{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:40:50Z","timestamp":1789170050574,"version":"build-2803163510"},"reference-count":115,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.cbi.2016.08.016","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T13:57:45Z","timestamp":1472133465000},"page":"79-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Effect of canagliflozin and metformin on cortical neurotransmitters in a diabetic rat model"],"prefix":"10.1016","volume":"258","author":[{"given":"Nadia M.S.","family":"Arafa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed-Assem S.","family":"Marie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Abdullah Mubarak","family":"AlAzimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl.\u00a01","key":"10.1016\/j.cbi.2016.08.016_bib1","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/dc10-S062","article-title":"Diagnosis and classification of diabetes mellitus","volume":"33","author":"Association AD","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cbi.2016.08.016_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/902873","article-title":"Type II diabetes mellitus in Arabic-speaking countries","volume":"2012","author":"Badran","year":"2012","journal-title":"Int. J. Endocrinol."},{"issue":"9","key":"10.1016\/j.cbi.2016.08.016_bib3","article-title":"The association of type 2 diabetes with obesity and other factors: in multinational community","volume":"6","author":"Arafat","year":"2014","journal-title":"Int. J. Pharm. Pharm. Sci."},{"issue":"05","key":"10.1016\/j.cbi.2016.08.016_bib4","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1017\/S0007114507853347","article-title":"Sex differences in fat storage, fat metabolism, and the health risks from obesity: possible evolutionary origins","volume":"99","author":"Power","year":"2008","journal-title":"Br. J. Nutr."},{"issue":"5","key":"10.1016\/j.cbi.2016.08.016_bib5","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S1734-1140(10)70357-1","article-title":"Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide","volume":"62","author":"\u0141abuzek","year":"2010","journal-title":"Pharmacol. Rep."},{"issue":"2","key":"10.1016\/j.cbi.2016.08.016_bib6","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/sj.ijo.802225","article-title":"Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study","volume":"27","author":"Elias","year":"2003","journal-title":"Int. J. Obes."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neurobiolaging.2005.08.019","article-title":"Obesity, diabetes and cognitive deficit: the Framingham heart study","volume":"26","author":"Elias","year":"2005","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/sj.ijo.0803114","article-title":"Interactive relations of central versus total obesity and blood pressure to cognitive function","volume":"30","author":"Waldstein","year":"2006","journal-title":"Int. J. Obes."},{"issue":"4","key":"10.1016\/j.cbi.2016.08.016_bib9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1529-8027.2009.00237.x","article-title":"Hyperlipidemia: a new therapeutic target for diabetic neuropathy","volume":"14","author":"Vincent","year":"2009","journal-title":"J.\u00a0Peripher. Nerv. Syst."},{"issue":"4","key":"10.1016\/j.cbi.2016.08.016_bib10","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.cbi.2016.08.016_bib11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF00971540","article-title":"Effects of fasting and diabetes on some enzymes and transport of glutamate in cortex slices or synaptosomes from rat brain","volume":"13","author":"Galanopoulos","year":"1988","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2005.04.048","article-title":"Alteration in dendritic morphology of cortical neurons in rats with diabetes mellitus induced by streptozotocin","volume":"1048","author":"Mart\u00ednez-Tellez","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.cbi.2016.08.016_bib13","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.brainres.2005.12.070","article-title":"Synaptic transmission changes in the pyramidal cells of the hippocampus in streptozotocin-induced diabetes mellitus in rats","volume":"1073","author":"Kamal","year":"2006","journal-title":"Brain Res."},{"issue":"7","key":"10.1016\/j.cbi.2016.08.016_bib14","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/sj.jcbfm.9600249","article-title":"The rat blood\u2013brain barrier transcriptome","volume":"26","author":"Enerson","year":"2006","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"issue":"5","key":"10.1016\/j.cbi.2016.08.016_bib15","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.2337\/dc06-2052","article-title":"Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity","volume":"30","author":"Last","year":"2007","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.cbi.2016.08.016_bib16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/00004647-199802000-00002","article-title":"Regional differences in cerebral blood flow and glucose utilization in diabetic man: the effect of