{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:01:40Z","timestamp":1762898500733,"version":"3.44.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Natural Science Founding of China","award":["30672441","30873057"],"award-info":[{"award-number":["30672441","30873057"]}]},{"name":"Key Basic Project of Shanghai Municipal Science and Technology Commission","award":["08JC1413600"],"award-info":[{"award-number":["08JC1413600"]}]},{"name":"Shanghai Municipal Education Committee","award":["J50201"],"award-info":[{"award-number":["J50201"]}]},{"name":"Ph.D. Program Foundation of Ministry of Education of China","award":["20050266003","20070248067"],"award-info":[{"award-number":["20050266003","20070248067"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.cbi.2009.09.020","type":"journal-article","created":{"date-parts":[[2009,10,2]],"date-time":"2009-10-02T04:23:39Z","timestamp":1254457419000},"page":"165-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Panaxynol protects cortical neurons from ischemia-like injury by up-regulation of HIF-1\u03b1 expression and inhibition of apoptotic cascade"],"prefix":"10.1016","volume":"183","author":[{"given":"Zhi-hui","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-hong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-hao","family":"Suo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-hui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cbi.2009.09.020_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.brainresrev.2006.11.003","article-title":"Molecular targets in cerebral ischemia for developing novel therapeutics","volume":"54","author":"Mehta","year":"2007","journal-title":"Brain Res. Rev."},{"issue":"10","key":"10.1016\/j.cbi.2009.09.020_bib2","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1136\/jcp.2003.015032","article-title":"The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis","volume":"57","author":"Greijer","year":"2004","journal-title":"J. Clin. Pathol."},{"issue":"3","key":"10.1016\/j.cbi.2009.09.020_bib3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.pneurobio.2008.04.003","article-title":"Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia","volume":"85","author":"Rami","year":"2008","journal-title":"Prog. Neurobiol."},{"issue":"16","key":"10.1016\/j.cbi.2009.09.020_bib4","doi-asserted-by":"crossref","first-page":"9082","DOI":"10.1073\/pnas.97.16.9082","article-title":"Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia","volume":"97","author":"Bruick","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.cbi.2009.09.020_bib5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.critrevonc.2007.03.001","article-title":"Role of erythropoietin in the brain","volume":"64","author":"Noguchi","year":"2007","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.cbi.2009.09.020_bib6","article-title":"BCL-xL is a target gene regulated by hypoxia-inducible factor-1-alpha","author":"Chen","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2009.09.020_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.brainres.2007.08.059","article-title":"Relationship between HIF-1alpha expression and neuronal apoptosis in neonatal rats with hypoxia-ischemia brain injury","volume":"1180","author":"Li","year":"2007","journal-title":"Brain Res."},{"issue":"6674","key":"10.1016\/j.cbi.2009.09.020_bib8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/32925","article-title":"Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha","volume":"392","author":"An","year":"1998","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.cbi.2009.09.020_bib9","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1523\/JNEUROSCI.5323-07.2008","article-title":"The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes","volume":"28","author":"Vangeison","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cbi.2009.09.020_bib10","first-page":"1050","article-title":"Progress in studies on naturally occurring polyacetylenes","volume":"33","author":"Nie","year":"2002","journal-title":"Chin. Tradit. Herbal Drugs"},{"issue":"5","key":"10.1016\/j.cbi.2009.09.020_bib11","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.neuropharm.2008.01.003","article-title":"Panaxydol and panaxynol protect cultured cortical neurons against Abeta25-35-induced toxicity","volume":"54","author":"Nie","year":"2008","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.cbi.2009.09.020_bib12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cbi.2008.04.041","article-title":"Effect of panaxydol on hypoxia-induced cell death and expression and secretion of neurotrophic factors (NTFs) in hypoxic primary cultured Schwann cells","volume":"174","author":"Zhu","year":"2008","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.cbi.2009.09.020_bib13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cbi.2006.02.001","article-title":"Protective effect of panaxydol and panaxynol on sodium nitroprusside-induced apoptosis in cortical neurons","volume":"160","author":"Nie","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2009.09.020_bib14","first-page":"490","article-title":"Study on the lipophilic components of Panax notoginseng","volume":"33","author":"Lin","year":"2002","journal-title":"Chin. Tradit. Herbal Drugs"},{"issue":"6","key":"10.1016\/j.cbi.2009.09.020_bib15","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1055\/s-2006-957763","article-title":"Polyacetylene analogs, isolated from hairy roots of Panax ginseng, inhibit Acyl-CoA: cholesterol acyltransferase","volume":"63","author":"Kwon","year":"1997","journal-title":"Planta Med."},{"issue":"7","key":"10.1016\/j.cbi.2009.09.020_bib16","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1055\/s-2000-8624","article-title":"Inducible nitric oxide synthase inhibitors from Saposhnikovia divaricata and Panax quinquefolium","volume":"66","author":"Wang","year":"2000","journal-title":"Planta Med."