{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:28:08Z","timestamp":1791210488012,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Funds of China","doi-asserted-by":"crossref","award":["31000768"],"award-info":[{"award-number":["31000768"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National High Tech Research and Development Program (863)","award":["2007AA10Z319"],"award-info":[{"award-number":["2007AA10Z319"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.cbi.2011.01.010","type":"journal-article","created":{"date-parts":[[2011,1,18]],"date-time":"2011-01-18T04:13:03Z","timestamp":1295323983000},"page":"16-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"title":["ROS-Ca2+ is associated with mitochondria permeability transition pore involved in surfactin-induced MCF-7 cells apoptosis"],"prefix":"10.1016","volume":"190","author":[{"given":"Xiao-hong","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-si","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-li","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-hua","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2011.01.010_bib0005","first-page":"112","article-title":"Breast cancer","volume":"7","author":"Carlson","year":"2009","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"10.1016\/j.cbi.2011.01.010_bib0010","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.6004\/jnccn.2009.0073","article-title":"Radiation therapy and breast cancer risk","volume":"7","author":"Ng","year":"2009","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"10.1016\/j.cbi.2011.01.010_bib0015","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1158\/1078-0432.CCR-08-1027","article-title":"A newtherapeutic strategy against hormone-dependent breast cancer: the preclinical development of a dual aromatase and sulfatase inhibitor","volume":"14","author":"Foster","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cbi.2011.01.010_bib0020","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nm0709-731","article-title":"Tumor immunotherapy: making an immortal army","volume":"15","author":"Koehn","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.cbi.2011.01.010_bib0025","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/abbs\/gmp104","article-title":"Apoptotic mechanism of MCF-7 breast cells in vivo and in vitro induced by photodynamic therapy with C-phycocyanin","volume":"42","author":"Li","year":"2010","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.cbi.2011.01.010_bib0030","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.febslet.2007.01.059","article-title":"Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression","volume":"581","author":"Kim","year":"2007","journal-title":"Fed. Eur. Biochem. Soc. Lett."},{"key":"10.1016\/j.cbi.2011.01.010_bib0035","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00217-010-1271-1","article-title":"Separation and extraction of antimicrobial lipopeptides produced by Bacillus amyloliquefaciens ES-2 with macroporous resin","volume":"231","author":"Wang","year":"2010","journal-title":"Eur. Food Res. Technol."},{"key":"10.1016\/j.cbi.2011.01.010_bib0040","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10989-010-9204-1","article-title":"Optimization of antifungal effect of surfactin and iturin to penicillium notatum in syrup of peach by RSM","volume":"16","author":"Huang","year":"2010","journal-title":"Int. J. Peptide Res. Ther."},{"key":"10.1016\/j.cbi.2011.01.010_bib0045","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/biol.1997.0099","article-title":"Mechanism of inactivation of enveloped viruses by the biosurfactant surfactin from Bacillus subtilis","volume":"25","author":"Vollenbroich","year":"1997","journal-title":"Biologicals"},{"key":"10.1016\/j.cbi.2011.01.010_bib0050","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1128\/aem.62.7.2482-2488.1996","article-title":"Purification and characterization of a fibrinolytic enzyme produced from Bacillus sp. strain CK 11-4 screened from Chungkook-Jang","volume":"62","author":"Kim","year":"1996","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.cbi.2011.01.010_bib0055","first-page":"123","article-title":"Review of Surfactin chemical properties and the potential biomedical applications","volume":"3","author":"Seydlov\u00e1","year":"2008","journal-title":"Cent. Eur. J. Med."},{"key":"10.1016\/j.cbi.2011.01.010_bib0060","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s12013-009-9065-4","article-title":"Surfactin induces apoptosis and G2\/M arrest in human breast cancer MCF-7 cells through cell cycle factor regulation","volume":"55","author":"Cao","year":"2009","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.cbi.2011.01.010_bib0065","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cbi.2009.11.027","article-title":"Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS\/JNK-mediated mitochondrial\/caspase pathway","volume":"183","author":"Cao","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2011.01.010_bib0070","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1042\/BA20070227","article-title":"Purification and antitumour activity of a lipopeptide biosurfactant produced by Bacillus natto TK-1","volume":"52","author":"Cao","year":"2009","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.cbi.2011.01.010_bib0075","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0300-9084(02)01375-5","article-title":"The