{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:34:37Z","timestamp":1789695277133,"version":"4.0.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002412","name":"Xi\u2019an Jiaotong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.cbi.2013.11.011","type":"journal-article","created":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T15:15:20Z","timestamp":1385910920000},"page":"18-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":111,"special_numbering":"C","title":["Protective effect of chelerythrine against ethanol-induced gastric ulcer in mice"],"prefix":"10.1016","volume":"208","author":[{"given":"Wei-Feng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding-Jun","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Min","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Feng","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.cbi.2013.11.011_b0005","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1365-2036.2008.03610.x","article-title":"Systematic review: ulcer definition in NSAID ulcer prevention trials","volume":"27","author":"Yeomans","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.cbi.2013.11.011_b0010","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jep.2011.01.009","article-title":"Pharmacological mechanisms underlying the anti-ulcer activity of methanol extract and canthin-6-one of Simabaferruginea A. St-Hil in animal models","volume":"134","author":"De Souza Almeida","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2013.11.011_b0015","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.physiol.63.1.119","article-title":"The gastrins: their production and biological activity","volume":"63","author":"Dockray","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cbi.2013.11.011_b0020","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0895-3988(10)60006-2","article-title":"Anti-ulcer activity of curcumin on experimental gastric ulcer in rats and its effect on oxidative stress\/antioxidant, IL-6 and enzyme activities","volume":"22","author":"Tuorkey","year":"2009","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.cbi.2013.11.011_b0025","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.freeradbiomed.2005.12.016","article-title":"Indomethacin inactivates gastric peroxidase to induce reactive-oxygenmediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen","volume":"40","author":"Chattopadhyay","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2013.11.011_b0230","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cbi.2009.09.015","article-title":"Effect of fucoidan on aspirin-induced stomach ulceration in rats","volume":"183","author":"Jongil","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2013.11.011_b0225","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-\u03baB and I\u03baB proteins: new discoveries and insights","volume":"14","author":"Baldwin","year":"1996","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cbi.2013.11.011_b0035","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1365-2796.2008.01953.x","article-title":"NF-\u03baB in inflammatory bowel disease","volume":"263","author":"Atreya","year":"2008","journal-title":"J. Intern. Med."},{"issue":"8","key":"10.1016\/j.cbi.2013.11.011_b0040","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1155\/1998\/398384","article-title":"Neutrophil-mediated gastrointestinal injury","volume":"12","author":"Elliot","year":"1998","journal-title":"Can. J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.cbi.2013.11.011_b0045","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0014-5793(98)00237-3","article-title":"Contribution of nitric oxide synthases to neutrophil infiltration in the gastric mucosal lesions in rats with water immersion restraint stress","volume":"425","author":"Nishida","year":"1998","journal-title":"FEBS Lett."},{"issue":"1\u20132","key":"10.1016\/j.cbi.2013.11.011_b0050","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0378-8741(99)00174-9","article-title":"Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced Gastric lesions","volume":"71","author":"La Casa","year":"2000","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.cbi.2013.11.011_b0055","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1007\/BF02091537","article-title":"Cold restraint stress-induced gastric mucosal dysfunction-role of nitric oxide","volume":"41","author":"Coskun","year":"1996","journal-title":"Dig. Dis. Sci."},{"issue":"4","key":"10.1016\/j.cbi.2013.11.011_b0060","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1159\/000007506","article-title":"Role of nitric oxide in pathogenesis of aspirin-induced gastric mucosal damage in rats","volume":"59","author":"Takeuchi","year":"1998","journal-title":"Digestion"},{"key":"10.1016\/j.cbi.2013.11.011_b0065","first-page":"7","article-title":"Benzo[c]phenanthridine alkaloids sanguinarine and CHE: biological activities and dental care applications","volume":"139","author":"Walterova","year":"1995","journal-title":"Acta Univ. Palacki. Olomuc. Fac. Med."