{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T01:33:26Z","timestamp":1789263206748,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000555","name":"British Microcirculation Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001428","name":"Amity University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.cbi.2017.10.018","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T16:04:03Z","timestamp":1508342643000},"page":"114-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Human kidney stone matrix: Latent potential to restrain COM induced cytotoxicity and inflammatory response"],"prefix":"10.1016","volume":"278","author":[{"given":"Shifa","family":"Narula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simran","family":"Tandon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Baligar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrawan Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanderdeep","family":"Tandon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2017.10.018_bib1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1590\/S1677-55382010000400011","article-title":"Diminution of oxalate induced renal tubular epithelial cell injury and inhibition of calcium oxalate crystallization in vitro by aqueous extract of Tribulus terrestris","volume":"36","author":"Aggarwal","year":"2010","journal-title":"Int. Braz J. Urol."},{"key":"10.1016\/j.cbi.2017.10.018_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/292953","article-title":"Nephrolithiasis: molecular mechanism of renal stone formation and the critical role played by modulators","volume":"2013","author":"Aggarwal","year":"2013","journal-title":"Biomed. Res. Int."},{"issue":"7","key":"10.1016\/j.cbi.2017.10.018_bib3","doi-asserted-by":"crossref","first-page":"69916","DOI":"10.1371\/journal.pone.0069916","article-title":"Peeping into human renal calcium oxalate stone matrix: characterization of novel proteins involved in the intricate mechanism of urolithiasis","volume":"8","author":"Aggarwal","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2017.10.018_bib4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.eeus.2007.03.002","article-title":"The role of urinary kidney stone inhibitors and promoters in the pathogenesis of calcium containing renal stones","volume":"5","author":"Basavaraj","year":"2007","journal-title":"EAU-EBU update Ser."},{"issue":"4","key":"10.1016\/j.cbi.2017.10.018_bib5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0002-9343(68)90203-9","article-title":"Organic matrix of human urinary concretions","volume":"45","author":"Boyce","year":"1968","journal-title":"Am. J. Med."},{"key":"10.1016\/j.cbi.2017.10.018_bib6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbi.2017.10.018_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1590\/S0100-879X2000000100015","article-title":"Mechanisms involved in calcium oxalate endocytosis by Madin-Darby canine kidney cells","volume":"33","author":"Campos","year":"2000","journal-title":"Braz J. Med. Biol. Res."},{"issue":"1","key":"10.1016\/j.cbi.2017.10.018_bib8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jsb.2005.04.005","article-title":"Intracrystalline proteins and calcium oxalate crystal degradation in MDCK II cells","volume":"151","author":"Chauvet","year":"2005","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.cbi.2017.10.018_bib9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s40620-015-0210-4","article-title":"Treatment effect, adherence, and safety of high fluid intake for the prevention of incident and recurrent kidney stones: a systematic review and meta-analysis","volume":"29","author":"Cheungpasitporn","year":"2016","journal-title":"J. Nephrol."},{"key":"10.1016\/j.cbi.2017.10.018_bib10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0945-053X(00)00108-6","article-title":"Osteopontin: a versatile regulator of inflammation and biomineralization","volume":"19","author":"Giachelli","year":"2000","journal-title":"Matrix Biol."},{"key":"10.1016\/j.cbi.2017.10.018_bib11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1046\/j.1464-410x.2001.00972.x","article-title":"Effect of experimental hyperoxaluria on renal calcium oxalate monohydrate binding proteins in the rat","volume":"87","author":"Kalaiselvi","year":"2001","journal-title":"Braz. J. Urol. Int."},{"key":"10.1016\/j.cbi.2017.10.018_bib12","first-page":"1","article-title":"Evaluation of the viability of L-929 cells in the presence of alendronate and absorption enhancers","volume":"31","author":"Karamustafa","year":"2006","journal-title":"Fabad J. Pharm. Sci."},{"key":"10.1016\/j.cbi.2017.10.018_bib13","first-page":"S457","article-title":"Crystal-cell interaction and apoptosis in oxalate-associated injury of renal epithelial cells","volume":"10","author":"Khan","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cbi.2017.10.018_bib14","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0022-5347(05)64621-6","article-title":"Expression of osteopontin in rat kidneys: induction during ethylene glycol induced calcium oxalate nephrolithiasis","volume":"168","author":"Khan","year":"2002","journal-title":"J. Urol."},{"key":"10.1016\/j.cbi.2017.10.018_bib15","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.2741\/1347","article-title":"Modulators of urinary stone formation","volume":"9","author":"Khan","year":"2004","journal-title":"Front. Biosci."},{"key":"10.1016\/j.cbi.2017.10.018_bib16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000283025","article-title":"Interactions between stone forming calcific crystals and macromolecules","volume":"59","author":"Khan","year":"2005","journal-title":"Urol. Int."},{"key":"10.1016\/j.cbi.2017.10.018_bib17","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1046\/j.1464-410X.2003.04139.x","article-title":"Cell-surface matrix proteins and sialic acids in cell-crystal adhesion; the effect of crystal binding on the viability of human CAKI-1 renal epithelial cells","volume":"91","author":"Kramer","year":"2003","journal-title":"Braz J. Urol. Int."