},{"issue":"1","key":"10.1016\/j.cbi.2009.09.020_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0092-8674(01)00518-9","article-title":"HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus","volume":"107","author":"Semenza","year":"2001","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.cbi.2009.09.020_bib18","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/j.1471-4159.2006.03828.x","article-title":"Activation of 5-lipoxygenase after oxygen-glucose deprivation is partly mediated via NMDA receptor in rat cortical neurons","volume":"97","author":"Ge","year":"2006","journal-title":"J. Neurochem."},{"issue":"20","key":"10.1016\/j.cbi.2009.09.020_bib19","doi-asserted-by":"crossref","first-page":"18426","DOI":"10.1074\/jbc.M301295200","article-title":"Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress","volume":"278","author":"Du","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cbi.2009.09.020_bib20","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1046\/j.1365-2990.2000.00252.x","article-title":"Caspase-cleaved actin (fractin) immunolabelling of Hirano bodies","volume":"26","author":"Rossiter","year":"2000","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.cbi.2009.09.020_bib21","article-title":"VEGF and Bcl-2 interact via MAPKs signaling pathway in the response to hypoxia in neuroblastoma","author":"Wang","year":"2008","journal-title":"Cell Mol. Neurobiol."},{"issue":"6938","key":"10.1016\/j.cbi.2009.09.020_bib22","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nature01627","article-title":"Humanin peptide suppresses apoptosis by interfering with Bax activation","volume":"423","author":"Guo","year":"2003","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.cbi.2009.09.020_bib23","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1128\/MCB.22.13.4929-4942.2002","article-title":"The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase","volume":"22","author":"Lei","year":"2002","journal-title":"Mol. Cell. Biol."},{"issue":"7","key":"10.1016\/j.cbi.2009.09.020_bib24","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1128\/MCB.24.7.2875-2889.2004","article-title":"Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance","volume":"24","author":"Erler","year":"2004","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.cbi.2009.09.020_bib25","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0006-291X(03)01557-2","article-title":"Hypoxia induces apoptosis in SV40-immortalized rat proximal tubular cells through the mitochondrial pathways, devoid of HIF1-mediated upregulation of Bax","volume":"309","author":"Tanaka","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbi.2009.09.020_bib26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1479-5876-4-12","article-title":"Establishment and characterization of multicellular spheroids from a human glioma cell line; implications for tumor therapy","volume":"4","author":"Khaitan","year":"2006","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.cbi.2009.09.020_bib27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/FJC.0b013e318181fb02","article-title":"Hydroxysafflor yellow A enhances survival of vascular endothelial cells under hypoxia via upregulation of the HIF-1 alpha-VEGF pathway and regulation of Bcl-2\/Bax","volume":"52","author":"Ji","year":"2008","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"23","key":"10.1016\/j.cbi.2009.09.020_bib28","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1523\/JNEUROSCI.0449-07.2007","article-title":"Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia","volume":"27","author":"Baranova","year":"2007","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.cbi.2009.09.020_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.expneurol.2008.03.028","article-title":"Minocycline protects Schwann cells from ischemia-like injury and promotes axonal outgrowth in bioartificial nerve grafts lacking Wallerian degeneration","volume":"212","author":"Keilhoff","year":"2008","journal-title":"Exp. Neurol."},{"issue":"3","key":"10.1016\/j.cbi.2009.09.020_bib30","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.neulet.2008.08.057","article-title":"Baicalein suppresses hypoxia-induced HIF-1alpha protein accumulation and activation through inhibition of reactive oxygen species and PI 3-kinase\/Akt pathway in BV2 murine microglial cells","volume":"444","author":"Hwang","year":"2008","journal-title":"Neurosci. Lett."},{"issue":"5","key":"10.1016\/j.cbi.2009.09.020_bib31","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s11095-009-9839-9","article-title":"Highly efficient transfection of rat cortical neurons using carbosilane dendrimers unveils a neuroprotective role for HIF-1alpha in early chemical hypoxia-mediated neurotoxicity","volume":"26","author":"Posadas","year":"2009","journal-title":"Pharm. Res."},{"issue":"5","key":"10.1016\/j.cbi.2009.09.020_bib32","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1074\/jbc.M409223200","article-title":"Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line","volume":"280","author":"Aminova","year":"2005","journal-title":"J. Biol. Chem."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279709004013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279709004013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:21:52Z","timestamp":1757856112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279709004013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0009279709004013"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2009.09.020","relation":{},"ISSN":["0009-2797"],"issn-type":[{"type":"print","value":"0009-2797"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Panaxynol protects cortical neurons from ischemia-like injury by up-regulation of HIF-1\u03b1 expression and inhibition of apoptotic cascade","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2009.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}