{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:55:18Z","timestamp":1767912918219,"version":"3.49.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.cbi.2017.05.008","type":"journal-article","created":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T11:47:08Z","timestamp":1494330428000},"page":"37-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin"],"prefix":"10.1016","volume":"272","author":[{"given":"Michael","family":"da Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamile","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidiane","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago","family":"Fiuza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria F.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana D.","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cec\u00edlia M.P.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria E.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2017.05.008_bib1","first-page":"2165","article-title":"Neurotransmitters in Alzheimer's disease","volume":"152","author":"Kristensen","year":"1990","journal-title":"Ugeskr. Laeger"},{"key":"10.1016\/j.cbi.2017.05.008_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2007.01.071","article-title":"Susceptibility of hippocampal neurons to A peptide toxicity is associated with perturbation of Ca 2+ homeostasis","volume":"11","author":"Resende","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.cbi.2017.05.008_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/jnnp.66.2.137","article-title":"The cholinergic hypothesis of Alzheimer's disease: a review of progress","volume":"66","author":"Francis","year":"1999","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.cbi.2017.05.008_bib4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pneurobio.2016.01.001","article-title":"Astrogliosis: an integral player in the pathogenesis of Alzheimer's disease","volume":"144","author":"Osborn","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.cbi.2017.05.008_bib5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bbadis.2015.11.011","article-title":"Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: recent developments in positron emission tomography","volume":"1862","author":"Janssen","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbi.2017.05.008_bib6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0039-6109(05)70141-9","article-title":"Islet cell tumors of the pancreas: the medical oncologist's perspective","volume":"81","author":"Brentjens","year":"2001","journal-title":"Surg. Clin. North. Am."},{"key":"10.1016\/j.cbi.2017.05.008_bib7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0736-5748(93)90021-5","article-title":"Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus","volume":"11","author":"Plaschke","year":"1993","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.cbi.2017.05.008_bib8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.bbr.2011.07.047","article-title":"Central angiotensin converting enzyme facilitates memory impairment in intracerebroventricular streptozotocin treated rats","volume":"226","author":"Tota","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.cbi.2017.05.008_bib9","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1037\/0735-7044.112.5.1199","article-title":"Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats","volume":"112","author":"Lannert","year":"1998","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.cbi.2017.05.008_bib10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cbi.2016.04.026","article-title":"N-acetylcysteine protects memory decline induced by streptozotocin in mice","volume":"253","author":"Costa","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2017.05.008_bib11","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbr.2011.04.039","article-title":"ICV STZ induced impairment in memory and neuronal mitochondrial function: a protective role of nicotinic receptor","volume":"224","author":"Saxena","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.cbi.2017.05.008_bib12","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.neuropharm.2009.01.005","article-title":"A\u00a0study of brain insulin receptors, AChE activity and oxidative stress in rat model of ICV STZ induced dementia","volume":"56","author":"Agrawal","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.cbi.2017.05.008_bib13","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1358\/dof.1999.024.04.668318","article-title":"Cholinergic therapies in Alzheimer's disease","volume":"24","author":"Siddiqui","year":"1999","journal-title":"Drugs Future"},{"key":"10.1016\/j.cbi.2017.05.008_bib14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1192\/apt.8.2.89","article-title":"Use of cholinesterase inhibitors in dementia","volume":"8","author":"Holden","year":"2002","journal-title":"Adv. Psychiatr. Treat."},{"key":"10.1016\/j.cbi.2017.05.008_bib15","series-title":"World Health Organization","author":"WHO Model List of Essential Medicines","year":"2014"},{"key":"10.1016\/j.cbi.2017.05.008_bib16","first-page":"168","article-title":"To conduct the first systematic literature review of clinical trials of N-acetylcysteine (NAC) for the treatment of substance abuse disorders and addictive behaviors","volume":"36","author":"Azevedo","year":"1999","journal-title":"Rev. Bras. Psiquiatr."},{"key":"10.1016\/j.cbi.2017.05.008_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1515\/jbcpp-2013-0150","article-title":"Neuroprotective effect of N-acetyl cysteine against streptozotocin-induced memory dysfunction and oxidative damage in rats","volume":"26","author":"Prakash","year":"2015","journal-title":"J.\u00a0Basic. Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.cbi.2017.05.008_bib18","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.pbb.2004.09.009","article-title":"Behavioral changes after acetylcholinesterase inhibition with physostigmine in mice","volume":"79","author":"Mach","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.cbi.2017.05.008_bib19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.phrs.2009.12.008","article-title":"Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat","volume":"61","author":"Agrawal","year":"2010","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cbi.2017.05.008_bib20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1476-5381.1957.tb01354.x","article-title":"Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse","volume":"12","author":"Haley","year":"1957","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.cbi.2017.05.008_bib21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0160-5402(86)90038-0","article-title":"Intracerebroventricular injections in mice: some methodological refinements","volume":"16","author":"Laursen","year":"1986","journal-title":"J.\u00a0Pharmacol. Methods"},{"key":"10.1016\/j.cbi.2017.05.008_bib22","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1037\/0033-2909.83.3.482","article-title":"The open-field test: a critical review","volume":"83","author":"Walsh","year":"1976","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.cbi.2017.05.008_bib23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0091-3057(95)02021-7","article-title":"Aniracetam restores object recognition impaired by age, scopolamine, and nucleus basalis lesions","volume":"53","author":"Bartolini","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.cbi.2017.05.008_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial-learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.cbi.2017.05.008_bib25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A\u00a0new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2017.05.008_bib26","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jalz.2014.04.514","article-title":"At the interface of sensory and motor dysfunctions and Alzheimer's disease","volume":"11","author":"Mark","year":"2015","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.cbi.2017.05.008_bib27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cogn. Process"},{"key":"10.1016\/j.cbi.2017.05.008_bib28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuropharm.2014.05.008","article-title":"The metabotropic glutamate 2\/3 receptor agonist LY379268 counteracted ketamine-and apomorphine-induced performance deficits in the object recognition task, but not object location task, in rats","volume":"85","author":"Pitsikas","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.cbi.2017.05.008_bib29","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","article-title":"Applications of the Morris water maze in the study of learning and memory","volume":"36","author":"D'Hooge","year":"2001","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.cbi.2017.05.008_bib30","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/297681a0","article-title":"Place navigation impaired in rats with hippocampal lesions","volume":"297","author":"Morris","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2017.05.008_bib31","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.bbr.2010.11.033","article-title":"Acetylcholine and attention","volume":"221","author":"Klinkenberg","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.cbi.2017.05.008_bib32","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.phymed.2010.03.009","article-title":"Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a nootropic Amazonian herbal (Marapuama)","volume":"17","author":"Figueir\u00f3","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cbi.2017.05.008_bib33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00002826-200405000-00011","article-title":"Acetylcholinesterase and its inhibition in Alzheimer disease","volume":"27","author":"Lane","year":"2004","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.cbi.2017.05.008_bib34","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1177\/193229680800200619","article-title":"Alzheimer's disease is type 3 diabetes-evidence reviewed","volume":"2","author":"de la Monte","year":"2008","journal-title":"J.\u00a0Diabetes Sci. Technol."},{"key":"10.1016\/j.cbi.2017.05.008_bib35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jnutbio.2012.06.012","article-title":"Therapeutic effect of organoselenium dietary supplementation in a sporadic dementia of Alzheimer's type model in rats","volume":"24","author":"Pinton","year":"2013","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.cbi.2017.05.008_bib36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3233\/JAD-2006-9102","article-title":"Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease","volume":"9","author":"Lester-Coll","year":"2006","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.cbi.2017.05.008_bib37","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuroscience.2016.03.023","article-title":"Brain-derived neurotrophic factor signaling is altered in the forebrain of Engrailed-2 knockout mice","volume":"324","author":"Zunino","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.cbi.2017.05.008_bib38","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/374450a0","article-title":"A\u00a0BDNF autocrine loop in adult sensory neurons prevents cell death","volume":"374","author":"Acheson","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2017.05.008_bib39","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","article-title":"Neurotrophins roles neuronal development and function","volume":"24","author":"Huang","year":"2001","journal-title":"Ann. Rev. Neurosci."},{"key":"10.1016\/j.cbi.2017.05.008_bib40","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1254\/jphs.91.267","article-title":"Brain-derived neurotrophic factor\/TrkB signaling in memory processes","volume":"91","author":"Yamada","year":"2003","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.cbi.2017.05.008_bib41","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1073\/pnas.0711863105","article-title":"BDNF is essential to promote persistence of long-term memory storage","volume":"105","author":"Bekinschtein","year":"2008","journal-title":"Proc. Natil. Acad. Sci. U.S.A."