{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:32:45Z","timestamp":1777905165958,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Scientific and Technological Project of Shenyang","award":["F13-318-1-20"],"award-info":[{"award-number":["F13-318-1-20"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.cbi.2016.08.018","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T04:09:32Z","timestamp":1472530172000},"page":"159-165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Hepatoprotective effect of apple polyphenols against concanavalin A-induced immunological liver injury in mice"],"prefix":"10.1016","volume":"258","author":[{"given":"Fang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunfu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2016.08.018_bib1","first-page":"201","article-title":"Relevance of apple polyphenols as antioxidants in human plasma: contrasting in\u00a0vitro and in\u00a0vivo effects","volume":"36","author":"Lotito","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2016.08.018_bib2","doi-asserted-by":"crossref","first-page":"e53725","DOI":"10.1371\/journal.pone.0053725","article-title":"Apple peel polyphenols and their beneficial actions on oxidative stress and inflammation","volume":"8","author":"Denis","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2016.08.018_bib3","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1271\/bbb.69.1974","article-title":"Inhibitory effect of polyphenol-enriched apple extracts on mast cell degranulation in\u00a0vitro targeting the binding between IgE and FcepsilonRI","volume":"69","author":"Tokura","year":"2005","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.cbi.2016.08.018_bib4","first-page":"7085","article-title":"Apple polyphenols decrease atherosclerosis and hepatic steatosis in ApoE(-\/-) mice through the ROS\/MAPK\/NF-kappaB pathway","volume":"7","author":"Xu","year":"2015","journal-title":"Nutr."},{"key":"10.1016\/j.cbi.2016.08.018_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11655-012-1243-3","article-title":"Hypotriglyceridemic effects of apple polyphenols extract via up-regulation of lipoprotein lipase in triton WR-1339-induced mice","volume":"20","author":"Yao","year":"2014","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.cbi.2016.08.018_bib6","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1080\/01635581.2014.951733","article-title":"Flavonoid-enriched apple fraction AF4 induces cell cycle arrest, DNA topoisomerase II inhibition, and apoptosis in human liver cancer HepG2 cells","volume":"66","author":"Sudan","year":"2014","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.cbi.2016.08.018_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neuro.2014.10.006","article-title":"Protective effect of apple (Ralls) polyphenol extract against aluminum-induced cognitive impairment and oxidative damage in rat","volume":"45","author":"Cheng","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.cbi.2016.08.018_bib8","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1021\/jf1046267","article-title":"Apple polyphenols extend the mean lifespan of Drosophila melanogaster","volume":"59","author":"Peng","year":"2011","journal-title":"J.\u00a0Agric. food Chem."},{"key":"10.1016\/j.cbi.2016.08.018_bib9","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/biof.5520220161","article-title":"Characteristics and physiological functions of polyphenols from apples","volume":"22","author":"Akazome","year":"2004","journal-title":"BioFactors"},{"key":"10.1016\/j.cbi.2016.08.018_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jamcollsurg.2003.08.014","article-title":"Protection against concanavalin A-induced hepatocyte apoptosis by molsidomine is time-dependent","volume":"198","author":"Ding","year":"2004","journal-title":"J.\u00a0Am. Coll. Surg."},{"key":"10.1016\/j.cbi.2016.08.018_bib11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/toxsci\/kft174","article-title":"Pretreatment with TCDD exacerbates liver injury from concanavalin A: critical role for NK cells","volume":"136","author":"Fullerton","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbi.2016.08.018_bib12","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1172\/JCI115836","article-title":"A\u00a0T cell-dependent experimental liver injury in mice inducible by concanavalin A","volume":"90","author":"Tiegs","year":"1992","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.cbi.2016.08.018_bib13","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.acthis.2013.12.002","article-title":"Epigallocatechin-3-gallate (EGCG) attenuates concanavalin A-induced hepatic injury in mice","volume":"116","author":"Liu","year":"2014","journal-title":"Acta Histochem."},{"key":"10.1016\/j.cbi.2016.08.018_bib14","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.intimp.2014.05.018","article-title":"Protective effects of hesperidin on concanavalin A-induced hepatic injury in mice","volume":"21","author":"Li","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cbi.2016.08.018_bib15","doi-asserted-by":"crossref","first-page":"6525","DOI":"10.1021\/jf903070a","article-title":"Hepatoprotective effects of apple polyphenols on CCl4-induced acute liver damage in mice","volume":"58","author":"Yang","year":"2010","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.cbi.2016.08.018_bib16","doi-asserted-by":"crossref","first-page":"e35523","DOI":"10.1371\/journal.pone.0035523","article-title":"Baicalin improves survival in a murine model of polymicrobial sepsis via suppressing inflammatory response and lymphocyte apoptosis","volume":"7","author":"Zhu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2016.08.018_bib17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11010-013-1674-y","article-title":"Ginsenoside Rg1 attenuates concanavalin A-induced hepatitis in mice through inhibition of cytokine secretion and lymphocyte infiltration","volume":"380","author":"Cao","year":"2013","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.cbi.2016.08.018_bib18","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.etap.2009.01.001","article-title":"Reduction of cyclophosphamide-induced DNA damage and apoptosis effects of ginsenoside Rb(1) on mouse bone marrow cells and