal-article","created":{"date-parts":[[2008,4,9]],"date-time":"2008-04-09T09:19:49Z","timestamp":1207732789000},"page":"148-158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Salubrious effect of Kalpaamruthaa, a modified indigenous preparation in adjuvant-induced arthritis in rats\u2014A biochemical approach"],"prefix":"10.1016","volume":"173","author":[{"given":"Rajendran","family":"Mythilypriya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palanivelu","family":"Shanthi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panchanadam","family":"Sachdanandam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2008.02.007_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1254\/jphs.FP0050637","article-title":"Anti-arthritic effects of Ephedra sinica STAPF herb-acupuncture: inhibition of lipopolysaccharide-induced inflammation and adjuvant-induced polyarthritis","volume":"100","author":"Yeom","year":"2006","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.cbi.2008.02.007_bib2","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/rheumatology\/37.5.546","article-title":"The clinical management of rheumatoid arthritis and osteoarthritis: strategies for improving clinical effectiveness","volume":"37","author":"Scott","year":"1998","journal-title":"Br. J. Rheumatol."},{"key":"10.1016\/j.cbi.2008.02.007_bib3","doi-asserted-by":"crossref","unstructured":"R. Mythilypriya, P. Shanthi, P. Sachdanandam, Oral acute and subacute toxicity studies with Kalpaamruthaa, a modified indigenous preparation, on rats, J. Health Sci. 54 (2007) 351\u2013358.","DOI":"10.1248\/jhs.53.351"},{"key":"10.1016\/j.cbi.2008.02.007_bib4","doi-asserted-by":"crossref","unstructured":"R. Mythilypriya, P. Shanthi, P. Sachdanandam, Restorative and synergistic efficacy of Kalpaamruthaa, a modified Siddha preparation, on an altered antioxidant status in adjuvant induced arthritic rat model, Chem. Bio. Int. 168 (2007) 193\u2013202","DOI":"10.1016\/j.cbi.2007.04.005"},{"key":"10.1016\/j.cbi.2008.02.007_bib5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cbi.2007.01.013","article-title":"Alteration of DMBA-induced oxidative stress by additive action of a modified indigenous preparation-Kalpaamruthaa","volume":"167","author":"Arulkumaran","year":"2007","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2008.02.007_bib6","doi-asserted-by":"crossref","unstructured":"R. Mythilypriya, P. Shanthi, P. Sachdanandam, Analgesic, antipyretic and Ulcerogenic properties of an indigenous formulation\u2014Kalpaamruthaa, Phytother. Res. 21 (2007) 574\u2013578.","DOI":"10.1002\/ptr.2116"},{"key":"10.1016\/j.cbi.2008.02.007_bib7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1248\/bpb.29.565","article-title":"Anticancer effect of Kalpaamruthaa on mammary carcinoma in rats with reference to glycoprotein components, lysosomal and marker enzymes","volume":"29","author":"Veena","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.cbi.2008.02.007_bib8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cbi.2006.03.003","article-title":"The biochemical alterations following administration of Kalpaamruthaa and Semecarpus anacardium in mammary carcinoma","volume":"161","author":"Veena","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2008.02.007_bib9","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/S0031-9422(00)84056-X","article-title":"A bioflavanoid from Semecarpus anacardium","volume":"22","author":"Murthy","year":"1983","journal-title":"Phytochemistry"},{"key":"10.1016\/j.cbi.2008.02.007_bib10","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0031-9422(00)83184-2","article-title":"Jeediflavanone\u2014a bioflavanoid from Semecarpus anacardium","volume":"24","author":"Murthy","year":"1985","journal-title":"Phytochemistry"},{"key":"10.1016\/j.cbi.2008.02.007_bib11","first-page":"398","article-title":"Naturally occurring biflavanoid derivatives part VII galluflavanone a new flavanoid from Semecarpus anacardium Linn","volume":"24","author":"Murthy","year":"1985","journal-title":"Indian J. Chem."},{"key":"10.1016\/j.cbi.2008.02.007_bib12","first-page":"632","article-title":"New dimeric flavone from Semecarpus anacardium Linn","volume":"53","author":"Murthy","year":"1987","journal-title":"Proc. Indian Natl. Sci. Acad."},{"key":"10.1016\/j.cbi.2008.02.007_bib13","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1016\/0031-9422(88)80721-0","article-title":"Naturally occurring biflavanoid derivatives. Part X. Semecarpetin, a bioflavonone from Semecarpus anacardium","volume":"27","author":"Murthy","year":"1988","journal-title":"Phytochemistry"},{"key":"10.1016\/j.cbi.2008.02.007_bib14","first-page":"33","article-title":"New bioflavonoid from Semecarpus anacardium Linn","volume":"20","author":"Murthy","year":"1992","journal-title":"Clin. Acta Turcica"},{"key":"10.1016\/j.cbi.2008.02.007_bib15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0891-5849(95)00011-L","article-title":"Interaction of flavonoids with ascorbate and determination of their univalent redox potentials: a pulse radiolysis study","volume":"19","author":"Bors","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2008.02.007_bib16","first-page":"941","article-title":"Active constituents of Emblica officinalis. Part I. The chemistry and anti-oxidant effect of two new hydrolysable tannins, Emblicanin A & B","volume":"35","author":"Ghosal","year":"1996","journal-title":"Indian J. Chem."