{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:38:02Z","timestamp":1778042282257,"version":"3.51.4"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.cbi.2013.05.007","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T09:46:13Z","timestamp":1369215973000},"page":"140-143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["In vitro metabolism of brucine by human liver microsomes and its interactions with CYP substrates"],"prefix":"10.1016","volume":"204","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2013.05.007_b0005","first-page":"263","article-title":"The Asian species of Strychnos. Part IV, the alkaloids","volume":"39","author":"Bisset","year":"1976","journal-title":"Lloydia"},{"key":"10.1016\/j.cbi.2013.05.007_b0010","first-page":"425","article-title":"Cytotoxicities of alkaloids from processed and unprocessed seeds of Styrchnos Nuxvomica","volume":"19","author":"Cai","year":"1998","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.cbi.2013.05.007_b0015","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0378-8741(03)00224-1","article-title":"Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos Nuxvomica","volume":"88","author":"Yin","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2013.05.007_b0020","first-page":"468","article-title":"Effect of brucine on mouse nonspecific immune responses","volume":"18","author":"Zhao","year":"1997","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.cbi.2013.05.007_b0025","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1007\/s10856-009-3773-6","article-title":"Preparation and pharmaceutical\/pharmacodynamic evaluation of topical brucine-loaded liposomal hydrogel","volume":"20","author":"Wang","year":"2009","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.cbi.2013.05.007_b0030","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0378-8741(92)90028-P","article-title":"Brucine lethality in mice","volume":"35","author":"Malone","year":"1992","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2013.05.007_b0035","first-page":"167","article-title":"Identification of Strychnine, brucine and their metabolites in body fluids by liquid chromatography-electrospray ion trap mass spectrometry","volume":"21","author":"Guo","year":"2001","journal-title":"Chin. J. Pharm. Anal."},{"key":"10.1016\/j.cbi.2013.05.007_b0040","unstructured":"Y.X. Mao, Z.Z. Fang, G.B. Ge, L. Yang, Characterization of in vitro metabolism of brucine using human liver microsomes, in: 18th International Symposium on Microsomes and Drug Oxidations 1, (2010) 278."},{"key":"10.1016\/j.cbi.2013.05.007_b0045","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0300-483X(02)00492-4","article-title":"Polymorphism of cytochrome P450 and xenobiotic toxicity","volume":"181\u2013182","author":"Ingelman-Sundberg","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.cbi.2013.05.007_b0050","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1124\/dmd.31.7.815","article-title":"The conduct of in vitro and in vivo drug\u2013drug interaction studies: a pharmaceutical research and manufacturers of America (PhRMA) perspective","volume":"31","author":"Bjornsson","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.cbi.2013.05.007_b0055","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0009-2797(02)00074-1","article-title":"In vitro metabolism of carbaryl by human cytochrome P450 and its inhibition by chlorpyrifos","volume":"141","author":"Tang","year":"2002","journal-title":"Chem Biol. Interact."},{"key":"10.1016\/j.cbi.2013.05.007_b0060","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1080\/00498250802037309","article-title":"In vitro metabolism of a novel PPAR agonist, KR-62980, and its stereoisomer, KR-63198, in human liver microsomes and by recombinant cytochrome P450s","volume":"38","author":"Kim","year":"2008","journal-title":"Xenobiotica"},{"key":"10.1016\/j.cbi.2013.05.007_b0065","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.lfs.2006.08.016","article-title":"The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes","volume":"79","author":"Yao","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.cbi.2013.05.007_b0070","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1124\/dmd.32.6.647","article-title":"Validated assays for human cytochrome P450 activities","volume":"32","author":"Walsky","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.cbi.2013.05.007_b0075","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1124\/dmd.31.7.955","article-title":"Cytochrome P450 inhibition using recombinant proteins and mass spectrometry\/multiple reaction monitoring technology in a cassette incubation","volume":"31","author":"Weaver","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.cbi.2013.05.007_b0080","first-page":"128","article-title":"Prediction of metabolic drug interaction in vivo by using in vitro drug metabolism data","volume":"19","author":"Zhou","year":"2003","journal-title":"Chin. J. Clin. Pharmacol."},{"key":"10.1016\/j.cbi.2013.05.007_b0085","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1124\/dmd.31.10.1227","article-title":"Stereoselective metabolism of Lansoprazole by human liver cytochrome P450 enzymes","volume":"31","author":"Kim","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.cbi.2013.05.007_b0090","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.toxlet.2006.06.002","article-title":"Characterization of the cytochrome P450 enzymes involved in the metabolism of a new cardioprotective agent KR-33028","volume":"166","author":"Kim","year":"2006","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbi.2013.05.007_b0095","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cbi.2004.03.002","article-title":"In vitro metabolism of fipronil by human and rat cytochrome P450 and its interactions with testosterone and diazepam","volume":"147","author":"Tang","year":"2004","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2013.05.007_b0100","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1054-3589(08)60200-8","article-title":"Role of cytochrome P450 enzymes in drug\u2013drug interactions","volume":"43","author":"Guengerich","year":"1997","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.cbi.2013.05.007_b0105","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.pa.35.040195.000333","article-title":"Structural basis of selective cytochrome P450 inhibition","volume":"35","author":"Halpert","year":"1995","journal-title":"Annu. Rev. Pharmacol. Toxicol."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279713001166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279713001166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:28:53Z","timestamp":1757856533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279713001166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0009279713001166"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2013.05.007","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro metabolism of brucine by human liver microsomes and its interactions with CYP substrates","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2013.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}