{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:23:18Z","timestamp":1790518998502,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002349","name":"ASRT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.cbi.2015.05.017","type":"journal-article","created":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T10:09:42Z","timestamp":1433585382000},"page":"74-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Anti-inflammatory effect of thalidomide dithiocarbamate and dithioate analogs"],"prefix":"10.1016","volume":"238","author":[{"given":"Roba","family":"Talaat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waheba","family":"El-Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein S.","family":"Agwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira M.","family":"Gamal-Eldeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaden","family":"Moawia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-1773","authenticated-orcid":false,"given":"Magdy A.H.","family":"Zahran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2015.05.017_b0005","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.semcancer.2004.06.006","article-title":"Inflammation as a tumor promoter in cancer induction","volume":"14","author":"Philip","year":"2004","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.cbi.2015.05.017_b0010","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.3390\/molecules18021434","article-title":"Cytotoxicity and anti-inflammatory activity of methylsulfanyl triazoloquinazolines","volume":"18","author":"Al-Salahi","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2015.05.017_b0015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/13813450802033958","article-title":"Role of curcumin in health and disease","volume":"114","author":"Pari","year":"2008","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.cbi.2015.05.017_b0020","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2015.05.017_b0025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35094017","article-title":"Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2","volume":"1","author":"Gupta","year":"2001","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cbi.2015.05.017_b0030","doi-asserted-by":"crossref","first-page":"R38","DOI":"10.1186\/bcr2089","article-title":"Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health-AARP Diet and Health Study","volume":"10","author":"Gierach","year":"2008","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.cbi.2015.05.017_b0035","unstructured":"B. Settles, A. Stevenson, K. Wilson, C. Mack, T. Ezell, M.F. Davis, L.D. Taylor, Down regulation of cell adhesion molecules LFA-l and ICAM-l after invitro treatment with the anti TNF alpha agent thalidomide. Cell Mol. Biol. 47 (200l) 1105\u20131114."},{"key":"10.1016\/j.cbi.2015.05.017_b0040","first-page":"92","article-title":"New insights into the pharmacological and toxicological effects of thalidomide","volume":"6","author":"Meierhofer","year":"2003","journal-title":"Curr. Opin. Drug Discov. Devel."},{"key":"10.1016\/j.cbi.2015.05.017_b0045","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1517\/14656566.1.4.615","article-title":"TNF-alpha antagonists for the treatment of Crohn\u2019s disease","volume":"1","author":"Kam","year":"2000","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.cbi.2015.05.017_b0050","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1053\/gast.2001.22556","article-title":"Anti-tumor necrosis factor monoclonal antibody therapy for gastrointestinal Behcet\u2019s disease: a case report","volume":"120","author":"Hassard","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cbi.2015.05.017_b0055","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1097\/00007890-199111000-00029","article-title":"Immunosuppressive properties of thalidomide. Inhibition of in vitro lymphocyte proliferation alone and in combination with cyclosporine or FK506","volume":"52","author":"Keenan","year":"1991","journal-title":"Transplantation"},{"key":"10.1016\/j.cbi.2015.05.017_b0060","doi-asserted-by":"crossref","first-page":"9708","DOI":"10.1016\/j.bmc.2008.09.071","article-title":"Design, synthesis and antitumor evaluation of novel thalidomide dithiocarbamate and dithioate analogs against Ehrlich ascites carcinoma-induced solid tumor in Swiss albino mice","volume":"16","author":"Zahran","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cbi.2015.05.017_b0065","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.intimp.2010.04.023","article-title":"Effect of thalidomide dithiocarbamate analogs on the intercellular adhesion molecule-1 expression","volume":"10","author":"Guirgis","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cbi.2015.05.017_b0070","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.biomag.2014.03.002","article-title":"Novel thalidomide analogs: antiangiogenic and apoptotic effects on Hep-G2 and MCF-7 cancer cell lines","volume":"4","author":"Talaat","year":"2014","journal-title":"Biomed. Aging Pathol."},{"key":"10.1016\/j.cbi.2015.05.017_b0075","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.exppara.2013.05.007","article-title":"Impact of Schistosoma mansoni and Echinococcus granulosus experimental coinfection on interleukin 10 and interferon gamma cytokines profile","volume":"134","author":"Talaat","year":"2013","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.cbi.2015.05.017_b0080","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0027-5107(02)00332-9","article-title":"Mechanism-based in vitro screening of potential cancer chemopreventive agents","volume":"523","author":"Gerh\u00e4user","year":"2003","journal-title":"Mutat. Res."},{"issue":"4","key":"10.1016\/j.cbi.2015.05.017_b0085","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1128\/iai.64.4.1309-1313.1996","article-title":"Nitric oxide induction by pertussis toxin in mouse spleen cells via gamma interferon","volume":"64","author":"Sakurai","year":"1996","journal-title":"Infect. Immun."