},{"key":"10.1016\/j.cbi.2008.02.007_bib17","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1248\/bpb.27.2028","article-title":"Antiinflammatory effect of Semecarpus anacardium Linn. Nut extract in acute and chronic inflammatory conditions","volume":"27","author":"Ramprasath","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.cbi.2008.02.007_bib18","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1248\/bpb.29.693","article-title":"Immunomodulatory and anti-inflammatory effects of Semecarpus anacardium Linn. Nut milk extract in experimental inflammatory conditions","volume":"29","author":"Ramprasath","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.cbi.2008.02.007_bib19","first-page":"1177","article-title":"Semecarpus anacardium Linn. nuts\u2014a boon in alternative medicine","volume":"38","author":"Premalatha","year":"2000","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.cbi.2008.02.007_bib20","first-page":"444","article-title":"Hypocholesterolemic activity of nut shell extract of Semecarpus anacardium (Bhilawa) in cholesterol fed rabbits","volume":"33","author":"Sharma","year":"1995","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.cbi.2008.02.007_bib21","first-page":"676","article-title":"Antioxidant activity of active tannoid principles of Emblica officinalis (amla)","volume":"37","author":"Bhattacharya","year":"1991","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.cbi.2008.02.007_bib22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0378-8741(00)00378-0","article-title":"Antitumour activity of Emblica officinalis","volume":"75","author":"Jose","year":"2001","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2008.02.007_bib23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0378-8741(95)01308-3","article-title":"Hypolipidemic effect of fruit juice of Emblica officinalis in cholesterol fed rabbits","volume":"50","author":"Mathur","year":"1996","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2008.02.007_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-8741(02)00041-7","article-title":"Antiulcerogenic effect of methanolic extract of Emblica officinalis: an experimental study","volume":"82","author":"Sairam","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2008.02.007_bib25","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0753-3322(03)00095-7","article-title":"Immunomodulatory effects of agents of plant origin","volume":"57","author":"Ganju","year":"2003","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cbi.2008.02.007_bib26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0014-2999(94)00672-T","article-title":"Suppression of adjuvant induced arthritis by selective inhibition of inducible nitric oxide synthase","volume":"273","author":"Connor","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbi.2008.02.007_bib27","series-title":"Formulary of Siddha Medicine","year":"1972"},{"key":"10.1016\/j.cbi.2008.02.007_bib28","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0306-3623(96)00042-0","article-title":"Effect of the milk extract of Semecarpus anacardium nut on adjuvant arthritis\u2014a dose-dependent study in Wistar albino rats","volume":"27","author":"Vijayalakshmi","year":"1996","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.cbi.2008.02.007_bib29","doi-asserted-by":"crossref","unstructured":"R. Mythilypriya, P. Shanthi, P. Sachdanandam, Therapeutic effect of Kalpaamruthaa, a herbal preparation on adjuvant induced arthritis in Wistar rats, Inflammopharmacology 16 (2008) 21\u201335","DOI":"10.1007\/s10787-007-1602-4"},{"key":"10.1016\/j.cbi.2008.02.007_bib30","series-title":"Practical Hematology","author":"Dacie","year":"1977"},{"key":"10.1016\/j.cbi.2008.02.007_bib31","first-page":"346","article-title":"Effect of acetic acid concentration on the colour reaction in the o-toludine boric acid for blood glucose determination","volume":"1","author":"Sasaki","year":"1972","journal-title":"Rinsho Kagaku"},{"key":"10.1016\/j.cbi.2008.02.007_bib32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/ajcp\/21.3_ts.275","article-title":"A rapid method for the estimation of urea in biological fluid by means of the reaction between diacetely and urea","volume":"21","author":"Natelson","year":"1951","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.cbi.2008.02.007_bib33","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with Folin's phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2008.02.007_bib34","series-title":"Standard Methods of Clinical Chemistry","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/B978-1-4831-9685-5.50029-7","article-title":"Uric acid","author":"Caraway","year":"1963"},{"key":"10.1016\/j.cbi.2008.02.007_bib35","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1042\/bj0580426","article-title":"Determination of creatinine in plasma (or) serum and in urine","volume":"58","author":"Owen","year":"1954","journal-title":"Biochem. J."