{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:30:53Z","timestamp":1790141453605,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission India","doi-asserted-by":"publisher","award":["42-631\/2013"],"award-info":[{"award-number":["42-631\/2013"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.cbi.2016.04.018","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T14:31:50Z","timestamp":1460471510000},"page":"87-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Evaluation of ameliorative potential of supranutritional selenium on enrofloxacin-induced testicular toxicity"],"prefix":"10.1016","volume":"252","author":[{"given":"Soya","family":"Rungsung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil Mehraj","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh Kumar","family":"Sood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyavan","family":"Rampal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simrat Pal","family":"Singh Saini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cbi.2016.04.018_bib1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3947\/ic.2014.46.4.226","article-title":"Clinical importance and epidemiology of quinolone resistance","volume":"46","author":"Kim","year":"2014","journal-title":"Infect. Chemother."},{"issue":"8","key":"10.1016\/j.cbi.2016.04.018_bib2","first-page":"489","article-title":"Enrofloxacin drug induced reactive oxygen species","volume":"1","author":"Ibrahim","year":"2011","journal-title":"Res. Opin. Anim. Vet. Sci."},{"issue":"2","key":"10.1016\/j.cbi.2016.04.018_bib3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1439-0272.2009.00961.x","article-title":"Long-term ofloxacin testicular toxicity: an experimental study","volume":"42","author":"El-Harouny","year":"2010","journal-title":"Andrologia"},{"key":"10.1016\/j.cbi.2016.04.018_bib4","first-page":"304","article-title":"Oxidative stress induced by fluoroquinolones on treatment for complicated urinary tract infections in Indian patients","volume":"3","author":"Talla","year":"2011","journal-title":"J.\u00a0Young. Pharm."},{"issue":"3","key":"10.1016\/j.cbi.2016.04.018_bib5","first-page":"125","article-title":"Assessment on the adverse effects of aminoglycosides and flouroquinolone on sperm parameters and male reproductive tissue: a systematic review","volume":"13","author":"Khaki","year":"2015","journal-title":"Iran. J. Reprod. Med."},{"key":"10.1016\/j.cbi.2016.04.018_bib6","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/0960327108092295","article-title":"Ofloxacin-associated retinopathy in rabbits: role of oxidative stress","volume":"27","author":"Rampal","year":"2008","journal-title":"Hum. Exp. Toxicol."},{"issue":"4","key":"10.1016\/j.cbi.2016.04.018_bib7","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/0960327114530743","article-title":"Evaluation of gatifloxacin for its potential to induce antioxidant imbalance and retinopathy in rabbits","volume":"34","author":"Kumbhar","year":"2015","journal-title":"Hum. Exp. Toxicol."},{"issue":"1\u20133","key":"10.1016\/j.cbi.2016.04.018_bib8","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s12011-013-9652-5","article-title":"Effect of dietary selenium and vitamin E on ganders' response to semen collection and ejaculate characteristics","volume":"153","author":"Jerysz","year":"2013","journal-title":"Biol. Trace. Elem. Res."},{"issue":"4","key":"10.1016\/j.cbi.2016.04.018_bib9","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s40011-014-0304-0","article-title":"Ameliorative effect of selenium on enrofloxacin-induced lipid peroxidation and antioxidant imbalance","volume":"84","author":"Rungsung","year":"2014","journal-title":"Proc. Natl. Acad. Sci. India. Sect. B. Biol. Sci."},{"key":"10.1016\/j.cbi.2016.04.018_bib10","first-page":"499","article-title":"Selenium. role of the essential metalloid in health","volume":"13","author":"Kurokawa","year":"2013","journal-title":"Met. Ions. Life. Sci."},{"key":"10.1016\/j.cbi.2016.04.018_bib11","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.anifeedsci.2010.02.006","article-title":"Short-term effect of dietary selenium-enriched yeast on semen parameters, antioxidant status and Se concentration in goat seminal plasma","volume":"157","author":"Shi","year":"2010","journal-title":"Anim. Feed. Sci. Technol."