{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T14:32:04Z","timestamp":1770474724908,"version":"3.49.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.cbi.2009.11.016","type":"journal-article","created":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T07:40:34Z","timestamp":1259134834000},"page":"30-38","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Integrating WHO 2001\u20132008 criteria for the diagnosis of Myelodysplastic Syndrome (MDS): A case\u2013case analysis of benzene exposure"],"prefix":"10.1016","volume":"184","author":[{"given":"Richard D.","family":"Irons","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherilyn A.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anh","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Ryder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Robert","family":"Schnatter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2009.11.016_bib1","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue","article-title":"WHO classification of tumours of haematopoietic and lymphoid tissue","author":"Swerdlow","year":"2008"},{"key":"10.1016\/j.cbi.2009.11.016_bib2","series-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","article-title":"World Health Organization classification of tumours. Pathology and genetics of tumours of haematopoietic and lymphoid tissues","author":"Jaffe","year":"2001"},{"key":"10.1016\/j.cbi.2009.11.016_bib3","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0145-2126(00)00088-6","article-title":"Validation of the WHO proposals for a new classification of primary myelodysplastic syndromes: a retrospective analysis of 1600 patients","volume":"24","author":"Germing","year":"2000","journal-title":"Leukemia Research"},{"key":"10.1016\/j.cbi.2009.11.016_bib4","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1182\/blood-2005-01-0040","article-title":"Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes","volume":"106","author":"Matsuda","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.cbi.2009.11.016_bib5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.leukres.2006.03.007","article-title":"Differences in epidemiology of MDS between Western and Eastern countries: ethnic differences or environmental influence?","volume":"31","author":"Kuendgen","year":"2007","journal-title":"Leukemia Research"},{"key":"10.1016\/j.cbi.2009.11.016_bib6","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/sj.leu.2403688","article-title":"Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries","volume":"19","author":"Chen","year":"2005","journal-title":"Leukemia"},{"key":"10.1016\/j.cbi.2009.11.016_bib7","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.leukres.2005.10.018","article-title":"Prevalence of MDS subtypes in Shanghai, China: a comparison of the World Health Organization and French American British classifications","volume":"30","author":"Irons","year":"2006","journal-title":"Leukemia Research"},{"key":"10.1016\/j.cbi.2009.11.016_bib8","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s12185-009-0403-5","article-title":"Prospective analysis of clinical and cytogenetic features of 435 cases of MDS diagnosed using the WHO (2001) classification: a prognostic scoring system for predicting survival in RCMD","volume":"90","author":"Wang","year":"2009","journal-title":"International Journal of Hematology"},{"key":"10.1016\/j.cbi.2009.11.016_bib9","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/0145-2126(92)90158-4","article-title":"Morphologic, immunologic and cytogenetic studies in acute myeloid leukemia following occupational exposure to pesticides and organic solvents","volume":"16","author":"Cuneo","year":"1992","journal-title":"Leukemia Research"},{"key":"10.1016\/j.cbi.2009.11.016_bib10","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1093\/jnci\/89.14.1065","article-title":"Benzene and the dose-related incidence of hematologic neoplasms in China","volume":"89","author":"Hayes","year":"1997","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1016\/j.cbi.2009.11.016_bib11","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.leukres.2005.08.019","article-title":"Chronic exposure to benzene results in a unique form of dysplasia","volume":"29","author":"Irons","year":"2005","journal-title":"Leukemia Research"},{"key":"10.1016\/j.cbi.2009.11.016_bib12","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.cbi.2009.11.008","article-title":"Exposure assessment for a case\u2013control epidemiology study based in Shanghai, China: summary of methods and results","volume":"184","author":"Armstrong","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2009.11.016_bib13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1182\/blood-2002-11-3343","article-title":"Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series","volume":"102","author":"Smith","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.cbi.2009.11.016_bib14","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1182\/blood-2004-01-0103","article-title":"Distinctive gene expression profiles of Cd34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities","volume":"104","author":"Chen","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.cbi.2009.11.016_bib15","doi-asserted-by":"crossref","first-page":"14925","DOI":"10.1073\/pnas.222491799","article-title":"Expression profiling of Cd34+ hematopoietic