permeability transition pore complex: another view","volume":"84","author":"Halestrap","year":"2002","journal-title":"Biochimie"},{"key":"10.1016\/j.cbi.2011.01.010_bib0080","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s10495-006-0525-7","article-title":"Role of the mitochondrial membrane permeability transition in cell death","volume":"12","author":"Tsujimoto","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.cbi.2011.01.010_bib0085","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.2174\/138161206777585111","article-title":"The voltage-dependent anion channel (VDAC): function in intracellular signalling, Cell Life and Cell Death","volume":"12","author":"Barmatz","year":"2006","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.cbi.2011.01.010_bib0090","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.bbabio.2006.02.007","article-title":"Properties of the permeability transition in VDAC1\u2212\/\u2212 mitochondria","volume":"1757","author":"Krauskopf","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbi.2011.01.010_bib0095","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/ncb1575","article-title":"Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death","volume":"9","author":"Baines","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cbi.2011.01.010_bib0100","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s10495-007-0747-3","article-title":"The permeability transition pore in cell death","volume":"12","author":"Grimm","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.cbi.2011.01.010_bib0105","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0300-9084(02)01366-4","article-title":"The adenine nucleotide translocator in apoptosis","volume":"84","author":"Belzacq","year":"2002","journal-title":"Biochimie"},{"key":"10.1016\/j.cbi.2011.01.010_bib0110","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature02229","article-title":"The ADP\/ATP translocator is not essential for the mitochondrial permeability transition pore","volume":"427","author":"Kokoszka","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2011.01.010_bib0115","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s00395-007-0675-y","article-title":"Opening of mitochondrial permeability transition pore induces hypercontracture in Ca2+ overloaded cardiac myocytes","volume":"102","author":"Marisol","year":"2007","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.cbi.2011.01.010_bib0120","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.cbi.2011.01.010_bib0125","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00395-009-0080-9","article-title":"Inhibition of mitochondrial permeability transition pore opening: the holy grail of cardioprotection","volume":"105","author":"Heusch","year":"2010","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.cbi.2011.01.010_bib0130","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.yjmcc.2006.09.013","article-title":"Cyclosporine A attenuates mitochondrial Permeability transition and improves mitochondrial Respiratory function in cardiomyoeytes isolated from dogs with heart failure","volume":"42","author":"Sharov","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.cbi.2011.01.010_bib0135","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10741-005-7545-1","article-title":"Inhibition of mitochondrial Permeability transition Pores by cyclosporine A improves cytochrome C oxidase function and increases rate of ATP synthesis in failing cardiomyocytes","volume":"10","author":"Sharov","year":"2006","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.cbi.2011.01.010_bib0140","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00395-009-0010-x","article-title":"The mitochondrial permeability transition pore as a target for preconditioning and postconditioning","volume":"104","author":"Hausenloy","year":"2009","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.cbi.2011.01.010_bib0145","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1534-5807(01)00116-2","article-title":"A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis","volume":"2","author":"Scorrano","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cbi.2011.01.010_bib0150","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.bbamcr.2006.04.006","article-title":"Structure and dynamics of the mitochondrial inner membrane cristae","volume":"1763","author":"Mannella","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbi.2011.01.010_bib0155","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1126\/science.275.5303.1129","article-title":"Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked","volume":"275","author":"Yang","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.cbi.2011.01.010_bib0160","doi-asserted-by":"crossref","first-page":"C852","DOI":"10.1152\/ajpcell.2000.279.3.C852","article-title":"Elevation of resting mitochondrial membrane potential of neural cells by cyclosporin A, BAPTA-AM, and bcl-2","volume":"279","author":"Kowaltowski","year":"2000","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.cbi.2011.01.010_bib0165","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s10495-007-0723-y","article-title":"The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis","volume":"12","author":"Rasola","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.cbi.2011.01.010_bib0170","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00418-004-0712-y","article-title":"Calcein-AM