},{"key":"10.1016\/j.cbi.2008.02.007_bib36","series-title":"Practical Clinical Enzymology","first-page":"191","article-title":"The phosphohydrolases-acid and alkaline phosphatases","author":"King","year":"1965"},{"key":"10.1016\/j.cbi.2008.02.007_bib37","first-page":"1423","article-title":"Cholesterol determination with ferric chloride\u2013uranyl acetate and sulphuric acid ferrous sulphate reagents","volume":"42","author":"Parekh","year":"1970","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbi.2008.02.007_bib38","article-title":"Triglycerides in serum","volume":"vol. 6","author":"Rice","year":"1970"},{"key":"10.1016\/j.cbi.2008.02.007_bib39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/clinchem\/7.3.249","article-title":"Suggested modifications of the micro determination of triglycerides","volume":"7","author":"Van Handel","year":"1961","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cbi.2008.02.007_bib40","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/BF02531316","article-title":"Two dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots","volume":"5","author":"Rouser","year":"1970","journal-title":"Lipids"},{"key":"10.1016\/j.cbi.2008.02.007_bib41","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0022-2275(20)41609-8","article-title":"A more sensitive and stable colorimetric determination of free fatty acid in plasma","volume":"18","author":"Itaya","year":"1977","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cbi.2008.02.007_bib42","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipids from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2008.02.007_bib43","first-page":"473","article-title":"A dual precipitation method for quantitative plasma lipoprotein measurement without ultracentrifugation","volume":"82","author":"Wilson","year":"1973","journal-title":"J. Lab Clin. Med."},{"key":"10.1016\/j.cbi.2008.02.007_bib44","first-page":"680","volume":"vol. 3","author":"Schneider","year":"1957"},{"key":"10.1016\/j.cbi.2008.02.007_bib45","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1042\/bj0620315","article-title":"The study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxy ribonucleic acid","volume":"62","author":"Burton","year":"1956","journal-title":"Biochem. J."},{"key":"10.1016\/j.cbi.2008.02.007_bib46","first-page":"69","article-title":"Clinical and biochemical studies on cateractous human lens. III. Quantitative study of protein, RNA and DNA","volume":"3","author":"Rawal","year":"1977","journal-title":"Arogya J. Health Sci."},{"key":"10.1016\/j.cbi.2008.02.007_bib47","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/BF02918422","article-title":"Human monocyte maturation\/differentiation during in vitro culture","volume":"2","author":"Musson","year":"1983","journal-title":"Surv. Immunol. Res."},{"key":"10.1016\/j.cbi.2008.02.007_bib48","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1159\/000046116","article-title":"Role of ginsenoside-RD in cisplatin induced renal injury: special reference to DNA fragmentation","volume":"89","author":"Yokozawa","year":"2001","journal-title":"Nephron"},{"key":"10.1016\/j.cbi.2008.02.007_bib49","first-page":"890","article-title":"Phytochemical investigation and evaluation of anti-inflammatory and anti-arthritic activities of essential oil of Strobilanthus ixiocephala Benth","volume":"41","author":"Agarwal","year":"2003","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.cbi.2008.02.007_bib50","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/art.1780311016","article-title":"Serum immunoreactive erythropoietin in rheumatoid arthritis: impaired response to anemia","volume":"31","author":"Hochberg","year":"1988","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cbi.2008.02.007_bib51","first-page":"106","article-title":"Anaemia in rheumatoid arthritis","volume":"2","author":"Mowat","year":"1971","journal-title":"Mod. Trends. Rheumatol."},{"key":"10.1016\/j.cbi.2008.02.007_bib52","first-page":"94","article-title":"Alteration of interleukin-1 activity and the acute phase response in adjuvant arthritic rats treated with disease modifying antirheumatic drugs","volume":"25","author":"Connolly","year":"1988","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.cbi.2008.02.007_bib53","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1172\/JCI109050","article-title":"Human leukocytic pyrogen induces release of specific granule contents from human neutrophils","volume":"61","author":"Klempner","year":"1978","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbi.2008.02.007_bib54","doi-asserted-by":"crossref","first-page":"C201","DOI":"10.1007\/BF01972766","article-title":"The pharmacologic evaluation of locomotor activity versus inflammatory parameters