peripheral blood leukocytes","volume":"27","author":"Zhang","year":"2009","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbi.2016.08.018_bib19","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.taap.2012.11.009","article-title":"2,3,7,8-TCDD enhances the sensitivity of mice to concanavalin A immune-mediated liver injury","volume":"266","author":"Fullerton","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2016.08.018_bib20","doi-asserted-by":"crossref","first-page":"706156","DOI":"10.1155\/2013\/706156","article-title":"Protective effects of necrostatin-1 against concanavalin A-induced acute hepatic injury in mice","volume":"2013","author":"Zhou","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.cbi.2016.08.018_bib21","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.antiviral.2012.10.003","article-title":"Anti-hepatitis B virus activities of alpha-DDB-FNC, a novel nucleoside-biphenyldicarboxylate compound in cells and ducks, and its anti-immunological liver injury effect in mice","volume":"96","author":"Yang","year":"2012","journal-title":"Antivir. Res."},{"key":"10.1016\/j.cbi.2016.08.018_bib22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.taap.2013.08.021","article-title":"Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice","volume":"273","author":"Xu","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2016.08.018_bib23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3748\/wjg.v18.i2.119","article-title":"Immune mechanisms of Concanavalin A model of autoimmune hepatitis","volume":"18","author":"Wang","year":"2012","journal-title":"World J. Gastroenterol. \u2013 WJG"},{"key":"10.1016\/j.cbi.2016.08.018_bib24","doi-asserted-by":"crossref","first-page":"e69592","DOI":"10.1371\/journal.pone.0069592","article-title":"Baicalein selectively induces apoptosis in activated lymphocytes and ameliorates concanavalin a-induced hepatitis in mice","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2016.08.018_bib25","first-page":"190","article-title":"Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor","volume":"21","author":"Gantner","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2016.08.018_bib26","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1053\/gast.1996.v111.pm8690213","article-title":"Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A","volume":"111","author":"Kusters","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cbi.2016.08.018_bib27","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejphar.2012.09.050","article-title":"Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice","volume":"697","author":"Wang","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbi.2016.08.018_bib28","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1172\/JCI23640","article-title":"The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury","volume":"115","author":"Klein","year":"2005","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.cbi.2016.08.018_bib29","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.metabol.2005.11.008","article-title":"T\u00a0cell-mediated hepatic inflammation modulates adiponectin levels in mice: role of tumor necrosis factor alpha","volume":"55","author":"Morris","year":"2006","journal-title":"Metabolism"},{"key":"10.1016\/j.cbi.2016.08.018_bib30","doi-asserted-by":"crossref","first-page":"e231","DOI":"10.1111\/j.1440-1746.2007.05083.x","article-title":"Expression of inducible nitric oxide synthase in the liver is under the control of nuclear factor kappa B in concanavalin A-induced hepatitis","volume":"23","author":"Ma","year":"2008","journal-title":"J.\u00a0Gastroenterol. Hepatol."},{"key":"10.1016\/j.cbi.2016.08.018_bib31","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1172\/JCI10613","article-title":"Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice","volume":"107","author":"Sass","year":"2001","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cbi.2016.08.018_bib32","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-2249.2006.03137.x","article-title":"(-)-Epigallocatechin-3-gallate protects mice from concanavalin A-induced hepatitis through suppressing immune-mediated liver injury","volume":"145","author":"Wang","year":"2006","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cbi.2016.08.018_bib33","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1742-7843.2008.00258.x","article-title":"Oxidative DNA damage induced by ethanol in mouse peripheral leucocytes","volume":"103","author":"Guo","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.cbi.2016.08.018_bib34","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.1021\/jf070440a","article-title":"Direct in\u00a0vivo evidence of protective effects of grape seed procyanidin fractions and other antioxidants against ethanol-induced oxidative DNA damage in mouse brain cells","volume":"55","author":"Guo","year":"2007","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.cbi.2016.08.018_bib35","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.fct.2011.10.046","article-title":"Differences in the activities of resveratrol and ascorbic acid in protection of ethanol-induced oxidative DNA damage in human peripheral lymphocytes","volume":"50","author":"Yan","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2016.08.018_bib36","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.fct.2004.02.008","article-title":"The toxicology and safety of apple polyphenol extract,","volume":"42","author":"Shoji","year":"2004","journal-title":"Food Chem. Toxicol."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279716303362?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279716303362?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:42:46Z","timestamp":1757857366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279716303362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":36,"alternative-id":["S0009279716303362"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2016.08.018","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatoprotective effect of apple polyphenols against concanavalin A-induced immunological liver injury in mice","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2016.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}