{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:06:36Z","timestamp":1787652396627,"version":"build-2736575974"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000774","name":"Defense Threat Reduction Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006229","name":"Oak Ridge Institute for Science and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010200","name":"U.S. Army Medical Research Institute of Chemical Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006229","name":"Oak Ridge Institute for Science and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010200","name":"U.S. Army Medical Research Institute of Chemical Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013101","name":"National Research Council","doi-asserted-by":"publisher","award":["P.L. 89-544"],"award-info":[{"award-number":["P.L. 89-544"]}],"id":[{"id":"10.13039\/100013101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010463","name":"U.S. Army Medical Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010463","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.cbi.2016.04.013","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T23:00:19Z","timestamp":1460502019000},"page":"233-241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"PB","title":["Assessing the stoichiometric efficacy of mammalian expressed paraoxonase-1 variant I-F11 to afford protection against G-type nerve agents"],"prefix":"10.1016","volume":"259","author":[{"given":"David G.","family":"Mata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveena","family":"Sabnekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cetara A.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Rezk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nageswararao","family":"Chilukuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2016.04.013_bib1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1073\/pnas.2536901100","article-title":"Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization","volume":"101","author":"Aharoni","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2016.04.013_bib2","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1172\/JCI1649","article-title":"Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase","volume":"101","author":"Aviram","year":"1998","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.cbi.2016.04.013_bib3","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.freeradbiomed.2012.01.019","article-title":"Purified human paraoxonase-1 interacts with plasma membrane lipid rafts and mediates cholesterol efflux from macrophages","volume":"52","author":"Berrougui","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2016.04.013_bib4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cbi.2008.04.009","article-title":"Adenovirus-mediated gene transfer of human butyrylcholinesterase results in persistent high-level transgene expression in\u00a0vivo","volume":"175","author":"Chilukuri","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2016.04.013_bib5","series-title":"Toxicology of Some Anticholinesterases Used as a Chemical Warfare Agents\u2014a Review","author":"Dacre","year":"1984"},{"key":"10.1016\/j.cbi.2016.04.013_bib6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/ATVBAHA.108.179317","article-title":"Proteomics of apolipoproteins and associated proteins from plasma high density lipoproteins","volume":"30","author":"Davidson","year":"2010","journal-title":"Aretrioscler. Thrombo. Vasc. Biol."},{"key":"10.1016\/j.cbi.2016.04.013_bib7","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/gt.2010.136","article-title":"Adenovirus-mediated human paraoxonase1 gene transfer to provide protection against the toxicity of the organophosphorous pesticide toxicant diazoxon","volume":"18","author":"Duysen","year":"2011","journal-title":"Gene Ther."},{"key":"10.1016\/j.cbi.2016.04.013_bib8","doi-asserted-by":"crossref","first-page":"11843","DOI":"10.1021\/bi050862i","article-title":"High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-1","volume":"44","author":"Gaidukov","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbi.2016.04.013_bib9","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.chembiol.2012.01.017","article-title":"Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification","volume":"19","author":"Goldsmith","year":"2012","journal-title":"Chem. Biol."},{"key":"10.1016\/j.cbi.2016.04.013_bib10","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1021\/pr100520x","article-title":"Proteomic characterization of human plasma high density lipoprotein fractionated by gel filtration chromatography","volume":"9","author":"Gordon","year":"2010","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.cbi.2016.04.013_bib11","doi-asserted-by":"crossref","first-page":"6386","DOI":"10.1074\/jbc.M115.696088","article-title":"Identification of critical paraoxonase1 residues involved in high density lipoprotein interaction","volume":"261","author":"Gu","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cbi.2016.04.013_bib12","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nchembio.510","article-title":"Directed evolution of hydrolases for prevention of G-type nerve agent intoxication","volume":"7","author":"Gupta","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cbi.2016.04.013_bib13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nsmb767","article-title":"Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzyme","volume":"11","author":"Harel","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.cbi.2016.04.013_bib14","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cbi.2005.10.025","article-title":"Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys","volume":"157\u2013158","author":"Lenz","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2016.04.013_bib15","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/00008571-200012000-00002","article-title":"Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds","volume":"10","author":"Li","year":"2000","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.cbi.2016.04.013_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"Lusis","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2016.04.013_bib17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2165\/00129784-200404040-00002","article-title":"The role of paraoxonase 1 activity in cardiovascular disease: potential for therapeutic intervention","volume":"4","author":"Mackness","year":"2004","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"10.1016\/j.cbi.2016.04.013_bib18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/00041433-199808000-00006","article-title":"Paraoxonase and coronary heart disease","volume":"9","author":"Mackness","year":"1998","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.cbi.2016.04.013_bib19","series-title":"Chemical Warfare Agents: Toxicology and Treatment","first-page":"221","article-title":"Riot Control agents","author":"Marrs","year":"1996"},{"key":"10.1016\/j.cbi.2016.04.013_bib20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1124\/jpet.114.213645","article-title":"Investigation of evolved paraoxonase-1 variants for prevention of organophosphorous pesticide compound intoxication","volume":"349","author":"Mata","year":"2014","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cbi.2016.04.013_bib21","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1194\/jlr.M700439-JLR200","article-title":"HDL subfraction distribution of paraoxonase-1 and its relevance to enzyme activity and resistance to oxidative stress","volume":"49","author":"Moren","year":"2008","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cbi.2016.04.013_bib22","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.cbi.2013.06.012","article-title":"Progress in the development of enzyme-based nerve agent bioscavengers","volume":"206","author":"Nachon","year":"2013","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2016.04.013_bib23","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.cbi.2010.02.022","article-title":"Purification and characterization of functional human paraoxonase-1 expressed in Trichoplusia ni larvae","volume":"187","author":"Otto","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2016.04.013_bib24","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1124\/jpet.110.175646","article-title":"Gene-delivered butrylcholinesterase is prophylactic aginast toxicity of chemical wasfare nerve agents and organophoshorous compounds","volume":"337","author":"Parikh","year":"2011","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cbi.2016.04.013_bib25","doi-asserted-by":"crossref","first-page":"7657","DOI":"10.1074\/jbc.M512595200","article-title":"The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux","volume":"281","author":"Rosenblat","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cbi.2016.04.013_bib26","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1161\/01.ATV.19.9.2214","article-title":"Human serum Paraoxonase\/arylesterase's retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids : apolipoprotein A-I stabilizes activity","volume":"19","author":"Sorenson","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cbi.2016.04.013_bib27","series-title":"The Pharmacological Basis of Therapeutics","first-page":"131","article-title":"Anticholinesterase agents","author":"Taylor","year":"1990"},{"key":"10.1016\/j.cbi.2016.04.013_bib28","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/dta.381","article-title":"Organophosphorous hydrolase as an in\u00a0vivo catalytic nerve agent bioscavenger","volume":"4","author":"Wales","year":"2012","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.cbi.2016.04.013_bib29","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s00204-014-1204-z","article-title":"Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in\u00a0vivo and to detoxify structurally different nerve agents in\u00a0vitro","volume":"88","author":"Worek","year":"2014","journal-title":"Arch. Toxicol."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279716301363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279716301363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:46:05Z","timestamp":1762112765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279716301363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":29,"alternative-id":["S0009279716301363"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2016.04.013","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing the stoichiometric efficacy of mammalian expressed paraoxonase-1 variant I-F11 to afford protection against G-type nerve agents","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2016.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}