{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:00:27Z","timestamp":1780527627453,"version":"3.54.1"},"reference-count":85,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.cbi.2009.01.001","type":"journal-article","created":{"date-parts":[[2009,1,18]],"date-time":"2009-01-18T04:03:03Z","timestamp":1232251383000},"page":"335-343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ameliorating effect of Kalpaamruthaa, a Siddha preparation in adjuvant induced arthritis in rats with reference to changes in proinflammatory cytokines and acute phase proteins"],"prefix":"10.1016","volume":"179","author":[{"given":"Rajendran","family":"Mythilypriya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palanivelu","family":"Shanthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panchanadam","family":"Sachdanandam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2009.01.001_bib1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1749-6632.1990.tb17943.x","article-title":"Mechanisms of matrix degradation in rheumatoid arthritis","volume":"580","author":"Krane","year":"1990","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cbi.2009.01.001_bib2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev.immunol.14.1.397","article-title":"Role of cytokines in rheumatoid arthritis","volume":"14","author":"Feldmann","year":"1996","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cbi.2009.01.001_bib3","first-page":"49","article-title":"The biological role of naturally-occurring cytokine inhibitors","volume":"30","author":"Arend","year":"1991","journal-title":"Br. J. Rheumatol."},{"key":"10.1016\/j.cbi.2009.01.001_bib4","first-page":"65","article-title":"Cytokines and anticytokines","volume":"8","author":"Panayi","year":"1990","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.cbi.2009.01.001_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/ard.52.1.27","article-title":"Cartilage degradation by polymorphonuclear leucocytes: in vitro assessment of the pathogenic mechanisms","volume":"52","author":"Moore","year":"1993","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2009.01.001_bib6","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/1529-0131(199906)42:6<1209::AID-ANR18>3.0.CO;2-M","article-title":"An assessment of the annual and long-term direct costs of rheumatoid arthritis: the impact of poor function and functional decline","volume":"42","author":"Yelin","year":"1999","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cbi.2009.01.001_bib7","first-page":"75","article-title":"The acute phase response: from hippocrates to cytokine biology","volume":"2","author":"Kushner","year":"1991","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.cbi.2009.01.001_bib8","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1053\/berh.1999.0046","article-title":"Established rheumatoid arthritis","volume":"13","author":"Conaghan","year":"1999","journal-title":"Bailliere Best. Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.cbi.2009.01.001_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0014-2999(94)00672-T","article-title":"Suppression of adjuvant induced arthritis by selective inhibition of inducible nitric oxide synthase","volume":"273","author":"Connor","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbi.2009.01.001_bib10","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1248\/jhs.53.351","article-title":"Oral acute and subacute toxicity studies with Kalpaamruthaa, a modified indigenous preparation, on rats","volume":"53","author":"Mythilypriya","year":"2007","journal-title":"J. Health Sci."},{"key":"10.1016\/j.cbi.2009.01.001_bib11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cbi.2007.04.005","article-title":"Restorative and synergistic efficacy of Kalpaamruthaa, a modified Siddha preparation, on an altered antioxidant status in adjuvant induced arthritic rat model","volume":"168","author":"Mythilypriya","year":"2007","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2009.01.001_bib12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11010-006-9199-2","article-title":"Restorative effect of Kalpaamruthaa, an indigenous preparation, on oxidative damage in mammary gland mitochondrial fraction in experimental mammary carcinoma","volume":"291","author":"Arulkumaran","year":"2006","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.cbi.2009.01.001_bib13","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/ptr.2116","article-title":"Analgesic, antipyretic and ulcerogenic properties of an indigenous formulation\u2014Kalpaamruthaa","volume":"21","author":"Mythilypriya","year":"2007","journal-title":"Phytother. Res."