{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:03:15Z","timestamp":1769043795090,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.cbi.2008.07.014","type":"journal-article","created":{"date-parts":[[2008,8,20]],"date-time":"2008-08-20T06:43:40Z","timestamp":1219214620000},"page":"196-203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["La3+ binds to BiP\/GRP78 and induces unfolded protein response in HepG2 cells"],"prefix":"10.1016","volume":"176","author":[{"given":"Chenxi","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaiquan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoda","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2008.07.014_bib1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/3-540-29717-0_3","article-title":"Protein folding in the endoplasmic reticulum and the unfolded protein response","author":"Zhang","year":"2006","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.cbi.2008.07.014_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/scdb.2000.0212","article-title":"ER calcium and the functions of intracellular organelles","volume":"12","author":"Ashby","year":"2001","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cbi.2008.07.014_bib3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0968-0004(97)01143-2","article-title":"The endoplasmic reticulum Ca2+ store: a view from the lumen","volume":"23","author":"Meldolesi","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.cbi.2008.07.014_bib4","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1016\/j.febslet.2007.04.045","article-title":"ER chaperones in mammalian development and human diseases","volume":"581","author":"Ni","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cbi.2008.07.014_bib5","doi-asserted-by":"crossref","first-page":"30873","DOI":"10.1074\/jbc.272.49.30873","article-title":"BiP, a major chaperone protein of the endoplasmic reticulum lumen, plays a direct and important role in the storage of the rapidly exchanging pool of Ca2+","volume":"272","author":"Lievremont","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2008.07.014_bib6","doi-asserted-by":"crossref","first-page":"8796","DOI":"10.1074\/jbc.M503964200","article-title":"The affinity of a major Ca2+ binding site on GRP78 is differentially enhanced by ADP and ATP","volume":"281","author":"Lamb","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2008.07.014_bib7","doi-asserted-by":"crossref","first-page":"20915","DOI":"10.1074\/jbc.M212328200","article-title":"Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation","volume":"278","author":"Reddy","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2008.07.014_bib8","doi-asserted-by":"crossref","first-page":"8608","DOI":"10.1038\/sj.onc.1207108","article-title":"Regulation of apoptosis by endoplasmic reticulum pathways","volume":"22","author":"Breckenridge","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.cbi.2008.07.014_bib9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0010-8545(99)00072-7","article-title":"Lanthanides-the future drugs?","volume":"190\u2013192","author":"Wang","year":"1999","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.cbi.2008.07.014_bib10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/17450390009381956","article-title":"Rare earth elements\u2013a new generation of growth promoters for pigs?","volume":"53","author":"He","year":"2000","journal-title":"Arch. Tierernahr."},{"key":"10.1016\/j.cbi.2008.07.014_bib11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1290\/1071-2690(2002)038<0373:EORECO>2.0.CO;2","article-title":"Effects of rare earth compounds on growth and apoptosis of leukemic cell lines","volume":"38","author":"Dai","year":"2002","journal-title":"In Vitro Cell Dev. Biol. Anim."},{"key":"10.1016\/j.cbi.2008.07.014_bib12","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1016\/S0006-3495(98)77937-8","article-title":"Surface charge and lanthanum block of calcium current in bullfrog sympathetic neurons","volume":"74","author":"Block","year":"1998","journal-title":"Biophys. J."},{"key":"10.1016\/j.cbi.2008.07.014_bib13","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1093\/ndt\/gfh282","article-title":"Reducing high phosphate levels in patients with chronic renal failure undergoing dialysis: a 4-week, dose-finding, open-label study with lanthanum carbonate","volume":"19","author":"Hutchison","year":"2004","journal-title":"Nephrol. Dial. Transplant"},{"key":"10.1016\/j.cbi.2008.07.014_bib14","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1523-1755.2005.00171.x","article-title":"Chronic renal failure is associated with increased tissue deposition of lanthanum after 28-day oral administration","volume":"67","author":"Lacour","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.cbi.2008.07.014_bib15","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/jcb.20303","article-title":"La3+-promoted proliferation is interconnected with apoptosis in NIH 3T3 cells","volume":"94","author":"Yu","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.cbi.2008.07.014_bib16","doi-asserted-by":"crossref","first-page":"11217","DOI":"10.1021\/bi060895d","article-title":"La3+-induced extracellular signal-regulated kinase (ERK) signaling via a metal-sensing mechanism linking proliferation and apoptosis in NIH 3T3 cells","volume":"45","author":"Yu","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbi.2008.07.014_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0009-2797(03)00072-3","article-title":"La3+, Gd3+,and Yb3+ induced changes in mitochondrial structure, membrane permeability, cytochrome c release and intracellular ROS level.","volume":"146","author":"Liu","year":"2003","journal-title":"Chemico-Biol. Interact."},{"key":"10.1016\/j.cbi.2008.07.014_bib18","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0143-4160(94)90031-0","article-title":"Lanthanum can be transported by the sodium\u2013calcium exchange pathway and directly triggers catecholamine release from bovine chromaffin cells","volume":"16","author":"Powis","year":"1994","journal-title":"Cell Calcium"},{"key":"10.1016\/j.cbi.2008.07.014_bib19","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1085\/jgp.95.4.679","article-title":"Blockade of current through single calcium channels by trivalent lanthanide cations. Effect of ionic radius on the rates of ion entry and exit","volume":"95","author":"Lansman","year":"1990","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.cbi.2008.07.014_bib20","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/jcp.1041510323","article-title":"Lanthanum influx into cultured human keratinocytes: effect on calcium flux and terminal differentiation","volume":"151","author":"Pillai","year":"1992","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.cbi.2008.07.014_bib21","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/jlb.60.4.487","article-title":"Gadolinium chloride inhibits Kupffer cell nitric oxide synthase (iNOS) induction","volume":"60","author":"Roland","year":"1996","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cbi.2008.07.014_bib22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/019262339702500301","article-title":"Gadolinium chloride toxicity in the rat","volume":"25","author":"Spencer","year":"1997","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.cbi.2008.07.014_bib23","first-page":"88","article-title":"Effects of La, Ce, Y, Tb on oxidation of ghost of human erythrocyte","volume":"18","author":"Liu","year":"2000","journal-title":"J. Chinese Rare Earths Soc."