in rat adjuvant arthritis","volume":"39","author":"Selph","year":"1993","journal-title":"Agents Actions"},{"key":"10.1016\/j.cbi.2008.02.007_bib55","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF02976479","article-title":"Toxicology of Kalopanax pictus extract and hematological effect of the isolated anti-rheumatoidal kalopanaxsaponin A on the Freunds complete adjuvant reagent-treated rat","volume":"24","author":"Choi","year":"2001","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.cbi.2008.02.007_bib56","first-page":"213","article-title":"Adjuvant induced disease in rats. Clinical findings and morphological and biochemical changes in blood and histological changes in internal organs","volume":"21","author":"Maria","year":"1983","journal-title":"Rheumatologia"},{"key":"10.1016\/j.cbi.2008.02.007_bib57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1529-1049(03)00048-5","article-title":"Assessment of serological markers associated with rheumatoid arthritis. Diagnostic autoantibodies and conventional disease activity markers","volume":"4","author":"Marcelletti","year":"2003","journal-title":"Clin. Appl. Immunol. Rev."},{"key":"10.1016\/j.cbi.2008.02.007_bib58","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1136\/ard.62.7.681","article-title":"Twenty eight joint count disease activity score in recent onset rheumatoid arthritis using C reactive protein instead of erythrocyte sedimentation rate","volume":"62","author":"Skogh","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2008.02.007_bib59","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0006-2952(64)90050-4","article-title":"Serum protein changes in rats with arthritis induced by mycobacterial adjuvant","volume":"13","author":"Lowe","year":"1964","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2008.02.007_bib60","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/1043-6618(95)80051-4","article-title":"Effect of pumpkin seed oil on the level of free radical scavengers induced during adjuvant-arthritis in rats","volume":"31","author":"Fahim","year":"1995","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cbi.2008.02.007_bib61","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s004020050374","article-title":"Large-dose ascorbic acid administration suppresses the development of arthritis in adjuvant-infected rats","volume":"119","author":"Sakai","year":"1999","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"10.1016\/j.cbi.2008.02.007_bib62","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1016\/0006-2952(76)90257-4","article-title":"Adjuvant-induced arthritis and drug-metabolizing enzymes","volume":"25","author":"Cawthorne","year":"1976","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2008.02.007_bib63","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1136\/ard.34.4.346","article-title":"Protein sulphydryl depression during adjuvant arthritis","volume":"34","author":"Lorber","year":"1975","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2008.02.007_bib64","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s000110050250","article-title":"A simple inflammation model that distinguishes between the actions of anti-inflammatory and anti-rheumatic drugs","volume":"47","author":"Lewis","year":"1998","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.cbi.2008.02.007_bib65","first-page":"270","article-title":"Correlation between albumin permeability and adenosine cyclic monophosphate levels in incubated rat mesentry tissue","volume":"170","author":"Kohn","year":"1976","journal-title":"C. R. Seances Soc. Biol. Fil."},{"key":"10.1016\/j.cbi.2008.02.007_bib66","first-page":"89","article-title":"Changes in glucose metabolising enzymes in adjuvant arthritis and its treatment with a Siddha drug: Serankottai Nei","volume":"30","author":"Vijayalakshmi","year":"1998","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.cbi.2008.02.007_bib67","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1749-6632.2002.tb04072.x","article-title":"A reassessment of the peroxynitrite scavenging activity of uric acid","volume":"962","author":"Whiteman","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cbi.2008.02.007_bib68","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1042\/bj2430803","article-title":"Measurement of allantoin and uric acid in human body fluids. A potential index of free-radical reactions in vivo?","volume":"243","author":"Grootveld","year":"1987","journal-title":"Biochem. J."