stem\/progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia","volume":"99","author":"Qian","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.cbi.2009.11.016_bib16","first-page":"1239","article-title":"The process of leukemogenesis","volume":"104","author":"Irons","year":"1996","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.cbi.2009.11.016_bib17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0301-472X(99)00144-7","article-title":"The benzene metabolite, hydroquinone, selectively induces 5q31\u2212 and \u22127 in human CD34+CD19\u2212 bone marrow cells","volume":"28","author":"Stillman","year":"2000","journal-title":"Experimental Hematology"},{"key":"10.1016\/j.cbi.2009.11.016_bib18","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/sj.leu.2400763","article-title":"The benzene metabolite, hydroquinone, induces dose-dependent hypoploidy in a human cell line","volume":"11","author":"Stillman","year":"1997","journal-title":"Leukemia"},{"key":"10.1016\/j.cbi.2009.11.016_bib19","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3109\/10428199909145730","article-title":"The benzene metabolites hydroquinone and catechol act in synergy to induce dose-dependent hypoploidy and \u22125q31 in a human cell line","volume":"35","author":"Stillman","year":"1999","journal-title":"Leukemia and Lymphoma"},{"key":"10.1016\/j.cbi.2009.11.016_bib20","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1093\/carcin\/21.8.1485","article-title":"Hydroquinone, a benzene metabolite, increases the level of aneusomy of chromosomes 7 and 8 in human CD34-positive blood progenitor cells","volume":"21","author":"Smith","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cbi.2009.11.016_bib21","first-page":"2176","article-title":"Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene","volume":"58","author":"Smith","year":"1998","journal-title":"Cancer Research"},{"key":"10.1016\/j.cbi.2009.11.016_bib22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0344-0338(11)80705-3","article-title":"Bone marrow morphology in patients with neutropenia due to chronic exposure to organic solvents (benzene): early lesions","volume":"190","author":"Ruiz","year":"1994","journal-title":"Pathology Research and Practice"},{"key":"10.1016\/j.cbi.2009.11.016_bib23","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1056\/NEJMp048266","article-title":"Myelodysplastic syndromes \u2013 coping with ineffective hematopoiesis","volume":"352","author":"Cazzola","year":"2005","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.cbi.2009.11.016_bib24","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.leukres.2004.06.001","article-title":"Myelodysplastic syndrome \u2013 an example of misguided immune surveillance?","volume":"28","author":"Barrett","year":"2004","journal-title":"Leukemia Research"},{"key":"10.1016\/j.cbi.2009.11.016_bib25","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/sj.leu.2401618","article-title":"A hypothesis for the pathogenesis of myelodysplastic syndromes: implications for new therapies","volume":"14","author":"Rosenfeld","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.cbi.2009.11.016_bib26","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1002\/(SICI)1097-0142(19970415)79:8<1548::AID-CNCR16>3.0.CO;2-Y","article-title":"Immunosuppressive therapy for hypoplastic myelodysplastic syndrome","volume":"79","author":"Biesma","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.cbi.2009.11.016_bib27","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0145-2126(02)00173-X","article-title":"Determination of T-cell receptors of clonal CD8-positive T-cells in myelodysplastic syndrome with erythroid hypoplasia","volume":"27","author":"Matsutani","year":"2003","journal-title":"Leukemia Research"},{"key":"10.1016\/j.cbi.2009.11.016_bib28","first-page":"150","article-title":"Immunological abnormalities in myelodysplastic syndromes","volume":"33","author":"Hamblin","year":"1996","journal-title":"Seminars in Hematology"},{"key":"10.1016\/j.cbi.2009.11.016_bib29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1365-2141.2001.02561.x","article-title":"Coincident myelodysplastic syndrome and T-cell large granular lymphocytic disease: clinical and pathophysiological features","volume":"112","author":"Saunthararajah","year":"2001","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.cbi.2009.11.016_bib30","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1046\/j.1365-2141.2001.02925.x","article-title":"Successful treatment with cyclosporin a for myelodysplastic syndrome with erythroid hypoplasia associated with T-cell receptor gene rearrangements","volume":"114","author":"Shimamoto","year":"2001","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.cbi.2009.11.016_bib31","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/S0301-472X(01)00736-6","article-title":"Increased cytotoxic T cells with effector phenotype in aplastic anemia and myelodysplasia","volume":"29","author":"Kook","year":"2001","journal-title":"Experimental Hematology"},{"key":"10.1016\/j.cbi.2009.11.016_bib32","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0140-6736(04)16724-X","article-title":"In-vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing","volume":"364","author":"Risitano","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.cbi.2009.11.016_bib33","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1172\/JCI200112687","article-title":"Limited heterogeneity of T cell receptor BV usage in aplastic