{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:28:32Z","timestamp":1761128912570,"version":"3.44.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.cbi.2011.08.010","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T01:16:11Z","timestamp":1315530971000},"page":"106-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["25-OCH3-PPD induces the apoptosis of activated t-HSC\/Cl-6 cells via c-FLIP-mediated NF-\u03baB activation"],"prefix":"10.1016","volume":"194","author":[{"given":"Yan-ling","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Jun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-Qing","family":"OuYang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Qing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Xing","family":"Nan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2011.08.010_b0005","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/S0168-8278(02)00429-4","article-title":"Liver fibrosis: from bench to bedside","volume":"38","author":"Friedman","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2011.08.010_b0010","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbi.2011.08.010_b0015","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1146\/annurev.pharmtox.45.120403.095906","article-title":"Hepaticfibrosis: molecular mechanisms and drug targets","volume":"45","author":"Lotersztajn","year":"2005","journal-title":"Ann. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.cbi.2011.08.010_b0020","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1056\/NEJM199306243282508","article-title":"Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies","volume":"328","author":"Friedman","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cbi.2011.08.010_b0025","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"Friedman","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2011.08.010_b0030","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/hep.1840150603","article-title":"Role of extracellular matrix in regulating fenestrations of sinusoidal endothelial cells isolated from normal rat liver","volume":"15","author":"McGuire","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2011.08.010_b0035","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1055\/s-2001-17552","article-title":"Extracellular matrix degradation and the role of stellate cells","volume":"21","author":"Benyon","year":"2001","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.cbi.2011.08.010_b0040","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jhep.2004.01.009","article-title":"Decreased fibrosis during corticosteroid therapy of autoimmune hepatitis","volume":"40","author":"Czaja","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2011.08.010_b0045","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/157340607779317508","article-title":"Isolation, structural determination, and evaluation of the biological activity of 20(S)-25-methoxyl-dammarane-3\u03b2, 12\u03b2, 20-triol [20(S)-25-OCH3-PPD], a novel natural product from Panax notoginseng","volume":"3","author":"Zhao","year":"2007","journal-title":"Med. Chem."},{"key":"10.1016\/j.cbi.2011.08.010_b0050","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1111\/j.1440-1681.2009.05203.x","article-title":"Anticancer activity of Panax notoginseng extract 20(s)-25-OCH3-PPD: targeting \u03b2-catenin signaling","volume":"36","author":"Bi","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.cbi.2011.08.010_b0055","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00280-006-0300-z","article-title":"In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng","volume":"59","author":"Wang","year":"2006","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.cbi.2011.08.010_b0060","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/sj.bjc.6604227","article-title":"20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol. A novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action","volume":"98","author":"Wang","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cbi.2011.08.010_b0065","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1172\/JCI31487","article-title":"Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases","volume":"117","author":"Wynn","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbi.2011.08.010_b0070","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cbi.2011.08.010_b0075","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0168-8278(98)80269-9","article-title":"Molecular regulation of hepatic fibrogenesis","volume":"29","author":"Olaso","year":"1998","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2011.08.010_b0080","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1172\/JCI118304","article-title":"Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression","volume":"96","author":"Lee","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbi.2011.08.010_b0085","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/hep.510310118","article-title":"Hydrogen peroxide: a link between acetaldehyde-elicited alpha1(I) collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells","volume":"31","author":"Greenwel","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2011.08.010_b0090","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1152\/jappl.1989.66.3.1029","article-title":"Modulation of endothelial GSH concentrations: effect of exogenous GSH and GSH monoethyl ester","volume":"66","author":"Tsan","year":"1989","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.cbi.2011.08.010_b0095","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","article-title":"Glutathione metabolism and its implications for health","volume":"134","author":"Wu","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.cbi.2011.08.010_b0100","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0891-5849(01)00812-7","article-title":"Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter","volume":"32","author":"Myhrstad","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2011.08.010_b0105","doi-asserted-by":"crossref","first-page":"20633","DOI":"10.1074\/jbc.M101780200","article-title":"Cellular fl ice-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the cd95 death-inducing signaling complex","volume":"276","author":"Krueger","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2011.08.010_b0110","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1074\/jbc.274.3.1541","article-title":"The role of c-FLIP in modulation of CD95-induced apoptosis","volume":"274","author":"Scaffidi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2011.08.010_b0115","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/386517a0","article-title":"Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors","volume":"386","author":"Thome","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2011.08.010_b0120","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0960-9822(00)00512-1","article-title":"The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways","volume":"10","author":"Kataoka","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cbi.2011.08.010_b0125","doi-asserted-by":"crossref","first-page":"10838","DOI":"10.1074\/jbc.275.15.10838","article-title":"Activation of NF-kappaB by FADD, Casper, and caspase-8","volume":"275","author":"Hu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2011.08.010_b0130","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/35095508","article-title":"Regulation of lymphocyte proliferation and death by FLIP","volume":"1","author":"Thome","year":"2001","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cbi.2011.08.010_b0135","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/S0092-8674(02)00703-1","article-title":"Missing pieces in the NF-kappaB puzzle","volume":"109","author":"Ghosh","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2011.08.010_b0140","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1101\/gad.1228704","article-title":"Signaling to NF-kappaB","volume":"18","author":"Hayden","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.cbi.2011.08.010_b0145","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/eji.200636956","article-title":"C-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival","volume":"38","author":"Hinshaw-Makepeace","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cbi.2011.08.010_b0150","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1084\/jem.20051556","article-title":"The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation","volume":"203","author":"Golks","year":"2006","journal-title":"J. Exp. Med."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279711002870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279711002870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:26:06Z","timestamp":1757856366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279711002870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":30,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0009279711002870"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2011.08.010","relation":{},"ISSN":["0009-2797"],"issn-type":[{"type":"print","value":"0009-2797"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"25-OCH3-PPD induces the apoptosis of activated t-HSC\/Cl-6 cells via c-FLIP-mediated NF-\u03baB activation","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2011.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}