},{"key":"10.1016\/j.cbi.2009.01.001_bib14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1248\/bpb.29.565","article-title":"Anticancer effect of Kalpaamruthaa on mammary carcinoma in rats with reference to glycoprotein components, lysosomal and marker enzymes","volume":"29","author":"Veena","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.cbi.2009.01.001_bib15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cbi.2006.03.003","article-title":"The biochemical alterations following administration of Kalpaamruthaa and Semecarpus anacardium in mammary carcinoma","volume":"161","author":"Veena","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2009.01.001_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0891-5849(95)00011-L","article-title":"Interaction of flavonoids with ascorbate and determination of their univalent redox potentials: a pulse radiolysis study","volume":"19","author":"Bors","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2009.01.001_bib17","first-page":"1177","article-title":"Semecarpus anacardium Linn. nuts\u2014a boon in alternative medicine","volume":"38","author":"Premalatha","year":"2000","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.cbi.2009.01.001_bib18","first-page":"941","article-title":"Active constituents of Emblica officinalis. Part I. The chemistry and anti-oxidant effect of two new hydrolysable tannins, Emblicanin A & B","volume":"35","author":"Ghosal","year":"1996","journal-title":"Indian J. Chem. B"},{"key":"10.1016\/j.cbi.2009.01.001_bib19","unstructured":"Formulary of Siddha Medicine, Published by the Indian Medical Practitioners Co-operative Pharmacy and Stores Ltd., Madras, India, 1972."},{"key":"10.1016\/j.cbi.2009.01.001_bib20","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0306-3623(96)00042-0","article-title":"Effect of the milk extract of Semecarpus anacardium nut on adjuvant arthritis\u2014a dose-dependent study in Wistar albino rats","volume":"27","author":"Vijayalakshmi","year":"1996","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.cbi.2009.01.001_bib21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10787-007-1602-4","article-title":"Therapeutic effect of Kalpaamruthaa a herbal preparation on adjuvant induced arthritis in Wistar rats","volume":"16","author":"Mythilypriya","year":"2007","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.cbi.2009.01.001_bib22","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0002-9378(71)90243-2","article-title":"C-reactive protein in pregnancy and contraception","volume":"110","author":"Connell","year":"1971","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cbi.2009.01.001_bib23","first-page":"161","article-title":"Improved colorimetric enzymatic assay of ceruloplasmin","volume":"58","author":"Ravin","year":"1961","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.cbi.2009.01.001_bib24","series-title":"Practical Clinical Biochemistry","first-page":"233","article-title":"Determination of plasma protein","author":"Lempert","year":"1969"},{"key":"10.1016\/j.cbi.2009.01.001_bib25","doi-asserted-by":"crossref","first-page":"848","DOI":"10.2460\/javma.1979.174.08.848","article-title":"Use of the glutaraldehyde coagulation test for the detection of hypogamma-globulinemia in neonatal calves","volume":"174","author":"Tennant","year":"1979","journal-title":"Am. J. Vet. Med."},{"key":"10.1016\/j.cbi.2009.01.001_bib26","first-page":"257","article-title":"Glutaraldehyde coagulation test standard curve and its applications to detect gammaglobulin level in kids","volume":"73","author":"Satpathy","year":"1996","journal-title":"Ind. Vet. J."},{"key":"10.1016\/j.cbi.2009.01.001_bib27","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/1043-4666(93)90060-I","article-title":"Elevated levels of TNF in the joints of adjuvant arthritic rats","volume":"5","author":"Smith-Oliver","year":"1993","journal-title":"Cytokine"},{"key":"10.1016\/j.cbi.2009.01.001_bib28","series-title":"Murine and Human Monoclonal Antibodies, Practical Manual","article-title":"Immunoassays","author":"Sharma","year":"1989"},{"key":"10.1016\/j.cbi.2009.01.001_bib29","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with Folin's phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2009.01.001_bib30","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2009.01.001_bib31","first-page":"239","article-title":"Role of interleukin 1 in antigen-induced exacerbations of murine arthritis","volume":"146","author":"van de Loo","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cbi.2009.01.001_bib32","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/art.1780360915","article-title":"The effect of an interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice","volume":"36","author":"Wooley","year":"1993","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cbi.2009.01.001_bib33","doi-asserted-by":"crossref","first-page":"8222","DOI":"10.1073\/pnas.95.14.8222","article-title":"Interleukin 6 plays a key role in the development of antigen-induced arthritis","volume":"95","author":"Ohshima","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cbi.2009.01.001_bib34","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/art.1780390513","article-title":"Anticytokine treatment of established type II collagen-induced arthritis in DBA\/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha\/beta, and IL-1Ra","volume":"39","author":"Joosten","year":"1996","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cbi.2009.01.001_bib35","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1056\/NEJMoa035075","article-title":"Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig","volume":"349","author":"Moreland","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cbi.2009.01.001_bib36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jep.2004.12.022","article-title":"Effect