{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:45:26Z","timestamp":1767771926180,"version":"3.44.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.cbi.2010.04.002","type":"journal-article","created":{"date-parts":[[2010,4,17]],"date-time":"2010-04-17T04:38:39Z","timestamp":1271479119000},"page":"9-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Gender-related differences in circadian rhythm of rat plasma acetyl- and butyrylcholinesterase: Effects of sex hormone withdrawal"],"prefix":"10.1016","volume":"186","author":[{"given":"Gracielle","family":"Alves-Amaral","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Pires-Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Luiza","family":"Andrade-Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago","family":"Chiavegatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosely Oliveira","family":"Godinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2010.04.002_bib1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/bj2600625","article-title":"Comparison of butyrylcholinesterase and acetylcholinesterase","volume":"260","author":"Chatonnet","year":"1989","journal-title":"Biochem. J."},{"key":"10.1016\/j.cbi.2010.04.002_bib2","doi-asserted-by":"crossref","first-page":"20829","DOI":"10.1016\/S0021-9258(17)31897-5","article-title":"Promoter and transcription start site of human and rabbit butyrylcholinesterase genes","volume":"269","author":"Jbilo","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2010.04.002_bib3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0022-3565(25)11853-3","article-title":"The relation between dose of succinylcholine and duration of apnea in man","volume":"120","author":"Kalow","year":"1957","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cbi.2010.04.002_bib4","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/BF03005113","article-title":"Use of serum-cholinesterase in succinylcholine apnea","volume":"24","author":"Scholler","year":"1977","journal-title":"Can. Anaesth. Soc. J."},{"key":"10.1016\/j.cbi.2010.04.002_bib5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0163-7258(95)00019-D","article-title":"Engineering of human cholinesterases explains and predicts diverse consequences of administration of various drugs and poisons","volume":"67","author":"Schwarz","year":"1995","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cbi.2010.04.002_bib6","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/taap.1997.8187","article-title":"Cocaine detoxification by human plasma butyrylcholinesterase","volume":"145","author":"Lynch","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2010.04.002_bib7","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1046\/j.1471-4159.2000.751320.x","article-title":"Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse","volume":"75","author":"Li","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cbi.2010.04.002_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0301-0082(93)90040-Y","article-title":"Molecular and cellular biology of cholinesterases","volume":"41","author":"Massoulie","year":"1993","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.cbi.2010.04.002_bib9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0197-0186(95)00101-8","article-title":"Non-classical actions of cholinesterases: Role in cellular differentiation, tumorigenesis and Alzheimer's disease","volume":"28","author":"Layer","year":"1996","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.cbi.2010.04.002_bib10","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/35067589","article-title":"Acetylcholinesterase\u2014new roles for an old actor","volume":"2","author":"Soreq","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cbi.2010.04.002_bib11","series-title":"Exploring the Vertebrate Central Cholinergic Nervous System","first-page":"81","article-title":"Metabolism of acetylcholine: synthesis and turnover","author":"Karczmar","year":"2007"},{"key":"10.1016\/j.cbi.2010.04.002_bib12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0014-5793(76)80912-X","article-title":"Serotonin-sensitive aryl acylamidase activity of acetylcholinesterase","volume":"71","author":"Fujimoto","year":"1976","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cbi.2010.04.002_bib13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1432-1033.1981.tb06447.x","article-title":"The aryl acylamidases and their relationship to cholinesterases in human-serum, erythrocyte and liver","volume":"121","author":"George","year":"1981","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.cbi.2010.04.002_bib14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cca.2007.02.001","article-title":"Human serum cholinesterase from liver pathological samples exhibit highly elevated aryl acylamidase activity","volume":"380","author":"Boopathy","year":"2007","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cbi.2010.04.002_bib15","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.cbi.2008.03.007","article-title":"The level of aryl acylamidase activity displayed by human butyrylcholinesterase depends on its molecular distribution","volume":"175","author":"Montenegro","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2010.04.002_bib16","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1471-4159.1993.tb03246.x","article-title":"Solubilization and biochemical-characterization of the melatonin deacetylase from xenopus-laevis retina","volume":"60","author":"Grace","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cbi.2010.04.002_bib17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1185\/03007990152673800","article-title":"A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase","volume":"17","author":"Greig","year":"2001","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.cbi.2010.04.002_bib18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1042\/cs0850077","article-title":"Relationship between serum butyrylcholinesterase activity, hypertriglyceridemia and insulin sensitivity in diabetes-mellitus","volume":"85","author":"Abbott","year":"1993","journal-title":"Clin. Sci."