},{"issue":"4","key":"10.1016\/j.cbi.2015.05.017_b0090","first-page":"209","article-title":"Nitric oxide production by murine spleen cells stimulated with Porphyromonas gingivalis-derived lipopolysaccharide","volume":"18","author":"Sosroseno","year":"2000","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"10.1016\/j.cbi.2015.05.017_b0095","doi-asserted-by":"crossref","unstructured":"R.M. Talaat, A.S. Abo-El-Atta, S.M. Farou, K.I. El-Dosoky, Therapeutic effect of dimethyl dimethoxy biphenyl dicarboxylate on collagen-induced arthritis in rats, Chin. J. Integr. Med. (2014) (Epub ahead of print).","DOI":"10.1007\/s11655-014-1746-1"},{"key":"10.1016\/j.cbi.2015.05.017_b0100","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbi.2015.05.017_b0105","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0891-5849(93)90027-R","article-title":"Oxygen-radical absorbance capacity assay for antioxidants","volume":"14","author":"Cao","year":"1993","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2015.05.017_b0110","first-page":"81","article-title":"Evaluation of Antioxidant, anti-inflammatory, and antinociceptive properties of aerial parts of Vicia sativa and its flavonoids","volume":"4","author":"Gamal Eldeen","year":"2004","journal-title":"J. Nat. Remedies"},{"key":"10.1016\/j.cbi.2015.05.017_b0115","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF03023520","article-title":"Effects of several salt marsh plants on mouse spleen and thymus cell proliferation using MTT assay","volume":"40","author":"Seo","year":"2005","journal-title":"Ocean Sci. J."},{"key":"10.1016\/j.cbi.2015.05.017_b0120","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1365-2133.2005.06747.x","article-title":"Thalidomide: dermatological indications, mechanisms of action and side-effects","volume":"153","author":"Wu","year":"2005","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.cbi.2015.05.017_b0125","first-page":"241","article-title":"The effect of two soluble thalidomide derivatives on lymphocyte stimulation","volume":"7","author":"Coulson","year":"1970","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cbi.2015.05.017_b0130","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1097\/00007890-199111000-00029","article-title":"Immunosuppressive properties of thalidomide. Inhibition of in vitro lymphocyte proliferation alone and in combination with cyclosporine or FK506","volume":"52","author":"Keenan","year":"1991","journal-title":"Transplantation"},{"key":"10.1016\/j.cbi.2015.05.017_b0135","first-page":"35","article-title":"Thalidomide induces imbalances in T-lymphocyte sub-populations in the circulating blood of healthy males","volume":"56","author":"Gad","year":"1985","journal-title":"Lepr. Rev."},{"key":"10.1016\/j.cbi.2015.05.017_b0140","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1089\/088922299310269","article-title":"Thalidomide stimulates T cell responses and interleukin 12 production in HIV-infected patients","volume":"15","author":"Haslett","year":"1999","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.cbi.2015.05.017_b0145","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4049\/jimmunol.163.1.380","article-title":"Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha","volume":"163","author":"Corral","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.cbi.2015.05.017_b0150","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1582-4934.2002.tb00184.x","article-title":"Thalidomide as an anti-cancer agent","volume":"6","author":"Kumar","year":"2002","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.cbi.2015.05.017_b0155","doi-asserted-by":"crossref","first-page":"E14","DOI":"10.1208\/aapsj070103","article-title":"Properties of thalidomide and its analogues: implications for anticancer therapy","volume":"7","author":"Teo","year":"2005","journal-title":"AAPS J."},{"key":"10.1016\/j.cbi.2015.05.017_b0160","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.biocel.2007.01.022","article-title":"The thalidomide saga","volume":"39","author":"Melchert","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.cbi.2015.05.017_b0165","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1128\/IAI.00819-13","article-title":"Global transcriptome analysis of staphylococcus aureus biofilms in response to innate immune cells","volume":"81","author":"Scherr","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cbi.2015.05.017_b0170","doi-asserted-by":"crossref","first-page":"19113","DOI":"10.1074\/jbc.M313867200","article-title":"Cytosolic phospholipase A2 translocates to forming phagosomes during phagocytosis of zymosan in macrophages","volume":"279","author":"Girotti","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2015.05.017_b0175","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0378-8741(01)00369-5","article-title":"Modulation of macrophage function activity by ethanolic extract of larvae of Holotrichia diomphalia","volume":"79","author":"Kang","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2015.05.017_b0180","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0378-8741(03)00278-2","article-title":"Immunomodulatory activities of Clausena excavata Burm. f. wood extracts","volume":"89","author":"Manosroi","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2015.05.017_b0185","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1055\/s-2001-16482","article-title":"A curcuminoid and sesquiterpenes as inhibitors of macrophage TNF-alpha release from Curcuma zedoaria","volume":"67","author":"Jang","year":"2001","journal-title":"Planta Med."