{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:23:42Z","timestamp":1787502222262,"version":"build-2736575974"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.cbi.2016.04.027","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T09:35:52Z","timestamp":1462008952000},"page":"343-351","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"PB","title":["Relationships of human \u03b1\/\u03b2 hydrolase fold proteins and other organophosphate-interacting proteins"],"prefix":"10.1016","volume":"259","author":[{"given":"Nicolas","family":"Lenfant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Bourne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Marchot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Chatonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2016.04.027_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2005.10.008","article-title":"Current issues in organophosphate toxicology","volume":"366","author":"Costa","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cbi.2016.04.027_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cbi.2012.10.004","article-title":"Cholinesterase confabs and cousins: approaching forty years","volume":"203","author":"Taylor","year":"2013","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2016.04.027_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tox.2012.03.012","article-title":"NTE and non-NTE esterases in brain membrane: kinetic characterization with organophosphates","volume":"297","author":"Mangas","year":"2012","journal-title":"Toxicology"},{"key":"10.1016\/j.cbi.2016.04.027_bib4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.pharmthera.2012.03.001","article-title":"Functional consequences of repeated organophosphate exposure: potential non-cholinergic mechanisms","volume":"134","author":"Terry","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cbi.2016.04.027_bib5","doi-asserted-by":"crossref","first-page":"D345","DOI":"10.1093\/nar\/gku1214","article-title":"The RCSB protein data bank: views of structural biology for basic and applied research and education","volume":"43","author":"Rose","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbi.2016.04.027_bib6","doi-asserted-by":"crossref","first-page":"D343","DOI":"10.1093\/nar\/gkv1118","article-title":"Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors","volume":"44","author":"Rawlings","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbi.2016.04.027_bib7","doi-asserted-by":"crossref","first-page":"D490","DOI":"10.1093\/nar\/gkt1178","article-title":"The carbohydrate-active enzymes database (CAZy) in 2013","volume":"42","author":"Lombard","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbi.2016.04.027_bib8","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jsb.2011.04.011","article-title":"Proteopedia: a status report on the collaborative, 3D web-encyclopedia of proteins and other biomolecules","volume":"175","author":"Prilusky","year":"2011","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.cbi.2016.04.027_bib9","article-title":"Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat","volume":"2015","author":"Babbitt","year":"2015","journal-title":"Database Oxford"},{"key":"10.1016\/j.cbi.2016.04.027_bib10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF00038687","article-title":"Compositional dissimilarity as a robust measure of ecological distance","volume":"69","author":"Faith","year":"1987","journal-title":"Vegetatio"},{"key":"10.1016\/j.cbi.2016.04.027_bib11","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1093\/molbev\/msv150","article-title":"FastME 2.0: A comprehensive, accurate, and fast distance-based phylogeny inference program","volume":"32","author":"Lefort","year":"2015","journal-title":"Mol. Biol. E"},{"key":"10.1016\/j.cbi.2016.04.027_bib12","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/BF01945541","article-title":"Insecticidal organophosphates: nature made them first","volume":"43","author":"Neumann","year":"1987","journal-title":"Experientia"},{"key":"10.1016\/j.cbi.2016.04.027_bib13","doi-asserted-by":"crossref","first-page":"D423","DOI":"10.1093\/nar\/gks1154","article-title":"ESTHER, the database of the alpha\/beta-hydrolase fold superfamily of proteins: tools to explore diversity of functions","volume":"41","author":"Lenfant","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbi.2016.04.027_bib14","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.cbi.2012.09.003","article-title":"Proteins with an alpha\/beta hydrolase fold: relationships between subfamilies in an ever-growing superfamily","volume":"203","author":"Lenfant","year":"2013","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2016.04.027_bib15","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.7164\/antibiotics.46.1315","article-title":"Cyclophostin, acetylcholinesterase inhibitor from Streptomyces lavendulae","volume":"46","author":"Kurokawa","year":"1993","journal-title":"J.\u00a0Antibiot. Tokyo"},{"key":"10.1016\/j.cbi.2016.04.027_bib16","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/BF02584093","article-title":"The in\u00a0vitro inhibitory effect of psilocybin and related compounds of human cholinesterases","volume":"4","author":"Zsigmond","year":"1963","journal-title":"Psychopharmacologia"},{"key":"10.1016\/j.cbi.2016.04.027_bib17","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/jo00054a013","article-title":"Ulosantoin, a potent insecticide from the sponge Ulosa ruetzleri","volume":"58","author":"Van Wagenen","year":"1993","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.cbi.2016.04.027_bib18","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.1002\/ejoc.200800654","article-title":"The new metabolite (S)-Cinnamoylphosphoramide from Streptomyces sp. and its total synthesis","author":"Quitschau","year":"2008","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.cbi.2016.04.027_bib19","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/0041-0101(87)90140-1","article-title":"Anatoxin-a(s), an anticholinesterase from the cyanobacterium Anabaena flos-aquae NRC-525-17","volume":"25","author":"Mahmood","year":"1987","journal-title":"Toxicon"},{"key":"10.1016\/j.cbi.2016.04.027_bib20","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1002\/cbic.200500013","article-title":"Novel