},{"key":"10.1016\/j.cbi.2013.11.011_b0070","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1055\/s-2006-957924","article-title":"Benzophenanthridine alkaloids of Chelidonium majus; I. Inhibition of 5- and 12-lipoxygenase by a non-redox mechanism","volume":"62","author":"Vavreckova","year":"1996","journal-title":"Planta Med."},{"key":"10.1016\/j.cbi.2013.11.011_b0075","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10565-007-9014-1","article-title":"Conventional protein kinase C isoenzymes undergo dephosphorylation in neutrophil-like HL-60 cells treated by CHE or sanguinarine","volume":"24","author":"Vrba","year":"2008","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.cbi.2013.11.011_b0080","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/sj.bjp.0705868","article-title":"CHE and other benzophenanthridine alkaloids block the human P2X(7) receptor","volume":"142","author":"Shemon","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbi.2013.11.011_b0085","doi-asserted-by":"crossref","first-page":"19078","DOI":"10.1074\/jbc.M501467200","article-title":"The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1","volume":"280","author":"Vogt","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2013.11.011_b0090","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.fitote.2011.01.020","article-title":"Effects of CHE, a specific inhibitor of cyclooxygenase-2, on acute inflammation in mice","volume":"82","author":"Niu","year":"2011","journal-title":"Fitoterapia"},{"issue":"6","key":"10.1016\/j.cbi.2013.11.011_b0095","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1007\/s10753-012-9502-1","article-title":"Effect of CHE against endotoxic shock in mice and its modulation of inflammatory mediators in peritoneal macrophages through the modulation of mitogen-activated protein kinase (MAPK) pathway","volume":"35","author":"Li","year":"2012","journal-title":"Inflammation"},{"key":"10.1016\/j.cbi.2013.11.011_b0100","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1248\/bpb.33.223","article-title":"Effects of Artichoke leaf extract on acute gastric mucosal injury in rats","volume":"33","author":"Kazuo","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.cbi.2013.11.011_b0105","first-page":"885","article-title":"Gastroprotective effects of morniflumate an esterified anti-inflammatory drug","volume":"34","author":"Schiantarelli","year":"1984","journal-title":"Arzneimittel-Forschung"},{"key":"10.1016\/j.cbi.2013.11.011_b0110","doi-asserted-by":"crossref","first-page":"e25878","DOI":"10.1371\/journal.pone.0025878","article-title":"Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by activation of antioxidant enzymes and attenuation of MDA increase","volume":"6","author":"Alvarez-Suarez","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.cbi.2013.11.011_b0115","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cbi.2011.11.008","article-title":"Gastroprotective activity and mechanism of novel dichlorido-zinc (II)-4-(2\u20135-methoxybenzylideneamino) ethyl piperazin-1-iumphenolate complex on ethanol-induced gastric ulceration","volume":"195","author":"Salga","year":"2011","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2013.11.011_b0120","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/0016-5085(88)90661-0","article-title":"Histology of alcoholic hemorrhagic \u201cgastritis\u201d: a prospective evaluation","volume":"94","author":"Laine","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cbi.2013.11.011_b0125","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00428-005-0002-7","article-title":"Tissue microarray of head and neck squamous carcinoma: validation of the methodology for the study of cutaneous fatty acid-binding protein, vascular endothelial growth factor, involucrin and Ki-67","volume":"447","author":"Gomaa","year":"2005","journal-title":"Virchows Arch."},{"key":"10.1016\/j.cbi.2013.11.011_b0130","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1039\/dt9810000902","article-title":"Dioxomolybdenum (VI) complexes of quadridentate chiral Schiff bases and the crystal and molecular structure of dioxo [(2R)-propane-1,2-diylbis (salicylideneiminato)] molybdenum(VI)","volume":"4","author":"Gullotti","year":"1981","journal-title":"J. Chem. Soc. Dalton"},{"issue":"3","key":"10.1016\/j.cbi.2013.11.011_b0135","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.cbi.2013.11.011_b0140","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1211\/jpp.60.1.0008","article-title":"Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments","volume":"60","author":"McConnell","year":"2008","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.cbi.2013.11.011_b0235","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0922-4106(91)90026-E","article-title":"Three regulation mechanisms of nitric oxide