},{"key":"10.1016\/j.cbi.2015.05.017_b0190","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nri1004","article-title":"Innate immune sensing and its roots: the story of endotoxin","volume":"3","author":"Beutler","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cbi.2015.05.017_b0195","doi-asserted-by":"crossref","first-page":"14635","DOI":"10.1073\/pnas.0507342102","article-title":"RelA repression of RelB activity induces selective gene activation downstream of TNF receptors","volume":"102","author":"Jacque","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.cbi.2015.05.017_b0200","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1582-4934.2004.tb00469.x","article-title":"Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury","volume":"8","author":"Ding","year":"2004","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.cbi.2015.05.017_b0205","first-page":"343","article-title":"NF-kappaB and its regulation on the immune system","volume":"1","author":"Liang","year":"2004","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.cbi.2015.05.017_b0210","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.iy.12.040194.001041","article-title":"Function and activation of NF-kappa B in the immune system","volume":"12","author":"Baeuerle","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cbi.2015.05.017_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1523-1747.1998.00084.x","article-title":"Nitric oxide in human skin: current status and future prospects","volume":"110","author":"Bruch-Gerharz","year":"1998","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.cbi.2015.05.017_b0220","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1590\/S0074-02762005000900004","article-title":"Regulation of endothelial derived nitric oxide in health and disease","volume":"1","author":"Sessa","year":"2005","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.cbi.2015.05.017_b0225","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000159039","article-title":"The nitric oxide synthase family of proteins","volume":"31","author":"Sessa","year":"1994","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.cbi.2015.05.017_b0230","doi-asserted-by":"crossref","first-page":"14214","DOI":"10.1074\/jbc.270.23.14214","article-title":"Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B","volume":"270","author":"Peng","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2015.05.017_b0235","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.4049\/jimmunol.161.4.1970","article-title":"Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation","volume":"161","author":"Peng","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.cbi.2015.05.017_b0240","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0891-5849(98)00094-X","article-title":"Modulation of leukocyte-endothelial interactions by reactive metabolites of oxygen and nitrogen: relevance to ischemic heart disease","volume":"25","author":"Grisham","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2015.05.017_b0245","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0891-5849(00)00218-5","article-title":"Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappa B","volume":"28","author":"Janssen-Heininger","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2015.05.017_b0250","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0162-3109(98)00010-1","article-title":"Differential regulation by thalidomide and dexamethasone of cytokine expression in human peripheral blood mononuclear cells","volume":"40","author":"Rowland","year":"1998","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.cbi.2015.05.017_b0255","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1084\/jem.173.3.699","article-title":"Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes","volume":"173","author":"Sampaio","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cbi.2015.05.017_b0260","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1084\/jem.177.6.1675","article-title":"Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation","volume":"177","author":"Moreira","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cbi.2015.05.017_b0265","doi-asserted-by":"crossref","first-page":"22382","DOI":"10.1074\/jbc.M100938200","article-title":"Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity","volume":"276","author":"Keifer","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2015.05.017_b0270","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1574-695X.2009.00567.x","article-title":"Thalidomide inhibits lipopolysaccharide-induced nitric oxide production and prevents lipopolysaccharide-mediated lethality in mice","volume":"56","author":"Noman","year":"2009","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.cbi.2015.05.017_b0275","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0024-3205(01)01124-9","article-title":"Increased oxidative stress in childhood atopic dermatitis","volume":"69","author":"Omata","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.cbi.2015.05.017_b0280","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1016\/S0024-3205(03)00145-0","article-title":"Oxidative stress and altered antioxidant defenses in children with acute exacerbation of atopic dermatitis","volume":"72","author":"Tsukahara","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.cbi.2015.05.017_b0285","doi-asserted-by":"crossref","first-page":"459","DOI":"10.33549\/physiolres.931844","article-title":"Some current insights into oxidative stress","volume":"59","author":"Durackov\u00e1","year":"2010","journal-title":"Physiol. Res."},{"key":"10.1016\/j.cbi.2015.05.017_b0290","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1126\/science.210504","article-title":"The biology of oxygen radicals","volume":"201","author":"Fridovich","year":"1978","journal-title":"Science"},{"key":"10.1016\/j.cbi.2015.05.017_b0295","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrm2256","article-title":"ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis","volume":"8","author":"D\u2019Autr\u00e9aux","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cbi.2015.05.017_b0300","doi-asserted-by":"crossref","first-page":"838","DOI":"10.4161\/auto.6.7.12113","article-title":"ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy","volume":"6","author":"Dewaele","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.cbi.2015.05.017_b0305","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0891-5849(92)90062-L","article-title":"Comments on review of free radicals in biology and medicine, second edition, by Barry Halliwell and John M.C. Gutteridge","volume":"12","author":"Gutteridge","year":"1992","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2015.05.017_b0310","first-page":"5","article-title":"Free radical-mediated mechanisms of anticonvulsant teratogenicity","volume":"2","author":"Winn","year":"1995","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.cbi.2015.05.017_b0315","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/(SICI)1096-9926(199603)53:3<196::AID-TERA7>3.0.CO;2-2","article-title":"Reactive oxygen species in developmental toxicity: review and hypothesis","volume":"53","author":"Fantel","year":"1996","journal-title":"Teratology"},{"key":"10.1016\/j.cbi.2015.05.017_b0320","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0027-5107(97)00175-9","article-title":"Oxidative damage in chemical teratogenesis","volume":"396","author":"Wells","year":"1997","journal-title":"Mutat. Res."