fluorescent phosphonic acid esters for discrimination of lipases and esterases","volume":"6","author":"Schmidinger","year":"2005","journal-title":"Chembiochem"},{"key":"10.1016\/j.cbi.2016.04.027_bib21","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1016\/S0021-9258(19)83644-X","article-title":"Fluorescent phosphonate labels for serine hydrolases. Kinetic and spectroscopic properties of (7-nitrobenz-2-oxa-1,3-diazole)aminoalkyl methylphosphonofluoridates and their conjugates with acetylcholinesterase molecular forms","volume":"260","author":"Berman","year":"1985","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cbi.2016.04.027_bib22","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nchembio.579","article-title":"Click-generated triazole ureas as ultrapotent in\u00a0vivo-active serine hydrolase inhibitors","volume":"7","author":"Adibekian","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cbi.2016.04.027_bib23","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1073\/pnas.1015248108","article-title":"Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors","volume":"108","author":"Bachovchin","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2016.04.027_bib24","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.bmcl.2014.11.038","article-title":"Combining cross-metathesis and activity-based protein profiling: new beta-lactone motifs for targeting serine hydrolases","volume":"25","author":"Camara","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.cbi.2016.04.027_bib25","doi-asserted-by":"crossref","first-page":"6334","DOI":"10.1021\/pr1005795","article-title":"Functional proteomic analysis of lipases and esterases in cultured human adipocytes","volume":"9","author":"Schicher","year":"2010","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.cbi.2016.04.027_bib26","doi-asserted-by":"crossref","first-page":"8851","DOI":"10.1021\/jacs.5b04883","article-title":"Highly selective, reversible inhibitor identified by comparative chemoproteomics modulates diacylglycerol lipase activity in neurons","volume":"137","author":"Baggelaar","year":"2015","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.cbi.2016.04.027_bib27","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1021\/tx8004218","article-title":"Activity-based protein profiling reveals broad reactivity of the nerve agent sarin","volume":"22","author":"Tuin","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbi.2016.04.027_bib28","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1073\/pnas.0501205102","article-title":"High-resolution functional proteomics by active-site peptide profiling","volume":"102","author":"Okerberg","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2016.04.027_bib29","doi-asserted-by":"crossref","first-page":"20941","DOI":"10.1073\/pnas.1011663107","article-title":"Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening","volume":"107","author":"Bachovchin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2016.04.027_bib30","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1021\/jf101747r","article-title":"Activity-based protein profiling of organophosphorus and thiocarbamate pesticides reveals multiple serine hydrolase targets in mouse brain","volume":"59","author":"Nomura","year":"2011","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.cbi.2016.04.027_bib31","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nchembio.86","article-title":"Activation of the endocannabinoid system by organophosphorus nerve agents","volume":"4","author":"Nomura","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cbi.2016.04.027_bib32","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cbpa.2015.11.007","article-title":"Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms","volume":"30","author":"Counihan","year":"2016","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.cbi.2016.04.027_bib33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1289\/ehp.0900824","article-title":"Mass spectrometric analyses of organophosphate insecticide oxon protein adducts","volume":"118","author":"Thompson","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cbi.2016.04.027_bib34","doi-asserted-by":"crossref","first-page":"5546","DOI":"10.1021\/bi00475a019","article-title":"Crystal structure of the complex of carboxypeptidase A with a strongly bound phosphonate in a new crystalline form: comparison with structures of other complexes","volume":"29","author":"Kim","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbi.2016.04.027_bib35","doi-asserted-by":"crossref","first-page":"15925","DOI":"10.1021\/bi00049a007","article-title":"Design and expression of organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase","volume":"34","author":"Millard","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbi.2016.04.027_bib36","doi-asserted-by":"crossref","first-page":"7464","DOI":"10.1073\/pnas.94.14.7464","article-title":"A\u00a0single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and confers insecticide resistance on a blowfly","volume":"94","author":"Newcomb","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2016.04.027_bib37","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.bbapap.2015.09.001","article-title":"A\u00a0rationally designed mutant of plasma platelet-activating factor acetylhydrolase hydrolyzes the organophosphorus nerve agent soman","volume":"1854","author":"Kirby","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbi.2016.04.027_bib38","doi-asserted-by":"crossref","first-page":"6195","DOI":"10.1073\/pnas.0501915102","article-title":"A\u00a0brain detoxifying enzyme for organophosphorus nerve poisons","volume":"102","author":"Nomura","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2016.04.027_bib39","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1007\/s00216-014-7953-y","article-title":"Biophysical aspects of lysozyme adduct with monocrotophos","volume":"406","author":"Amaraneni","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.cbi.2016.04.027_bib40","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.brainres.2006.02.070","article-title":"Function-specific