{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:08:12Z","timestamp":1791108492908,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.cbi.2011.05.008","type":"journal-article","created":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T06:07:12Z","timestamp":1306303632000},"page":"191-203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Protective effect of zinc against cadmium hepatotoxicity depends on this bioelement intake and level of cadmium exposure: A study in a rat model"],"prefix":"10.1016","volume":"193","author":[{"given":"Joanna","family":"Rogalska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Pilat-Marcinkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata M.","family":"Brz\u00f3ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2011.05.008_b0005","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2009.04.020","article-title":"Current status of cadmium as an environmental health problem","volume":"238","author":"J\u00e4rup","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2011.05.008_b0010","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.taap.2009.03.015","article-title":"Historical perspectives on cadmium toxicology","volume":"238","author":"Nordberg","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2011.05.008_b0015","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s10534-010-9343-z","article-title":"Cadmium exposure in the population: from health risks to strategies of prevention","volume":"23","author":"Nawrot","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.cbi.2011.05.008_b0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.toxlet.2010.05.008","article-title":"Benchmark dose for cadmium-induced osteoporosis in women","volume":"197","author":"Suwazono","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbi.2011.05.008_b0025","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/alcalc\/agg006","article-title":"Liver and kidney function and histology in rats exposed to cadmium and ethanol","volume":"38","author":"Brz\u00f3ska","year":"2003","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.cbi.2011.05.008_b0030","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s00204-003-0499-y","article-title":"Time-course of cadmium-induced acute hepatotoxicity in the rat liver: the role of apoptosis","volume":"77","author":"Tzirogiannis","year":"2003","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2011.05.008_b0035","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11010-005-9017-2","article-title":"Evaluation of the effects of cadmium on rat liver","volume":"284","author":"Koyu","year":"2006","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.cbi.2011.05.008_b0040","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.etp.2009.03.010","article-title":"Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin","volume":"62","author":"Renugadevi","year":"2010","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.cbi.2011.05.008_b0045","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.fct.2003.10.005","article-title":"Antioxidant enzymes activity and lipid peroxidation in liver and kidney of rats exposed to cadmium and ethanol","volume":"42","author":"Jurczuk","year":"2004","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2011.05.008_b0050","first-page":"599","article-title":"Vitamins E and C concentrations in the liver and kidney of rats exposed to cadmium and ethanol","volume":"14","author":"Jurczuk","year":"2005","journal-title":"Pol. J. Environ. Stud."},{"key":"10.1016\/j.cbi.2011.05.008_b0055","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1023\/B:CBTO.0000038462.39859.2f","article-title":"Zinc pretreatment prevents hepatic stellate cells from cadmium-produced oxidative damage","volume":"20","author":"Souza","year":"2004","journal-title":"Cell. Biol. Toxicol."},{"key":"10.1016\/j.cbi.2011.05.008_b0060","first-page":"483","article-title":"Involvement of some low-molecular thiols in the destructive mechanism of cadmium and ethanol action on rat livers and kidneys","volume":"14","author":"Moniuszko-Jakoniuk","year":"2005","journal-title":"Pol. J. Environ. Stud."},{"key":"10.1016\/j.cbi.2011.05.008_b0065","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1177\/0960327107073810","article-title":"Effects of diallyl tetrasulfide on cadmium-induced oxidative damage in the liver of rats","volume":"26","author":"Murugavel","year":"2007","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.cbi.2011.05.008_b0070","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jtemb.2008.08.002","article-title":"Metals and apoptosis: recent developments","volume":"22","author":"Rana","year":"2008","journal-title":"J. Trace. Elem. Med. Biol."},{"key":"10.1016\/j.cbi.2011.05.008_b0075","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.ecoenv.2008.12.006","article-title":"Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver of the rat: effects on the oxidative stress","volume":"72","author":"Jihen","year":"2009","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2011.05.008_b0080","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cbi.2010.03.040","article-title":"Multiple roles of cadmium in cell death and survival","volume":"188","author":"Templeton","year":"2010","journal-title":"Chem. Biol. Interact."},{"issue":"4 Suppl.","key":"10.1016\/j.cbi.2011.05.008_b0085","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1542\/peds.113.S3.1097","article-title":"Liver","volume":"113","author":"Pi\u00f1eiro-Carrero","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.cbi.2011.05.008_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/BTER:75:1-3:1","article-title":"Protective effect of zinc on cadmium toxicity in rodents","volume":"75","author":"Claverie","year":"2000","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.cbi.2011.05.008_b0095","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0278-6915(01)00048-5","article-title":"Interactions between cadmium and zinc in the organism","volume":"29","author":"Brz\u00f3ska","year":"2001","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2011.05.008_b0100","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tox.2007.05.001","article-title":"Effect of zinc supplementation on bone metabolism in male rats chronically exposed to cadmium","volume":"237","author":"Brz\u00f3ska","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.cbi.2011.05.008_b0105","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cbi.2007.11.007","article-title":"Beneficial effect of zinc supplementation on biomechanical properties of femoral distal end and femoral diaphysis of male rats chronically exposed to cadmium","volume":"171","author":"Brz\u00f3ska","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2011.05.008_b0110","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.etp.2010.03.010","article-title":"Zinc supplementation can protect from enhanced risk of femoral neck fracture in male rats chronically exposed to cadmium","volume":"63","author":"Brz\u00f3ska","year":"2011","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.cbi.2011.05.008_b0115","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jtemb.2007.08.001","article-title":"Protective effect of zinc supplementation on blood antioxidant defense system in rats exposed to cadmium","volume":"21","author":"Jemai","year":"2007","journal-title":"J. Trace. Elem. Med. Biol."