},{"key":"10.1016\/j.cbi.2015.05.017_b0325","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.taap.2005.01.061","article-title":"Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species","volume":"207","author":"Wells","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2015.05.017_b0330","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.freeradbiomed.2007.06.027","article-title":"An epigenetic perspective on the free radical theory of development","volume":"43","author":"Hitchler","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2015.05.017_b0335","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/toxsci\/kfn263","article-title":"Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer","volume":"108","author":"Wells","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbi.2015.05.017_b0340","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.2741\/1667","article-title":"Reactive oxygen species in tumor progression","volume":"1","author":"Storz","year":"2005","journal-title":"Front. Biosci."},{"key":"10.1016\/j.cbi.2015.05.017_b0345","first-page":"240","article-title":"New insights on oxidative stress in cancer","volume":"12","author":"Visconti","year":"2009","journal-title":"Curr. Opin. Drug Discov. Devel."},{"key":"10.1016\/j.cbi.2015.05.017_b0350","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer: how are they linked?","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2015.05.017_b0355","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/8466","article-title":"Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity","volume":"5","author":"Parman","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.cbi.2015.05.017_b0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/152308604771978291","article-title":"A novel hypothesis for thalidomide-induced limb teratogenesis: redox misregulation of the NF-kappaB pathway","volume":"6","author":"Hansen","year":"2004","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cbi.2015.05.017_b0365","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1096\/fj.06-7603com","article-title":"Thalidomide induces limb deformities by perturbing the Bmp\/Dkk1\/Wnt signaling pathway","volume":"21","author":"Knobloch","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.cbi.2015.05.017_b0370","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1021\/jf00035a014","article-title":"Evaluation of the antioxidant and prooxidant action of gallic acid and its derivatives","volume":"41","author":"Aruoma","year":"1993","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cbi.2015.05.017_b0375","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/S0006-2952(03)00541-0","article-title":"(\u2013)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA","volume":"66","author":"Furukawa","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2015.05.017_b0380","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1096\/fj.04-2915fje","article-title":"Green tea extract and (\u2212)-epigallocatechin-3-gallate, the major tea catechin, exert oxidant but lack antioxidant activities","volume":"19","author":"Elbling","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.cbi.2015.05.017_b0385","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1182\/blood-2007-01-065201","article-title":"Thalidomide induces gamma-globin gene expression through increased reactive oxygen species-mediated p38 MAPK signaling and histone H4 acetylation in adult erythropoiesis","volume":"110","author":"Aerbajinai","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.cbi.2015.05.017_b0390","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1038\/sj.leu.2403868","article-title":"Synergistic interactions between MEK1\/2 and histone deacetylase inhibitors in BCR\/ABL+ human leukemia cells","volume":"19","author":"Yu","year":"2005","journal-title":"Leukemia"},{"key":"10.1016\/j.cbi.2015.05.017_b0395","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.bbrc.2005.11.131","article-title":"Blockade of the ERK pathway markedly sensitizes tumor cells to HDAC inhibitor-induced cell death","volume":"339","author":"Ozaki","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbi.2015.05.017_b0400","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0002-9440(10)64714-1","article-title":"Thalidomide inhibits angiogenesis in embryoid bodies by the generation of hydroxyl radicals","volume":"156","author":"Sauer","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cbi.2015.05.017_b0405","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s00018-010-0619-9","article-title":"Teratogenic effects of thalidomide: molecular mechanisms","volume":"68","author":"Ito","year":"2011","journal-title":"Cell. Mol. Life Sci."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279715002239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279715002239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:36:30Z","timestamp":1757856990000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279715002239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":81,"alternative-id":["S0009279715002239"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2015.05.017","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-inflammatory effect of thalidomide dithiocarbamate and dithioate analogs","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2015.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}