},{"key":"10.1016\/j.cbi.2010.04.002_bib19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/00365510260296564","article-title":"Butyrylcholinesterase activity and risk factors for coronary artery disease","volume":"62","author":"Alcantara","year":"2002","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"10.1016\/j.cbi.2010.04.002_bib20","first-page":"RA214","article-title":"Acetylcholinesterase and butyrylcholinesterase as possible markers of low-grade systemic inflammation","volume":"13","author":"Das","year":"2007","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.cbi.2010.04.002_bib21","doi-asserted-by":"crossref","first-page":"F680","DOI":"10.1152\/ajprenal.90505.2008","article-title":"Sex, diabetes and the kidney","volume":"296","author":"Maric","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.cbi.2010.04.002_bib22","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/0014-4886(82)90122-4","article-title":"Cholinesterase activity in developing rat skeletal muscles","volume":"76","author":"Dias","year":"1982","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.cbi.2010.04.002_bib23","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/0014-4886(87)90218-4","article-title":"Trophic control of cholinesterase activity in a testosterone-dependent muscle of the rat: effects of castration and denervation","volume":"96","author":"Godinho","year":"1987","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.cbi.2010.04.002_bib24","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/BF00967703","article-title":"Testosterone control of endplate and non-endplate acetylcholinesterase in the rat levator ani muscle","volume":"19","author":"Godinho","year":"1994","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.cbi.2010.04.002_bib25","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.bcp.2008.01.016","article-title":"Effects of estrogen on intracellular signaling pathways linked to activation of muscarinic acetylcholine receptors and on acetylcholinesterase activity in rat hippocampus","volume":"75","author":"Pereira","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2010.04.002_bib26","first-page":"246","article-title":"Influence of sex hormones on central and peripheral cholinesterase levels of male and female rats","volume":"40","author":"Alves-Amaral","year":"2010","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.cbi.2010.04.002_bib27","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000458549","article-title":"Sex-differences of plasma cholinesterase in rat","volume":"23","author":"Schmidt","year":"1978","journal-title":"Enzyme"},{"key":"10.1016\/j.cbi.2010.04.002_bib28","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0009-2797(99)00045-9","article-title":"Glucocorticoids differentially control synthesis of acetylcholinesterase and butyrylcholinesterase in rat liver and brain","volume":"119\u2013120","author":"Weber","year":"1999","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2010.04.002_bib29","first-page":"1001","article-title":"Circadian-rhythms of hepatic estrogen and androgen receptors","volume":"5","author":"Francavilla","year":"1985","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2010.04.002_bib30","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1210\/endo-43-6-389","article-title":"Progesterone and estrogen in the experimental control of ovulation time and other features of the estrous cycle in the rat","volume":"43","author":"Everett","year":"1948","journal-title":"Endocrinology"},{"key":"10.1016\/j.cbi.2010.04.002_bib31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/sj.bjp.0704069","article-title":"Short- and long-term influences of calcitonin gene-related peptide on the synthesis of acetylcholinesterase in mammalian myotubes","volume":"133","author":"da Costa","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbi.2010.04.002_bib32","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1159\/000084202","article-title":"Effects of estrogen on muscarinic acetylcholine receptors in the rat hippocampus","volume":"80","author":"Cardoso","year":"2004","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.cbi.2010.04.002_bib33","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1210\/endo-29-6-975","article-title":"The effects of castration and testosterone propionate on the striated perineal musculature in the rat","volume":"29","author":"Wainman","year":"1941","journal-title":"Endocrinology"},{"key":"10.1016\/j.cbi.2010.04.002_bib34","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2010.04.002_bib35","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1210\/endo-108-5-1737","article-title":"Endocrine regulation of rat serum-cholinesterase activity","volume":"108","author":"Illsley","year":"1981","journal-title":"Endocrinology"},{"key":"10.1016\/j.cbi.2010.04.002_bib36","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.1460-9568.2009.06648.x","article-title":"Age matters","volume":"29","author":"McCutcheon","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.cbi.2010.04.002_bib37","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1081\/DCT-120014794","article-title":"Sexual maturation data for Crl Sprague\u2013Dawley rats: criteria and confounding factors","volume":"25","author":"Lewis","year":"2002","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.cbi.2010.04.002_bib38","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.neuroscience.2008.12.058","article-title":"Estrogen impairs glucocorticoid dependent negative feedback on the hypothalamic-pituitary-adrenal axis via estrogen receptor alpha within the hypothalamus","volume":"159","author":"Weiser","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.cbi.2010.04.002_bib39","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1210\/endo-68-5-818","article-title":"Sex differences in adrenal cortical secretion in the rat","volume":"68","author":"Kitay","year":"1961","journal-title":"Endocrinology"},{"key":"10.1016\/j.cbi.2010.04.002_bib40","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1152\/ajplegacy.1963.205.5.807","article-title":"Sex difference in resting pituitary-adrenal function in the rat","volume":"205","author":"Critchlow","year":"1963","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cbi.2010.04.002_bib41","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1365-2826.2004.01195.x","article-title":"Gonadectomy reverses the sexually diergic patterns of circadian and stress-induced hypothalamic-pituitary-adrenal axis activity in male and female rats","volume":"16","author":"Seale","year":"2004","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.cbi.2010.04.002_bib42","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/j.1365-2826.2004.01258.x","article-title":"Gonadal steroid replacement reverses gonadectomy-induced changes in the corticosterone pulse profile and stress-induced hypothalamic-pituitary-adrenal axis activity of male and female rats","volume":"16","author":"Seale","year":"2004","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.cbi.2010.04.002_bib43","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/hep.21071","article-title":"Changes in liver and plasma acetylcholinesterase in rats with cirrhosis induced by bile duct