synthase","volume":"206","author":"Hiki","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbi.2013.11.011_b0150","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev.med.48.1.489","article-title":"Nitric oxide synthase: role in the genesis of vascular disease","volume":"48","author":"Cooke","year":"1997","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.cbi.2013.11.011_b0155","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0079-6123(08)63210-0","article-title":"Nitric oxide in neurodegeneration","volume":"118","author":"Dawson","year":"1998","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.cbi.2013.11.011_b0160","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.immunol.15.1.323","article-title":"Nitric oxide and macrophage function","volume":"15","author":"MacMicking","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cbi.2013.11.011_b0165","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ni1001-907","article-title":"Nitric oxide and the immune response","volume":"2","author":"Bogdan","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cbi.2013.11.011_b0170","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1600-079X.2005.00250.x","article-title":"Effect of melatonin on secreted and induced matrix metalloproteinase 9 and 2 activity during prevention of indomethacin induced gastric ulcer","volume":"39","author":"Ganguly","year":"2005","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.cbi.2013.11.011_b0175","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00204-007-0263-9","article-title":"Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction","volume":"82","author":"Sivalingam","year":"2008","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2013.11.011_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1248\/bpb.24.1","article-title":"Recent advances in gastrointestinal pathophysiology: role of heat shock proteins in mucosal defense and ulcer healing","volume":"24","author":"Tsukimi","year":"2001","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.cbi.2013.11.011_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep.510290101","article-title":"Death receptors in liver biology and pathobiology","volume":"29","author":"Faubion","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2013.11.011_b0190","first-page":"21","article-title":"Glomerular tumor necrosis factor and interleukin 1 during acute aminonucleoside nephrosis","volume":"64","author":"Diamond","year":"1991","journal-title":"Lab. Invest."},{"key":"10.1016\/j.cbi.2013.11.011_b0195","doi-asserted-by":"crossref","first-page":"92642","DOI":"10.1155\/MI\/2006\/92642","article-title":"Effects of ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-\u03b1, NF-\u03baBp65, IL-6) in TNBS-induced colitis in rats","volume":"5","author":"Zhou","year":"2006","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.cbi.2013.11.011_b0200","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1002\/j.1460-2075.1994.tb06578.x","article-title":"Zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro","volume":"13","author":"Diaz-Meco","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.cbi.2013.11.011_b0205","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1128\/MCB.19.3.2180","article-title":"Activation of IkappaB kinase beta by protein kinase C isoforms","volume":"19","author":"Lallena","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cbi.2013.11.011_b0210","doi-asserted-by":"crossref","first-page":"C512","DOI":"10.1152\/ajpcell.00444.2002","article-title":"PKC zeta participates in activation of inflammatory response induced by enteropathogenic E. coli","volume":"285","author":"Savkovic","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.cbi.2013.11.011_b0215","doi-asserted-by":"crossref","first-page":"C906","DOI":"10.1152\/ajpcell.2000.279.4.C906","article-title":"Protein kinase C-zeta mediates TNF-alpha-induced ICAM-1 gene transcription in endothelial cells","volume":"279","author":"Rahman","year":"2000","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.cbi.2013.11.011_b0220","doi-asserted-by":"crossref","first-page":"13594","DOI":"10.1074\/jbc.274.19.13594","article-title":"Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells","volume":"274","author":"Anrather","year":"1999","journal-title":"J. Biol. Chem."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927971300313X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927971300313X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:29:55Z","timestamp":1757856595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000927971300313X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":45,"alternative-id":["S000927971300313X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2013.11.011","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of chelerythrine against ethanol-induced gastric ulcer in mice","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2013.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}