},{"issue":"2","key":"10.1016\/j.cbi.2016.04.018_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3109\/01480545.2011.589446","article-title":"Protective effect of selenium on gentamicin-induced oxidative stress and nephrotoxicity in rats","volume":"35","author":"Randjelovic","year":"2012","journal-title":"Drug. Chem. Toxicol."},{"issue":"5","key":"10.1016\/j.cbi.2016.04.018_bib13","doi-asserted-by":"crossref","first-page":"1184e1","DOI":"10.1016\/j.urology.2011.12.006","article-title":"Selenium and lycopene attenuate cisplatin-induced testicular toxicity associated with oxidative stress in Wistar rats","volume":"79","author":"Salem","year":"2012","journal-title":"Urology"},{"key":"10.1016\/j.cbi.2016.04.018_bib14","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.toxrep.2014.10.002","article-title":"Monosodium glutamate induced testicular toxicity and the possible ameliorative role of vitamin E or selenium in male rats","volume":"1","author":"Hamzaa","year":"2014","journal-title":"Toxicol. Rep."},{"issue":"1","key":"10.1016\/j.cbi.2016.04.018_bib15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1590\/S1516-8913201400025","article-title":"Lead nitrate induced testicular toxicity in diabetic and non-diabetic rats: protective role of sodium selenite","volume":"58","author":"Apaydin","year":"2015","journal-title":"Braz. Arch. Biol. Technol."},{"key":"10.1016\/j.cbi.2016.04.018_bib16","series-title":"Plumb's Veterinary Drug Handbook","author":"Plumb","year":"2008"},{"key":"10.1016\/j.cbi.2016.04.018_bib17","series-title":"Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology","author":"Luna","year":"1968"},{"key":"10.1016\/j.cbi.2016.04.018_bib18","series-title":"Applied Animal Reproduction","first-page":"147","article-title":"Semen Collection","author":"Bearden","year":"1997"},{"issue":"3","key":"10.1016\/j.cbi.2016.04.018_bib19","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.rvsc.2006.09.004","article-title":"Pharmacokinetics of enrofloxacin in turkeys","volume":"82","author":"Dimitrova","year":"2007","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.cbi.2016.04.018_bib20","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1365-2885.1993.tb00212.x","article-title":"Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intravenous and oral administration of enrofloxacin in dogs","volume":"16","author":"K\u00fcng","year":"1993","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.cbi.2016.04.018_bib21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.cbi.2016.04.018_bib22","first-page":"273","article-title":"Catalase","volume":"3","author":"Aebi","year":"1983"},{"key":"10.1016\/j.cbi.2016.04.018_bib23","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1093\/jn\/104.5.580","article-title":"Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat","volume":"104","author":"Hafeman","year":"1974","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.cbi.2016.04.018_bib24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0378-4274(84)90093-6","article-title":"Lead\u2013induced regional lipid peroxidation in brain","volume":"21","author":"Rehman","year":"1984","journal-title":"Toxicol. Lett."},{"issue":"13","key":"10.1016\/j.cbi.2016.04.018_bib25","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1001\/jama.2012.383","article-title":"Oral fluoroquinolones and the risk of retinal detachment","volume":"307","author":"Etminan","year":"2012","journal-title":"J.\u00a0Am. Med. Assoc."},{"issue":"12","key":"10.1016\/j.cbi.2016.04.018_bib26","doi-asserted-by":"crossref","first-page":"950","DOI":"10.14202\/vetworld.2013.950-954","article-title":"Effect of meloxicam and its combination with levofloxacin, pazufloxacin and enrofloxacin on the plasma antioxidative activity and body weight of rabbits","volume":"6","author":"Khan","year":"2013","journal-title":"Vet. World"},{"key":"10.1016\/j.cbi.2016.04.018_bib27","first-page":"105","article-title":"Ultra structural study of gentamicin and ofloxacin effect on testis tissue in rats: light and transmission electron microscopy","volume":"3","author":"Khaki","year":"2009","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"10.1016\/j.cbi.2016.04.018_bib28","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1177\/1933719113477482","article-title":"Role of mitochondria in ciprofloxacin-induced apoptosis in murine sperm cells","volume":"20","author":"Zobeiri","year":"2013","journal-title":"Reprod. Sci."