ligation","volume":"43","author":"Garcia-Ayllon","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2010.04.002_bib44","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1471-4159.1985.tb05452.x","article-title":"Polymorphism of pseudocholinesterase in torpedo-marmorata tissues\u2014comparative-study of the catalytic and molecular-properties of this enzyme with acetylcholinesterase","volume":"44","author":"Toutant","year":"1985","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cbi.2010.04.002_bib45","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/j.1471-4159.1982.tb07918.x","article-title":"Divergent regulation of acetylcholinesterase and butyrylcholinesterase in tissues of the rat","volume":"38","author":"Edwards","year":"1982","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cbi.2010.04.002_bib46","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3748\/wjg.v8.i5.883","article-title":"Estrogen reduces CCL4-induced liver fibrosis in rats","volume":"8","author":"Xu","year":"2002","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cbi.2010.04.002_bib47","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3748\/wjg.v8.i2.363","article-title":"Protective effect of estradiol on hepatocytic oxidative damage","volume":"8","author":"Liu","year":"2002","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cbi.2010.04.002_bib48","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1210\/me.2004-0486","article-title":"Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes","volume":"19","author":"Bjornstrom","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.cbi.2010.04.002_bib49","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1210\/me.2003-0044","article-title":"Genomic targets of nuclear estrogen receptors","volume":"18","author":"O\u2019Lone","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.cbi.2010.04.002_bib50","first-page":"1046","article-title":"Hepatic androgen receptor\u2014effects of hormonal alteration","volume":"5","author":"Eagon","year":"1985","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2010.04.002_bib51","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0016-5085(86)90456-7","article-title":"Circadian-rhythm of hepatic cytosolic and nuclear estrogen and androgen receptors","volume":"91","author":"Francavilla","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cbi.2010.04.002_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2010.03.009","article-title":"Cholinesterases (ChEs) and the Cholinergic System in Ontogenesis and Phylogenesis; and Non-Classical Roles of Cholinesterases\u2013A Review","author":"Karczmar","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2010.04.002_bib53","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1124\/pr.55.2.2","article-title":"Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters","volume":"55","author":"Simonneaux","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cbi.2010.04.002_bib54","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/j.1471-4159.1979.tb11049.x","article-title":"Melatonin-deacetylation to 5-methoxytryptamine by liver but not brain aryl acylamidase","volume":"32","author":"Rogawski","year":"1979","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cbi.2010.04.002_bib55","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1111\/j.1471-4159.1981.tb10827.x","article-title":"In vivo formation of 5-methoxytryptamine from melatonin in rat","volume":"36","author":"Beck","year":"1981","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cbi.2010.04.002_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2010.02.009","article-title":"Is modulation of nicotinic acetylcholine receptors by melatonin relevant for therapy with cholinergic drugs?","author":"Markus","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cbi.2010.04.002_bib57","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1210\/jc.2003-030833","article-title":"Molecular changes underlying reduced pineal melatonin levels in Alzheimer disease: alterations in preclinical and clinical stages","volume":"88","author":"Wu","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cbi.2010.04.002_bib58","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/S0006-2952(97)00676-X","article-title":"Inhibition of cholinesterase-associated aryl acylamidase activity by anticholinesterase agents: focus on drugs potentially effective in Alzheimer's disease","volume":"55","author":"Costagli","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2010.04.002_bib59","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1111\/j.1742-4658.2006.05322.x","article-title":"Melatonin\u2014nature's most versatile biological signal?","volume":"273","author":"Pandi-Perumal","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.cbi.2010.04.002_bib60","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/ana.410360506","article-title":"Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia","volume":"36","author":"Mesulam","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cbi.2010.04.002_bib61","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1517\/17425250902915555","article-title":"The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease, Expert Opin","volume":"5","author":"Duysen","year":"2009","journal-title":"Drug Metab. Toxicol."},{"key":"10.1016\/j.cbi.2010.04.002_bib62","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.etap.2004.12.008","article-title":"Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice","volume":"19","author":"Lockridge","year":"2005","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.cbi.2010.04.002_bib63","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tox.2006.11.069","article-title":"Sensitivity of butyrylcholinesterase knockout mice to (\u2212)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission","volume":"233","author":"Duysen","year":"2007","journal-title":"Toxicology"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279710002425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279710002425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:21:42Z","timestamp":1757856102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279710002425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0009279710002425"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2010.04.002","relation":{},"ISSN":["0009-2797"],"issn-type":[{"type":"print","value":"0009-2797"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gender-related differences in circadian rhythm of rat plasma acetyl- and butyrylcholinesterase: Effects of sex hormone withdrawal","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2010.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}