{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T10:54:25Z","timestamp":1784026465304,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T00:00:00Z","timestamp":1533254400000},"content-version":"am","delay-in-days":336,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007069","name":"Oklahoma State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000774","name":"Defense Threat Reduction Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.cbi.2017.07.019","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T23:16:15Z","timestamp":1501110975000},"page":"86-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Polyionic complexes of butyrylcholinesterase and poly-l-lysine-g-poly(ethylene glycol): Comparative kinetics of catalysis and inhibition and in\u00a0vitro inactivation by proteases and heat"],"prefix":"10.1016","volume":"275","author":[{"given":"Kirstin","family":"Hester","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lester G.","family":"Sultatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyi","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Brimijoin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Ramsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Hartson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8851-496X","authenticated-orcid":false,"given":"Ashish","family":"Ranjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9936-3589","authenticated-orcid":false,"given":"Carey","family":"Pope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2017.07.019_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.envpol.2014.09.012","article-title":"Organophosphorus flame retardants and plasticizers: sources, occurrence, toxicity and human exposure","volume":"196","author":"Wei","year":"2015","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2017.07.019_bib2","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.chemosphere.2012.03.067","article-title":"Phosphorus flame retardants: properties, production, environmental occurrence, toxicity and analysis","volume":"88","author":"van der Veen","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbi.2017.07.019_bib3","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1021\/jf60067a001","article-title":"Mode of action of pesticides, metabolism of organophosphorus insecticides in relation to their antiesterase activity, stability, and residual properties","volume":"4","author":"Casida","year":"1956","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.cbi.2017.07.019_bib4","series-title":"Casarett and Doull's Toxicology","first-page":"763","article-title":"Toxic effects of pesticides","author":"Ecobichon","year":"2001"},{"key":"10.1016\/j.cbi.2017.07.019_bib5","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0749-0704(05)70374-2","article-title":"Chemical warfare. Nerve agent poisoning","volume":"13","author":"Holstege","year":"1997","journal-title":"Crit. Care. Clin."},{"key":"10.1016\/j.cbi.2017.07.019_bib6","series-title":"Handbook of Toxicology of Chemical Warfare Agents","author":"Gupta","year":"2015"},{"key":"10.1016\/j.cbi.2017.07.019_bib7","first-page":"115","article-title":"Aum Shinrikyo's chemical and biological weapons: more than sarin","volume":"26","author":"Tu","year":"2014","journal-title":"Forensic Sci. Rev."},{"key":"10.1016\/j.cbi.2017.07.019_bib8","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/nm1013-1194","article-title":"Syrian gas attack reinforces need for better anti-sarin drugs","volume":"19","author":"Dolgin","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.cbi.2017.07.019_bib9","doi-asserted-by":"crossref","first-page":"644","DOI":"10.7326\/M13-2799","article-title":"Lessons learned from the Syrian sarin attack: evaluation of a clinical syndrome through social media","volume":"160","author":"Rosman","year":"2014","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cbi.2017.07.019_bib10","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1097\/00003246-200210000-00026","article-title":"A\u00a0review of nerve agent exposure for the critical care physician","volume":"30","author":"Leikin","year":"2002","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.cbi.2017.07.019_bib11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2165\/00139709-200625040-00009","article-title":"The role of oximes in the treatment of nerve agent poisoning in civilian casualties","volume":"25","author":"Marrs","year":"2006","journal-title":"Toxicol. Rev."},{"key":"10.1016\/j.cbi.2017.07.019_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2165\/00139709-200423030-00002","article-title":"The role of diazepam in the treatment of nerve agent poisoning in a civilian population","volume":"23","author":"Marrs","year":"2004","journal-title":"Toxicol. Rev."},{"key":"10.1016\/j.cbi.2017.07.019_bib13","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.neuro.2012.03.011","article-title":"Organophosphate-induced brain damage: mechanisms, neuropsychiatric and neurological consequences, and potential therapeutic strategies","volume":"33","author":"Chen","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.cbi.2017.07.019_bib14","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1289\/ehp.011091169","article-title":"Effects of sarin on the nervous system in rescue team staff members and police officers 3 years after the Tokyo subway sarin attack","volume":"109","author":"Nishiwaki","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cbi.2017.07.019_bib15","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0272-0590(87)90048-0","article-title":"Acetylcholinesterase prophylaxis against organophosphate toxicity","volume":"9","author":"Wolfe","year":"1987","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.cbi.2017.07.019_bib16","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.cbi.2013.06.012","article-title":"Progress in the development of enzyme-based nerve agent bioscavengers","volume":"206","author":"Nachon","year":"2013","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2017.07.019_bib17","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1021\/tx0499259","article-title":"Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets","volume":"17","author":"Casida","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbi.2017.07.019_bib18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pharmthera.2014.11.011","article-title":"Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses","volume":"148","author":"Lockridge","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cbi.2017.07.019_bib19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1385\/JMN:30:1:145","article-title":"Bioscavenger for protection from toxicity of organosphosphorus compounds","volume":"30","author":"Saxena","year":"2006","journal-title":"J.