},{"issue":"1","key":"10.1016\/j.cbi.2017.10.018_bib18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000046293","article-title":"Cell-crystal interactions and kidney stone formation","volume":"81","author":"Lieske","year":"1999","journal-title":"Nephron"},{"key":"10.1016\/j.cbi.2017.10.018_bib19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00467-008-0960-5","article-title":"History, epidemiology and regional diversities of urolithiasis","volume":"25","author":"L\u00f3pez","year":"2010","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.cbi.2017.10.018_bib20","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1038\/ki.1997.243","article-title":"Osteopontin regulation in cultured rat renal epithelial cells","volume":"51","author":"Malyankar","year":"1997","journal-title":"Kidney Int."},{"key":"10.1016\/j.cbi.2017.10.018_bib21","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s00018-004-4464-6","article-title":"Hsp70 chaperones: cellular functions and molecular mechanism","volume":"62","author":"Mayer","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.cbi.2017.10.018_bib22","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ymeth.2007.06.006","article-title":"Heat shock protein 70 (Hsp70): membrane location, export and immunological relevance","volume":"43","author":"Multhoff","year":"2007","journal-title":"Methods"},{"key":"10.1016\/j.cbi.2017.10.018_bib23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.lfs.2016.08.026","article-title":"Kidney stone matrix proteins ameliorate calcium oxalate monohydrate induced apoptotic injury to renal epithelial cells","volume":"164","author":"Narula","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.cbi.2017.10.018_bib24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cca.2009.06.041","article-title":"Mass spectrometric identification of human phosphate cytidylyltransferase 1 as a novel calcium oxalate crystal growth inhibitor purified from human renal stone matrix","volume":"408","author":"Pathak","year":"2009","journal-title":"Clin. Chim. Acta."},{"key":"10.1016\/j.cbi.2017.10.018_bib25","doi-asserted-by":"crossref","first-page":"38536","DOI":"10.1038\/srep38536","article-title":"Caffeine prevents kidney stone formation by translocation of apical surface annexin A1 crystal-binding protein into cytoplasm: in vitro evidence","volume":"6","author":"Peerapen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2017.10.018_bib26","doi-asserted-by":"crossref","first-page":"28882","DOI":"10.1038\/srep28882","article-title":"Osteopontin deficiency reduces kidney damage from hypercholesterolemia in Apolipoprotein E-deficient mice","volume":"6","author":"Pei","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2017.10.018_bib27","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/jcp.2004.019588","article-title":"Chemical pathology clinical investigation and management of nephrolithiasis","volume":"58","author":"Reynolds","year":"2005","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.cbi.2017.10.018_bib28","first-page":"e89","article-title":"Kidney stones: a global picture of prevalence, incidence, and associated risk factors","volume":"12","author":"Romero","year":"2010","journal-title":"Rev. Urol."},{"key":"10.1016\/j.cbi.2017.10.018_bib29","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s002400000150","article-title":"Renal tubular injury induced by hyperoxaluria: evaluation of apoptotic changes","volume":"29","author":"Sarica","year":"2001","journal-title":"Urol. Res."},{"key":"10.1016\/j.cbi.2017.10.018_bib30","doi-asserted-by":"crossref","first-page":"e2013","DOI":"10.1038\/cddis.2015.359","article-title":"New view in cell death mode: effect of crystal size in renal epithelial cells","volume":"6","author":"Sun","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2017.10.018_bib31","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1039\/C4TB01626B","article-title":"Size-dependent toxicity and interactions of calcium oxalate dihydrate crystals on Vero renal epithelial cells","volume":"3","author":"Sun","year":"2015","journal-title":"J. Mat. Chem. B"},{"key":"10.1016\/j.cbi.2017.10.018_bib32","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.cca.2005.11.033","article-title":"Factors determining types and morphologies of calcium oxalate crystals: molar concentrations, buffering, pH, stirring and temperature","volume":"367","author":"Thongboonkerd","year":"2006","journal-title":"Clin. Chim. Acta."},{"issue":"11","key":"10.1016\/j.cbi.2017.10.018_bib33","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1021\/pr8002408","article-title":"Proteomic analysis of calcium oxalate monohydrate crystal-induced cytotoxicity in distal renal tubular cells","volume":"7","author":"Thongboonkerd","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cbi.2017.10.018_bib34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1046\/j.1523-1755.2002.00106.x","article-title":"Oxalate ions and calcium oxalate crystals stimulate MCP-1 expression by renal epithelial cells","volume":"61","author":"Umekawa","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.cbi.2017.10.018_bib35","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1681\/ASN.V1351210","article-title":"Osteopontin synthesis and localization along the human nephron","volume":"13","author":"Verhulst","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cbi.2017.10.018_bib36","first-page":"F958","article-title":"Increased calcium oxalat monohydrate crystal binding to injured renal tubular epithelial cells in culture","volume":"274","author":"Verkoelen","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cbi.2017.10.018_bib37","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1046\/j.1523-1755.2000.00934.x","article-title":"Sialic acid and crystal binding","volume":"57","author":"Verkoelen","year":"2000","journal-title":"Kidney Int."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279717307184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279717307184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:46:24Z","timestamp":1757857584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279717307184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":37,"alternative-id":["S0009279717307184"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2017.10.018","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human kidney stone matrix: Latent potential to restrain COM induced cytotoxicity and inflammatory response","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2017.10.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}