},{"key":"10.1016\/j.cbi.2008.02.007_bib69","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/sj.bjp.0705600","article-title":"Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis","volume":"141","author":"Bezerra","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbi.2008.02.007_bib70","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/ard.25.5.441","article-title":"Renal disease and drug therapy in rheumatoid arthritis","volume":"25","author":"Lawson","year":"1966","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2008.02.007_bib71","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1136\/ard.31.1.65","article-title":"Reduced glomerular function in rheumatoid arthritis","volume":"31","author":"Burry","year":"1972","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2008.02.007_bib72","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0049-0172(90)90095-W","article-title":"Renal disorders in rheumatoid arthritis","volume":"20","author":"Boers","year":"1990","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.cbi.2008.02.007_bib73","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/ard.54.3.189","article-title":"Microalbuminuria in patients with rheumatoid arthritis","volume":"54","author":"Pedersen","year":"1995","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2008.02.007_bib74","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1023\/A:1021695625457","article-title":"The urea cycle in the liver of arthritic rats","volume":"243","author":"Filho","year":"2003","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.cbi.2008.02.007_bib75","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1248\/bpb.25.1436","article-title":"Anti-inflammatory and anti-allergic activities of hydroxylamine and related compounds","volume":"25","author":"Kataoka","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.cbi.2008.02.007_bib76","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/BF01965926","article-title":"Adjuvant polyarthritis in rats: is this a satisfactory model for screening anti-arthritic drugs?","volume":"12","author":"Rainsford","year":"1982","journal-title":"Agents Actions"},{"key":"10.1016\/j.cbi.2008.02.007_bib77","first-page":"1195","article-title":"Chemical changes in adjuvant induced polyarthritis of rats","volume":"26","author":"Myles Glenn","year":"1965","journal-title":"Ann. J. Ven. Res."},{"key":"10.1016\/j.cbi.2008.02.007_bib78","first-page":"581","article-title":"Alkaline phasphatase (ALP) activity in rheumatoid arthritis-its clinical significance and synthesis of ALP in RA synovium","volume":"38","author":"Niino-Nanke","year":"1998","journal-title":"Ryumachi"},{"key":"10.1016\/j.cbi.2008.02.007_bib79","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/ar305","article-title":"Bone loss. Therapeutic approaches for preventing bone loss in inflammatory arthritis","volume":"3","author":"Rehman","year":"2001","journal-title":"Arthritis Res."},{"key":"10.1016\/j.cbi.2008.02.007_bib80","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1002\/art.1780331102","article-title":"Aspirin, hydroxychloroquine and hepatic enzyme abnormalities with methotrexate in rheumatoid arthritis","volume":"33","author":"Fries","year":"1990","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cbi.2008.02.007_bib81","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0090-6980(97)00147-0","article-title":"The contribution of synovial fluid lipoproteins to the chronic synovitis of rheumatoid arthritis","volume":"54","author":"Prete","year":"1997","journal-title":"Prostaglandins"},{"key":"10.1016\/j.cbi.2008.02.007_bib82","first-page":"1701","article-title":"Lipid profiles in untreated patients with rheumatoid arthritis","volume":"26","author":"Park","year":"1999","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.cbi.2008.02.007_bib83","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/ard.56.6.341","article-title":"Dyslipidaemia and rheumatoid arthritis","volume":"56","author":"Situnayake","year":"1997","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2008.02.007_bib84","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1136\/ard.50.6.366","article-title":"Lipoprotein (a), lipids, and lipoproteins in patients with rheumatoid arthritis","volume":"50","author":"Rantapaa-Dahlqvist","year":"1991","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2008.02.007_bib85","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1186\/ar428","article-title":"Cardiovascular risk in rheumatoid arthritis versus osteoarthritis: acute phase response related decreased insulin sensitivity and high-density lipoprotein as well as clustering of metabolic syndrome features in rheumatoid arthritis","volume":"4","author":"Dessein","year":"2002","journal-title":"Arthritis Res."},{"key":"10.1016\/j.cbi.2008.02.007_bib86","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.semarthrit.2005.03.004","article-title":"Rheumatoid arthritis: a disease associated with accelerated atherogenesis","volume":"35","author":"Gonzalez-Gay","year":"2005","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.cbi.2008.02.007_bib87","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cca.2005.08.010","article-title":"Effects of repeated infliximab therapy on serum lipid profile in patients with refractory rheumatoid arthritis B","volume":"365","author":"Allanore","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cbi.2008.02.007_bib88","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0163-7258(83)90062-1","article-title":"Models of arthritis and the search for antiarthritic