blockage of M(1) and M(3) muscarinic acetylcholine receptors by VX and echothiophate","volume":"1085","author":"Pittel","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.cbi.2016.04.027_bib41","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0378-4274(02)00251-5","article-title":"Cannabinoid CB1 receptor as a target for chlorpyrifos oxon and other organophosphorus pesticides","volume":"135","author":"Quistad","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbi.2016.04.027_bib42","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.taap.2005.10.007","article-title":"Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice","volume":"211","author":"Quistad","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2016.04.027_bib43","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1126\/science.8066444","article-title":"Crystal structure of a catalytic antibody with a serine protease active site","volume":"265","author":"Zhou","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.cbi.2016.04.027_bib44","doi-asserted-by":"crossref","first-page":"13526","DOI":"10.1073\/pnas.200360497","article-title":"Enzyme mimicry by the antiidiotypic antibody approach","volume":"97","author":"Kolesnikov","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2016.04.027_bib45","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/nchembio.1498","article-title":"Design of activated serine-containing catalytic triads with atomic-level accuracy","volume":"10","author":"Rajagopalan","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cbi.2016.04.027_bib46","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.taap.2013.03.021","article-title":"Protein tyrosine adduct in humans self-poisoned by chlorpyrifos","volume":"269","author":"Li","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2016.04.027_bib47","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.cbi.2009.03.018","article-title":"Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine","volume":"180","author":"Grigoryan","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2016.04.027_bib48","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1073\/pnas.90.5.1852","article-title":"Roles of Ser101, Asp236, and His237 in catalysis of thioesterase II and of the C-terminal region of the enzyme in its interaction with fatty acid synthase","volume":"90","author":"Tai","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2016.04.027_bib49","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1559-0275-10-17","article-title":"Proteomic characterization of serine hydrolase activity and composition in normal urine","volume":"10","author":"Navarrete","year":"2013","journal-title":"Clin. Proteom."},{"key":"10.1016\/j.cbi.2016.04.027_bib50","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1271\/bbb.130428","article-title":"Immobilization of an esterase inhibitor on a porous hollow-fiber membrane by radiation-induced graft polymerization for developing a diagnostic tool for feline kidney diseases","volume":"77","author":"Matsuno","year":"2013","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.cbi.2016.04.027_bib51","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature14259","article-title":"Notum deacylates Wnt proteins to suppress signalling activity","volume":"519","author":"Kakugawa","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2016.04.027_bib52","doi-asserted-by":"crossref","first-page":"23847","DOI":"10.1074\/jbc.M002758200","article-title":"Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride","volume":"275","author":"Das","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cbi.2016.04.027_bib53","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0969-2126(01)00684-0","article-title":"The structure of the feruloyl esterase module of xylanase 10B from Clostridium thermocellum provides insights into substrate recognition","volume":"9","author":"Prates","year":"2001","journal-title":"Structure"},{"key":"10.1016\/j.cbi.2016.04.027_bib54","doi-asserted-by":"crossref","first-page":"7199","DOI":"10.1016\/j.bmc.2015.10.016","article-title":"Structure-activity relationships of amide-phosphonate derivatives as inhibitors of the human soluble epoxide hydrolase","volume":"23","author":"Kim","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cbi.2016.04.027_bib55","doi-asserted-by":"crossref","first-page":"11892","DOI":"10.1074\/jbc.M109.072629","article-title":"Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine","volume":"285","author":"Ishizuka","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cbi.2016.04.027_bib56","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.neuron.2007.11.013","article-title":"Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion","volume":"56","author":"Fabrichny","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.cbi.2016.04.027_bib57","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1194\/jlr.M051151","article-title":"Comparative gene identification 58\/alpha\/beta hydrolase domain 5 lacks lysophosphatidic acid acyltransferase activity","volume":"55","author":"McMahon","year":"2014","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cbi.2016.04.027_bib58","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.cmet.2015.08.023","article-title":"Endogenous and synthetic ABHD5 ligands regulate ABHD5-perilipin interactions and lipolysis in fat and muscle","volume":"22","author":"Sanders","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.cbi.2016.04.027_bib59","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2174\/092986612799080284","article-title":"Enzymatic activity and protein interactions in alpha\/beta hydrolase fold proteins: moonlighting versus promiscuity","volume":"19","author":"Marchot","year":"2012","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.cbi.2016.04.027_bib60","doi-asserted-by":"crossref","first-page":"7032","DOI":"10.1021\/bi982678l","article-title":"Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level","volume":"38","author":"Millard","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbi.2016.04.027_bib61","doi-asserted-by":"crossref","first-page":"16011","DOI":"10.1021\/ja804941z","article-title":"Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation","volume":"130","author":"Carletti","year":"2008","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.cbi.2016.04.027_bib62","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.bbalip.2010.07.002","article-title":"Non-lipolytic