insulin","volume":"18","author":"Cranston","year":"1998","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"issue":"9131","key":"10.1016\/j.cbi.2016.08.016_bib17","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0140-6736(98)07037-8","article-title":"Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)","volume":"352","author":"Group UPDS","year":"1998","journal-title":"Lancet"},{"issue":"7503","key":"10.1016\/j.cbi.2016.08.016_bib18","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/bmj.38415.708634.F7","article-title":"Metformin and reduced risk of cancer in diabetic patients","volume":"330","author":"Evans","year":"2005","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.cbi.2016.08.016_bib19","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1463-1326.2004.00448.x","article-title":"Metformin revisited: re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents","volume":"7","author":"Goodarzi","year":"2005","journal-title":"Diabetes Obes. Metab."},{"issue":"9","key":"10.1016\/j.cbi.2016.08.016_bib20","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.2337\/dc08-2175","article-title":"New users of metformin are at low risk of incident cancer a cohort study among people with type 2 diabetes","volume":"32","author":"Libby","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cbi.2016.08.016_bib21","article-title":"Weight considerations in pharmacotherapy for type 2 diabetes","volume":"2011","author":"Cheng","year":"2010","journal-title":"J.\u00a0Obes."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s40265-014-0337-y","article-title":"Pharmacodynamics, efficacy and safety of sodium\u2013glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus","volume":"75","author":"Scheen","year":"2015","journal-title":"Drugs"},{"issue":"11","key":"10.1016\/j.cbi.2016.08.016_bib23","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J.\u00a0Nutr."},{"issue":"4","key":"10.1016\/j.cbi.2016.08.016_bib24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.phrs.2005.05.004","article-title":"Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening","volume":"52","author":"Srinivasan","year":"2005","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/oby.2007.14","article-title":"Could the quality of dietary fat, and not just its quantity, be related to risk of obesity?","volume":"16","author":"Moussavi","year":"2008","journal-title":"Obesity"},{"issue":"46","key":"10.1016\/j.cbi.2016.08.016_bib26","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.5897\/AJPP2015.4455","article-title":"Effect of canagliflozin or metformin on metabolic disorders in obese diabetic rats","volume":"9","author":"Marie","year":"2015","journal-title":"Afr. J. Pharm. Pharmacol."},{"issue":"2","key":"10.1016\/j.cbi.2016.08.016_bib27","doi-asserted-by":"crossref","first-page":"e30555","DOI":"10.1371\/journal.pone.0030555","article-title":"Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models","volume":"7","author":"Liang","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.cbi.2016.08.016_bib28","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/0748233713475517","article-title":"The potent effects of ginseng root extract and memantine on cognitive dysfunction in male albino rats","volume":"31","author":"Al-Hazmi","year":"2015","journal-title":"Toxicol. Ind. Health"},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib29","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s11064-012-0905-z","article-title":"Evaluation of the possible epileptogenic activity of ciprofloxacin: the role of Nigella sativa on amino acids neurotransmitters","volume":"38","author":"Arafa","year":"2013","journal-title":"Neurochem. Res."},{"issue":"3","key":"10.1016\/j.cbi.2016.08.016_bib30","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1177\/0960327111405863","article-title":"Monoamine concentrations changes in the PTU-induced hypothyroid rat brain and the ameliorating role of folic acid","volume":"31","author":"Tousson","year":"2012","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.cbi.2016.08.016_bib31","series-title":"Theory and Practice of Histological Techniques","author":"Bancroft","year":"1996"},{"issue":"11","key":"10.1016\/j.cbi.2016.08.016_bib32","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1053\/meta.2000.17721","article-title":"A\u00a0new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat","volume":"49","author":"Reed","year":"2000","journal-title":"Metab. Clin. Exp."},{"issue":"6","key":"10.1016\/j.cbi.2016.08.016_bib33","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.etp.2010.12.009","article-title":"Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet\/streptozotocin-induced diabetes in mice","volume":"64","author":"Bansal","year":"2012","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.cbi.2016.08.016_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/752870","article-title":"An experimental approach for selecting appropriate rodent diets for research studies on metabolic disorders","volume":"2013","author":"Sasidharan","year":"2013","journal-title":"BioMed Res. Int."