\u00a0Mol. Neurosci."},{"key":"10.1016\/j.cbi.2017.07.019_bib20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cbi.2005.10.025","article-title":"Protection against soman or VX poisoning by human butyrylcholinesterase in Guinea pigs and cynomolgus monkeys","volume":"157\u2013158","author":"Lenz","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2017.07.019_bib21","doi-asserted-by":"crossref","first-page":"20251","DOI":"10.1073\/pnas.1009021107","article-title":"Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents","volume":"107","author":"Geyer","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.a."},{"key":"10.1016\/j.cbi.2017.07.019_bib22","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/1098-2299(200007\/08)50:3\/4<298::AID-DDR13>3.0.CO;2-X","article-title":"Prospective of human butyrylcholinesterase as a detoxifying antidote and potential regulator of controlled-release drugs","volume":"50","author":"Ashani","year":"2000","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.cbi.2017.07.019_bib23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cbi.2005.10.013","article-title":"Polyethylene glycosylation prolongs the circulatory stability of recombinant human butyrylcholinesterase","volume":"157\u2013158","author":"Chilukuri","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2017.07.019_bib24","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cbi.2010.01.005","article-title":"Visualization of exogenous delivery of nanoformulated butyrylcholinesterase to the central nervous system","volume":"187","author":"Gaydess","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2017.07.019_bib25","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.bcp.2015.10.005","article-title":"In\u00a0vitro characterization of cationic copolymer-complexed recombinant human butyrylcholinesterase","volume":"98","author":"Pope","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2017.07.019_bib26","first-page":"1","article-title":"Synthesis and storage stability of diisopropylfluorophosphate","author":"Heiss","year":"2016","journal-title":"J.\u00a0Chem."},{"key":"10.1016\/j.cbi.2017.07.019_bib27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ab.2004.02.038","article-title":"Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants","volume":"329","author":"Wang","year":"2004","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbi.2017.07.019_bib28","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1021\/bi048238d","article-title":"Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging","volume":"44","author":"Nachon","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbi.2017.07.019_bib29","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.msec.2016.01.092","article-title":"Effect of cationic grafted copolymer structure on the encapsulation of bovine serum albumin","volume":"62","author":"Flynn","year":"2016","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.cbi.2017.07.019_bib30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A\u00a0new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellamn","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2017.07.019_bib31","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1432-1033.1972.tb01689.x","article-title":"Inactivation, stabilization and some properties of ATP: glutamine synthetase adenylyltransferase from Escherichia coli B","volume":"25","author":"Wolf","year":"1972","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.cbi.2017.07.019_bib32","doi-asserted-by":"crossref","first-page":"21530","DOI":"10.1074\/jbc.M112.372961","article-title":"Serum albumin prevents protein aggregation and amyloid formation and retains chaperone-like activity in the presence of physiological ligands","volume":"287","author":"Finn","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cbi.2017.07.019_bib33","series-title":"Handbook of Toxicology of Chemical Warfare Agents","first-page":"859","article-title":"Biomarkers and biosensors of delayed neuropathic agents","author":"Richardson","year":"2015"},{"key":"10.1016\/j.cbi.2017.07.019_bib34","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1007\/s00253-013-5053-0","article-title":"Improved thermostability of a Bacillus subtilis esterase by domain exchange","volume":"98","author":"Gall","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.cbi.2017.07.019_bib35","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1134\/S0006297912100070","article-title":"Time-dependent kinetic complexities in cholinesterase-catalyzed reactions","volume":"77","author":"Masson","year":"2012","journal-title":"Biochem. Mosc"},{"key":"10.1016\/j.cbi.2017.07.019_bib36","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cbi.2012.12.005","article-title":"The significance of low substrate concentration measurements for mechanistic interpretation in cholinesterases","volume":"203","author":"Stojan","year":"2013","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2017.07.019_bib37","unstructured":"U.S. EPA, Estimation Programs Interface Suite for Microsoft Windows, (n.d.)."},{"key":"10.1016\/j.cbi.2017.07.019_bib38","first-page":"96","article-title":"\u00dcber die Dissociationsw\u00e4rme und den Einfluss der Temperatur auf den Dissociationsgrad der Elektrolyte","volume":"4","author":"Arrhenius","year":"1889","journal-title":"Z.\u00a0Phys. Chem."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279717304830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279717304830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:46:23Z","timestamp":1762112783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279717304830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":38,"alternative-id":["S0009279717304830"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2017.07.019","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polyionic complexes of butyrylcholinesterase and poly-l-lysine-g-poly(ethylene glycol): Comparative kinetics of catalysis and inhibition and in\u00a0vitro inactivation by proteases and heat","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2017.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}