},{"issue":"1","key":"10.1016\/j.cbi.2016.04.018_bib29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.rvsc.2007.04.007","article-title":"The effect of enrofloxacin on sperm quality in male mice","volume":"84","author":"Aral","year":"2008","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.cbi.2016.04.018_bib30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.etap.2003.08.010","article-title":"Potential role of vitamins in chromium induced spermatogenesis in Swiss mice","volume":"15","author":"Acharya","year":"2004","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbi.2016.04.018_bib31","first-page":"131","article-title":"The effect of ciprofloxacin on sperm DNA damage, fertility potential and early embryonic development in NMRI mice","volume":"3","author":"Zobeiri","year":"2012","journal-title":"Vet. Res. Forum"},{"key":"10.1016\/j.cbi.2016.04.018_bib32","doi-asserted-by":"crossref","first-page":"11153","DOI":"10.3390\/molecules180911153","article-title":"Metal complexes of quinolone antibiotics and their applications: an update","volume":"18","author":"Uivarosi","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2016.04.018_bib33","first-page":"36","article-title":"Serum concentration of testosterone, epididymal mast cell population and histamine content in relation to sperm count and their motility in albino rats following H2 receptor blocker treatment","volume":"8","author":"Sinha","year":"2006","journal-title":"Nepal. Med. Coll. J."},{"issue":"4","key":"10.1016\/j.cbi.2016.04.018_bib34","first-page":"399","article-title":"Effect of repeated oral administration of pazufloxacin mesylate and meloxicam on the anti-oxidant status in rabbits","volume":"53","author":"Khan","year":"2014","journal-title":"J.\u00a0Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.cbi.2016.04.018_bib35","article-title":"Effect of repeated oral administration of levofloxacin, enrofloxacin, and meloxicam on antioxidant parameters and lipid peroxidation in rabbits","author":"Khan","year":"2016","journal-title":"Hum. Exp. Toxicol."},{"issue":"5\/6","key":"10.1016\/j.cbi.2016.04.018_bib36","first-page":"1","article-title":"Effect of selenium on cadmium-induced oxidative stress and esterase activity in rat organs","volume":"109","author":"Dzobo","year":"2013","journal-title":"S.\u00a0Afr. J. Sci."},{"key":"10.1016\/j.cbi.2016.04.018_bib37","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/aja.2011.40","article-title":"The effect of environmental contaminants on testicular function","volume":"13","author":"Mathur","year":"2011","journal-title":"Asian. J. Androl."},{"key":"10.1016\/j.cbi.2016.04.018_bib38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1758-5996-3-17","article-title":"Biochemical study of oxidative stress markers in the liver, kidney and heart of high fat diet induced obesity in rats","volume":"3","author":"Noeman","year":"2011","journal-title":"Diabetol. Metab. Syndr."},{"issue":"5","key":"10.1016\/j.cbi.2016.04.018_bib39","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/humupd\/dmh034","article-title":"Regulation of sperm function by reactive oxygen species","volume":"10","author":"Ford","year":"2004","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.cbi.2016.04.018_bib40","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2164\/jandrol.108.005132","article-title":"Oxidative stress: a common factor in testicular dysfunction","volume":"5","author":"Turner","year":"2008","journal-title":"J.\u00a0Androl."},{"issue":"4","key":"10.1016\/j.cbi.2016.04.018_bib41","first-page":"294","article-title":"Long-term effect of ciprofloxacin on testicular tissue: evidence for biochemical and histochemical changes","volume":"6","author":"Zobeiri","year":"2013","journal-title":"Int. J. Fertil. Steril."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279716301417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279716301417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:40:10Z","timestamp":1757857210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279716301417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":41,"alternative-id":["S0009279716301417"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2016.04.018","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of ameliorative potential of supranutritional selenium on enrofloxacin-induced testicular toxicity","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2016.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}