},{"issue":"5","key":"10.1016\/j.cbi.2016.08.016_bib35","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1538\/expanim.52.401","article-title":"The rat model of type 2 diabetic mellitus and its glycometabolism characters","volume":"52","author":"Zhang","year":"2003","journal-title":"Exp. Anim."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/2251-6581-12-60","article-title":"Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans","volume":"12","author":"Eleazu","year":"2013","journal-title":"J.\u00a0Diabetes Metab. Disord."},{"issue":"3","key":"10.1016\/j.cbi.2016.08.016_bib37","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/bph.12297","article-title":"TAK-875, a GPR40\/FFAR1 agonist, in combination with metformin prevents progression of diabetes and \u03b2-cell dysfunction in Zucker diabetic fatty rats","volume":"170","author":"Ito","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib38","doi-asserted-by":"crossref","first-page":"e0116851","DOI":"10.1371\/journal.pone.0116851","article-title":"Beneficial effects of canagliflozin in combination with pioglitazone on insulin sensitivity in rodent models of obese type 2 diabetes","volume":"10","author":"Watanabe","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.cbi.2016.08.016_bib39","doi-asserted-by":"crossref","first-page":"399","DOI":"10.4239\/wjd.v5.i3.399","article-title":"Canagliflozin-current status in the treatment of type 2 diabetes mellitus with focus on clinical trial data","volume":"5","author":"Bhatia","year":"2014","journal-title":"World J. diabetes"},{"key":"10.1016\/j.cbi.2016.08.016_bib40","first-page":"683","article-title":"Emerging treatments in type 2 diabetes: focus on canagliflozin","volume":"10","author":"Rosiak","year":"2014","journal-title":"Ther. Clin. Risk Manag."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib41","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2337\/db11-0416","article-title":"Sirtuin 1\u2013mediated cellular metabolic memory of high glucose via the LKB1\/AMPK\/ROS pathway and therapeutic effects of metformin","volume":"61","author":"Zheng","year":"2012","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.cbi.2016.08.016_bib42","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.2337\/diabetes.54.9.2638","article-title":"Type 2 diabetes causes remodeling of cerebrovasculature via differential regulation of matrix metalloproteinases and collagen synthesis role of endothelin-1","volume":"54","author":"Harris","year":"2005","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.cbi.2016.08.016_bib43","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.2337\/db11-1528","article-title":"Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling","volume":"61","author":"Prakash","year":"2012","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib44","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1748-1716.2010.02230.x","article-title":"Pressure-independent cerebrovascular remodelling and changes in myogenic reactivity in diabetic Goto-Kakizaki rat in response to glycaemic control","volume":"203","author":"Kelly-Cobbs","year":"2011","journal-title":"Acta Physiol."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib45","doi-asserted-by":"crossref","first-page":"228","DOI":"10.2337\/db09-0902","article-title":"Adaptive cerebral neovascularization in a model of type 2 diabetes relevance to focal cerebral ischemia","volume":"59","author":"Li","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.cbi.2016.08.016_bib46","article-title":"Effects of metformin on the cerebral metabolic changes in type 2 diabetic patients","volume":"2014","author":"Huang","year":"2014","journal-title":"Sci. World J."},{"issue":"3","key":"10.1016\/j.cbi.2016.08.016_bib47","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0361-9230(99)00047-7","article-title":"Impact of diabetes on CNS: role of signal transduction cascade","volume":"49","author":"Bhardwaj","year":"1999","journal-title":"Brain Res. Bull."},{"issue":"12","key":"10.1016\/j.cbi.2016.08.016_bib48","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1038\/sj.jcbfm.9600152","article-title":"Cortical fluoro-Jade staining and blunted adrenomedullary response to hypoglycemia after noncoma hypoglycemia in rats","volume":"25","author":"Tkacs","year":"2005","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"issue":"3","key":"10.1016\/j.cbi.2016.08.016_bib49","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1476-5381.1990.tb14127.x","article-title":"Acetylcholinesterase activity in regions of mouse brain following acute and chronic treatment with a benzodiazepine inverse agonist","volume":"101","author":"Appleyard","year":"1990","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.cbi.2016.08.016_bib50","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0022-3565(24)39312-7","article-title":"Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase","volume":"293","author":"Xie","year":"2000","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2004.10.036","article-title":"Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats","volume":"77","author":"Sonkusare","year":"2005","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib52","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejphar.2007.08.001","article-title":"Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences","volume":"576","author":"Kuhad","year":"2007","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib53","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/(SICI)1098-1136(199709)21:1<2::AID-GLIA2>3.0.CO;2-C","article-title":"Glucose