of sinomenine on cytokine expression of macrophages and synoviocytes in adjuvant arthritis rats","volume":"98","author":"Wang","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2009.01.001_bib37","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/1043-4666(92)90021-I","article-title":"Direct stimulation of cytokines (IL-1 beta, TNF-alpha, IL-6, IL-2, IFN-gamma and GM-CSF) in whole blood. II. Application to rheumatoid arthritis and osteoarthritis","volume":"4","author":"Zangerle","year":"1992","journal-title":"Cytokine"},{"key":"10.1016\/j.cbi.2009.01.001_bib38","series-title":"Textbook of Rheumatology","first-page":"267","article-title":"Cytokines and growth factors","author":"Dayer","year":"1997"},{"key":"10.1016\/j.cbi.2009.01.001_bib39","doi-asserted-by":"crossref","first-page":"R1023","DOI":"10.1186\/ar1778","article-title":"Expression of CD147 on monocytes\/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production","volume":"7","author":"Zhu","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.cbi.2009.01.001_bib40","doi-asserted-by":"crossref","first-page":"I40","DOI":"10.1136\/ard.58.2008.i40","article-title":"Role of tumour necrosis factor alpha in experimental arthritis: separate activity of interleukin 1beta in chronicity and cartilage destruction","volume":"58","author":"van den Berg","year":"1999","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2009.01.001_bib41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cbi.2008.07.008","article-title":"Efficacy of Siddha formulation Kalpaamruthaa in ameliorating joint destruction in rheumatoid arthritis in rats","volume":"176","author":"Mythilypriya","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2009.01.001_bib42","doi-asserted-by":"crossref","first-page":"I32","DOI":"10.1136\/ard.58.2008.i32","article-title":"The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease","volume":"58","author":"Kollias","year":"1999","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2009.01.001_bib43","doi-asserted-by":"crossref","first-page":"ii3","DOI":"10.1093\/rheumatology\/keg326","article-title":"The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis","volume":"42","author":"Dayer","year":"2003","journal-title":"Rheumatology"},{"key":"10.1016\/j.cbi.2009.01.001_bib44","first-page":"140","article-title":"Tumour necrosis factor. Genetics, cell action mechanism and involvement in inflammation","volume":"16","author":"Liz-Grana","year":"2001","journal-title":"Allergol. Immunol. Clin."},{"key":"10.1016\/j.cbi.2009.01.001_bib45","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1002\/1529-0131(200012)43:12<2648::AID-ANR4>3.0.CO;2-M","article-title":"Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models of rheumatoid arthritis","volume":"43","author":"Bendele","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cbi.2009.01.001_bib46","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2249.1993.tb05992.x","article-title":"The effects of cytokines on metalloproteinase inhibitors (TIMP) and collagenase production by human chondrocytes and TIMP production by synovial cells and endothelial cells","volume":"94","author":"Shingu","year":"1993","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cbi.2009.01.001_bib47","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/rheumatology\/41.9.972","article-title":"Blocking the effects of IL-1 in rheumatoid arthritis protects bone and cartilage","volume":"41","author":"Abramson","year":"2002","journal-title":"Rheumatology"},{"key":"10.1016\/j.cbi.2009.01.001_bib48","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1063-4584(96)80009-4","article-title":"The increased synthesis of inducible nitric oxide inhibits IL-1ra synthesis by human articular chondrocytes: possible role in osteoarthritic cartilage degradation","volume":"4","author":"Pelletier","year":"1996","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.cbi.2009.01.001_bib49","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s11926-000-0019-5","article-title":"COX-2, NO, and cartilage damage and repair","volume":"2","author":"Amin","year":"2000","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.cbi.2009.01.001_bib50","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1172\/JCI117130","article-title":"Interleukin-11: a new cytokine critical for osteoclast development","volume":"93","author":"Girasole","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbi.2009.01.001_bib51","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1212\/WNL.45.6_Suppl_6.S39","article-title":"Inhibitory cytokines and cytokine inhibitors","volume":"45","author":"Burger","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.cbi.2009.01.001_bib52","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cbi.2005.11.009","article-title":"Curative effect of Semecarpus anacardium Linn. nut milk extract against adjuvant arthritis\u2014with