},{"key":"10.1016\/j.cbi.2017.05.008_bib42","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.nlm.2007.08.018","article-title":"BDNF: a key regulator for protein synthesis dependent LTP and long term memory","volume":"89","author":"Lu","year":"2008","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.cbi.2017.05.008_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/JNEUROSCI.19-06-02069.1999","article-title":"Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons","volume":"19","author":"Mowla","year":"1999","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cbi.2017.05.008_bib44","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1089\/ars.2015.6318","article-title":"Mitochondrial dysfunction due to lack of manganese superoxide dismutase promotes hepatocarcinogenesis. Antioxid","volume":"10","author":"Konzack","year":"2015","journal-title":"Redox Signal"},{"key":"10.1016\/j.cbi.2017.05.008_bib45","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/00005072-199708000-00011","article-title":"Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease","volume":"56","author":"Sze","year":"1997","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.cbi.2017.05.008_bib46","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/BF02284844","article-title":"Comparative evaluation of synaptophysin-based methods for quantification of synapses","volume":"25","author":"Calhoun","year":"1996","journal-title":"J.\u00a0Neurocytol."},{"key":"10.1016\/j.cbi.2017.05.008_bib47","doi-asserted-by":"crossref","first-page":"14299","DOI":"10.1523\/JNEUROSCI.3383-10.2010","article-title":"Effects of synaptic modulation on b-amyloid, synaptophysin and memory performance in Alzheimer's disease transgenic mice","volume":"30","author":"Tampellini","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cbi.2017.05.008_bib48","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1113\/jphysiol.1973.sp010273","article-title":"Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the performant path","volume":"232","author":"Bliss","year":"1973","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.cbi.2017.05.008_bib49","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0378-5955(03)00302-2","article-title":"Microtubule-associated protein 2 (MAP2) expression during synaptic plasticity in the Guinea pig cochlea","volume":"186","author":"Ladrech","year":"2003","journal-title":"Hear. Res."},{"key":"10.1016\/j.cbi.2017.05.008_bib50","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.biopsych.2014.12.029","article-title":"Loss of microtubule-associated protein 2 immunoreactivity linked to dendritic spine loss in schizophrenia","volume":"78","author":"Shelton","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.cbi.2017.05.008_bib51","first-page":"399","article-title":"Astrocytes in Alzheimer's disease","volume":"7","author":"Verkhratsky","year":"2010","journal-title":"Neuro. Therapeutics"},{"key":"10.1016\/j.cbi.2017.05.008_bib52","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: biology and pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.cbi.2017.05.008_bib53","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/path.1645","article-title":"Astrocyte intermediate filaments in CNS pathologies and regeneration","volume":"204","author":"Pekny","year":"2004","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.cbi.2017.05.008_bib54","series-title":"Glial Physiology and Pathophysiology","author":"Verkhratsky","year":"2013"},{"key":"10.1016\/j.cbi.2017.05.008_bib55","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/sj.mp.4000696","article-title":"Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium","volume":"5","author":"Johnston-Wilson","year":"2000","journal-title":"Molec. Psyc"},{"key":"10.1016\/j.cbi.2017.05.008_bib56","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1161\/01.STR.32.5.1208","article-title":"Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain","volume":"32","author":"Ito","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.cbi.2017.05.008_bib57","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0006-8993(02)04159-8","article-title":"Acetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with \u03b2-amyloid peptides","volume":"965","author":"Saez-Valero","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.cbi.2017.05.008_bib58","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/S0047-6374(01)00309-8","article-title":"Acetylcholinesterase in Alzheimer's disease","volume":"122","author":"Talesa","year":"2001","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.cbi.2017.05.008_bib59","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.neuint.2012.09.017","article-title":"L-Tyrosine administration increases acetylcholinesterase activity in rats","volume":"61","author":"Ferreira","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.cbi.2017.05.008_bib60","first-page":"CD001499","article-title":"Physostigmine for Alzheimer's disease","author":"Coelho","year":"2001","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.cbi.2017.05.008_bib61","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.freeradbiomed.2004.11.034","article-title":"Tissue-specific changes of mitochondrial functions in aged rats: effect of a long-term dietary treatment with N-acetylcysteine","volume":"38","author":"Cocco","year":"2005","journal-title":"Free Radic. Biol. Med."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279717301011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279717301011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:44:18Z","timestamp":1757857458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279717301011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":61,"alternative-id":["S0009279717301011"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2017.05.008","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2017.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}