transporter proteins in brain: delivery of glucose to neurons and glia","volume":"21","author":"Vannucci","year":"1997","journal-title":"Glia"},{"issue":"10","key":"10.1016\/j.cbi.2016.08.016_bib54","doi-asserted-by":"crossref","first-page":"12629","DOI":"10.3390\/ijms131012629","article-title":"The role of glucose transporters in brain disease: diabetes and Alzheimer's disease","volume":"13","author":"Shah","year":"2012","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.cbi.2016.08.016_bib55","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2337\/diab.36.5.597","article-title":"Quantitative changes of cerebral neocortical structure in insulin-treated long-term streptozocin-lnduced diabetes in rats","volume":"36","author":"Jakobsen","year":"1987","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.cbi.2016.08.016_bib56","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0891-5849(03)00408-8","article-title":"Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats","volume":"35","author":"Baydas","year":"2003","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.cbi.2016.08.016_bib57","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00401-011-0834-y","article-title":"Vascular \u03b2-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcA\u03b2 mice","volume":"122","author":"Merlini","year":"2011","journal-title":"Acta Neuropathol."},{"issue":"11","key":"10.1016\/j.cbi.2016.08.016_bib58","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1016\/j.neurobiolaging.2015.07.022","article-title":"Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe\/PS1dE9 mice","volume":"36","author":"Yeh","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","article-title":"Glutamate uptake","volume":"65","author":"Danbolt","year":"2001","journal-title":"Prog. Neurobiol."},{"issue":"4","key":"10.1016\/j.cbi.2016.08.016_bib60","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.neuint.2003.11.001","article-title":"Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission","volume":"45","author":"Schousboe","year":"2004","journal-title":"Neurochem. Int."},{"issue":"5","key":"10.1016\/j.cbi.2016.08.016_bib61","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/jnr.10061","article-title":"Elucidation of the quantitative significance of pyruvate carboxylation in cultured cerebellar neurons and astrocytes","volume":"66","author":"Waagepetersen","year":"2001","journal-title":"J.\u00a0Neurosci. Res."},{"issue":"4","key":"10.1016\/j.cbi.2016.08.016_bib62","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/(SICI)1097-4547(19990815)57:4<417::AID-JNR1>3.0.CO;2-N","article-title":"Astrocytes: glutamate producers for neurons","volume":"57","author":"Hertz","year":"1999","journal-title":"J.\u00a0Neurosci. Res."},{"issue":"10","key":"10.1016\/j.cbi.2016.08.016_bib63","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1007\/s11064-010-0210-7","article-title":"Decreased GABA receptor binding in the cerebral cortex of insulin induced hypoglycemic and streptozotocin induced diabetic rats","volume":"35","author":"Antony","year":"2010","journal-title":"Neurochem. Res."},{"issue":"8","key":"10.1016\/j.cbi.2016.08.016_bib64","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/jcbfm.2010.61","article-title":"Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis","volume":"30","author":"Sickmann","year":"2010","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib65","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0006-8993(00)02426-4","article-title":"The effect of topical insulin on the release of excitotoxic and other amino acids from the rat cerebral cortex during streptozotocin-induced hyperglycemic ischemia","volume":"872","author":"Guyot","year":"2000","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(02)01486-3","article-title":"Ageing and diabetes: implications for brain function","volume":"441","author":"Biessels","year":"2002","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib67","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0006-8993(91)90677-N","article-title":"Effects of short and long-lasting diabetes mellitus on mouse brain monoamines","volume":"552","author":"Chen","year":"1991","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.cbi.2016.08.016_bib68","doi-asserted-by":"crossref","first-page":"E338","DOI":"10.1152\/ajpendo.1992.262.3.E338","article-title":"Insulin secretion from ob\/ob mouse pancreatic islets: effects of neurotransmitters","volume":"262","author":"Tassava","year":"1992","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.cbi.2016.08.016_bib69","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000234466","article-title":"Effects of Nigella sativa oil and thymoquinone on oxidative stress and neuropathy in