special reference to bone metabolism","volume":"160","author":"Ramprasath","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2009.01.001_bib53","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.4049\/jimmunol.163.6.3474","article-title":"Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity","volume":"163","author":"Jobin","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.cbi.2009.01.001_bib54","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0022-3565(24)29679-8","article-title":"Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages","volume":"296","author":"Xagorari","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cbi.2009.01.001_bib55","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/S0006-2952(03)00203-X","article-title":"Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages","volume":"65","author":"Lin","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2009.01.001_bib56","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1124\/mol.105.012518","article-title":"Gallotannin inhibits the expression of chemokines and inflammatory cytokines in A549 cells","volume":"68","author":"Erdelyi","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.cbi.2009.01.001_bib57","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/S0960-894X(01)00332-8","article-title":"In vitro and in vivo inhibition of LPS-stimulated tumor necrosis factor-alpha secretion by the gallotannin beta-D-pentagalloylglucose","volume":"11","author":"Feldman","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.cbi.2009.01.001_bib58","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cyto.2004.02.004","article-title":"Effects of vitamin C on intracytoplasmic cytokine production in human whole blood monocytes and lymphocytes","volume":"27","author":"Hartel","year":"2004","journal-title":"Cytokine"},{"key":"10.1016\/j.cbi.2009.01.001_bib59","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0006-2952(68)90291-8","article-title":"The systemic response to inflammation","author":"Glenn","year":"1968","journal-title":"Biochem. Pharmacol. Suppl."},{"key":"10.1016\/j.cbi.2009.01.001_bib60","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0140-6736(94)91049-9","article-title":"Generalised bone loss in patients with early rheumatoid arthritis","volume":"344","author":"Gough","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.cbi.2009.01.001_bib61","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/oxfordjournals.rheumatology.a031490","article-title":"Prognostic factors in early rheumatoid arthritis","volume":"39","author":"Scott","year":"2000","journal-title":"Rheumatology"},{"key":"10.1016\/j.cbi.2009.01.001_bib62","first-page":"790","article-title":"The relationship between interleukin-1 activity in adjuvant rats and changes in plasma fibronectin, C-reactive protein and albumin levels","volume":"46","author":"Stecher","year":"1987","journal-title":"Fed. Proc."},{"key":"10.1016\/j.cbi.2009.01.001_bib63","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/art.10943","article-title":"The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover","volume":"48","author":"Wong","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cbi.2009.01.001_bib64","first-page":"143","article-title":"Macrophages and acute-phase proteins","volume":"60","author":"Mortensen","year":"1994","journal-title":"Immunol. Ser."},{"key":"10.1016\/j.cbi.2009.01.001_bib65","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4049\/jimmunol.144.1.231","article-title":"Characterization and isolation of a C-reactive protein receptor from the human monocytic cell line U-937","volume":"144","author":"Tebo","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.cbi.2009.01.001_bib66","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/jlb.53.4.439","article-title":"C-reactive protein increases production of IL-1 alpha, IL-1 beta, and TNF-alpha, and expression of mRNA by human alveolar macrophages","volume":"53","author":"Galve-de Rochemonteix","year":"1993","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cbi.2009.01.001_bib67","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0946-672X(00)80007-3","article-title":"Immunochemical and enzymatic study of ceruloplasmin in rheumatoid arthritis","volume":"14","author":"Louro","year":"2000","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.cbi.2009.01.001_bib68","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00541344","article-title":"Caeruloplasmin concentration and activity in polyarthritis","volume":"8","author":"Dixon","year":"1988","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.cbi.2009.01.001_bib69","first-page":"395","article-title":"Oligo-elements essentials et affectations rhumatismales","volume":"42","author":"Peretz","year":"1987","journal-title":"J. Pharm. Belg."