},{"key":"10.1016\/j.cbi.2008.07.014_bib24","doi-asserted-by":"crossref","first-page":"33917","DOI":"10.1074\/jbc.M505818200","article-title":"Tumor necrosis factor alpha (TNF-\u03b1) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNF\u03b1","volume":"280","author":"Xue","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2008.07.014_bib25","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/0003-9861(88)90086-0","article-title":"Lanthanum as a calcium-substituting ion for binding to sarcoplasmic reticulum ATPase","volume":"267","author":"Fernandez-Belda","year":"1988","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cbi.2008.07.014_bib26","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1749-6632.1997.tb52284.x","article-title":"On the mechanism of inhibition of the PMCa2+-ATPase by lanthanum","volume":"834","author":"Herscher","year":"1997","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.cbi.2008.07.014_bib27","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S1046-2023(02)00029-4","article-title":"Immunoprecipitation techniques for the analysis of transcription factor complexes","volume":"26","author":"Klenova","year":"2002","journal-title":"Methods"},{"key":"10.1016\/j.cbi.2008.07.014_bib28","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1101\/gad.964702","article-title":"IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response","volume":"16","author":"Lee","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.cbi.2008.07.014_bib29","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ymeth.2004.10.012","article-title":"Quantitative measurement of events in the mammalian unfolded protein response","volume":"35","author":"Shang","year":"2005","journal-title":"Methods"},{"key":"10.1016\/j.cbi.2008.07.014_bib30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ymeth.2004.10.010","article-title":"The ER chaperone and signaling regulator GRP78\/BiP as a monitor of endoplasmic reticulum stress","volume":"35","author":"Lee","year":"2005","journal-title":"Methods"},{"key":"10.1016\/j.cbi.2008.07.014_bib31","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/S0006-291X(05)81368-3","article-title":"The thapsigargin-sensitive intracellular Ca2+ pool is more important in plasma membrane Ca2+ entry than the IP3-sensitive intracellular Ca2+ pool in neuronal cell lines","volume":"180","author":"Takemura","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbi.2008.07.014_bib32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1359-6446(01)01712-3","article-title":"Screening for human ADME\/Tox drug properties in drug discovery","volume":"6","author":"Li","year":"2001","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.cbi.2008.07.014_bib33","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1101\/gad.839400","article-title":"The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response","volume":"14","author":"Tirasophon","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.cbi.2008.07.014_bib34","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0092-8674(01)00611-0","article-title":"XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor","volume":"107","author":"Yoshida","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2008.07.014_bib35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.biocel.2005.09.018","article-title":"Coordination of ER and oxidative stress signaling: The PERK\/Nrf2 signaling pathway","volume":"38","author":"Cullinan","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.cbi.2008.07.014_bib36","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.neuint.2005.12.012","article-title":"Depletion of intracellular Ca2+ store itself may be a major factor in thapsigargin-induced ER stress and apoptosis in PC12 cells","volume":"48","author":"Yoshida","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.cbi.2008.07.014_bib37","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/cvr\/cvm047","article-title":"Bidirectional regulation of Ca2+ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes","volume":"77","author":"Yan","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cbi.2008.07.014_bib38","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/j.1460-2075.1992.tb05201.x","article-title":"Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells","volume":"11","author":"Dorner","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.cbi.2008.07.014_bib39","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1534-5807(02)00203-4","article-title":"ER stress regulation of ATF6 localization by dissociation of BiP\/GRP78 binding and unmasking of Golgi localization signals","volume":"3","author":"Shen","year":"2002","journal-title":"Dev. Cell."},{"key":"10.1016\/j.cbi.2008.07.014_bib40","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/35014014","article-title":"Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response","volume":"2","author":"Bertolotti","year":"2000","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.cbi.2008.07.014_bib41","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1091\/mbc.e02-11-0708","article-title":"Genetic evidence for a role of BiP\/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins","volume":"14","author":"Kimata","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cbi.2008.07.014_bib42","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1083\/jcb.200405153","article-title":"A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1","volume":"167","author":"Kimata","year":"2004","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.cbi.2008.07.014_bib43","doi-asserted-by":"crossref","first-page":"17680","DOI":"10.1074\/jbc.M300418200","article-title":"Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha","volume":"278","author":"Liu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2008.07.014_bib44","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/BJ20050640","article-title":"An essential dimer-forming subregion of the endoplasmic reticulum stress sensor Ire1","volume":"391","author":"Oikawa","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.cbi.2008.07.014_bib45","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1073\/pnas.94.9.4289","article-title":"Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5p","volume":"94","author":"Welihinda","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.cbi.2008.07.014_bib46","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1002\/j.1460-2075.1996.tb00666.x","article-title":"Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus","volume":"15","author":"Shamu","year":"1996","journal-title":"EMBO J."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279708003967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279708003967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:16:06Z","timestamp":1757855766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279708003967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":46,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0009279708003967"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2008.07.014","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"La3+ binds to BiP\/GRP78 and induces unfolded protein response in HepG2 cells","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2008.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}