and lipolytic sequence-related carboxylesterases: a comparative study of the structure-function relationships of rabbit liver esterase 1 and bovine pancreatic bile-salt-activated lipase","volume":"1801","author":"Chahinian","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbi.2016.04.027_bib63","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.bbalip.2008.07.005","article-title":"Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte\/macrophages","volume":"1781","author":"Crow","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbi.2016.04.027_bib64","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1021\/bi700246n","article-title":"Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun","volume":"46","author":"Fleming","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbi.2016.04.027_bib65","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1124\/mol.109.062356","article-title":"Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin","volume":"77","author":"Hemmert","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.cbi.2016.04.027_bib66","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1021\/acs.molpharmaceut.5b00414","article-title":"Substrate-competitive activity-based profiling of ester prodrug activating enzymes","volume":"12","author":"Xu","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.cbi.2016.04.027_bib67","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1080\/00498250902807338","article-title":"Influence of carboxylesterase 2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients","volume":"39","author":"Fujiyama","year":"2009","journal-title":"Xenobiotica"},{"key":"10.1016\/j.cbi.2016.04.027_bib68","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nchembio.1429","article-title":"Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes","volume":"10","author":"Dominguez","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cbi.2016.04.027_bib69","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1124\/dmd.109.026567","article-title":"Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis","volume":"37","author":"Watanabe","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.cbi.2016.04.027_bib70","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nchembio.659","article-title":"Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids","volume":"7","author":"Long","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cbi.2016.04.027_bib71","doi-asserted-by":"crossref","first-page":"26465","DOI":"10.1074\/jbc.M604660200","article-title":"Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha\/beta-hydrolase 4 in this pathway","volume":"281","author":"Simon","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cbi.2016.04.027_bib72","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/nn.2601","article-title":"The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors","volume":"13","author":"Marrs","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cbi.2016.04.027_bib73","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1021\/ja412431g","article-title":"Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived beta-lactone","volume":"136","author":"Lajkiewicz","year":"2014","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.cbi.2016.04.027_bib74","doi-asserted-by":"crossref","first-page":"5068","DOI":"10.1021\/ja300799t","article-title":"Competitive activity-based protein profiling identifies aza-beta-lactams as a versatile chemotype for serine hydrolase inhibition","volume":"134","author":"Zuhl","year":"2012","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.cbi.2016.04.027_bib75","doi-asserted-by":"crossref","first-page":"9240","DOI":"10.1074\/jbc.M111.271288","article-title":"Human alpha\/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver","volume":"287","author":"Iwamura","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cbi.2016.04.027_bib76","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nchembio.1721","article-title":"Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay","volume":"11","author":"Kamat","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cbi.2016.04.027_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109869","article-title":"Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5\/ABHD16A)","volume":"9","author":"Savinainen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2016.04.027_bib78","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0167-4838(02)00232-7","article-title":"Kynurenine formamidase: determination of primary structure and modeling-based prediction of tertiary structure and catalytic triad","volume":"1596","author":"Pabarcus","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbi.2016.04.027_bib79","doi-asserted-by":"crossref","first-page":"25348","DOI":"10.1074\/jbc.M302055200","article-title":"Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase","volume":"278","author":"Kim","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cbi.2016.04.027_bib80","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.bmcl.2012.11.061","article-title":"Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2)","volume":"23","author":"Nagano","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.cbi.2016.04.027_bib81","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0049-3848(97)00084-4","article-title":"Cathepsin A-like activity in thrombin-activated human platelets. Substrate specificity, pH dependence, and inhibitory profile","volume":"86","author":"Ostrowska","year":"1997","journal-title":"Thromb. Res."