drugs","volume":"21","author":"Billingham","year":"1983","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cbi.2008.02.007_bib89","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0006-2952(78)90389-1","article-title":"Adjuvant induced and carrageenan induced inflammation and lipid peroxidation in rat liver, spleen and lungs","volume":"27","author":"Roback","year":"1978","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2008.02.007_bib90","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1254\/jjp.44.15","article-title":"Suppression of adjuvant arthritis in rats by cholesterol","volume":"44","author":"Kunitomo","year":"1987","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.cbi.2008.02.007_bib91","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0021-5198(19)39775-6","article-title":"Auniform alteration in serum lipid metabolism occurring during inflammation in mice","volume":"58","author":"Kitagawa","year":"1992","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.cbi.2008.02.007_bib92","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1210\/endo.132.5.8477669","article-title":"Tumor necrosis factor mediates the effect of endotoxin on cholesterol and triglyceride metabolism in mice","volume":"132","author":"Memon","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.cbi.2008.02.007_bib93","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1074\/jbc.273.9.5053","article-title":"Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neural shingomyelinase","volume":"273","author":"Lawler","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2008.02.007_bib94","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0021-5198(19)42420-7","article-title":"Abnormal lipid metabolism in adjuvant arthritic rats","volume":"50","author":"Yamaguchi","year":"1989","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.cbi.2008.02.007_bib95","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0005-2760(89)90192-6","article-title":"Influence of serum amyloid A on cholesterol esterification in human plasma","volume":"1006","author":"Steinmetz","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbi.2008.02.007_bib96","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1016\/0024-3205(87)90506-6","article-title":"Interleukin-1 (IL-1) depresses cytochrome P450 levels and activities in mice","volume":"40","author":"Shedlofsky","year":"1987","journal-title":"Life Sci."},{"key":"10.1016\/j.cbi.2008.02.007_bib97","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1084\/jem.154.3.631","article-title":"Cerami, studies of endotoxin-induced decrease in lipoprotein lipase activity","volume":"154","author":"Kawakami","year":"1981","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cbi.2008.02.007_bib98","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1348-0421.1986.tb03012.x","article-title":"Lipid metabolism in endotoxic rats: decrease in hepatic triglyceride lipase activity","volume":"30","author":"Kawakami","year":"1986","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.cbi.2008.02.007_bib99","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2337\/diab.41.2.S97","article-title":"Role of cytokines in inducing hyperlipidemia","volume":"41","author":"Grunfeld","year":"1992","journal-title":"Diabetes"},{"key":"10.1016\/j.cbi.2008.02.007_bib100","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1136\/ard.56.6.374","article-title":"Effect of disease modifying agents on the lipid profiles of patients with rheumatoid arthritis","volume":"56","author":"Munro","year":"1997","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2008.02.007_bib101","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1093\/ajcn\/30.8.1311","article-title":"Fat metabolism in normal and abnormal status","volume":"30","author":"Masoro","year":"1977","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cbi.2008.02.007_bib102","first-page":"119","article-title":"On the aetiopathogenesis of rheumatoid arthritis","volume":"7","author":"Olhagen","year":"1975","journal-title":"Ann. Clin. Res."},{"key":"10.1016\/j.cbi.2008.02.007_bib103","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0140-6736(78)90091-0","article-title":"HDL secretion from human intestinal tract (Letter)","volume":"11","author":"Johansson","year":"1978","journal-title":"Lancet"},{"key":"10.1016\/j.cbi.2008.02.007_bib104","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1136\/ard.62.9.842","article-title":"Influence of glucocorticoids and disease activity on total and high density lipoprotein cholesterol in patients with rheumatoid arthritis","volume":"62","author":"Boers","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2008.02.007_bib105","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/PL00011174","article-title":"Lipoprotein (a) and lipids in relation to inflammation in rheumatoid arthritis","volume":"19","author":"Lee","year":"2000","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.cbi.2008.02.007_bib106","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jep.2003.11.009","article-title":"Acute and chronic toxicological studies of Ajuga iva in experimental animals","volume":"91","author":"Hilaly","year":"2004","journal-title":"J. Ethanopharmacol."