},{"key":"10.1016\/j.cbi.2009.01.001_bib70","doi-asserted-by":"crossref","first-page":"515","DOI":"10.7326\/0003-4819-104-4-515","article-title":"The erythrocyte sedimentation rate. Guidelines for rational use","volume":"104","author":"Sox","year":"1986","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cbi.2009.01.001_bib71","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0165-2427(97)00062-7","article-title":"Nephelometric determination of rat fibrinogen as a marker of inflammatory response","volume":"59","author":"Larsson","year":"1997","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.cbi.2009.01.001_bib72","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0049-0172(96)80041-2","article-title":"Role of cytokines, acute-phase proteins, and chemokinesin the progression of rheumatoid arthritis","volume":"26","author":"Badolato","year":"1996","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.cbi.2009.01.001_bib73","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0006-2952(69)90209-3","article-title":"Fibrinogen and experimental inflammation","volume":"26","author":"Glenn","year":"1969","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2009.01.001_bib74","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1136\/ard.52.3.232","article-title":"Serum interleukin 6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity","volume":"52","author":"Madhok","year":"1993","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2009.01.001_bib75","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10753-008-9090-2","article-title":"Synergistic effect of Kalpaamruthaa on antiarthritic and antiinflammatory properties\u2014its mechanism of action","volume":"31","author":"Mythilypriya","year":"2008","journal-title":"Inflammation"},{"key":"10.1016\/j.cbi.2009.01.001_bib76","first-page":"1002","article-title":"Effects of resveratrol and ethanol on production of pro-inflammatory factors from endotoxin activated murine macrophages","volume":"23","author":"Feng","year":"2002","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.cbi.2009.01.001_bib77","first-page":"1037","article-title":"Routine measurement of IgM, IgG and IgA rheumatoid factors: high sensitivity, specificity and predictive value of rheumatoid arthritis","volume":"24","author":"Swedler","year":"1977","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.cbi.2009.01.001_bib78","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1136\/ard.26.5.412","article-title":"Levels of serum immunoglobulins in patients with rheumatoid arthritis","volume":"26","author":"Marcolongo","year":"1967","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2009.01.001_bib79","first-page":"850","article-title":"Serum immunoglobulins in rheumatoid arthritis","volume":"67","author":"Claman","year":"1966","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.cbi.2009.01.001_bib80","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1136\/ard.43.5.673","article-title":"Prospective study of early rheumatoid arthritis. I. Prognostic value of IgA rheumatoid factor","volume":"43","author":"Teitsson","year":"1984","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2009.01.001_bib81","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1136\/ard.45.10.809","article-title":"Serum immune complexes containing IgA appear to predict erosive arthritis in a longitudinal study in rheumatoid arthritis","volume":"45","author":"Westedt","year":"1986","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2009.01.001_bib82","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF00290265","article-title":"Clinical significance of rheumatoid factor isotypes in seropositive arthritis","volume":"12","author":"Jonsson","year":"1992","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.cbi.2009.01.001_bib83","first-page":"51","article-title":"Collagen induced arthritis: an experimental model for rheumatoid arthritis with involvement of both DTH and immune complex mediated mechanisms","volume":"7","author":"Holmdahl","year":"1989","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.cbi.2009.01.001_bib84","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev.iy.05.040187.000545","article-title":"Rheumatoid factor and immune networks","volume":"5","author":"Carson","year":"1987","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cbi.2009.01.001_bib85","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0367-326X(03)00042-X","article-title":"Studies on the immunomodulatory activity of flavonoidal fraction of Tephrosia purpurea","volume":"74","author":"Damre","year":"2003","journal-title":"Fitoterapia"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279709000040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279709000040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:20:01Z","timestamp":1757856001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279709000040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":85,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0009279709000040"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2009.01.001","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ameliorating effect of Kalpaamruthaa, a Siddha preparation in adjuvant induced arthritis in rats with reference to changes in proinflammatory cytokines and acute phase proteins","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2009.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}