},{"key":"10.1016\/j.cbi.2016.04.027_bib82","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/bph.12013","article-title":"A\u00a0novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects","volume":"169","author":"Bisogno","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbi.2016.04.027_bib83","doi-asserted-by":"crossref","first-page":"34691","DOI":"10.1074\/jbc.M405400200","article-title":"Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV","volume":"279","author":"Bjelke","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cbi.2016.04.027_bib84","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/B978-0-12-800280-3.00009-8","article-title":"Application of activity-based protein profiling to study enzyme function in adipocytes","volume":"538","author":"Galmozzi","year":"2014","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cbi.2016.04.027_bib85","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1016\/j.biocel.2004.05.006","article-title":"Purification, identification and characterisation of seprase from bovine serum","volume":"36","author":"Collins","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.cbi.2016.04.027_bib86","doi-asserted-by":"crossref","first-page":"15757","DOI":"10.1073\/pnas.1112334108","article-title":"Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid","volume":"108","author":"Zhang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2016.04.027_bib87","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1248\/cpb.30.214","article-title":"Effect of organophosphate pesticides on the activities of lecithin-cholesterol acyltransferase and cholinesterase in rat serum","volume":"30","author":"Nakagawa","year":"1982","journal-title":"Chem. Pharm. Bull. Tokyo"},{"key":"10.1016\/j.cbi.2016.04.027_bib88","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1161\/ATVBAHA.113.302448","article-title":"Novel lipid droplet-associated serine hydrolase regulates macrophage cholesterol mobilization","volume":"34","author":"Goo","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cbi.2016.04.027_bib89","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1021\/tx500221a","article-title":"Effects of toxicologically relevant xenobiotics and the lipid-derived electrophile 4-hydroxynonenal on macrophage cholesterol efflux: silencing carboxylesterase 1 has paradoxical effects on cholesterol uptake and efflux","volume":"27","author":"Ross","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbi.2016.04.027_bib90","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/toxsci\/kfj124","article-title":"Each lipase has a unique sensitivity profile for organophosphorus inhibitors","volume":"91","author":"Quistad","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbi.2016.04.027_bib91","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.bmc.2015.01.028","article-title":"Rat hormone sensitive lipase inhibition by cyclipostins and their analogs","volume":"23","author":"Vasilieva","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cbi.2016.04.027_bib92","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1021\/bi00218a022","article-title":"Inactivation of gastric and pancreatic lipases by diethyl p-nitrophenyl phosphate","volume":"30","author":"Moreau","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbi.2016.04.027_bib93","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.abb.2015.11.034","article-title":"Interaction of the Serine Hydrolase KIAA1363 with organophosphorus agents: evaluation of potency and kinetics","volume":"590","author":"Ross","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cbi.2016.04.027_bib94","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1074\/jbc.272.4.2192","article-title":"Serine phospholipid-specific phospholipase A that is secreted from activated platelets. A new member of the lipase family","volume":"272","author":"Sato","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cbi.2016.04.027_bib95","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.bcp.2009.04.018","article-title":"Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes","volume":"78","author":"Samanta","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2016.04.027_bib96","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.1038\/ncomms7250","article-title":"Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase","volume":"6","author":"Glukhova","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbi.2016.04.027_bib97","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1021\/bi00009a003","article-title":"The 2.46 A resolution structure of the pancreatic lipase-colipase complex inhibited by a C11 alkyl phosphonate","volume":"34","author":"Egloff","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbi.2016.04.027_bib98","doi-asserted-by":"crossref","first-page":"9553","DOI":"10.1021\/bi8005576","article-title":"Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation","volume":"47","author":"Eydoux","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbi.2016.04.027_bib99","doi-asserted-by":"crossref","first-page":"7559","DOI":"10.1021\/bi401138s","article-title":"Identification of palmitoyl protein thioesterase 1 in human THP-1 monocytes\/macrophages and characterization of unique biochemical activities for this enzyme","volume":"52","author":"Wang","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbi.2016.04.027_bib100","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1182\/blood-2003-07-2510","article-title":"Recombinant prolylcarboxypeptidase activates plasma prekallikrein","volume":"103","author":"Shariat-Madar","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.cbi.2016.04.027_bib101","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1002\/cbic.201200445","article-title":"Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9","volume":"13","author":"Liu","year":"2012","journal-title":"Chembiochem"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279716301508?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279716301508?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:45:23Z","timestamp":1757857523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279716301508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":101,"alternative-id":["S0009279716301508"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2016.04.027","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relationships of human \u03b1\/\u03b2 hydrolase fold proteins and other organophosphate-interacting proteins","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2016.04.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}