is a detector of intracellular oxidative activity","volume":"122","author":"Uggeri","year":"2004","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.cbi.2011.01.010_bib0175","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.canlet.2008.11.007","article-title":"CLP induces apoptosis in human leukemia K562 cells through Ca2+ regulating extracellular-related protein kinase ERK activation","volume":"276","author":"Wang","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cbi.2011.01.010_bib0180","doi-asserted-by":"crossref","first-page":"31199","DOI":"10.1074\/jbc.C000405200","article-title":"Cytochrome c promotes caspase-9 acitvation by inducing nucleotide bingding to Apaf-1","volume":"275","author":"Jiang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2011.01.010_bib0185","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/carcin\/bgp067","article-title":"PLAB induction in fenretinide-induced apoptosis of ovarian cancer cells occurs via a ROS-dependent mechanism involving ER stress and JNK activation","volume":"30","author":"Appierto","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cbi.2011.01.010_bib0190","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1006\/jmcc.2002.2082","article-title":"Cardiac energy metabolism homeostasis: role of cytoplasmic calcium","volume":"34","author":"Balaban","year":"2002","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.cbi.2011.01.010_bib0195","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1085\/jgp.200609660","article-title":"Depolarization-induced calcium responses in sympathetic neurons: relative contributions from Ca2+ entry, extrusion, ER\/mitochondrial Ca2+ uptake and release, and Ca2+ buffering","volume":"129","author":"Patterson","year":"2007","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.cbi.2011.01.010_bib0200","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nature02246","article-title":"The mitochondrial calcium uniporter is a highly selective ion channel","volume":"427","author":"Kirichok","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2011.01.010_bib0205","doi-asserted-by":"crossref","first-page":"21482","DOI":"10.1074\/jbc.M101486200","article-title":"Identification of a ryanodine receptor in rat heart mitochondria","volume":"276","author":"Beutner","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2011.01.010_bib0210","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1054\/ceca.2000.0168","article-title":"Mitochondrial calcium transport: mechanisms and functions","volume":"28","author":"Gunter","year":"2000","journal-title":"Cell Calcium"},{"key":"10.1016\/j.cbi.2011.01.010_bib0215","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1016\/S0006-3495(03)74754-7","article-title":"Quantitative analysis of spontaneous mitochondrial depolarizations","volume":"85","author":"O\u2019Reilly","year":"2003","journal-title":"Biophys. J."},{"key":"10.1016\/j.cbi.2011.01.010_bib0220","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1152\/ajpcell.00139.2004","article-title":"Calcium, ATP, and ROS: a mitochondrial love-hate triangle","volume":"287","author":"Brookes","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.cbi.2011.01.010_bib0225","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1096\/fj.01-0269fje","article-title":"The permeability transition pore signals apoptosis by directing Bax translocation and multimerization","volume":"16","author":"De","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.cbi.2011.01.010_bib0230","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4161\/cbt.4.2.1508","article-title":"Overview of cell death signaling pathways","volume":"4","author":"Jin","year":"2005","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.cbi.2011.01.010_bib0235","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11693-009-9022-y","article-title":"Mathematical modeling of the formation of apoptosome in intrinsic pathway of apoptosis","volume":"2","author":"Seongho Ryu","year":"2008","journal-title":"Syst. Synth. Biol."},{"key":"10.1016\/j.cbi.2011.01.010_bib0240","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1081\/DMR-120026497","article-title":"Formation of the Apaf-1 apoptosome, Chemical-induced apoptosis","volume":"35","author":"Cain","year":"2003","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.cbi.2011.01.010_bib0245","doi-asserted-by":"crossref","first-page":"17545","DOI":"10.1073\/pnas.0507900102","article-title":"Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1","volume":"102","author":"Kim","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279711000159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279711000159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:23:51Z","timestamp":1757856231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279711000159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0009279711000159"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2011.01.010","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ROS-Ca2+ is associated with mitochondria permeability transition pore involved in surfactin-induced MCF-7 cells apoptosis","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2011.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}