},{"key":"10.1016\/j.cbi.2008.02.007_bib107","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1749-6632.1975.tb29299.x","article-title":"Ascorbic acid in cholesterol and bile acid metabolism","volume":"258","author":"Ginter","year":"1975","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cbi.2008.02.007_bib108","first-page":"1744","article-title":"Binding of taurocholate by pectin in the presence of calcium ions","volume":"52","author":"Koseki","year":"1987","journal-title":"J. Federal Sci."},{"key":"10.1016\/j.cbi.2008.02.007_bib109","first-page":"715","article-title":"The beneficial effects of plants sterols on serum cholesterol","volume":"17","author":"Wong","year":"2001","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.cbi.2008.02.007_bib110","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/ar92","article-title":"Apoptosis and p53 expression in rat adjuvant arthritis","volume":"2","author":"Tak","year":"2000","journal-title":"Arthritis Res."},{"key":"10.1016\/j.cbi.2008.02.007_bib111","first-page":"1631","volume":"96","author":"Firestein","year":"1995","journal-title":"Apoptosis in rheumatoid arthritis synovium"},{"key":"10.1016\/j.cbi.2008.02.007_bib112","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/art.1780380405","article-title":"Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes","volume":"38","author":"Nakajima","year":"1995","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cbi.2008.02.007_bib113","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/ar1447","article-title":"Oxidation in rheumatoid arthritis","volume":"6","author":"Hitchon","year":"2004","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.cbi.2008.02.007_bib114","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0167-5699(99)01552-2","article-title":"Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases","volume":"21","author":"Tak","year":"2000","journal-title":"Immunol. Today"},{"key":"10.1016\/j.cbi.2008.02.007_bib115","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/ard.52.9.659","article-title":"Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases","volume":"52","author":"Bashir","year":"1993","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2008.02.007_bib116","doi-asserted-by":"crossref","first-page":"R234","DOI":"10.1186\/ar787","article-title":"Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis","volume":"5","author":"Hajizadeh","year":"2003","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.cbi.2008.02.007_bib117","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11010-005-3202-1","article-title":"Semecarpus anacardium Linn. nut milk extract, an indigenous drug preparation, modulates reactive oxygen\/nitrogen species levels and antioxidative system in adjuvant arthritic rats","volume":"276","author":"Ramprasath","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.cbi.2008.02.007_bib118","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1002\/art.1780400820","article-title":"Nitric oxide as S-nitroso proteins in rheumatoid arthritis","volume":"40","author":"Hilliquin","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cbi.2008.02.007_bib119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-8741(97)00074-3","article-title":"Effect of milk extract of Semecarpus anacardium nuts on glycohydrolases and lysosomal stability in adjuvant arthritis in rats","volume":"58","author":"Vijayalakshmi","year":"1997","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2008.02.007_bib120","doi-asserted-by":"crossref","first-page":"10895","DOI":"10.1073\/pnas.94.20.10895","article-title":"Somatic mutations in the p53 tumour suppressor gene in rheumatoid arthritis synovium","volume":"94","author":"Firestein","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cbi.2008.02.007_bib121","doi-asserted-by":"crossref","first-page":"10025","DOI":"10.1073\/pnas.152333199","article-title":"Regional analysis in rheumatoid arthritis synovium","volume":"99","author":"Yamanishi","year":"2002","journal-title":"Proc. Natl. Acad. Sci."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279708001129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279708001129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:15:01Z","timestamp":1757855701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279708001129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":121,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0009279708001129"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2008.02.007","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salubrious effect of Kalpaamruthaa, a modified indigenous preparation in adjuvant-induced arthritis in rats\u2014A biochemical approach","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2008.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}