{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:24:02Z","timestamp":1777983842424,"version":"3.51.4"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.cbi.2015.09.012","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T11:27:09Z","timestamp":1442057229000},"page":"74-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Promising toxicological biomarkers for the diagnosis of liver injury types: Bile acid metabolic profiles and oxidative stress marker as screening tools in drug development"],"prefix":"10.1016","volume":"255","author":[{"given":"Noriko","family":"Masubuchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Nishiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Imaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoko","family":"Mizumaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.cbi.2015.09.012_bib1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/0895-4356(93)90101-6","article-title":"Causality assessment of adverse reactions to drugs\u2013I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries","volume":"46","author":"Danan","year":"1993","journal-title":"J.\u00a0Clin. Epidemiol."},{"issue":"2","key":"10.1016\/j.cbi.2015.09.012_bib2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/gut.12.2.145","article-title":"Serum bile acids in liver disease","volume":"12","author":"Neale","year":"1971","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.cbi.2015.09.012_bib3","first-page":"7","article-title":"Clinical aspects of bile acid metabolism in liver diseases","volume":"7","author":"Iwamura","year":"1982","journal-title":"Tokai J. Exp. Clin. Med."},{"key":"10.1016\/j.cbi.2015.09.012_bib4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.bi.44.070175.001313","article-title":"Bile acid metabolism","volume":"44","author":"Danielsson","year":"1975","journal-title":"Annu. Rev. Biochem."},{"issue":"90","key":"10.1016\/j.cbi.2015.09.012_bib5","first-page":"299","article-title":"Clinical significance of measuring urinary sulfated bile acids in adult patients with hepatobiliary diseases","volume":"56","author":"Nanashima","year":"2009","journal-title":"Hepato-gastroenterology"},{"issue":"6","key":"10.1016\/j.cbi.2015.09.012_bib6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0168-8278(03)00096-5","article-title":"Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis","volume":"38","author":"Zollner","year":"2003","journal-title":"J.\u00a0Hepatol."},{"issue":"9","key":"10.1016\/j.cbi.2015.09.012_bib7","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1124\/dmd.107.015610","article-title":"Hepatobiliary transporter expression in intercellular adhesion molecule 1 knockout and Fas receptor-deficient mice after common bile duct ligation is independent of the degree of inflammation and oxidative stress","volume":"35","author":"Wagner","year":"2007","journal-title":"Drug Metab. Dispos."},{"issue":"11","key":"10.1016\/j.cbi.2015.09.012_bib8","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1172\/JCI18945","article-title":"Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis","volume":"112","author":"Liu","year":"2003","journal-title":"J.\u00a0Clin. Invest."},{"issue":"1","key":"10.1016\/j.cbi.2015.09.012_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/toxsci\/kfp094","article-title":"Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice","volume":"110","author":"Cui","year":"2009","journal-title":"Toxicol. Sci."},{"issue":"4","key":"10.1016\/j.cbi.2015.09.012_bib10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1210\/er.2000-0035","article-title":"Bile acid regulation of gene expression: roles of nuclear hormone receptors","volume":"23","author":"Chiang","year":"2002","journal-title":"Endocr. Rev."},{"issue":"5","key":"10.1016\/j.cbi.2015.09.012_bib11","doi-asserted-by":"crossref","first-page":"G798","DOI":"10.1152\/ajpgi.00319.2004","article-title":"Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver","volume":"289","author":"Zollner","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"1","key":"10.1016\/j.cbi.2015.09.012_bib12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1248\/bpb.28.143","article-title":"Soybean oil fat emulsion prevents cytochrome P450 mRNA down-regulation induced by fat-free overdose total parenteral nutrition in infant rats","volume":"28","author":"Yamaguchi","year":"2005","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.cbi.2015.09.012_bib13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2133\/dmpk.20.46","article-title":"Role of soybean oil fat emulsion in the prevention of hepatic xenobiotic transporter mRNA up- and down-regulation induced by overdose of fat-free total parenteral nutrition in infant rats","volume":"20","author":"Nishimura","year":"2005","journal-title":"Drug Metab. Pharmacokinet."},{"issue":"4","key":"10.1016\/j.cbi.2015.09.012_bib14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2133\/dmpk.21.297","article-title":"Regulation of mRNA expression of MDR1, MRP1, MRP2 and MRP3 by prototypical microsomal enzyme inducers in primary cultures of human and rat hepatocytes","volume":"21","author":"Nishimura","year":"2006","journal-title":"Drug Metab. Pharmacokinet."},{"issue":"12","key":"10.1016\/j.cbi.2015.09.012_bib15","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1021\/tx800225q","article-title":"Bile acids metabonomic study on the CCl4- and alpha-naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry","volume":"21","author":"Yang","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbi.2015.09.012_bib16","article-title":"Oxidative stress markers, secondary bile acids and sulfated bile acids classify the clinical liver injury type: promising diagnostic biomarkers for cholestasis","author":"Masubuchi","year":"2015","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.cbi.2015.09.012_bib17","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0016-5085(03)01068-0","article-title":"Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice","volume":"125","author":"Wagner","year":"2003","journal-title":"Gastroenterology"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927971530065X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927971530065X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:39:56Z","timestamp":1757857196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000927971530065X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":17,"alternative-id":["S000927971530065X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2015.09.012","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Promising toxicological biomarkers for the diagnosis of liver injury types: Bile acid metabolic profiles and oxidative stress marker as screening tools in drug development","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2015.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}