streptozotocin-induced diabetic rats","volume":"84","author":"Hamdy","year":"2009","journal-title":"Pharmacology"},{"issue":"5","key":"10.1016\/j.cbi.2016.08.016_bib70","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2337\/diab.41.5.557","article-title":"The impact of diabetes on the CNS","volume":"41","author":"McCall","year":"1992","journal-title":"Diabetes"},{"issue":"16","key":"10.1016\/j.cbi.2016.08.016_bib71","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0024-3205(97)00084-2","article-title":"Streptozotocin-induced diabetes provokes changes in serotonin concentration and on 5-HT 1A and 5-HT 2 receptors in the rat brain","volume":"60","author":"Sandrini","year":"1997","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.cbi.2016.08.016_bib72","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0893-133X(96)00185-6","article-title":"The effect of streptozotocin-induced diabetes on dopamine 2, serotonin 1A and serotonin 2A receptors in the rat brain","volume":"16","author":"Sumiyoshi","year":"1997","journal-title":"Neuropsychopharmacology"},{"issue":"1\u20132","key":"10.1016\/j.cbi.2016.08.016_bib73","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1006938713276","article-title":"Enhancement of [m-methoxy3H] MDL100907 binding to 5HT2A receptors in cerebral cortex and brain stem of streptozotocin induced diabetic rats","volume":"199","author":"Jackson","year":"1999","journal-title":"Mol. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib74","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2012.09.023","article-title":"Dopaminergic modulation of synaptic transmission in cortex and striatum","volume":"76","author":"Tritsch","year":"2012","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib75","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0149-7634(99)00063-9","article-title":"Structure and function of dopamine receptors","volume":"24","author":"Vallone","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib76","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1046\/j.1471-4159.1998.70010190.x","article-title":"Effects of 2-Deoxy-d-Glucose on methamphetamine-induced dopamine and serotonin neurotoxicity","volume":"70","author":"Callahan","year":"1998","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.cbi.2016.08.016_bib77","doi-asserted-by":"crossref","unstructured":"T.P. Kumar, S. Antony, G. Gireesh, N. George, C. Paulose. Research curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats, (2010).","DOI":"10.1186\/1423-0127-17-43"},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib78","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1471-4159.1991.tb02559.x","article-title":"Brain histamine in rats with hepatic encephalopathy","volume":"56","author":"Fogel","year":"1991","journal-title":"J.\u00a0Neurochem."},{"issue":"2","key":"10.1016\/j.cbi.2016.08.016_bib79","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.brainresrev.2005.08.002","article-title":"Cerebral ischemia and brain histamine","volume":"50","author":"Adachi","year":"2005","journal-title":"Brain Res. Rev."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib80","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.brainres.2005.01.061","article-title":"Prevention of brain infarction by postischemic administration of histidine in rats","volume":"1039","author":"Adachi","year":"2005","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib81","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1254\/jphs.08114FP","article-title":"Alleviation of ischemia-induced brain edema by activation of the central histaminergic system in rats","volume":"108","author":"Irisawa","year":"2008","journal-title":"J.\u00a0Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.cbi.2016.08.016_bib82","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1152\/physrev.00043.2007","article-title":"Histamine in the nervous system","volume":"88","author":"Haas","year":"2008","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.cbi.2016.08.016_bib83","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1111\/j.1471-4159.2006.04002.x","article-title":"N-methyl-d-aspartate receptor antagonists enhance histamine neuron activity in rodent brain","volume":"98","author":"Faucard","year":"2006","journal-title":"J.\u00a0Neurochem."},{"issue":"14","key":"10.1016\/j.cbi.2016.08.016_bib84","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1111\/j.1742-4658.2008.06515.x","article-title":"d-Amino acids in the brain: d-serine in neurotransmission and neurodegeneration","volume":"275","author":"Wolosker","year":"2008","journal-title":"FEBS J."},{"issue":"6","key":"10.1016\/j.cbi.2016.08.016_bib85","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1042\/BST20130220","article-title":"The serine shuttle between glia and neurons: implications for neurotransmission and neurodegeneration","volume":"41","author":"Wolosker","year":"2013","journal-title":"Biochem. Soc. Trans."