anemia","volume":"108","author":"Zeng","year":"2001","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.cbi.2009.11.016_bib34","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1038\/sj.leu.2400887","article-title":"Heteroduplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations","volume":"11","author":"Langerak","year":"1997","journal-title":"Leukemia"},{"key":"10.1016\/j.cbi.2009.11.016_bib35","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1046\/j.1365-2141.1998.00551.x","article-title":"Cyclosporin A therapy in hypoplastic MDS patients and certain refractory anaemias without hypoplastic bone marrow","volume":"100","author":"Jonasova","year":"1998","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.cbi.2009.11.016_bib36","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0168-8278(02)00218-0","article-title":"Decrease in CD3-negative-CD8dim(+) and Vdelta2\/Vgamma9 TcR+ peripheral blood lymphocyte counts, low perforin expression and the impairment of natural killer cell activity is associated with chronic hepatitis C virus infection","volume":"37","author":"Par","year":"2002","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.cbi.2009.11.016_bib37","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1046\/j.1365-2141.2003.04684.x","article-title":"Core-binding factor-beta positive acute myeloid leukaemia cells induce T-cell responses","volume":"123","author":"Banat","year":"2003","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.cbi.2009.11.016_bib38","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.4049\/jimmunol.172.5.2894","article-title":"Different potentials of gamma delta T cell subsets in regulating airway responsiveness: V gamma 1+ cells, but not V gamma 4+ cells, promote airway hyperreactivity, Th2 cytokines, and airway inflammation","volume":"172","author":"Hahn","year":"2004","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.cbi.2009.11.016_bib39","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1164\/ajrccm.164.12.2012059","article-title":"Tumor necrosis factor-alpha negatively regulates airway hyperresponsiveness through gamma\u2013delta T cells","volume":"164","author":"Kanehiro","year":"2001","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.cbi.2009.11.016_bib40","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.leukres.2007.01.014","article-title":"The TNF-alpha 238a polymorphism is associated with susceptibility to persistent bone marrow dysplasia following chronic exposure to benzene","volume":"31","author":"Lv","year":"2007","journal-title":"Leukemia Research"},{"key":"10.1016\/j.cbi.2009.11.016_bib41","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1073\/pnas.89.9.3691","article-title":"Synergistic action of the benzene metabolite hydroquinone on myelopoietic stimulating activity of granulocyte\/macrophage colony-stimulating factor in vitro","volume":"89","author":"Irons","year":"1992","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.cbi.2009.11.016_bib42","first-page":"785","article-title":"Enrichment of CD34 (My10)-positive myeloid and erythroid progenitors from human marrow and their growth in cultures supplemented with recombinant human granulocyte\u2013macrophage colony-stimulating factor","volume":"16","author":"Baines","year":"1988","journal-title":"Experimental Hematology"},{"key":"10.1016\/j.cbi.2009.11.016_bib43","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0301-472X(00)00516-6","article-title":"Tumor necrosis factor-alpha-induced proliferation requires synthesis of granulocyte\u2013macrophage colony-stimulating factor","volume":"28","author":"Quentmeier","year":"2000","journal-title":"Experimental Hematology"},{"key":"10.1016\/j.cbi.2009.11.016_bib44","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/stem.5530110311","article-title":"Cell proliferation and differentiation in chemical leukemogenesis","volume":"11","author":"Irons","year":"1993","journal-title":"Stem Cells"},{"issue":"Suppl. 6","key":"10.1016\/j.cbi.2009.11.016_bib45","first-page":"1247","article-title":"Impact of benzene metabolites on differentiation of bone marrow progenitor cells","volume":"104","author":"Irons","year":"1996","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.cbi.2009.11.016_bib46","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1038\/sj.leu.2403389","article-title":"Hydroquinone modulates the GM-CSF signaling pathway in TF-1 cells","volume":"18","author":"Zheng","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.cbi.2009.11.016_bib47","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1182\/blood-2003-10-3413","article-title":"An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder","volume":"104","author":"Jordan","year":"2004","journal-title":"Blood"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279709004876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279709004876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:20:55Z","timestamp":1757856055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279709004876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":47,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0009279709004876"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2009.11.016","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrating WHO 2001\u20132008 criteria for the diagnosis of Myelodysplastic Syndrome (MDS): A case\u2013case analysis of benzene exposure","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2009.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}