},{"key":"10.1016\/j.cbi.2011.05.008_b0120","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1016\/j.fct.2008.08.037","article-title":"Protective effect of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver and kidney of the rat: histology and Cd accumulation","volume":"46","author":"Jihen","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2011.05.008_b0125","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.toxlet.2010.04.006","article-title":"Cadmium retention increase: a probable key mechanism for the protective effect of zinc on cadmium-induced toxicity in the kidney","volume":"196","author":"Jihen","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbi.2011.05.008_b0130","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.cbi.2008.09.011","article-title":"Enhanced zinc consumption prevents cadmium-induced alterations in lipid metabolism in male rats","volume":"177","author":"Rogalska","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2011.05.008_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00204-005-0009-5","article-title":"Zinc: a multipurpose trace element","volume":"80","author":"Stefanidou","year":"2006","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2011.05.008_b0140","first-page":"443","article-title":"Zinc, antioxidant systems and metallothionein in metal mediated-apoptosis: biochemical and cytochemical aspects","volume":"146","author":"Formigari","year":"2007","journal-title":"Comp. Biochem. Physiol. Part C"},{"key":"10.1016\/j.cbi.2011.05.008_b0145","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bcp.2009.04.009","article-title":"Zinc supplementation attenuates ethanol- and acetaldehyde-induced liver satellite cell activation by inhibiting reactive oxygen species (ROS) production and by influencing intracellular signaling","volume":"78","author":"Szuster-Ciesielska","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2011.05.008_b0150","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s10534-010-9336-y","article-title":"Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals","volume":"23","author":"Moulis","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.cbi.2011.05.008_b0155","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3923\/ijp.2006.79.88","article-title":"Role of zinc in the protection against cadmium induced hepatotoxicty","volume":"2","author":"Bashandy","year":"2006","journal-title":"Int. J. Pharmacol."},{"key":"10.1016\/j.cbi.2011.05.008_b0160","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3390\/medicina44020017","article-title":"Subacute effects of cadmium and zinc ions on protein synthesis and cell death in mouse liver","volume":"44","author":"Stanevi\u010diene","year":"2008","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.cbi.2011.05.008_b0165","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3923\/jpt.2011.76.81","article-title":"Toxic effects of various dietary levels of combined cadmium chloride and zinc chloride on male Wistar rats","volume":"6","author":"Rhman","year":"2011","journal-title":"J. Pharmacol. Toxicol."},{"key":"10.1016\/j.cbi.2011.05.008_b0170","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1080\/01635580903285122","article-title":"Zinc in cancer prevention","volume":"61","author":"Prasad","year":"2009","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.cbi.2011.05.008_b0175","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Path."},{"key":"10.1016\/j.cbi.2011.05.008_b0180","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.taap.2004.06.007","article-title":"Disorders in bone metabolism of female rats chronically exposed to cadmium","volume":"202","author":"Brz\u00f3ska","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2011.05.008_b0185","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s002440010273","article-title":"Tissue-specific cadmium accumulation, metallothionein induction, and tissue zinc and copper levels during chronic sublethal cadmium exposure in juvenile rainbow trout","volume":"41","author":"Hollis","year":"2001","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.cbi.2011.05.008_b0190","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s10534-010-9351-z","article-title":"Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs","volume":"23","author":"Saboili\u0107","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.cbi.2011.05.008_b0195","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cbi.2009.01.014","article-title":"Oxidative damage to proteins and DNA in rats exposed to cadmium and\/or ethanol","volume":"180","author":"Gala\u017cyn-Sidorczuk","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2011.05.008_b0200","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s10534-010-9329-x","article-title":"Cadmium stress: an oxidative challenge","volume":"23","author":"Cuypers","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.cbi.2011.05.008_b0205","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.taap.2010.11.012","article-title":"The involvement of oxidative stress in the mechanisms of damaging cadmium action in bone tissue: a study in a rat model of moderate and relatively high human exposure","volume":"250","author":"Brz\u00f3ska","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2011.05.008_b0210","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3923\/jpt.2011.24.29","article-title":"Pathways of hepatic regeneration and pharmacological approaches for hepatoprotection: a brief approach","volume":"6","author":"Ansari","year":"2011","journal-title":"J. Pharmacol. Toxicol."},{"key":"10.1016\/j.cbi.2011.05.008_b0215","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mrfmmm.2008.12.011","article-title":"Divergence to apoptosis from ROS induced cell cycle arrest: effect of cadmium","volume":"663","author":"Chatterjee","year":"2009","journal-title":"Mut. Res."},{"key":"10.1016\/j.cbi.2011.05.008_b0220","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tox.2010.06.011","article-title":"Low micromolar zinc exerts cytotoxic action under H2O2-induced oxidative stress: excessive increase in intracellular Zn2+ concentration","volume":"276","author":"Matsui","year":"2010","journal-title":"Toxicology"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279711002195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279711002195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:26:03Z","timestamp":1757856363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279711002195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0009279711002195"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2011.05.008","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of zinc against cadmium hepatotoxicity depends on this bioelement intake and level of cadmium exposure: A study in a rat model","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2011.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}