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib86","first-page":"72","article-title":"d-serine: physiology and pathology","volume":"16","author":"Radzishevsky","year":"2013","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"issue":"4","key":"10.1016\/j.cbi.2016.08.016_bib87","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1523\/JNEUROSCI.4297-09.2010","article-title":"Serine racemase deletion protects against cerebral ischemia and excitotoxicity","volume":"30","author":"Mustafa","year":"2010","journal-title":"J.\u00a0Neurosci."},{"issue":"5","key":"10.1016\/j.cbi.2016.08.016_bib88","doi-asserted-by":"crossref","first-page":"e561","DOI":"10.1038\/tp.2015.52","article-title":"d-serine levels in Alzheimer's disease: implications for novel biomarker development","volume":"5","author":"Madeira","year":"2015","journal-title":"Transl. psychiatry"},{"issue":"8","key":"10.1016\/j.cbi.2016.08.016_bib89","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1177\/1060028014529412","article-title":"Cerebrovascular accident in a high-risk patient during the early initiation phase with canagliflozin","volume":"48","author":"Foushee","year":"2014","journal-title":"Ann. Pharmacother."},{"issue":"12","key":"10.1016\/j.cbi.2016.08.016_bib90","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.2337\/db06-0531","article-title":"Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing","volume":"55","author":"O'Malley","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.cbi.2016.08.016_bib91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2014.09.018","article-title":"Carcinogenicity in rats of the SGLT2 inhibitor canagliflozin","volume":"224","author":"De Jonghe","year":"2014","journal-title":"Chem. Biol. Interact."},{"issue":"6","key":"10.1016\/j.cbi.2016.08.016_bib92","doi-asserted-by":"crossref","first-page":"C1277","DOI":"10.1152\/ajpcell.00296.2010","article-title":"Functional expression of SGLTs in rat brain","volume":"299","author":"Amy","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"10","key":"10.1016\/j.cbi.2016.08.016_bib93","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.metabol.2014.07.003","article-title":"Canagliflozin, a sodium glucose co-transporter 2 inhibitor, reduces post-meal glucose excursion in patients with type 2 diabetes by a non-renal mechanism: results of a randomized trial","volume":"63","author":"Stein","year":"2014","journal-title":"Metab. Clin. Exp."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib94","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0168-0102(95)00876-U","article-title":"A\u00a0sodium-and energy-dependent glucose transporter with similarities to SGLT1\u20132 is expressed in bovine cortical vessels","volume":"22","author":"Nishizaki","year":"1995","journal-title":"Neurosci. Res."},{"issue":"2","key":"10.1016\/j.cbi.2016.08.016_bib95","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1124\/jpet.108.146589","article-title":"A\u00a0functional role for sodium-dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation","volume":"328","author":"Vemula","year":"2009","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.cbi.2016.08.016_bib96","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S2213-8587(13)70050-0","article-title":"SGLT inhibitors in management of diabetes","volume":"1","author":"Tahrani","year":"2013","journal-title":"Lancet Diabetes & Endocrinol."},{"key":"10.1016\/j.cbi.2016.08.016_bib97","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.brainres.2012.10.020","article-title":"Post-ischemic hyperglycemia exacerbates the development of cerebral ischemic neuronal damage through the cerebral sodium-glucose transporter","volume":"1489","author":"Yamazaki","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.cbi.2016.08.016_bib98","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neulet.2015.08.004","article-title":"Relationship between cerebral sodium\u2013glucose transporter and hyperglycemia in cerebral ischemia","volume":"604","author":"Yamazaki","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cbi.2016.08.016_bib99","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainres.2013.09.041","article-title":"Neuroprotective effect through the cerebral sodium\u2013glucose transporter on the development of ischemic damage in global ischemia","volume":"1541","author":"Harada","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.cbi.2016.08.016_bib100","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2174\/18715273113126660160","article-title":"Invokana (canagliflozin) as a dual inhibitor of acetylcholinesterase and sodium glucose Co-Transporter 2: advancement in Alzheimer's disease-diabetes type 2 linkage via an enzoinformatics study","volume":"13","author":"Rizvi","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"5","key":"10.1016\/j.cbi.2016.08.016_bib101","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1152\/jn.1992.67.5.1222","article-title":"Cholinergic suppression specific to intrinsic not afferent fiber synapses in rat piriform (olfactory) cortex","volume":"67","author":"Hasselmo","year":"1992","journal-title":"J.\u00a0Neurophysiol."},{"issue":"6","key":"10.1016\/j.cbi.2016.08.016_bib102","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0197-0186(97)00026-0","article-title":"Inhibitory cholinergic control of endogenous GABA release from electrically stimulated cortical slices and K+-depolarized synaptosomes","volume":"31","author":"Ferraro","year":"1997","journal-title":"Neurochem. Int."},{"issue":"2","key":"10.1016\/j.cbi.2016.08.016_bib103","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1152\/jn.1997.77.2.709","article-title":"Distinct muscarinic receptor subtypes suppress excitatory and inhibitory synaptic responses in cortical neurons","volume":"77","author":"Kimura","year":"1997","journal-title":"J.\u00a0Neurophysiol."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib104","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0022-3565(25)38795-1","article-title":"Noradrenergic modulation of cortical acetylcholine release is both direct and gamma-aminobutyric acid-mediated","volume":"236","author":"Beani","year":"1986","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.cbi.2016.08.016_bib105","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/0006-8993(95)01471-3","article-title":"Involvement of GABA systems in acetylcholine release induced by 5-HT 3 receptor blockade in slices from rat entorhinal cortex","volume":"712","author":"Ramirez","year":"1996","journal-title":"Brain Res."},{"issue":"13","key":"10.1016\/j.cbi.2016.08.016_bib106","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s000110050044","article-title":"GABAergic mechanism in histamine H 3 receptor inhibition of K+-evoked release of acetylcholine from rat cortex in\u00a0vivo","volume":"46","author":"Giorgetti","year":"1997","journal-title":"Inflamm. Res."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib107","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1046\/j.0953-816x.2001.01619.x","article-title":"Inhibition of synaptically evoked cortical acetylcholine release by intracortical glutamate: involvement of GABAergic neurons","volume":"14","author":"Materi","year":"2001","journal-title":"Eur. J. Neurosci."},{"issue":"9","key":"10.1016\/j.cbi.2016.08.016_bib108","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/1440-1681.12265","article-title":"Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus","volume":"41","author":"Guo","year":"2014","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib109","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1161\/01.HYP.35.1.108","article-title":"Metformin improves vascular function in insulin-resistant rats","volume":"35","author":"Katakam","year":"2000","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.cbi.2016.08.016_bib110","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.lfs.2011.11.005","article-title":"Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats","volume":"90","author":"Lobato","year":"2012","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib111","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1677\/joe.1.05844","article-title":"Insulin sensitizing drugs increase the endogenous dopaminergic tone in obese insulin-resistant women with polycystic ovary syndrome","volume":"184","author":"Ortega-Gonzalez","year":"2005","journal-title":"J.\u00a0Endocrinol."},{"issue":"8","key":"10.1016\/j.cbi.2016.08.016_bib112","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI13505","article-title":"Role of AMP-activated protein kinase in mechanism of metformin action","volume":"108","author":"Zhou","year":"2001","journal-title":"J.\u00a0Clin. Investig."},{"issue":"2\u20133","key":"10.1016\/j.cbi.2016.08.016_bib113","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3109\/01677063.2015.1067203","article-title":"AMPK-mediated regulation of neuronal metabolism and function in brain diseases","volume":"29","author":"Liu","year":"2015","journal-title":"J.\u00a0Neurogenet."},{"issue":"5","key":"10.1016\/j.cbi.2016.08.016_bib114","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2174\/1568026615666150813142423","article-title":"Targeting insulin signaling for the treatment of Alzheimer's disease","volume":"16","author":"Chen","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"issue":"1","key":"10.1016\/j.cbi.2016.08.016_bib115","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s12035-014-8866-7","article-title":"Chronic metformin preconditioning provides neuroprotection via suppression of NF-\u03baB-mediated inflammatory pathway in rats with permanent cerebral ischemia","volume":"52","author":"Zhu","year":"2015","journal-title":"Mol. Neurobiol."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279716303349?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279716303349?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:41:49Z","timestamp":1757857309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279716303349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":115,"alternative-id":["S0009279716303349"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2016.08.016","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of canagliflozin and metformin on cortical neurotransmitters in a diabetic rat model","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2016.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}